scholarly journals Formulation and evaluation of bilayer tablets: Glimepiride in floating drug delivery and Metformin in sustained release

2019 ◽  
Vol 10 (3) ◽  
pp. 1602-1607
Author(s):  
Harish Choodappa ◽  
Subramanian Somaskandan
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Guar Gum ◽  
Release Kinetics ◽  
Dose Frequency ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Bilayer Tablets ◽  
Weight Variation ◽  
Floating Drug Delivery

In this study, we aimed to prepare bilayer tablets of Glimepiride in floating drug delivery and Metformin in sustained release formulation. Glimepiride is chosen in floating drug delivery to overcome the gastric irritation and gastric emptying time. Glimepiride was prepared by different polymers such as guar gum, xanthan gum, carbopol and sodium bicarbonate act as effervescent agent, and other excipients were mixed and compressed by direct compression as the first layer.  Metformin was chosen in sustained release to reduce dose frequency using different polymer HPMC K100M, methylcellulose, PVP K30 in different ratio and other excipients were mixed and compressed as the second layer. The first layer and second layer are combined as a bilayer tablet. Tablets were evaluated for hardness, friability, thickness, weight variation; the In vitro studies were done for all formulation. Among all formulation, F2 was selected as best formulation and release kinetics studies were evaluated for formulation F2.

scholarly journals Formulation and Evaluation of Sustained Release Verapamil Hydrochloride Using Natural Polymers

2016 ◽  
Vol 1 (02) ◽  
pp. 76-87
Author(s):  
B. Ramu ◽  
S. Ullas Kumar ◽  
G. Srikanth ◽  
Bigala Rajkamal
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Guar Gum ◽  
Release Kinetics ◽  
Natural Polymers ◽  
Release Formulation ◽  
Verapamil Hydrochloride ◽  
Sustained Release Formulation ◽  
Release Pattern ◽  
Zero Order Release

The aim of the present study was to develop sustained release formulation of Verapamil Hydrochloride to maintain constant therapeutic levels of the drug for over 12 hrs. Various grades of HPMC polymers, Guar gum, and Xanthum gum were employed as polymers. Verapamil Hydrochloride dose was fixed as 120 mg. Total weight of the tablet was considered as 400 mg. Polymers were used in the concentration of 60, 120 and 180 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e.,96.10 % in 12 hours containing Guar gum polymer in the concentration of 180mg. It followed zero order release kinetics. For the optimized formulation alcohol effect has been studied by using various concentrations of alcohol in dissolution medium. As the concentration of alcohol increased the sustained action of polymer was decreased. Hence it was concluded that alcohol has significant effect on drug release pattern.

scholarly journals Formulation of Isoniazide Sustained Release Formulation by Using Carbopol 934 P

2016 ◽  
Vol 1 (02) ◽  
pp. 60-69
Author(s):  
Addanki Gopikrishna ◽  
B. Ramu ◽  
G. Srikanth ◽  
Bigala Rajkamal
Keyword(s):  
Sustained Release ◽  
Guar Gum ◽  
Release Kinetics ◽  
Zero Order ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Dissolution Studies ◽  
Zero Order Release ◽  
Physicochemical Evaluation ◽  
Evaluation Parameters

The aim of the present study was to develop sustained release formulation of Isoniazide to maintain constant therapeutic levels of the drug for over 12 hrs. Various polymers such as Guar gum, HPMCK100 M, PEG 6000 and Carbopol 934 p were employed as polymers. Isoniazide dose was fixed as 100 mg. Total weight of the tablet was considered as 400 mg. Polymers were used in the concentration of 100, 150 and 200 mg. All the formulations passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e.,96.10 % in 12 hours. It followed zero order release kinetics.

Sustained release formulation of Ondansetron HCl using osmotic drug delivery approach

2020 ◽  
Vol 46 (3) ◽  
pp. 343-355
Author(s):  
Ramakant Gundu ◽  
Sanjay Pekamwar ◽  
Santosh Shelke ◽  
Santosh Shep ◽  
Deepak Kulkarni
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Delivery Approach

scholarly journals Formulation and in vitro Evaluation of Glimepiride Sustained Release Tablets: Comparison with Immediate Release Tablets

2015 ◽  
Vol 18 (2) ◽  
pp. 157-162
Author(s):  
Samira Karim ◽  
Mohiuddin Ahmed Bhuiyan ◽  
Md Sohel Rana
Keyword(s):  
Sustained Release ◽  
Immediate Release ◽  
Pharmaceutical Journal ◽  
In Vitro Dissolution ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Zero Order Kinetics ◽  
Weight Variation ◽  
Sustained Release Tablets

This work aims at the design of a sustained release formulation of glimepiride which is currently available in the treatment of type 2 diabetes mellitus and to investigate the effect of polymers on the release profile of glimepiride. Glimepiride sustained release tablets were prepared by direct compression method using different ratios of various release retarding polymers such as carbopol, ethyl cellulose, methocel K4 MCR, methocel K15 MCR, methocel K100 MCR and xanthum gum. These formulations were also compared with glimepiride immediate release tablets. The prepared tablets were subjected to various physical parameter tests including weight variation, friability, hardness, thickness, diameter, etc. In vitro dissolution studies of the formulations were done at pH 6.8 in phosphate buffer using USP apparatus 2 (paddle method) at 50 rpm. The percent releases of all the formulations (30) were 73.11%- 98.76% after 8 hours. The release pattern followed zero order kinetics and the release of the drug was hindered by the polymers used in the study. On the other hand, 100% drug was released within 1 hour from the immediate release tablet of glimepiride. The study reveals that the polymers used have the capacity to retard the release of the drug from the sustained release tablets and the more is the amount of the polymer in the formulation the less is the release of drug showing more retardation of drug release.Bangladesh Pharmaceutical Journal 18(2): 157-162, 2015

scholarly journals Optimization of floating bilayered tablets of Ketorolac Tromethamine

2017 ◽  
Vol 4 (1) ◽  
pp. 14
Author(s):  
Hitesh Jain ◽  
Kinjal Patel ◽  
Neha Savant ◽  
Umesh Upadhyay
Keyword(s):  
Sustained Release ◽  
Sodium Bicarbonate ◽  
Immediate Release ◽  
Ketorolac Tromethamine ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
Sodium Starch Glycolate ◽  
Promising Tool ◽  
Weight Variation ◽  
Floating Layer

Objective: The aim of the present study was to formulate the floating bilayer tablets of Ketorolac tromethamine, first immediate release layer and second sustained release floating layer which would provide initial loading dose of drug and remain in stomach and upper part of GIT for prolonged period of time in a view to maximize solubility of drug which is necessary for its absorption.Methods: The floating bilayered tablets of Ketorolac tromethamine were prepared by using 32 factorial designs by direct compression method. For this, polymers like sodium starch glycolate and polyox WSR 303 were used in various concentrations. Sodium bicarbonate was used as a floating effervescent agent. The formulations were evaluated for hardness, friability, weight variation, swelling index, floating lag time, floating time, % CDR etcResults: From the result obtained, S3 having 23% Polyox WSR 303 and 12% sodium bicarbonate showed better results.Conclusions: The results showed that Polyox WSR is promising tool to designing of sustained release formulation.

scholarly journals Formulation of Metformin Sustained Release Tablet Using Natural Polymer

2021 ◽  
Vol 11 (2) ◽  
pp. 31-37
Author(s):  
Mehak Siddiqui ◽  
L. K. Omray ◽  
Pushpendra Soni
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Guar Gum ◽  
Release Kinetics ◽  
Methyl Cellulose ◽  
Matrix Tablets ◽  
Absolute Bioavailability ◽  
Dissolution Time ◽  
Content Uniformity ◽  
Weight Variation

The overall objective of the present work was to develop an oral sustained-release (SR) Metformin tablet that is prepared by the direct compression method by using hydrophilic hydroxyl propyl methyl cellulose (HPMC) and Guar gum polymer alone as well as in combination at different concentrations. Metformin is a biguanide that has a relatively short plasma half-life. It has low absolute bioavailability. All the properties were evaluated for thickness, weight variation, hardness and drug content uniformity and in vitro drug release. The mean dissolution time is used to characterize the drug release rate from a dosage form that indicates the drug release-retarding efficiency of the polymer. The hydrophilic matrix of HPMC alone could not control the Metformin release effectively for 12 h but when combined with Guar gum, it could slow down the release of drug and, thus, can be successfully employed for formulating Sustain Release matrix tablets. Keywords: Guar gum, hydroxylpropylmethylcellulose, matrix tablets, release kinetics,

scholarly journals Preparation andin vitro/in vivocharacterisation of a melt pelletised paracetamol/stearic acid sustained release delivery system

2004 ◽  
Vol 18 (2) ◽  
pp. 375-386 ◽  
Author(s):  
Mario Grassi ◽  
Dario Voinovich ◽  
Iztok Grabnar ◽  
Erica Franceschinis ◽  
Beatrice Perissutti ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Sustained Release ◽  
Stearic Acid ◽  
Photoelectron Spectroscopy ◽  
Release Kinetics ◽  
Size Fraction ◽  
Drug Dissolution ◽  
Release Mechanism ◽  
Release Formulation ◽  
Sustained Release Formulation

The potential of a sustained release formulation for paracetamol produced by melt pelletisation was investigated. After the production of the pellets, based on the combination of stearic acid as a melting binder and anhydrous lactose as a filler, the 3000–2000μm size fraction was selected in the light of the promisingin vitrodissolution results for further characterisations, including scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), specific surface area and true density determination. Hence the release mechanism was analysed with the help of an appropriate mathematical model. The mathematical model was built on the hypotheses that drug diffusion and solid drug dissolution in the release environment are the key phenomena affecting drug release kinetics. Bioavailability of the developed formulation was evaluated in anin vivostudy in eight subjects.

FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF CANDESARTAN CELEXETIL BY DIRECT COMPRESSION

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (03) ◽  
pp. 23-27
Author(s):  
Y Dange ◽  
D Randive ◽  
S Bhinge ◽  
M. Bhutkar ◽  
G. Wadkar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Magnesium Stearate ◽  
Direct Compression ◽  
Floating Tablets ◽  
Weight Variation ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

The objective was to develop optimized gastric floating drug delivery system (GFDDS) of candesartan celexetil floating tablets by using various polymers like Eudragit and MCC. In the present work, attempts have been made to prepare candesartan celexetil by direct compression method by using Citric acid, NaHCO3, Magnesium stearate, Eudragit and MCC. Formulations (F1 to F4) of floating tablets of candesartan celexetil were prepared using variable concentrations of Eudragit and MCC. The prepared formulations were evaluated for thickness, hardness, weight variation, friability, drug content and uniformity. The buoyancy lag time and the total floating time was studied for all the formulations. Formulation F4 of sustained release tablet of Candesartan celexetil containing a combination of both polymers was found to be the optimized formulation for 13 hours release as it fulfilled all the requirement of floating drug delivery system of sustained release dosage form.

scholarly journals Study and Evaluation of Release Kinetics of Tramadol HCl from Lipid Based Sustained Release Capsules by Melt Matrix

2013 ◽  
Vol 11 (2) ◽  
pp. 137-145
Author(s):  
Irin Dewan ◽  
Ananta Saha ◽  
SM Ashraful Islam ◽  
Mahjabeen Gazi ◽  
Tasnuva Amin ◽  
...  
Keyword(s):  
Sustained Release ◽  
Release Kinetics ◽  
Correlation Coefficients ◽  
Extended Period ◽  
Tween 80 ◽  
Tramadol Hydrochloride ◽  
Shell Size ◽  
Release Formulation ◽  
Sustained Release Formulation ◽  
The Matrix

The aim of our study was to improve the dissolution of Tramadol hydrochloride (TH) via its semisolid filled lipid based capsules. Sustained release formulation is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. Semisolid matrixes of TH were prepared by melt-matrix method and were filled in hard gelatin capsule shell (size 0). In this experiment, a mixture of Glycerol monostearate (GMS) and lipid materials like different lipophilic oils and surfactants were used to improve the matrix integrity and drug release. The effects of different oils like Arachis oil, Soyabean oil, castor oil, neobee oil and olive oil and different surfactants such as Span 80, Tween 80, PEG 400, Chremophore RH 40, Cremophor EL were analyzed by formulating at various ratios. The matrices were subjected to the paddle dissolution method using 900 ml of phosphate buffer (pH 6.8). The dissolution test was performed at 100 RPM and the temperature was set at 37 ± 0.50C. The amount of drug was measured from the absorbance with a UV spectrophotometer at 270 nm. The release of drug was plotted in zero order-, 1st order- and Higuchi-release patterns. The correlation coefficients values of the trend lines of the graphs revealed that the formulations best fit in Higuchian release pattern. So it can be said that the pharmaceutical quality of Tramadol HCl capsules can be improved by using a semisolid lipophilic matrix filled in hard gelatin capsules. DOI: http://dx.doi.org/10.3329/dujps.v11i2.14572 Dhaka Univ. J. Pharm. Sci. 11(2): 137-145, 2012 (December)

Formulation and Evaluation of Sustained Release Dosage Forms of Norfloxacin

2018 ◽  
Vol 11 (6) ◽  
pp. 4331-4337
Author(s):  
C Suja ◽  
Sismy C
Keyword(s):  
Sustained Release ◽  
Guar Gum ◽  
In Vitro Release ◽  
Angle Of Repose ◽  
Prolonged Release ◽  
Weight Variation ◽  
Sustained Release Tablets ◽  
Release Study ◽  
Vitro Release

The goal of this study was to formulate and evaluate norfloxacin sustained release tablets. Norfloxacin sustained release tablets were prepared by wet granulation method using two polymers such as HPMC K 100 M (hydrophilic polymer) and guar gum (natural polymer) and with three polymer ratios (0.5, 1.0 and 1.5). The prepared granules were evaluated to preformulation studies such as angle of repose, bulk density, tapped density, bulkiness, compressibility index and Hauser’s ratio. All the parameters shows that the granules having good flow properties. Then the formulated tablets were taken to evaluation studies such as hardness, weight variation, friability, drug content and thickness. All the parameters were within the acceptable limits. IR spectral analysis showed that there was no interaction between the drug and polymers. The in vitro release study was performed in phosphate buffer pH 7.4 at 293 nm. The in vitro release study showed that if the polymer ratio is increased, then the release of the drug is prolonged. HPMC K 100M shows a prolonged release when compared to guar gum.

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