scholarly journals Nootropic drugs for correction of cognitive functions through the focus of evidence-based medicine (literature review)

2021 ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Literature Review ◽  
Cognitive Functions ◽  
Evidence Based Medicine ◽  
Randomized Trials ◽  
Evidence Based ◽  
Nootropic Drugs ◽  
High Quality ◽  
Based Medicine

Relevance. In today's world, the first cause of death is pathology of the cardiovascular system. Vascular disease is influenced by many factors: lack of sleep, physical inertia, poorly balanced diet, obesity, heart disease. The fast pace of life forces a person to be in permanent stress, so as not to miss anything and have time for all the goals. This is why there is a demand for excipients and substances that could improve the peak of human cognitive abilities, maintain psychological stability. Today, the pharmaceutical market offers drugs that, according to pharmaceutical marketers, have solutions to the problems outlined above. These substances are classified to group of nootropic drugs (racetams). Objective. Review of high quality research on the effectiveness of nootropic drugs. Materials and methods. The literature review was performed using such scientometric databases as: PubMed, Cochrane Library, Scopus, BMJ Evidence-Based Medicine, Ingecta, Web of Science, UpToDate. The review included studies of randomized trials, placebo-controlled randomized trials, meta-analyzes, and systematic reviews. Data meet criteria A and B of evidence-based medicine. In the absence of high quality studies, studies with a lower level of evidence were selected. The search was made by topics: improving of cognitive functions, improving ability to work, improving sleep, improving mood, treatment of mental and psychiatric pathologies (Alzheimer's disease, dementia with various etiologies, depression), application in pediatrics. Results. The literature review included more than 40 high quality studies, but no conclusive evidence was found on the effectiveness of any drug. Conclusions. Data on the undeniable efficacy in relation to the cognitive functions of any of these nootropic drugs were not found in any study. In the treatment of Alzheimer's disease, some (Cerebrolysin, Nicergoline) drugs show controversial results of efficacy and safety. They require continued clinical research and they need to be approved by the FDA.

Are we really tackling the "evidence-based medicine issue" in Alzheimer's disease?

2016 ◽  
Vol 35 ◽  
pp. e29-e30 ◽  
Author(s):  
Marco Canevelli ◽  
Giuseppe Bruno ◽  
Nicola Vanacore ◽  
Carlo de Lena ◽  
Matteo Cesari
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Evidence Based Medicine ◽  
Evidence Based ◽  
Based Medicine

Are Health Sciences Librarians Taking the Evidence-Based Medicine Challenge?

2013 ◽  
Author(s):  
Ping Li ◽  
Lin Wu
Keyword(s):  
Content Analysis ◽  
Literature Review ◽  
Evidence Based Medicine ◽  
Health Sciences ◽  
Evidence Based ◽  
Revue De La Littérature ◽  
Job Advertisements ◽  
Based Medicine

This study sought to find out whether and how health sciences librarians’ roles have been changing to support the evidence-based medicine (EBM) practice. Both content analysis of job advertisements and literature review were employed. Results revealed that there exist some disconnects between what are expected of health sciences librarians in…Cette étude visait à déterminer si le rôle des bibliothécaires du domaine des sciences de la santé a évolué et de quelle manière ce rôle est en mesure de subvenir aux besoins de la médecine fondée sur les preuves (MFP). L’analyse de contenu des offres d’emploi et la revue de la littérature a été employée. Les résultats ont révélé qu’il existe un fossé entre ce que l’on attend des bibliothécaires des sciences de la santé en… 

scholarly journals Evidence-Based Medicine, Systematic Reviews, and Guidelines in Interventional Pain Management: Part 4: Observational Studies

2009 ◽  
Vol 1;12 (1;1) ◽  
pp. 73-108 ◽  
Author(s):  
Laxmaiah Manchikanti
Keyword(s):  
Cohort Studies ◽  
Medical Research ◽  
Evidence Based Medicine ◽  
Observational Studies ◽  
Randomized Trials ◽  
Evidence Based ◽  
Cross Sectional ◽  
Cross Sectional Studies ◽  
Based Medicine ◽  
Strobe Statement

Evidence-based medicine (EBM) stresses the examination of evidence from clinical research and describes it as a shift in medical paradigms, in contrast to intuition, unsystematic clinical experience, and pathophysiologic rationale. While the importance of randomized trials has been created by the concept of the hierarchy of evidence in guiding therapy, much of the medical research is observational. There is competition, contrast, and a feeling of inferiority and uselessness for observational studies, created by a lack of understanding of medical research. However, observational studies and randomized clinical trials (RCTs) can be viewed as the steps of observation and experimentation that form the basis of the scientific methodology. Further, rational healthcare practices require knowledge about the etiology and pathogenesis, diagnosis, prognosis, and treatment of disorders. The reporting of observational research is often not detailed and clear enough with insufficient quality and poor reporting, which hampers the assessment of strengths and weaknesses of the study and the generalizability of the mixed results. Thus, design, implementation, and reporting of observational studies is crucial. The biased interpretation of results from observational studies, either in favor of or opposed to a treatment, and lack of proper understanding of observational studies, leads to a poor appraisal of the quality. Similar to the Consolidated Standards of Reporting Trials (CONSORT) statement for the reporting of randomized trials, the Strengthening of the Reporting of Observational Studies in Epidemiology (STROBE) statement was developed with recommendations to improve the quality of reporting observational studies. The STROBE statement consists of a checklist of 22 items, which relate to the title, abstract, introduction, methods, results, and discussion sections of articles. Multiple types of observational studies are conducted; however, 3 types have been highlighted in the STROBE document and also in the present review, which include cohort studies, case-controlled studies, and cross-sectional studies. This comprehensive review provides an introduction and rationale, types, design, and reporting of observational studies; outcomes assessment and data presentation and analysis; statistical analysis, results, and a discussion of observational studies. Key words: Observational studies, cohort studies, case control studies, cross-sectional studies, allocation bias, sample size, Strengthening of the Reporting of Observational Studies in Epidemiology (STROBE)

Sign in / Sign up

Export Citation Format

Share Document