SINTESIS DAN KARAKTERISASI NANOPARTIKEL KITOSAN – EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana)

2013 ◽  
Vol 14 (3) ◽  
Author(s):  
Eriawan Rismana ◽  
Susi Kusumaningrum ◽  
Olivia Bunga P ◽  
Idah Rosidah ◽  
Marhamah Marhamah
Keyword(s):  
Particle Size ◽  
Sodium Tripolyphosphate ◽  
Chitosan Solution ◽  
The Other ◽  
Ionic Gelation ◽  
Garcinia Mangostana ◽  
Particle Size Analyzer ◽  
Cadmium Lead ◽  
Solvent Residue ◽  
Mold And Yeast

The chitosan – Garcinia Mangostana extract nanoparticles has been prepared by ionic gelation reaction by mixture 0.2 % chitosan solution in acetic acid with Garcinia Mangostana extract and it’s continued by reaction process with 0.1 % sodium tripolyphosphate. The particle size of material was determined by Particle Size Analyzer (PSA) that it showed in the range of 200 – 500 nm. The color, pH, water, α- mangostin, mercury, arsenic, cadmium, lead, totally microbe aerobic, totally mold and yeast, and solvent residue contents of nanoparticles were also examined by many methods that these resulted are yellow, 4.50 – 5.50, 89 – 90 %, 1.05 %, < 0.005 ppm, < 0.01 ppm, < 0.01 ppm, < 0.05 ppm, < 10 CFU/g, < 10 CFU/g and not detected, respectively. The other characterization was also observed that it’sincluded stability andTLC chromatogram. A mixture of nanoparticles with cosmetics bases was showed that it’s increased stability, homogeneity and easy to formed.

scholarly journals Chitosan Nanocarrier Entrapping Hydrophilic Drugs as Advanced Polymeric System for Dual Pharmaceutical and Cosmeceutical Application: A Comprehensive Analysis Using Box-Behnken Design

Polymers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 677
Author(s):  
Sara A. Abosabaa ◽  
Aliaa N. ElMeshad ◽  
Mona G. Arafa
Keyword(s):  
Particle Size ◽  
Sodium Tripolyphosphate ◽  
Chitosan Nanoparticles ◽  
Optimization Procedure ◽  
Entrapment Efficiency ◽  
Chitosan Solution ◽  
Polydispersity Index ◽  
Successful Implementation ◽  
Solution Ph ◽  
Box Behnken Design

The objective of the present research is to propose chitosan as a nanocarrier for caffeine—a commonly used drug in combating cellulite. Being a hydrophilic drug, caffeine suffers from insufficient topical penetration upon application on the skin. Chitosan nanoparticles loaded with caffeine were prepared via the ionic gelation technique and optimized according to a Box–Behnken design. The effect of (A) chitosan concentration, (B) chitosan solution pH, and (C) chitosan to sodium tripolyphosphate mass ratio on (Y1) entrapment efficiency percent, (Y2) particle size, (Y3) polydispersity index, and (Y4) zeta potential were studied. Subsequently, the desired constraints on responses were applied, and validation of the optimization procedure was confirmed by the parameters exhibited by the optimal formulation. A caffeine entrapment efficiency percent of 17.25 ± 1.48%, a particle size of 173.03 ± 4.32 nm, a polydispersity index of 0.278 ± 0.01, and a surface charge of 41.7 ± 3.0 mV were attained. Microscopical evaluation using transmission electron microscope revealed a typical spherical nature of the nanoparticles arranged in a network with a further confirmation of the formation of particles in the nano range. The results proved the successful implementation of the Box–Behnken design for optimization of chitosan-based nanoparticles in the field of advanced polymeric systems for pharmaceutical and cosmeceutical applications.

scholarly journals Optical Nonlinear Properties of Gold Nanoparticles Synthesized by Laser Ablation in Polymer Solution

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
M. Tajdidzadeh ◽  
A. B. Zakaria ◽  
Z. Abidin Talib ◽  
A. S. Gene ◽  
S. Shirzadi
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Laser Ablation ◽  
Volume Fraction ◽  
Chitosan Solution ◽  
The Other ◽  
Distilled Water ◽  
Nonlinear Properties ◽  
Glycol Solution

In the present study, gold nanoparticles were synthesized in various polymer solutions by means of employing laser ablation technique at the same ablation time. Specifically, gold nanoparticles were synthesized in polyethylene glycol and chitosan solutions, in order to compare the effects of the liquid media which served as stabilizers for particle size and volume fraction of nanoparticles. In addition, this experiment was repeated in distilled water for reference purposes. As the findings indicated, the particle size which was obtained in polyethylene glycol was about 7.49 nm, that is, smaller than those of chitosan solution and distilled water, respectively. In contrast, it was observed that the volume fraction of gold nanoparticles increased in polyethylene glycol in comparison with the other media which indicated an effect on the formation of NPs. On the other hand,Z-scan technique was employed to measure the nonlinear refractive index and nonlinear absorption coefficient of nanofluids containing gold nanoparticles. Consequently, the nonlinear properties of nanofluids pointed to a significant contribution with the number of nanoparticles observed in fluids and both optical nonlinear parameters were observed to increase by means of a prior increase in the volume fraction of Au-NPs in polyethylene glycol solution.

scholarly journals Aqueous Behaviour of Chitosan

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
D. P. Chattopadhyay ◽  
Milind S. Inamdar
Keyword(s):  
Molecular Weight ◽  
Particle Size ◽  
Chitosan Solution ◽  
Capillary Viscometer ◽  
Processing Unit ◽  
Textile Processing ◽  
Molecular Weights ◽  
Unit Operations ◽  
Particle Size Analyzer ◽  
Hydrolysis Of

Chitosan, a versatile biopolymer, finds numerous applications in textile processing unit operations such as preparation, dyeing, printing, and finishing. However, the accessibility of this biopolymer by the textile material depends on the viscosity of its solution which in turn is a function of its molecular weight. In this work, therefore, the effect of molecular weight, storage life, presence of electrolyte, and particle size of chitosan on its viscosity was investigated. Chitosan of different molecular weights was synthesized by nitrous acid hydrolysis of parent chitosan solution. The synthesized low molecular weight products were analysed by FTIR spectroscopy. Chitosan of nanoconfiguration was prepared by Ionotropic gelation method and characterized by particle size analyzer. The viscosity of different chitosan solutions was determined using Ubbelohde capillary viscometer. As an extension to this study, the chelation property of chitosan was also evaluated.

scholarly journals Chitosan anchored nanoparticles for breast cancer: preparation and evaluation: part-I

2019 ◽  
Vol 9 (1) ◽  
pp. 1-5
Author(s):  
Rajkumari Thagele ◽  
Archana Bagre ◽  
Mohan Lal Kori
Keyword(s):  
Breast Cancer ◽  
Particle Size ◽  
Sodium Tripolyphosphate ◽  
Polymeric Nanoparticles ◽  
Research Work ◽  
Chitosan Nanoparticles ◽  
Physical Factors ◽  
Ionic Gelation ◽  
Shell Nanoparticles ◽  
Preparation And Evaluation

The objective of present research work was to develop methotrexate loaded chitosan anchored shell nanoparticles for drug delivery in breast cancer. Chitosan nanoparticles (CS-NPs) were synthesized by ionic gelation of chitosan using sodium tripolyphosphate (STPP). The optimized nanoparticles were characterized for particle size and polydispersity index (PDI) revealed particle size were found to be between 57.08 nm to169.5 nm and PDI 0.252 to 0.639 respectively. The results signpost that stirring speed during ionic gelation reaction was also decisive parameters for the size of the nanoparticles obtained. Further characterization involved to show polymer-drug interaction was FTIR and DSC. This paper grants a revision of the physical factors elaborate in attaining nanoparticles in order to regulate the particle size of polymeric nanoparticles made from chitosan, without any surplus chemical treatment. Keywords: Breast cancer, Nanoparticles, Chitosan, Methotrexate

scholarly journals Formulasi dan Evaluasi Sediaan Tablet Nanopartikel Ekstrak Daun Salam (Syzygium Polyanthum) dengan Variasi Konsentrasi Na Alginat dan Avicel PH 102

2020 ◽  
Vol 17 (1) ◽  
pp. 24-30
Author(s):  
Agung Setiawan ◽  
Naelaz Zukhruf Wakhidatul Kiromah ◽  
Tri Cahyani Widiastuti
Keyword(s):  
Particle Size ◽  
Leaf Extract ◽  
Ethanol Extract ◽  
Chitosan Solution ◽  
Reduce Blood Pressure ◽  
Disintegration Time ◽  
Pressing Method ◽  
Traditional Medicines ◽  
Particle Size Analyzer ◽  
Herbal Plants

The use of traditional medicines is an alternative treatment which is considered safer in terms of side effects and toxicity. One of the herbal plants that have properties that can reduce blood pressure is bay leaf (Syzigium polyanthum) because it contains essential oils (citral, eugenol), tannin, and flavonoids. Ethanol extract of bay leaves (Syzigium polyanthum) with antihypertensive potential needs to be made into dosage forms. This study aimed to determine the optimal formula of the preparation of bay leaf (Syzigium polyanthum) nanoparticles tablet with variations in the concentration of Na alginate and Avicel PH 102. Salam leaf extract was made using maceration method using  ethanol 96%, followed by evaporation until thick extract was formed. Colloidal nanoparticles were prepared by mixing bay leaf extract into  technical ethanol 96% and aquadest, chitosan solution in acetic acid and NaTTP solution. Further, it was measured using PSA (Particle Size Analyzer) to determine the particle size. Tablets were prepared using 4 formulas with variations in the concentration of sodium alginate and avicel PH 102 using the direct pressing method. The results of this study indicate that variations in the concentration of Na alginate and Avicel PH 102 affect the physical properties of tablets. The addition of Avicel PH 102 can increase the hardness and disintegration time of the tablet. While the addition of Na alginate can increase the fragility of tablets. Based on the evaluation results, the optimum formulation of tablet formulas is formula 4.

scholarly journals Preparation and Characterization of Glucosamine Nanoparticle by Ionic Gelation Method Using Chitosan and Alginate

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Yuli Agung Prasetyo ◽  
Taofik Rusdiana ◽  
Marline Abdassah
Keyword(s):  
Insulin Resistance ◽  
Particle Size ◽  
Volume Ratio ◽  
Oral Route ◽  
Ionic Gelation ◽  
Polyelectrolyte Complexes ◽  
Particle Size Analyzer ◽  
First Pass ◽  
Nanoparticle System

Osteoarthritis is a chronic degenerative disease of the joints that usually treated by NSAID drugs in the long term leading to cardiovascular and gastrointestinal disorders. Glucosamine is a precursor in the formation of progression of joint which have not a significantly side effect. The problem in glucosamine administration occured when it is administered through the oral route resulting in first pass metabolism, while when it is administered via intavena route resulting in insulin resistance. Those problems can be solved by developing glucosamine into nanoglucosamine in order to increase the enzymatic stability which will protect the active ingredient from diminishing by the first pass effect hence the dose can be reduced, consequenlty it will reduce the insulin resistance, and increase the permeation. In this study, the nanoparticles of glucosamine with chitosan polymer and crosslinker alginate was prepared by the ionic gelation method with the principle of continued cross forming polyelectrolyte complexes. This study started from preformulation such as solubility and identify study by FTIR, then the formulations of chitosan: glucosamine: alginate = 5:1:1 (volume ratio) with the variation of concentration in the FI (chitosan: glucosamine: alginate = 0.08 %: 0.1%: 0.08%) and FII (chitosan: glucosamine: alginate = 0.1%: 0.1%: 0.08%). Results of nanoparticle characterization by particle size analyzer in the FI showed the better formula indicating a foggy coloid, no precipitation, the pH was 2.90±0.05, and the percent transmittance was  99.35%. The distribution of particle size, polydispersity index, and zeta potential for the formula I were 76.0 ± 21.8 nm; 0.300; and -0.30 mV, respectively. It could be concluded that the nanoparticle system of glucosamine can be better prepared from the 0.08% of chitosan, 0.1% of glucosamine and 0.08% of alginate.Keywords: alginate, chitosan, ionic gelation method, glucosamine nanoparticle

scholarly journals Parijoto Fruit Extract Nanoparticles As Glucose-Lowering Agent In Vitro

2020 ◽  
Vol 14 (2) ◽  
pp. 75
Author(s):  
Fania Putri Luhurningtyas
Keyword(s):  
Particle Size ◽  
Chitosan Solution ◽  
Ionic Gelation ◽  
Fruit Extract ◽  
Glucose Lowering ◽  
Clinical Phase ◽  
Glucose Levels ◽  
Glucose Lowering Effect ◽  
Low Solubility

Parijoto fruit is an herbal that is the potential to be used for the treatment of lowering blood glucose. The active compound in parijoto fruit can decrease glucose levels is flavonoids. The use of natural materials is limit because of their low solubility. It often failed in the clinical phase. The solution to this problem is that the parijoto fruit extract is formulated in the form of nanoparticles using chitosan and STPP as encapsulate materials. This study aims to determine the activity of nano chitosan parijoto fruit extract (NPFE) as a glucose-lowering agent by applying nanoparticle technology. PFE was made by ionic gelation reaction by mixing extract chitosan solution of 0.2% concentration, and NaTPP concentration of 0.1%. The characteristic of NPFE was particle size, PdI, and % transmittance. The effect of a glucose-lowering agent of NPFE tested by the Nelson Somogyi method. The particle size of the NPFE result is 269.3 nm, PdI value is 0.372, and the percentage of transmittance is 99.397%. The glucose-lowering effect of NPFE was more significant (EC50 <2 ppm ) than parijoto fruit extract (EC50 48,750 ppm) and quercetin (EC50 6,831 ppm). Nano chitosan parijoto fruit extract affects a glucose-lowering agent.

Synthesis and Properties of Poly-Acrylate Emulsion Modified by Organ Silicone

2011 ◽  
Vol 314-316 ◽  
pp. 82-85
Author(s):  
Yu Xin Liu ◽  
Yao Hui Lv ◽  
Shu Zhang ◽  
Fu Jia Xu ◽  
Bin Shi Xu
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Particle Size ◽  
Particle Diameter ◽  
The Other ◽  
Trade Name ◽  
Particle Size Analyzer ◽  
Acrylate Emulsion ◽  
Emulsion Film ◽  
Scanning Electron

An acrylate emulsion was modified by vinyltriethoxy silane (VTES, trade name A-151) to synthesize the acrylosilane emulsion with high properties. The effect of the amount of A-151 on the properties pf the emulsion was investigated. It found that adding 6 % of A-151, the fraction extensibility of the emulsion film could be increased to 530 % and its water absorption was reduced to 4.2 % while adding 10 % of A-151. On the other side, the particle size and distribution of the emulsion were analyzed by Scanning Electron Microscopy (SEM) and Malvern Particle Size Analyzer (PSA) respectively. The measuring results showed that the particle diameter of the modified emulsion could be between 100 and 700 nanometers, and the properties of the emulsion could be apparently improved by adding A-151 into the system of emulsion polymerization.

Karakterisasi Dan Optimasi Formula Sediaan Gel Ekstrak Etanol Kulit Buah Pisang Kapas (Musa paradisiaca Linn.)

2021 ◽  
Vol 1 ◽  
pp. 872-884
Author(s):  
Dina Rahma Ulya ◽  
St. Rahmatullah ◽  
W Wirasti ◽  
Dwi Bagus Pambudi
Keyword(s):  
Particle Size ◽  
Colloidal Particles ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Banana Peel ◽  
Ionic Gelation ◽  
Cycling Test ◽  
Musa Paradisiaca ◽  
Particle Size Analyzer ◽  
Gel Preparation

AbstractCotton banana peel (Musa paradisiaca Linn.) has not been used by the community. Nanoparticles are solid colloidal particles with a diameter of 10-1000 nm. This study aims to make ethanol extract of cotton banana peel (Musa paradisiaca Linn.) as an active substance in the form of nanoparticles formulated in gel preparations and to determine the evaluation of cotton banana peel (Musa paradisiaca Linn.) nanoparticle gel. The method of making nanoparticles of ethanolic extract of cotton banana peel (Musa paradisiaca Linn.) in this research is ionic gelation. Nanoparticles of ethanolic extract of cotton banana peel (Musa paradisiaca Linn.) were characterized using particle size analyzer. Evaluation of gel preparations included organoleptic tests, homogeneity, pH, dispersibility, adhesion, viscosity and cycling tests. The cycling test includes organoleptic, pH and viscosity testing. Cycling test observations were carried out for 6 cycles. Characterization of nanoparticles of ethanolic extract of cotton banana peel (Musa paradisiaca Linn.) had a particle size of 220.3 nm with a polydipsia index of 0.139. Evaluation of pH preparations has a pH of 6, viscosity ranges from 7116 cps – 8095 cps, dispersion ranges from 5.1 cm to 5.4 cm, adhesion ranges from 1.11 seconds to 7.54 seconds. The results of the cycling test showed a change in the color of the preparation, while the cycling test for pH and viscosity did not change the stability. Conclusion The cotton banana peel extract (Musa paradisiaca Linn.) can be made into smaller particles or nanoparticles using the ionic gelation method and the evaluation of the nanoparticle gel preparation of the cotton banana peel (Musa paradisiaca Linn.) extract has met the requirements.Keywords: Cotton banana peel, gel, nanoparticles, evaluation AbstrakKulit buah pisang kapas (Musa paradisiaca Linn.) belum dimanfaatkan oleh masyarakat. Nanopartikel merupakan partikel koloid padatan dengan diameter 10-1000 nm. Penelitian ini bertujuan untuk membuat ekstrak etanol kulit buah pisang kapas (Musa paradisiaca Linn.) sebagai zat aktif dalam bentuk nanopartikel yang diformulasi dalam sediaan gel dan untuk mengetahui evaluasi gel nanopartikel kulit buah pisang kapas (Musa paradisiaca Linn.). Metode pembuatan nanopartikel ekstrak etanol kulit buah pisang kapas (Musa paradisiaca Linn.) pada penelitian ini yaitu gelasi ionik. Nanopartikel ekstrak etanol kulit buah pisang kapas (Musa paradisiaca Linn.) dikarakterisasi menggunakan particle size analyzer. Evaluasi sediaan gel meliputi uji organoleptis, homogenitas, pH, daya sebar, daya lekat, viskositas dan cycling test. Pengujian cycling test meliputi pengujian organoleptis, pH dan viskositas. Pengamatan cycling test dilakukan selama 6 siklus.Karakterisasi nanopartikel ekstrak etanol kulit buah pisang kapas (Musa paradisiaca Linn.) memiliki ukuran partikel 220,3 nm dengan indeks polidipersitas 0,139. Evaluasi sediaan pH memiliki pH 6, viskositas rentang 7116 cps – 8095 cps, daya sebar rentang 5,1 cm -5,4 cm, daya lekat rentang 1,11 detik – 7,54 detik. Hasil pengujian cycling test terdapat perubahan warna dari sediaan, sedangkan pengujian cycling test terhadap pH dan viskositas tidak mengalami perubahan stabilitas. Kesimpulan ekstrak kulit buah pisang kapas (Musa paradisiaca Linn.) dapat dibuat dalam partikel yang lebih kecil atau nanopartikel dengan menggunkan metode gelasi ionik dan evaluasi sediaan gel nanopartikel ekstrak etanil kulit buah pisang kapas (Musa paradisiaca Linn.) telah memenuhi persyaratan.Kata kunci: Kulit buah pisang kapas, gel, nanopartikel, evaluasi

scholarly journals Pembuatan Dan Karaterisasi Nanopartikel Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata (L.f.) Schott) Menggunakan Metode Gelasi Ionik

2018 ◽  
Vol 1 (3) ◽  
pp. 029-033
Author(s):  
Dian Ayumi ◽  
Sumaiyah Sumaiyah ◽  
Masfria Masfria
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Particle Size ◽  
Particle Size Distribution ◽  
Surface Structure ◽  
Size Distribution ◽  
Ethanol Extract ◽  
Ionic Gelation ◽  
Particle Size Analyzer ◽  
Scanning Electron

Pengobatan tradisional masih diminati. Salah satu tumbuhannya adalah daun ekor naga (Rhaphidophora pinnata (L.f.) Schott) yang digunakan sebagai obat antikanker dan antibakteri. Penggunaan nanoteknologi dalam sistem penghantaran obat terus diteliti dan dikembangkan. Penelitian ini bertujuan untuk membuat dan mengetahui sifat-sifat nanopartikel ekstrak etanol daun ekor naga (Rhaphidophora pinnata (L.f.) Schott) menggunakan metode gelasi ionik. Ekstrak daun ekor naga dibuat dengan metode maserasi menggunakan pelarut etanol 96%. Nanopartikel dibuat dengan metode gelasi ionik, yaitu menggunakan larutan natrium tripolipospat 0,1% dan kitosan 0,2%, Nanopartikel kemudian dikarakterisasi menggunakan Particle Size Analyzer untuk mengetahui distribusi ukuran partikel dan Scanning Electron Microscopy untuk mengetahui bentuk permukaan partikel. Nanopartikel yang dihasilkan berupa serbuk berwarna coklat muda dengan distribusi ukuran partikel 234,49-1479,50 nm pada perbandingan kitosan 0,2% dan natrium tripolipospat 0,1% (5:1). Bentuk permukaan nanopartikel ekstrak etanol daun ekor naga yaitu tidak rata dan membentuk agregat longgar. Ekstrak etanol daun ekor naga dapat dibuat menjadi nanopartikel dengan kitosan 0,2% dan natrium tripolipospat 0,1% menggunakan metode gelasi ionik.   Traditional medicine is still popular. One of them is ekor naga Leaves (Rhaphidophora pinnata (L.f.) Schott) that has been used as anti-cancer and anti-bacteria. Nanotechnology in drug delivery system is still being studied and developed. This research aimed to prepare and evaluate the characterization of nanoparticle of Ekor Naga Leaves Ethanol Extract (Rhaphidophora pinnata (L.f.) Schott) by Ionic Gelation Method. The Ekor naga leaves extract was prepared by maceration with ethanol 96%. Nanoparticle was prepared by ionic gelation method, using sodium trypholiphosphat 0.1% and chitosan 0.2%, then it was characterized using Particle Size Analyzer to determine particle size distribution and Scanning Electron Microscopy to determine surface structure  particle. The nanoparticle was light brown with particle size distribution of  234.49-1479.50 nm in ratio of chitosan 0.2% and sodium trypholiphosphat 0.1% was 5:1. The surface structure of nanoparticle of ekor naga leaves extract was not smooth and form loose aggregates. The ethanol extract of ekor naga leaves can be prepared into nanoparticle with sodium trypholiphosphat 0.1% and chitosan 0.2% by Ionic Gelation Method

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