scholarly journals Mechanism of action of triclosan as an endocrine-disrupting chemical with its impact on human health – literature review

2021 ◽  
Author(s):  
Marcela Maksymowicz ◽  
Piotr Machowiec ◽  
Gabriela Ręka ◽  
Anna Korzeniowska ◽  
Patryk Leszczyk ◽  
...  
Keyword(s):  
Literature Review ◽  
Human Health ◽  
Mechanism Of Action ◽  
Endocrine Disrupting Chemical ◽  
Health Literature ◽  
Endocrine Disrupting

scholarly journals Fusarium mycotoxins and human health

2011 ◽  
Vol 64 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Gordon Shephard
Keyword(s):  
Human Health ◽  
Food Additives ◽  
Expert Committee ◽  
Diverse Range ◽  
Endocrine Disrupting Chemical ◽  
Toxicological Effects ◽  
Naturally Occurring ◽  
Carcinogenic Potential ◽  
Endocrine Disrupting ◽  
Daily Intakes

Fusariummycotoxins and human healthSpecies within the genusFusariumproduce a diverse range of mycotoxins, many of which have significant impacts on human health. Of the five generally recognised major mycotoxins, three (fumonisins, deoxynivalenol (DON) and zearalenone (ZON)) are produced by Fusaria. Apart from DON, other trichothecenes such as T-2 toxin, have received considerable international attention due to their impact on human health. The fumonisins, which occur ubiquitously in maize and its products, have been linked to oesophageal cancer, liver cancer and neural tube defects. DON, a frequent contaminant of maize, wheat and their products, although showing no carcinogenic potential, is immunomodulatory and produces emesis and growth retardation in animals. ZON is a naturally occurring endocrine disrupting chemical. Acute exposure to these mycotoxins has in each case been linked to outbreaks of human disease - gastro-intestinal effects in the case of fumonisins and DON, and precocious pubertal changes in the case of ZON. Concern over their toxicological effects has led to risk assessments by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which has set maximum tolerable daily intakes (TDI) of 2 μg/ kg body weight (bw) for fumonisins and 0.5 μg/kg bw for ZON. The initial TDI set for DON, namely 1 μg/kg bw has recently been updated by JECFA to include both 3 - and 15-acetylDON. Apart from the above mycotoxins, a number of other secondary metabolites (moniliformin, beauvericin and fusaproliferin) are produced by different Fusaria and their effects on human health, either alone or in combination with other mycotoxins, is largely unexplored.

scholarly journals Bisphenol A Analogues: A Brief Review of their Occurrence in Food, Biological Samples and Endocrine Effects

2020 ◽  
Vol 2 (4) ◽  
pp. 89-94
Author(s):  
Nikola Knizatova ◽  
Katarína Tokárová ◽  
Hana Greifová ◽  
Tomáš Jambor ◽  
Peter Massányi ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Health ◽  
Human Exposure ◽  
Food Packaging ◽  
In Vitro Tests ◽  
Endocrine Disrupting Chemical ◽  
Endocrine Disrupting ◽  
Made In

Bisphenol A (BPA) is the most well-known compound from the bisphenol family. There is increasing evidence that bisphenol BPA used in plastics, receipts, food packaging, and other products might be harmful to human health due to its actions as an endocrine-disrupting chemical, therefore BPA is being replaced by compounds very similar in structure, but data on the occurrence and effects of these BPA analogs are limited. Therefore, there is increasing concern regarding human exposure to bisphenol analogs (BPs) due to their widespread use and potential adverse effects. The main objective of this work was to investigate human exposure to BPs and the associated endocrine activities. We performed a literature review of the available research made in humans, in in vivo and in vitro tests. The findings support the idea that exposure to BPs may have an impact on human health, especially in terms of endocrine disruption.

scholarly journals Rapamycin: Drug Repurposing in SARS-CoV-2 Infection

2021 ◽  
Vol 14 (3) ◽  
pp. 217
Author(s):  
Jiri Patocka ◽  
Kamil Kuca ◽  
Patrik Oleksak ◽  
Eugenie Nepovimova ◽  
Martin Valis ◽  
...  
Keyword(s):  
Literature Review ◽  
Human Health ◽  
World Economy ◽  
Web Of Science ◽  
Drug Repurposing ◽  
Final Analysis ◽  
High Rate ◽  
Suitable Candidate ◽  
Promising Strategy ◽  
The World

Since December 2019, SARS-CoV-2 (COVID-19) has been a worldwide pandemic with enormous consequences for human health and the world economy. Remdesivir is the only drug in the world that has been approved for the treating of COVID-19. This drug, as well as vaccination, still has uncertain effectiveness. Drug repurposing could be a promising strategy how to find an appropriate molecule: rapamycin could be one of them. The authors performed a systematic literature review of available studies on the research describing rapamycin in association with COVID-19 infection. Only peer-reviewed English-written articles from the world’s acknowledged databases Web of Science, PubMed, Springer and Scopus were involved. Five articles were eventually included in the final analysis. The findings indicate that rapamycin seems to be a suitable candidate for drug repurposing. In addition, it may represent a better candidate for COVID-19 therapy than commonly tested antivirals. It is also likely that its efficiency will not be reduced by the high rate of viral RNA mutation.

scholarly journals Endocrine disrupting chemical-associated hair product use during pregnancy and gestational age at delivery: a pilot study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Emma V. Preston ◽  
Victoria Fruh ◽  
Marlee R. Quinn ◽  
Michele R. Hacker ◽  
Blair J. Wylie ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Black Women ◽  
Pilot Study ◽  
Gestational Age ◽  
Endocrine Disrupting Chemical ◽  
Product Use ◽  
Frequent Use ◽  
Increased Risk ◽  
Endocrine Disrupting ◽  
Gestational Age At Delivery

Abstract Background Prenatal endocrine disrupting chemical (EDC) exposure has been associated with increased risk of preterm birth. Non-Hispanic Black women have higher incidence of preterm birth compared to other racial/ethnic groups and may be disproportionately exposed to EDCs through EDC-containing hair products. However, research on the use of EDC-associated hair products during pregnancy and risk of preterm birth is lacking. Therefore, the objective of this pilot study was to estimate associations of prenatal hair product use with gestational age at delivery in a Boston, Massachusetts area pregnancy cohort. Methods The study population consisted of a subset of participants enrolled in the Environmental Reproductive and Glucose Outcomes (ERGO) Study between 2018 and 2020. We collected self-reported data on demographics and hair product use using a previously validated questionnaire at four prenatal visits (median: 12, 19, 26, 36 weeks’ gestation) and abstracted gestational age at delivery from medical records. We compared gestational age and hair product use by race/ethnicity and used linear regression to estimate covariate-adjusted associations of product use and frequency of use at each study visit with gestational age at delivery. Primary models were adjusted for maternal age at enrollment and delivery method. Results Of the 154 study participants, 7% delivered preterm. Non-Hispanic Black participants had lower mean gestational age at delivery compared to non-Hispanic White participants (38.2 vs. 39.2 weeks) and were more likely to report ever and more frequent use of hair products. In regression models, participants reporting daily use of hair oils at visit 4 had lower mean gestational age at delivery compared to non-users (β: -8.3 days; 95% confidence interval: -14.9, -1.6). We did not find evidence of associations at earlier visits or with other products. Conclusions Frequent use of hair oils during late pregnancy may be associated with shorter gestational duration. As hair oils are more commonly used by non-Hispanic Black women and represent potentially modifiable EDC exposure sources, this may have important implications for the known racial disparity in preterm birth.

Review: Etnotaksonomi dan bioekologi tumbuhan pasak bumi (Eurycoma longifolia Jack.)

2021 ◽  
Vol 11 (2) ◽  
pp. 177-178
Author(s):  
Syafitri Hidayati ◽  
Ervizal A.M. Zuhud ◽  
Ivan Khofian Adiyaksa ◽  
Primadhika Al Manar
Keyword(s):  
Literature Review ◽  
Southeast Asia ◽  
Tropical Forest ◽  
Human Health ◽  
Natural Regeneration ◽  
Literature Study ◽  
High Rainfall ◽  
Eurycoma Longifolia ◽  
Economical Benefit ◽  
Eurycoma Longifolia Jack

Eurycoma longifolia (EL) is a species that have economical benefit as medicinal ingredients for human health. This species grows in tropical forest areas with high rainfall. Research on the ecology of EL has been done a lot, but research related to ethnotaxonomic, bioecology that includes morphology, ecology, and the association of EL with other plants hasn’t been done much. This study aim to analyze the bioecology of EL plant. The method is literature study, which is looking for literature on the results of research that has been carried out related to EL. The results showed that EL has long been known by the communities of Indonesia and other countries in Southeast Asia with several local names. This plant is also associated with other plants around where it grows, one of which is kempas (Koompassia malaccensis). Based on the results of literature review, research on natural regeneration of EL hasn’t been done much. Therefore, there is a need for research related to the natural regeneration of EL. In addition, it is necessary to conduct research related to the characteristics of the place to grow for optimal cultivation of EL. Thus, the preservation of EL in the future can be maintained.

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