The special role of CXCL13 in Lyme neuroborreliosis: a case report

The diagnosis of chronic lyme neuroborreliosis can be a challenge even for experienced neurologists. The clinical picture may be multifaceted, including polyradiculitis to cranial nerve palsies, meningitis, encephalomyelitis, encephalopathy and peripheral neuropathy. We report on a patient presenting with basal leptomeningoencephalitis associated with vasculopathy where the chemokine CXCL13 in cerebrospinal fluid played an important diagnostic role.

Anticancer and Antibiotic Rhenium Tri- and Dicarbonyl Complexes: Current Research and Future Perspectives

Organometallic compounds are increasingly recognized as promising anticancer and antibiotic drug candidates. Among the transition metal ions investigated for these purposes, rhenium occupies a special role. Its tri- and dicarbonyl complexes, in particular, attract continuous attention due to their relative ease of preparation, stability and unique photophysical and luminescent properties that allow the combination of diagnostic and therapeutic purposes, thereby permitting, e.g., molecules to be tracked within cells. In this review, we discuss the anticancer and antibiotic properties of rhenium tri- and dicarbonyl complexes described in the last seven years, mainly in terms of their structural variations and in vitro efficacy. Given the abundant literature available, the focus is initially directed on tricarbonyl complexes of rhenium. Dicarbonyl species of the metal ion, which are slowly gaining momentum, are discussed in the second part in terms of future perspective for the possible developments in the field.

Problems of Decision-Making in Implementation of Technological Innovations in Transport Industry

The article considers the features of transport as an object of technological innovation, due, on the one hand, to the service nature of the main activity and the specifics of innovative processes during provision of transport and logistics services, and, on the other hand, to the high capital intensity and technological complexity of the infrastructure transport complex, which is the focus point of technological innovation.The objective of the article is to substantiate the initial prerequisites for developing an alternative approach to making strategic decisions on development of transport organisations based on technological innovations, which, besides the traditional justification of economic efficiency, considers several non-economic factors. The method of substantiation is a systemic strategic analysis, which allows to study the features of the transport complex in the context of the factors of external environment and their dynamics.Regarding the Russian Federation, the scale of the national territory, natural and climatic diversity and uneven territorial distribution of the resource and production base determine the special role and place of transport in the national economy, which quite often leads to the need to make decisions on development of the transport complex based on predominantly non-economic factors (such as security, reliability, environmental friendliness, etc.) and on scientific, technical, political and socio-economic forecasts. At the same time, private enterprises (with or without participation of the state) dominate currently almost all transport sectors where they operate on the principles of profitability, investment attractiveness and competitiveness, which leads to inconsistency of internal decision-making criteria in the field of technological strategies.The ongoing change in the technological paradigm is an additional and significant factor determining trends in transport developments. It is based on the processes of digitalisation and digital transformation of the transport and logistics business. The problems of decision-making in implementation of technological innovations in transport industry, arising from its peculiarities, necessitate a revision of approaches since economic assessments of efficiency are not always able to reflect the real needs and feasibility of choosing mainstream trends in technological development of the transport system.The analysis of the features of the transport and logistics industry based on universal experience and cases in Russian practices in the context of formation of a new technological paradigm makes it possible to substantiate the methodology for making strategic decisions on implementation of technological innovations.

An App about Healthy Habits as an Educational Resource during the Pandemic

Educational institutions and their agents play a fundamental role in improving people’s health literacy and quality of life. We intend here to describe and justify an educational resource embodied in an application for mobile devices developed through a subsidized project by the Ministry of Health (Government of Andalusia); the purpose of this app is to educate young people in healthy habits. The application was designed to be easily used in both smartphones and tablets with the aim of achieving good physical, psychological and social health. The project comprises several phases and the results we have so far show that, from an early age, health institutions and educational settings must work in partnership, increasing health literacy levels. This cooperative work combined with the use of this innovative approach presents an important potential for change in the lifestyles of younger generations. This type of intervention took on a special role in the pandemic context, allowing for the maintenance of the educational stimulus in a safe context.

Explaining Valence Asymmetries in Value Learning: A Reinforcement Learning Account

To understand how acquired value impacts how we perceive and process stimuli, psychologists have developed the Value Learning Task (VLT; e.g., Raymond & O’Brien, 2009). The task consists of a series of trials in which participants attempt to maximize accumulated winnings as they make choices from a pair of presented images associated with probabilistic win, loss, or no-change outcomes. Despite the task having a symmetric outcome structure for win and loss pairs, people learn win associations better than loss associations (Lin, Cabrera-Haro, & Reuter-Lorenz, 2020). This asymmetry could lead to differences when the stimuli are probed in subsequent tasks, compromising inferences about how acquired value affects downstream processing. We investigate the nature of the asymmetry using a standard error-driven reinforcement learning model with a softmax choice rule. Despite having no special role for valence, the model yields the asymmetry observed in human behavior, whether the model parameters are set to maximize empirical fit, or task payoff. The asymmetry arises from an interaction between a neutral initial value estimate and a choice policy that exploits while exploring, leading to more poorly discriminated value estimates for loss stimuli. We also show how differences in estimated individual learning rates help to explain individual differences in the observed win-loss asymmetries, and how the final value estimates produced by the model provide a simple account of a post-learning explicit value categorization task.

BOOSTING STUDENTS’ MOTIVATION IN THE PROCESS OF STUDYING PRACTICAL COURSE OF THE GERMAN LANGUAGE DURING DISTANCE LEARNING

The article considers the question of boosting motivation of language specialty students during distance learning. The problem of increasing students’ motivation during distance learning is complex, completely unresolved and relevant. It is closely related to the questions of lesson organization and conducting, ways of intensifying students’ cognitive activities in the study group, the ability to provide constructive support and exchange views on different topics. The purpose of the given article is to check on the basis of the obtained practical results what means and methods can increase students’ motivation in the process of studying practical course of the German language. It is established that the crucial prerequisite for successful online learning is a conscious consideration of the motivational factor and the ability to manage it throughout the learning process. The effective factors of online lessons are indicated in the paper: well-selected and prepared material, teaching methods tested by experience and based on technical tools on various educational platforms, selected, structured and appropriately used content, forms and teaching aids. The means and methods of boosting students’ motivation in the process of studying Practical course of the German language are analyzed, considering the specific nature of this subject. It is established that the implementation of the conceptual ideas of education is carried out with the help of information technology, which is based on the fundamental didactic principles – activation, autonomy, constructiveness and a special role is paid to the whole study group. The functions and tasks of the tutor, his role in the formation of a sense of group unity in order to intensify students’ activities during distance learning are revealed. Recommendations for boosting students’ motivation in the process of online studying Practical course of the German language are developed.

Phylogenetic and protein prediction analysis reveals the taxonomically diverse distribution of virulence factors in the Bacillus cereus group

Bacillus cereus is a food contaminant with widely varying enterotoxic potential of its virulence proteins. In this article, phylogenetic analysis of the whole-genome amino acid sequences of 41 strains, evolutionary distance calculation of the amino acid sequences of the virulence genes, and functional and structural prediction of the virulence proteins were performed to reveal the taxonomically diverse distribution of virulence factors. The genome evolution of the strains showed a clustering trend based on the coding virulence genes. The strains of B. cereus have evolved into non-toxic risk and toxic risk clusters with medium-high- and medium-low-risk clusters. The distances of evolutionary transfer relative to housekeeping genes of incomplete virulence genes were greater than those of complete virulence genes, and the distance values of HblACD were higher than those of nheABC and CytK among the complete virulence genes. Cytoplasmic localization was impossible for all the virulence proteins, and NheB, NheC, Hbl-B, and Hbl-L 1 were extracellular according to predictive analysis. Nhe and Hbl proteins except CytK had similar spatial structures. The predicted structures of Nhe and Hbl mainly showed ‘head’ and ‘tail’ domains. The ‘head’ of NheA and Hbl-B, including two α-helices separated by β-tongue strands, might play a special role in Nhe trimers and Hbl trimers, respectively. The ‘cap’ of CytK, which includes two ‘latches’ with many β-sheets, formed a β-barrel structure with pores, and a ‘rim’ balanced the structure. The evolution of B. cereus strains showed a clustering tendency based on the coding virulence genes, and the complete virulence-gene operon combination had higher relative genetic stability. The beta-tongue or latch associated with β-sheet folding might play an important role in the binding of virulence structures and pore-forming toxins in B. cereus .

EXPRESS: Are animates special? Exploring the effects of selective attention and animacy on visual statistical learning

Our visual system is built to extract regularities in how objects within our visual environment appear in relation to each other across time and space (‘visual statistical learning’). Existing research indicates that visual statistical learning is modulated by selective attention. Our attentional system prioritises information that enables behaviour; for example, animates are prioritised over inanimates (the ‘animacy advantage’). The present study examined the effects of selective attention and animacy on visual statistical learning in young adults (N = 284). We tested visual statistical learning of attended and unattended information across four animacy conditions: (i) living things that can self-initiate movement (animals); (ii) living things that cannot self-initiate movement (fruits and vegetables); (iii) non-living things that can generate movement (vehicles); and (iv) non-living things that cannot generate movement (tools and kitchen utensils). We implemented a four-point confidence-rating scale as an assessment of participants’ awareness of the regularities in the visual statistical learning task. There were four key findings. First, selective attention plays a critical role by modulating visual statistical learning. Second, animacy does not play a special role in visual statistical learning. Third, visual statistical learning of attended information cannot be exclusively accounted for by unconscious knowledge. Fourth, performance on the visual statistical learning task is associated with the proportion of stimuli that were named or labelled. Our findings support the notion that visual statistical learning is a powerful mechanism by which our visual system resolves an abundance of sensory input over time.

State Support of Plant Protection (by the Example of Novosibirsk Region)

Modern crop production in the conditions of total reduction of tilled area is one of the priorities in effective farming. The adaptive intensification of crop production, which provides sustainable growth of yield, resource conservation and ecological safety, requires increase of financing and involvement of plant protection measures in the mechanism of state support, the use of genetic selection potential of plants, the use of agrotechnical measures, technical and technological upgrade, for the purpose of adjustment of arable crops growth conditions, improvement of grain quality, as well as soil conservation and enrichment. Scientifically proven measures regarding plant protection against hazardous organisms play a special role in the mechanism of state support and stimulation of agricultural goods producers. This approach will make it possible to abandon abusive application of chemical agents and replace them with biological ones against the same variety of pathogens; it will facilitate increase in arable crops yield, improve of quality of goods produced, cost saving and growth of net profit, in comparison with traditional technologies, as well as mitigate risks related to the influence of chemical agents on the environment. It will increase the field competitiveness both at internal and external market. The offered measures were developed with provision for the WTO requirements which make it bin­ding to implement the methods of state support without distorting influence of activities of companies, i.e. implement the support within the «green box». The «green box» includes the costs of plant protection measures and productive infrastructure formation.

Romanian naval dimplomacy, continuous evolution in the swirl of external diplomacy

From ancient times the dominion of the seas has been a condition for gaining power and influence, and the position of a state near a sea has been an advantage for both its development and the neighboring region. Due to its geographical position, the Black Sea is a region of great importance for all actors claiming leading positions in the world hierarchy and the intensification of economic relations between the states of the region after the end of the Soviet monopoly and its connection to the world market generated auspices for a new cycle development and regional prosperity. The relocation of the EU border to the Black Sea, along with the integration of Romania and Bulgaria, brings in many economic benefits, given its dependence on oil imports, but its expansion, like that of NATO, does not only mean benefits. The EU and NATO must also take on vulnerabilities in the area, such as underperforming economies, arms, drug and human trafficking, illegal immigration or frozen conflicts, and thus try to help stabilize the region. In recent years, the military has not only played a destabilizing role, but has made a decisive contribution to ensuring the security of the Black Sea region. In this sense, the military naval forces of the riparian countries, including Romania, had a special role. Through the wide range of missions in which the Romanian Naval Forces participate in the Danubian-Pontic space, both internally and externally, in cooperation with the states bordering the Black Sea and with the NATO member states, Romania contributes to the promotion of regional security and stability. The naval diplomacy actions carried out in the last thirty years thus reveal not only the role and purpose of the Romanian Naval Forces within NATO in the actions of maintaining and consolidating good relations with the states bordering the Black Sea, as well as maintaining security with allies in the distant maritime districts. They also point out that naval diplomacy has contributed to the expression of foreign policy in different areas and with means that have increased its effect, impact and efficiency.