scholarly journals Triclabendazole and fascioliasis: a new drug to combat an age-old disease

1998 ◽  
Vol 4 (2) ◽  
pp. 385-387
Author(s):  
Keyword(s):  
Abdominal Pain ◽  
Side Effects ◽  
Chronic Phase ◽  
Biliary System ◽  
Cure Rate ◽  
Split Dose ◽  
Human Fascioliasis ◽  
Human Use ◽  
Upper Abdominal ◽  
Mild Fever

The tolerance and efficacy of triclabendazole CGP 23030, specially prepared for human use, were assessed in 50 patients in the chronic phase of fascioliasis. After clinical examination, investigation and ultrasonography of the liver and biliary system, triclabendazole 10 mg/kg, either as a single or split dose, was administered. The clinical picture was studied daily for six days and the investigations were repeated 6, 30 and 60 days after treatment. The drug was tolerated. Its side-effects, which included upper abdominal pain, mild fever and limited derangement of liver function, were considered negligible. The cure rate at 2 months was 94% when assessed by the disappearance of eggs in stools and 88% when assessed by both the absence of eggs in stools and of worms in the biliary system. The use of triclabendazole for the treatment of human fascioliasis was found to be justified

scholarly journals Triclabendazole in the treatment of established human fascioliasis

1998 ◽  
Vol 4 (2) ◽  
pp. 244-251
Author(s):  
H. F. Farag ◽  
T. A. El Khoby ◽  
A. I. Salem ◽  
M. Abou El Hoda ◽  
G. A. Amin
Keyword(s):  
Abdominal Pain ◽  
Side Effects ◽  
Chronic Phase ◽  
Biliary System ◽  
Cure Rate ◽  
Split Dose ◽  
Human Fascioliasis ◽  
Human Use ◽  
Upper Abdominal ◽  
Mild Fever

The tolerance and efficacy of triclabendazole CGP 23030, specially prepared for human use, were assessed in 50 patients in the chronic phase of fascioliasis. After clinical examination, investigation and ultrasonography of the liver and biliary system, triclabendazole 10 mg/kg, either as a single or split dose, was administered. The clinical picture was studied daily for six days and the investigations were repeated 6, 30 and 60 days after treatment. The drug was tolerated. Its side-effects, which included upper abdominal pain, mild fever and limited derangement of liver function, were considered negligible. The cure rate at 2 months was 94% when assessed by the disappearance of eggs in stools and 88% when assessed by both the absence of eggs in stools and of worms in the biliary system. The use of triclabendazole for the treatment of human fascioliasis was found to be justified

scholarly journals Hepatic fascioliasis: case report and review

1996 ◽  
Vol 38 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Salha Abdul-Hadi ◽  
Rosa Contretas ◽  
Claudio Tombazzi ◽  
Marta Alvarez ◽  
Maribel Melendez
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Side Effects ◽  
Clinical Manifestations ◽  
Documented Case ◽  
Human Fascioliasis ◽  
Oral Doses

A well documented case of hepatic fascioliasis (HF), successfully treated with triclabendazole, is reported. Predominant clinical manifestations were fever, marked eosinophilia and abdominal pain. Triclabendazole was given as two single oral doses of 10 mg/kg each. Neither side effects nor clinical or parasitological relapses were seen after three months of follow up Based on this experience and few other similar reports in the literature, triclabendazole might be a valid therapeutical alternative in the treatment of human fascioliasis.

scholarly journals Laparoscopic de-roofing of liver cyst with biliary communication, success or failure: case report

2020 ◽  
Vol 7 (10) ◽  
pp. 3483
Author(s):  
Priyanka Pant ◽  
Samindra Nath Basak
Keyword(s):  
Abdominal Pain ◽  
Cyst Wall ◽  
Primary Closure ◽  
Cystic Lesion ◽  
Bile Leak ◽  
Biliary System ◽  
Simple Cyst ◽  
Right Lobe ◽  
Upper Abdominal ◽  
Space Occupying Lesion

A 39 year old gentleman complained of right upper abdominal pain. Ultrasonography revealed cholelithiasis with a cystic space occupying lesion in liver of around 14 cm. Computed tomograpy of whole abdomen was done which revealed a cystic lesion of 14.1×10.6×12.4 cm dimensions in right lobe of liver suggestive of simple cyst. Laparoscopic cholecystectomy was done along with de-roofing of cyst wall, bile leak was noted from a tiny orifice which was found communicating with biliary system by intraoperative cholangiography. Primary closure of opening done by suturing laparoscopically. Patient did well postoperatively and followed for 2 years with no complications and/or recurrence.A 39 year old gentleman complained of right upper abdominal pain. Ultrasonography revealed cholelithiasis with a cystic space occupying lesion in liver of around 14 cm. Computed tomograpy of whole abdomen was done which revealed a cystic lesion of 14.1×10.6×12.4 cm dimensions in right lobe of liver suggestive of simple cyst. Laparoscopic cholecystectomy was done along with deroofing of cyst wall, bile leak was noted from a tiny orifice which was found communicating with biliary system by intraop cholangiography. Primary closure of opening done by suturing laparoscopically. Patient did well postoperatively and followed for 2 years with no complications and/or recurrence. A 39 year old gentleman complained of right upper abdominal pain. Ultrasonography revealed cholelithiasis with acystic space occupying lesion in liver of around 14 cm. Computed tomograpy of whole abdomen was done whichrevealed a cystic lesion of 14.1×10.6×12.4 cm dimensions in right lobe of liver suggestive of simple cyst. Laparoscopiccholecystectomy was done along with de-roofing of cyst wall, bile leak was noted from a tiny orifice which was foundcommunicating with biliary system by intraoperative cholangiography. Primary closure of opening done by suturinglaparoscopically. Patient did well postoperatively and followed for 2 years with no complications and/or recurrence.

scholarly journals Celiac Plexus Block and Neurolysis in the Management of Chronic Upper Abdominal Pain

2017 ◽  
Vol 34 (04) ◽  
pp. 376-386 ◽  
Author(s):  
Joshua Cornman-Homonoff ◽  
Daniel Holzwanger ◽  
Kyungmouk Lee ◽  
David Madoff ◽  
David Li
Keyword(s):  
Quality Of Life ◽  
Abdominal Pain ◽  
Side Effects ◽  
Celiac Trunk ◽  
Celiac Plexus ◽  
Opiate Dependence ◽  
Celiac Plexus Block ◽  
Upper Abdominal ◽  
Plexus Block

AbstractChronic upper abdominal pain occurs as a complication of various malignant and benign diseases including pancreatic cancer and chronic pancreatitis, and when present may contribute to lower quality of life and higher mortality. Though various pain management strategies are available as part of a multimodal approach, they are often incompletely effective and accompanied by side effects. Pain originating in upper abdominal viscera is transmitted through the celiac plexus, which is an autonomic plexus located in the retroperitoneum at the root of the celiac trunk. Direct intervention at the level of the plexus, referred to as celiac plexus block or neurolysis depending on the injectate, is a minimally invasive therapeutic strategy which has been demonstrated to decrease pain, improve function, and reduce opiate dependence. Various percutaneous techniques have been reported, but, with appropriate preprocedural planning, use of image guidance (usually computed tomography), and postprocedural care, the frequency and severity of complications is low and the success rate high regardless of approach. The main benefit of the intervention may be in reduced opiate dependence and opiate-associated side effects, which in turn improves quality of life. Celiac plexus block and neurolysis are safe and effective treatments for chronic upper abdominal pain and should be considered early in patients experiencing such symptoms.

Efficacy of a Combination of Ketamine and Morphine for Intravenous Patient Controlled-Analgesia in Upper Abdominal Surgery: A Prospective, Double-blind, Randomized Controlled Trial

2021 ◽  
Vol 104 (9) ◽  
pp. 1528-1534
Keyword(s):  
Abdominal Pain ◽  
Side Effects ◽  
Abdominal Surgery ◽  
Rating Scale ◽  
Morphine Consumption ◽  
Patient Controlled Analgesia ◽  
Double Blind ◽  
Upper Abdominal Surgery ◽  
Upper Abdominal ◽  
Postoperative Morphine

Background: Most postoperative upper abdominal pain is severe, and various methods can be employed to control it. Presently, morphine is the main drug used for anesthesia, but it may contribute to the occurrence of many uncomfortable side effects. Ketamine is an analgesic drug that inhibits NMDA receptors, making it a synergistic effect of morphine. Objective: To investigate the efficacy of a combination of ketamine and morphine in controlling postoperative upper abdominal pain. Materials and Methods: Informed consents were obtained from patients enrolled into the present double-blind randomized study that divided into two groups, (i) the M group, which received 1 mg/mL of morphine, and (ii) the MK group, which received 1 mg of ketamine plus 1 mg/mL of morphine as intravenous patient-controlled analgesia (IV-PCA) post-operation. All patients were assessed based on postoperative morphine consumption, a numeric rating scale (NRS) used to rate pain, and the presence of side effects. Results: Sixty-seven patients completed the study including 34 patients in the MK group and 33 patients in the M group. Cumulative postoperative morphine consumption at 24 and 48 hours was significantly lower in the MK group at 27.91±11.11 and 46.44±15.21 mg compared to the M group at 43.24±15.32 and 71.33±19.67 mg, respectively (p<0.001). NRS were similar between the two groups and no observable differences regarding to side effects. Conclusion: A combination of ketamine and morphine via IV PCA is effective in controlling postoperative upper abdominal pain. Keywords: Ketamine; Morphine; Upper abdominal surgery; Intravenous patient-controlled analgesia

scholarly journals The Comparative Study of the Effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in Treatment of Children with Dyspepsia

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Seyed Mohsen Dehghani ◽  
Mohammad Hadi Imanieh ◽  
Roya Oboodi ◽  
Mahmood Haghighat
Keyword(s):  
Clinical Trial ◽  
Abdominal Pain ◽  
Side Effects ◽  
Comparative Study ◽  
Functional Dyspepsia ◽  
Medical Therapy ◽  
Visceral Hypersensitivity ◽  
Chronic Disorder ◽  
Upper Abdominal ◽  
The Comparative Study

Background. Functional dyspepsia is a common chronic disorder with non specific upper abdominal pain or discomfort. Different approaches with anti-secretory, spasmolytic, prokinetic and anti-inflammatory effects and most preferably reduction of visceral hypersensitivity seem logical. In this study, we compared the effectiveness of the four most drugs used for treatment of dyspepsia in children. Methods. 169 patients between 2 to 16 years old that 47.3% was male and 52.7% was female were enrolled in this clinical trial study by the diagnosis of functional dyspepsia. Then for each patient one of the drugs; Omeprazole, Famotidine, Ranitidine or Cimetidine was administered, for a period of 4 weeks. Patients were followed after 2 and 6 weeks from the beginning of the treatment. Results. The distribution of drugs between these patients were including; 21.9% with Cimetidine, 21.3% with Famotidine, 30.8% with Omeperazole and 26% with Ranitidine that the proportion of patients with all symptoms relief were: 21.6% for Cimetidine, 44.4% for Famotidine, 53.8% for Omeprazole and 43.2% for Cimetidine (). In followups within 2 and 6 weeks after beginning medical therapy, no side effects due to drugs were seen. Conclusion. If a cure is defined as all symptoms relief after a period of 4 weeks treatment, our findings showed that Omeperazole are superior to Ranitidine, Famotidine, and Cimetidine for management of functional dyspepsia.

Enterogastric Reflux: an Uncommon Diagnosis Analyzed by Hepatobiliary Imaging

2019 ◽  
Vol 8 (2) ◽  
Author(s):  
Peter Wang
Keyword(s):  
Abdominal Pain ◽  
Digestive Enzymes ◽  
Gallbladder Disease ◽  
Hepatobiliary Scintigraphy ◽  
Hepatobiliary Imaging ◽  
Upper Gi ◽  
Gi Symptoms ◽  
Upper Abdominal ◽  
Enterogastric Reflux

Enterogastric reflux (EGR) is the reflux of bile and digestive enzymes from the small bowel into the stomach. While it is a normal physiologic process in small amounts, excessive reflux and chronic EGR can cause upper GI symptoms often mimicking more common diseases such as gallbladder disease and GERD that often leads to its underdiagnosis. Identifying EGR is significant as it has been associated with the development of gastroesophogeal pathology including gastritis, esophagitis, ulcers, and mucosal metaplasia. This article presents a 22-year-old male with enterogastric reflux causing upper abdominal pain and will discuss the role of hepatobiliary scintigraphy in its diagnosis.

scholarly journals Foreign Body in abdomen

2015 ◽  
Vol 14 (2) ◽  
pp. 210-212
Author(s):  
Md Zakirul Alam ◽  
Mohibul Aziz
Keyword(s):  
Abdominal Pain ◽  
Foreign Body ◽  
Medical Science ◽  
X Ray ◽  
Diagnostic Center ◽  
History Of ◽  
Upper Abdominal ◽  
Married Female

A 19 years old married female presented with severe upper abdominal pain, repeated vomiting having history of swallowing a knife 7 months ago was admitted in Mordern Clinic and Diagnostic center, Joypurhat, Bangladesh. USG abdomen & X-ray (fig-1) abdomen were done when presence of a large foreign body (knife fig-3) in abdomen was made which latter on confirmed by Endoscopy of upper GIT (fig-2). Surprisingly the patient kept it in her abdomen for 7 months without any symptoms until the symptoms got worse and compelled her to seek medical help. The knife was removed by laparotomy, gastrotomy with uneventful recovery.Bangladesh Journal of Medical Science Vol.14(2) 2015 p.210-212

Unusual case of hyperemesis in a pregnant patient with prior antireflux surgery

2021 ◽  
Vol 14 (8) ◽  
pp. e241935
Author(s):  
Abimbola Obisesan ◽  
Eleanor Lucy Townsend ◽  
John Lin Hieng Wong ◽  
Vinod Menon
Keyword(s):  
Decision Making ◽  
Abdominal Pain ◽  
Antireflux Surgery ◽  
Unusual Case ◽  
Nissen Fundoplication ◽  
Hyperemesis Gravidarum ◽  
Pregnant Patient ◽  
Emergency Laparotomy ◽  
Laparoscopic Nissen ◽  
Upper Abdominal

A 33-year-old, 8 weeks pregnant, presented with severe upper abdominal pain with vomiting on a background of a previous laparoscopic Nissen fundoplication for reflux disease. An urgent MRI had shown herniation of the fundoplication wrap through the diaphragmatic hiatus. The cause of her symptoms was attributed to hyperemesis gravidarum. The plan was to manage this patient conservatively until the conclusion of her pregnancy. This plan was revised when she presented for the second time and developed worsening pain and haematemesis. An emergency gastroscopy showed ischaemic changes in most of the stomach requiring the patient to undergo an emergency laparotomy. In pregnant patients, presenting with abdominal pain, vomiting as well as haematemesis, having had previous antireflux surgery, incarceration of the stomach must be considered as a differential. Prompt assessment and early senior decision-making is extremely important in avoiding a potentially catastrophic outcome for such patients.

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