scholarly journals Non-invasive haemodynamic assessments among hypertensive patients in a routine family doctor’s office

2021 ◽  
Author(s):  
Bartosz Trzeciak ◽  
Piotr Gutknecht ◽  
Natalia Marek-Trzonkowska ◽  
Andrzej Molisz ◽  
Rafał Czaja ◽  
...  
Keyword(s):  
Hypertensive Patients ◽  
Non Invasive ◽  
Doctor's Office

Myocardial work in Stage 1 and 2 hypertensive patients

2021 ◽  
Author(s):  
Akshar Jaglan ◽  
Sarah Roemer ◽  
Ana Cristina Perez Moreno ◽  
Bijoy K Khandheria
Keyword(s):  
Ejection Fraction ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Non Invasive ◽  
Significant Difference ◽  
Lv Ejection Fraction ◽  
Global Work ◽  
Stage 1

Abstract Aims Myocardial work (MW) is a novel parameter that can be used in a clinical setting to assess left ventricular (LV) pressures and deformation. We sought to distinguish patterns of global MW index in hypertensive vs. non-hypertensive patients and to look at differences between categories of hypertension. Methods and results Sixty-five hypertensive patients (mean age 65 ± 13 years; 30 male) and 15 controls (mean age 38 ± 12 years; 7 male) underwent transthoracic echocardiography at rest. Hypertensive patients were subdivided into Stage 1 (n = 32) and Stage 2 (n = 33) hypertension based on 2017 American College of Cardiology guidelines. Exclusion criteria were suboptimal image quality for myocardial deformation analysis, reduced ejection fraction, valvular heart disease, intracardiac shunt, and arrhythmia. Global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency were estimated from LV pressure–strain loops utilizing proprietary software from speckle-tracking echocardiography. LV systolic and diastolic pressures were estimated using non-invasive brachial artery cuff pressure. Global longitudinal strain and LV ejection fraction were preserved between the groups with no statistically significant difference, whereas there was a statically significant difference between the control and two hypertension groups in GWI (P = 0.01), GCW (P < 0.001), and GWW (P < 0.001). Conclusion Non-invasive MW analysis allows better understanding of LV response under conditions of increased afterload. MW is an advanced assessment of LV systolic function in hypertension patients, giving a closer look at the relationship between LV pressure and contractility in settings of increased load dependency than LV ejection fraction and global longitudinal strain.

Non-invasive evaluation of arterial abnormalities in hypertensive patients

1997 ◽  
Vol 15 ◽  
pp. S99-S107 ◽  
Author(s):  
Roland G. Asmar ◽  
Jirar A. Topouchian ◽  
Athanase Benetos ◽  
Fady A. Sayegh ◽  
Jean-Jacques Mourad ◽  
...  
Keyword(s):  
Hypertensive Patients ◽  
Non Invasive ◽  
Invasive Evaluation

scholarly journals Decreased Urinary Levels of SIRT1 as Non-Invasive Biomarker of Early Renal Damage in Hypertension

2020 ◽  
Vol 21 (17) ◽  
pp. 6390
Author(s):  
Olga Martinez-Arroyo ◽  
Ana Ortega ◽  
Miriam Galera ◽  
Elena Solaz ◽  
Sergio Martinez-Hervas ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
High Glucose ◽  
Renal Damage ◽  
Strong Association ◽  
Hypertensive Patients ◽  
Non Invasive ◽  
Treatment Conditions ◽  
Invasive Method ◽  
Polymerase Chain

Sirtuins have become important players in renal damage in hypertension and diabetes, but their value as biomarkers is poorly assessed. The aims of the study were to evaluate the levels of sirtuin1 (SIRT1), and two miRNAs that regulate SIRT1 expression in hypertensive patients with incipient renal damage with and without diabetes. We quantified urinary SIRT1 and claudin 1 (CLDN1) mRNA and miR34-a and miR-200a levels by quantitative real-time polymerase chain reaction (RT-qPCR) from patients and in cultured podocytes treated with high glucose and angiotensin II. Western blot and fluorescence analyses were also performed. We found decreased SIRT1 levels in patients with increased urinary albumin excretion (UAE), the lowest with diabetes presence, and a strong association with UAE, discriminating incipient renal damage. In vitro experiments also showed SIRT1 overall decreases in podocyte cultures under treatment conditions. In urine samples, miR-34a was reduced and miR-200a increased, both related to UAE levels. However, both miRNAs were generally increased in podocyte cultures under high glucose and angiotensin-II treatment. These results show a significant urinary SIRT1 decrease in albuminuric hypertensive patients, strongly associated with albuminuria, suggesting that SIRT1 could be a potential and non-invasive method to assess incipient renal damage in hypertensive patients.

NON INVASIVE DETECTION OF CONDUIT ARTERY ENDOTHELIAL DYSFUNCTION BY HAND SKIN HEATING IN UNTREATED HYPERTENSIVE PATIENTS

2004 ◽  
Vol 22 (Suppl. 2) ◽  
pp. S51-S52
Author(s):  
J. Bellien ◽  
R. Joannides ◽  
C. Thurlure ◽  
M. lacob ◽  
C. Thuillez
Keyword(s):  
Endothelial Dysfunction ◽  
Hypertensive Patients ◽  
Conduit Artery ◽  
Non Invasive

scholarly journals Detection of coronary in hypertensive patients: Are non-invasive adequate?

1990 ◽  
Vol 15 (2) ◽  
pp. A141
Author(s):  
Susan P. Graham ◽  
Helen M. Sheehan ◽  
John McB Hodgson ◽  
Pramod K. Mohanty
Keyword(s):  
Hypertensive Patients ◽  
Non Invasive

A Non-Invasive γ-Camera Technique for the Measurement of Intrarenal Flow Distribution in Man

1981 ◽  
Vol 61 (4) ◽  
pp. 385-389 ◽  
Author(s):  
S. M. Gruenewald ◽  
C. C. Nimmon ◽  
M. K. Nawaz ◽  
K. E. Britton
Keyword(s):  
Flow Distribution ◽  
Region Of Interest ◽  
Human Kidney ◽  
Normal Subjects ◽  
Hypertensive Patients ◽  
Renal Autoregulation ◽  
Non Invasive ◽  
Transit Times ◽  
Left And Right ◽  
The Mean

1. A new method, based on the transit time of o-iodohippurate sodium (Hippuran) through the kidney, is proposed as an accurate non-invasive means of measuring the intrarenal flow distribution in man. 2. Data from [123I]Hippuran γ-camera renography are utilized in this method which employs region of interest selection, deconvolution, cross-correlation and curve subtraction to obtain the spectrum of transit times through the cortical and juxtamedullary nephrons. 3. In 12 normal subjects the mean percentage cortical flow was 83.9% (sem 0.7%) which is approximately the anatomical proportion of cortical nephrons in the human kidney. 4. Cortical flow as a percentage of total was significantly reduced in 21 hypertensive patients, all of whom had no evidence of primary renal disease (mean 74.6%, sem 1.5%). 5. In both the normotensive and hypertensive groups there was a good correlation between the results obtained from the left and right kidneys of the same patient showing the parallel physiological response of the two kidneys (mean difference 4%, P < 0.001). 6. Reduction in the distribution of flow to the cortical nephrons in the essential hypertensive patients supports the hypothesis that renal autoregulation is important in this syndrome.

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