scholarly journals The Comparative Study of the Effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in Treatment of Children with Dyspepsia

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Seyed Mohsen Dehghani ◽  
Mohammad Hadi Imanieh ◽  
Roya Oboodi ◽  
Mahmood Haghighat
Keyword(s):  
Clinical Trial ◽  
Abdominal Pain ◽  
Side Effects ◽  
Comparative Study ◽  
Functional Dyspepsia ◽  
Medical Therapy ◽  
Visceral Hypersensitivity ◽  
Chronic Disorder ◽  
Upper Abdominal ◽  
The Comparative Study

Background. Functional dyspepsia is a common chronic disorder with non specific upper abdominal pain or discomfort. Different approaches with anti-secretory, spasmolytic, prokinetic and anti-inflammatory effects and most preferably reduction of visceral hypersensitivity seem logical. In this study, we compared the effectiveness of the four most drugs used for treatment of dyspepsia in children. Methods. 169 patients between 2 to 16 years old that 47.3% was male and 52.7% was female were enrolled in this clinical trial study by the diagnosis of functional dyspepsia. Then for each patient one of the drugs; Omeprazole, Famotidine, Ranitidine or Cimetidine was administered, for a period of 4 weeks. Patients were followed after 2 and 6 weeks from the beginning of the treatment. Results. The distribution of drugs between these patients were including; 21.9% with Cimetidine, 21.3% with Famotidine, 30.8% with Omeperazole and 26% with Ranitidine that the proportion of patients with all symptoms relief were: 21.6% for Cimetidine, 44.4% for Famotidine, 53.8% for Omeprazole and 43.2% for Cimetidine (). In followups within 2 and 6 weeks after beginning medical therapy, no side effects due to drugs were seen. Conclusion. If a cure is defined as all symptoms relief after a period of 4 weeks treatment, our findings showed that Omeperazole are superior to Ranitidine, Famotidine, and Cimetidine for management of functional dyspepsia.

scholarly journals Triclabendazole and fascioliasis: a new drug to combat an age-old disease

1998 ◽  
Vol 4 (2) ◽  
pp. 385-387
Author(s):  
Keyword(s):  
Abdominal Pain ◽  
Side Effects ◽  
Chronic Phase ◽  
Biliary System ◽  
Cure Rate ◽  
Split Dose ◽  
Human Fascioliasis ◽  
Human Use ◽  
Upper Abdominal ◽  
Mild Fever

The tolerance and efficacy of triclabendazole CGP 23030, specially prepared for human use, were assessed in 50 patients in the chronic phase of fascioliasis. After clinical examination, investigation and ultrasonography of the liver and biliary system, triclabendazole 10 mg/kg, either as a single or split dose, was administered. The clinical picture was studied daily for six days and the investigations were repeated 6, 30 and 60 days after treatment. The drug was tolerated. Its side-effects, which included upper abdominal pain, mild fever and limited derangement of liver function, were considered negligible. The cure rate at 2 months was 94% when assessed by the disappearance of eggs in stools and 88% when assessed by both the absence of eggs in stools and of worms in the biliary system. The use of triclabendazole for the treatment of human fascioliasis was found to be justified

scholarly journals Triclabendazole in the treatment of established human fascioliasis

1998 ◽  
Vol 4 (2) ◽  
pp. 244-251
Author(s):  
H. F. Farag ◽  
T. A. El Khoby ◽  
A. I. Salem ◽  
M. Abou El Hoda ◽  
G. A. Amin
Keyword(s):  
Abdominal Pain ◽  
Side Effects ◽  
Chronic Phase ◽  
Biliary System ◽  
Cure Rate ◽  
Split Dose ◽  
Human Fascioliasis ◽  
Human Use ◽  
Upper Abdominal ◽  
Mild Fever

The tolerance and efficacy of triclabendazole CGP 23030, specially prepared for human use, were assessed in 50 patients in the chronic phase of fascioliasis. After clinical examination, investigation and ultrasonography of the liver and biliary system, triclabendazole 10 mg/kg, either as a single or split dose, was administered. The clinical picture was studied daily for six days and the investigations were repeated 6, 30 and 60 days after treatment. The drug was tolerated. Its side-effects, which included upper abdominal pain, mild fever and limited derangement of liver function, were considered negligible. The cure rate at 2 months was 94% when assessed by the disappearance of eggs in stools and 88% when assessed by both the absence of eggs in stools and of worms in the biliary system. The use of triclabendazole for the treatment of human fascioliasis was found to be justified

Efficacy of Acupuncture in Treating Upper Abdominal Pain in Cancer Patients: Study Protocol for A Randomized Controlled Pilot Clinical Trial

2014 ◽  
Vol 31 (1) ◽  
pp. 33-39
Author(s):  
Jin-yong Jung ◽  
Hyun-jong Lee ◽  
Jung-Chul Seo ◽  
Bo-Mi Min ◽  
Min-su Cho ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Abdominal Pain ◽  
Cancer Patients ◽  
Study Protocol ◽  
Randomized Controlled ◽  
Upper Abdominal

scholarly journals Celiac Plexus Block and Neurolysis in the Management of Chronic Upper Abdominal Pain

2017 ◽  
Vol 34 (04) ◽  
pp. 376-386 ◽  
Author(s):  
Joshua Cornman-Homonoff ◽  
Daniel Holzwanger ◽  
Kyungmouk Lee ◽  
David Madoff ◽  
David Li
Keyword(s):  
Quality Of Life ◽  
Abdominal Pain ◽  
Side Effects ◽  
Celiac Trunk ◽  
Celiac Plexus ◽  
Opiate Dependence ◽  
Celiac Plexus Block ◽  
Upper Abdominal ◽  
Plexus Block

AbstractChronic upper abdominal pain occurs as a complication of various malignant and benign diseases including pancreatic cancer and chronic pancreatitis, and when present may contribute to lower quality of life and higher mortality. Though various pain management strategies are available as part of a multimodal approach, they are often incompletely effective and accompanied by side effects. Pain originating in upper abdominal viscera is transmitted through the celiac plexus, which is an autonomic plexus located in the retroperitoneum at the root of the celiac trunk. Direct intervention at the level of the plexus, referred to as celiac plexus block or neurolysis depending on the injectate, is a minimally invasive therapeutic strategy which has been demonstrated to decrease pain, improve function, and reduce opiate dependence. Various percutaneous techniques have been reported, but, with appropriate preprocedural planning, use of image guidance (usually computed tomography), and postprocedural care, the frequency and severity of complications is low and the success rate high regardless of approach. The main benefit of the intervention may be in reduced opiate dependence and opiate-associated side effects, which in turn improves quality of life. Celiac plexus block and neurolysis are safe and effective treatments for chronic upper abdominal pain and should be considered early in patients experiencing such symptoms.

Efficacy of a Combination of Ketamine and Morphine for Intravenous Patient Controlled-Analgesia in Upper Abdominal Surgery: A Prospective, Double-blind, Randomized Controlled Trial

2021 ◽  
Vol 104 (9) ◽  
pp. 1528-1534
Keyword(s):  
Abdominal Pain ◽  
Side Effects ◽  
Abdominal Surgery ◽  
Rating Scale ◽  
Morphine Consumption ◽  
Patient Controlled Analgesia ◽  
Double Blind ◽  
Upper Abdominal Surgery ◽  
Upper Abdominal ◽  
Postoperative Morphine

Background: Most postoperative upper abdominal pain is severe, and various methods can be employed to control it. Presently, morphine is the main drug used for anesthesia, but it may contribute to the occurrence of many uncomfortable side effects. Ketamine is an analgesic drug that inhibits NMDA receptors, making it a synergistic effect of morphine. Objective: To investigate the efficacy of a combination of ketamine and morphine in controlling postoperative upper abdominal pain. Materials and Methods: Informed consents were obtained from patients enrolled into the present double-blind randomized study that divided into two groups, (i) the M group, which received 1 mg/mL of morphine, and (ii) the MK group, which received 1 mg of ketamine plus 1 mg/mL of morphine as intravenous patient-controlled analgesia (IV-PCA) post-operation. All patients were assessed based on postoperative morphine consumption, a numeric rating scale (NRS) used to rate pain, and the presence of side effects. Results: Sixty-seven patients completed the study including 34 patients in the MK group and 33 patients in the M group. Cumulative postoperative morphine consumption at 24 and 48 hours was significantly lower in the MK group at 27.91±11.11 and 46.44±15.21 mg compared to the M group at 43.24±15.32 and 71.33±19.67 mg, respectively (p<0.001). NRS were similar between the two groups and no observable differences regarding to side effects. Conclusion: A combination of ketamine and morphine via IV PCA is effective in controlling postoperative upper abdominal pain. Keywords: Ketamine; Morphine; Upper abdominal surgery; Intravenous patient-controlled analgesia

scholarly journals Comparative study between injection parecoxib and butorphanol for postoperative analgesia in laparotomy patients

2017 ◽  
Vol 5 (3) ◽  
pp. 773
Author(s):  
Dnyaneshwar R. Fating ◽  
N. G. Tirpude
Keyword(s):  
Side Effects ◽  
Comparative Study ◽  
Postoperative Analgesia ◽  
Postoperative Period ◽  
Subjective Experience ◽  
Background Pain ◽  
Inflammatory Drugs ◽  
Group B ◽  
Upper Abdominal

Background: Pain is a complex, subjective experience comprising both physical and emotional components. Upper abdominal surgeries cause most intense pain and distress. Opioids and Nonsteroidal anti-inflammatory drugs are used for postoperative analgesia. Aim of this study was to compare the efficacy of analgesia between injection parecoxib and butorphanol.Methods: Prospective randomised comparative study included total 60 patients posted for laparotomy under general anaesthesia. Patients were randomly allocated in two groups. One group received injection paecoxib sodium (Group-P) and other group received injection Butorphanol (Group- B) half an hour before extubation. Pain score was recorded as per visual analogue scale at 0, 4,8,12 hours. The side effects if any were recorded and vomiting and sedation score was recorded.Results: Immediately in postoperative period VAS was less in Group B, but at 8 hours. VAS was less in Group P.Conclusions: Parecoxib has better quality of pain relief, minimal side effects compared to butorphanol which has good analgesia in immediate postoperative period.

scholarly journals A comparative study of topical retinoids tretinoin-0.04% and adapalene - 0.1% in acne grade 1 and grade 2

2021 ◽  
Vol 7 (3) ◽  
pp. 217-221
Author(s):  
Selva Sudha ◽  
Vella Pandi
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Comparative Study ◽  
Sample Size ◽  
Inflammatory Disease ◽  
Acne Vulgaris ◽  
Pilosebaceous Unit ◽  
Topical Tretinoin ◽  
Topical Retinoids ◽  
Grade Ii

Acne is a chronic, self-limiting inflammatory disease of pilosebaceous unit. It is multifactorial, of which Propioniobacterium acne and Sebum play an important role in etiopathogenesis.The aim of the study is to compare efficacy of Tretinoin and Adapalene in Acne Vulgaris and to compare the side effects of topical tretinoin and adapalene.Randomized prospective comparative clinical trial with sample size of 50 patients who are recruited from department of dermatology of MMCH&RI.Adapalene 0. 1% produced numerically greater lesion reduction than tretinoin 0. 04% for all lesion types. Thus, Adapalene was found superior to Tretinoin in reducing average number of lesions. Highest reduction in number of lesions with both topical retinoids was for comedones (p&#60; 0. 001) followed by papules (p&#60;0. 00) and pustule (p= 0.001).In Patients who applied adapalene, most of them were reduced to grade 0 and grade I and only few were in grade II. Whereas in patients who applied tretinoin only few were reduced to grade 0 and many were in grade I and grade II. Side effects were more commonly seen in patient treated with topical Tretinoin than with topical Adapalene. Adapalene was better tolerated than tretinoin. Hence adapalene is a safe and effective in treatment of acne.

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