scholarly journals Pharmacological assessment of the aqueous extract of rose oil waste from Rosa x damascena Herrm cultivated in Georgia

2021 ◽  
Vol 7 (1) ◽  
pp. 001-008
Author(s):  
Karen Mulkijanyan ◽  
Natela Gogitidze ◽  
Marine Sulakvelidze ◽  
Nadezhda Mushkiashvili ◽  
Zhana Novikova ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Animal Models ◽  
Aqueous Extract ◽  
Pharmacological Study ◽  
Oil Production ◽  
Hepatoprotective Activity ◽  
Gastric Injury ◽  
Pharmacological Properties ◽  
Active Constituents ◽  
Rose Oil

Among Rosaceae family's most popular and important plants Rosa x damascena Herrm. holds one of the top places due to its centuries-long application in perfumery, cosmetics, aromatherapy and medicine. Despite this, the chemical and pharmacological study of different products obtained from R. damascena still does not lose its relevance. Currently, considerable attention is paid to the valorization of the waste from rose oil production in order to fully utilize valuable physiologically active constituents. The present study provides data on some pharmacological properties of the aqueous extract of rose oil waste from the R. damascena cultivated in Georgia. In particular, evaluation of gastro- and hepatoprotective activity of the aforesaid extract has been carried out in animal models and revealed its efficacy. The extract appeared to dose dependently stimulate leucopoiesis (up to 75%) and prevent ethanol-induced gastric injury (20-80%). As well, the extract ameliorated hepatoxic effects of carbon tetrachloride by 63%.

scholarly journals Medicinal plants with hepatoprotective potentials against carbon tetrachloride-induced toxicity: a review

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chidiebere Emmanuel Ugwu ◽  
Stephen Monday Suru
Keyword(s):  
Carbon Tetrachloride ◽  
Animal Models ◽  
Medicinal Plants ◽  
Liver Diseases ◽  
Hepatoprotective Activity ◽  
Main Body ◽  
Marker Enzymes ◽  
Liver Injuries ◽  
Herbal Plants ◽  
Hepatoprotective Agents

Abstract Background Carbon tetrachloride (CCl4) is a well-characterized hepatotoxic agent. With rising cases of liver diseases, the identification, assessment, and development of hepatoprotective agents from plants source has become imperative. Main body With arrays of literature on plants with hepatoprotective potentials, this review sourced published literatures between 1998 and 2020 and systematically highlighted about 92 medicinal plants that have been reported to protect against CCl4-induced liver injury in animal models. The results show that herbal plants provide protection for the liver against CCl4 by downregulation of the liver marker enzymes and activation of antioxidant capacity of the liver cells with the restoration of liver architecture. We also provided the traditional and accompanying pharmacological uses of the plants. A variety of phytochemicals mostly flavonoids and polyphenols compounds were suggested to offer protection against liver injuries. Conclusion It can be concluded that there are a variety of phytochemicals in plant products with hepatoprotective activity against CCl4-induced toxicity in animal models.

Hepatoprotective activity ofTrichilia rokaon carbon tetrachloride-induced liver damage in rats

2001 ◽  
Vol 53 (11) ◽  
pp. 1569-1574 ◽  
Author(s):  
M. P. Germanò ◽  
V. D'Angelo ◽  
R. Sanogo ◽  
A. Morabito ◽  
S. Pergolizzi ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Hepatoprotective Activity

In-vitro and in-vivo Evaluation of Anti-asthmatic Activity of Eugenia jambolana bark

2021 ◽  
pp. 3337-3342
Author(s):  
Bhong Prabha N. ◽  
Naikawade Nilofar. S. ◽  
Mali Pratibha. R. ◽  
Bindu Madhavi. S.
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Animal Models ◽  
Aqueous Extract ◽  
Guinea Pigs ◽  
Bark Extract ◽  
Eugenia Jambolana ◽  
In Vivo Animal Models

Objectives: The present study designed to evaluate the Antiasthmatic activity of aqueous extract of bark of Eugenia Jambolana (AEEJ) on in vitro and in vivo animal models. Materials and methods: Different in vitro and in vivo animal models was used to study the anti asthmatic activity as isolated goat tracheal chain preparation, Acetylcholine and Histamine induced bronconstriction in guinea pigs, effect of drug extract on histamine release from mast cell was checked by clonidine-induced mast cell degranulation, and milk-induced eosinophilia and leukocytosis. Results: In-vitro study on goat tracheal chain preparation revealed that aqueous extract of Eugenia jambolana (AEEJ)bark exerted antagonistic effect on the histamine induced contraction. (P<0.05) The guinea pigs when exposed to 0.2% histamine aerosol showed signs of progressive dyspnoea leading to convulsions. AEEJ significantly prolonged the latent period of convulsions (PCT) as compared to control following the exposure of histamine (0.2%) aerosol (P<0.01). The observation of present study indicates aqueous extract of Eugenia jambolana shows significant inhibition of milk induced eosinophilia and leukocytosis. Group of animals pretreated with aqueous Eugenia jambolana bark extract showed significant reduction in degranulation of mast cells when challenged with clonidine. The prevention of degranulation process by the aqueous Eugenia jambolana bark extract (P<0.01) indicates a possible stabilizing effect on the mast cells, indicating mast cell stabilizing activity. Conclusions: Thus, AEEJ showed antihistaminic, mast cell stabilizing and protective in guinea pigs against histamine induced PCD, reduced eosinophilia and leukocytosis and hence possesses potential role in the treatment of asthma.

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