scholarly journals A case of Good's syndrome with refractory diarrhea after pleurectomy for recurrent thymoma

2021 ◽  
Vol 35 (5) ◽  
pp. 590-595
Author(s):  
Nobutaka Kobayashi ◽  
Daisuke Nakamura ◽  
Kentaro Miura ◽  
Masahisa Miyazawa
Keyword(s):  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jinyao Ni ◽  
Junwu Zhang ◽  
Yanxia Chen ◽  
Weizhong Wang ◽  
Jinlin Liu

Abstract Background Good's syndrome (GS) is a rare secondary immunodeficiency disease presenting as thymoma and hypogammaglobulinemia. Due to its rarity, the diagnosis of GS is often missed. Methods We used the hospital information system to retrospectively screen thymoma and hypogammaglobulinemia patients at the First Affiliated Hospital of Wenzhou Medical University from Apr 2012 to Apr 2020. The clinical, laboratory, treatment, and outcome data for these patients were collected and analyzed. Results Among the 181 screened thymoma patients, 5 thymoma patients with hypogammaglobulinemia were identified; 3 patients had confirmed diagnoses of GS, and the other 2 did not have a diagnosis of GS recorded in the hospital information system. A retrospective review of the clinical characteristics, laboratory results, and follow-up data for these 2 undiagnosed patients confirmed the diagnosis of GS. All 5 GS patients presented with pneumonia, 2 patients presented with recurrent skin abscesses, 2 patients presented with recurrent cough and expectoration, 1 patient presented with recurrent oral lichen planus and diarrhea, and 1 patient presented with tuberculosis and granulomatous epididymitis. In the years after the diagnosis of hypogammaglobulinemia with mild symptoms, all 5 patients had received irregular intravenous immunoglobulin (IVIG) treatment. As the course of the disease progressed, the clinical symptoms of all patients worsened, but the symptoms were partly resolved with IVIG in these patients. However, 4 patients died due to comorbidities. Conclusion GS should be investigated as a possible diagnosis in thymoma patients who present with hypogammaglobulinemia, especially those with recurrent opportunistic infections, recurrent skin abscesses, chronic diarrhea, or recurrent lichen planus.


2013 ◽  
Vol 24 ◽  
pp. e143
Author(s):  
S. Ersan ◽  
G. Ersan ◽  
C. Arslan ◽  
S. Atalay ◽  
S. Kose

2013 ◽  
Vol 4 ◽  
Author(s):  
Messaoudani Nesrine ◽  
Djidjik Reda ◽  
Baough Leila ◽  
Nekhla Ahmed ◽  
Benserai Fatma Zohra ◽  
...  

2008 ◽  
Vol 23 (4) ◽  
pp. 219 ◽  
Author(s):  
Seung Heon Lee ◽  
Sang-Min Lee ◽  
Seok-Chul Yang ◽  
Chul-Gyu Yoo ◽  
Young Whan Kim ◽  
...  

Cureus ◽  
2021 ◽  
Author(s):  
Saiara Choudhury ◽  
Sudhakar Papineni ◽  
Srikanth Ramachandruni ◽  
Jurairat Molina ◽  
Salim Surani

2002 ◽  
Vol 41 (11) ◽  
pp. 1062-1064 ◽  
Author(s):  
Toshihiko HASHIZUME

2015 ◽  
Vol 100 (5) ◽  
pp. 1903-1905 ◽  
Author(s):  
Zachary M. DeBoard ◽  
Benedict J.W. Taylor

2018 ◽  
Vol 5 (7) ◽  
Author(s):  
Daniel B Chastain ◽  
Joeanna I Sams ◽  
Gregory M Steele ◽  
Lindsey O Lowder ◽  
Carlos Franco-Paredes

Abstract In this brief report, we describe a 76-year-old patient with thymoma who underwent craniotomy for a left parietal lobe mass with pathologic findings consistent with Toxoplasma gondii encephalitis in the absence of any features of thymoma with immunodeficiency/Good’s syndrome. His clinical course suggested likely Toxoplasma reactivation.


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