scholarly journals KEHAMILAN KEMBAR DISERTAI MOLA HIDATIDOSA

2019 ◽  
Vol 8 (2) ◽  
pp. 75-83
Author(s):  
Harya Narottama ◽  
◽  
Erry Gumilar ◽  
Brahmana Askandar ◽  
◽  
...  
Keyword(s):  
Vaginal Bleeding ◽  
Rare Case ◽  
Twin Pregnancy ◽  
Ultrasound Examination ◽  
Hydatidiform Mole ◽  
Molar Pregnancy ◽  
Premature Labor ◽  
Triplet Pregnancy ◽  
Diagnostic Approaches

Twin pregnancy with Hydatidiform Mole is a rare case, only about 1 in 22.000 to 100.000 pregnancies. Molar pregnancy with triplet pregnancy is even rarer, which is only 6 cases reported and mostly occurred in women who received therapy for infertility. Management in cases of twin pregnancy with hydatidiform mole is dilemmatic both for the patient and physician. We present a case of 29 years old woman with her first pregnancy of twin fetuses complicated with hydatidiform mole. Diagnostic approaches were made mainly by ultrasound examination, continued with laboratory and radiology examinations which some did not performed due to worsened vaginal bleeding. This case ended with premature labor with the result of delivery of two babies and placenta with vesicles which is a characteristic of hydatidiform mole.

scholarly journals THYROTOXICOSIS IN PATIENTS WITH HYDATID MOLE

2021 ◽  
Vol 4 (1) ◽  
pp. 76
Author(s):  
Rahadianto Tjandra ◽  
Maimun Z. Arthamin
Keyword(s):  
Rare Case ◽  
Hydatidiform Mole ◽  
Age Groups ◽  
Sudden Onset ◽  
Thyroid Stimulating Hormone ◽  
Molar Pregnancy ◽  
Maternal Circulation ◽  
Free T4 ◽  
Long Period ◽  
Life Threatening

<p>Hydatid Mole, also often called grape pregnancy, is a pregnancy characterized by abnormal trophoblast development. The incidence of hydatidiform mole per 1,000 pregnancies occurs in Asia. In Indonesia, in 2002 cases of hydatidiform mole were found 1: 123 pregnancy, and in 2003 found cases of hydatidiform mole 1: 245 pregnancy. While the results of research conducted in the same place in 2012-2013 obtained 39 cases of hydatidiform mole that were distributed based on age groups, parity, education, and hemoglobin levels of patients. Trophoblastic hyperthyroidism is a rare case but can be life threatening. Alpha subunit-human chorionic gonadotropin (HCG) is similar to alpha sub-unit-thyroid stimulating hormone (TSH). If HCG concentrations increase over a long period of time, it can increase free T4 and free T3 levels. In this patient there was also a sudden onset of hypertension, proteinuria 3+, ketonuria 3+, hematuria 3+, leukosituria 1+, bacteriuria which could possibly be caused by the occurrence of a pre-eclampsia or UTI in this patient. The cause of pre-eclampsia in molar pregnancy is thought to be due to excessive levels of soluble fms-like tyrosine kinase 1 (sFlt1) in the circulation, an endogenous anti-angiogenic protein that enters the maternal circulation after overproduction in the placenta.</p><p><strong>Keywords: Mola hydatidosa, HCG, TSH, sFlt1</strong></p>

scholarly journals Coexistent molar pregnancy with a normal fetus-a rare presentation of gestational trophoblastic disease

2021 ◽  
Vol 10 (10) ◽  
pp. 3962
Author(s):  
Catarina J. Nascimento ◽  
Mariana Veiga ◽  
Ana Rita Silva ◽  
Joana Cominho
Keyword(s):  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Healthy Woman ◽  
Clinical Approach ◽  
Molar Pregnancy ◽  
Complete Hydatidiform Mole ◽  
Consensus Protocol ◽  
Rare Presentation ◽  
Normal Fetus ◽  
Increased Risk

A coexistent molar pregnancy with a normal fetus is rare, with an incidence of 1 in 22.000 to 100.000 pregnancies-only 200 cases reported in the last two decades. The ultrasound is essential for an earlier diagnosis, and the management of these cases is challenging due to the increased risk of obstetrics complications and the possibility of posterior gestational trophoblastic neoplasia. Here we describe a 33-year-old healthy woman with a first-trimester twin pregnancy, presented with a normal fetus and a heterogeneous and vacuolar structure suggestive of complete hydatidiform mole. The pregnancy was interrupted, and a histological diagnosis confirmed complete hydatidiform mole in dichorionic/diamniotic twin pregnancy at 14 weeks. Molar twin pregnancy is a rare condition, and do not exist any consensus protocol to guide the clinical approach, so the decision to continue the pregnancy depends on the couple’s desire and maternal and fetal complications.

scholarly journals Management of twin pregnancy with a hydatidiform mole and surviving healthy co-existent fetus

2017 ◽  
Vol 6 (12) ◽  
pp. 5636
Author(s):  
Hale Goksever Celik ◽  
Gözde Meriç Demirezen ◽  
Baki Erdem ◽  
Alev Atış Aydın ◽  
Volkan Ülker
Keyword(s):  
Maternal Morbidity ◽  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Uterine Cavity ◽  
First Trimester ◽  
Molar Pregnancy ◽  
Complete Mole ◽  
Live Fetus ◽  
Twin Pregnancies ◽  
Normal Placenta

Twin pregnancies with complete mole and a coexisting live fetus are rare obstetric conditions seen in 1 case of 22000 to 100000 pregnancies. In our case, a twin molar pregnancy was diagnosed in the first trimester by ultrasound. In a 27-year-old patient with the first pregnancy, a 12-week live fetus with a normal placenta and a twin molar pregnancy appearance were observed on a routine ultrasonographic examination of the uterine cavity. Twin molar pregnancies are reported to be terminated by live birth in the literature, but termination of pregnancy is an important option to prevent maternal morbidity since molar pregnancy may lead to complications ranging from theca lutein cysts to gestational trophoblastic neoplasia.

scholarly journals Partial molar pregnancy associated with a normal appearing foetus: a case report and review of the literature

2017 ◽  
Vol 6 (6) ◽  
pp. 2681
Author(s):  
Sujata Singh ◽  
Sasmita Swain ◽  
Lucy Das ◽  
Pravat Chandra Das
Keyword(s):  
Case Report ◽  
Trisomy 21 ◽  
Vaginal Bleeding ◽  
Hydatidiform Mole ◽  
Molar Pregnancy ◽  
Rare Entity ◽  
Review Of The Literature ◽  
Cystic Changes ◽  
Β Hcg ◽  
Moderate Anaemia

Partial molar pregnancy is a rare entity in which there is usually a triploid abnormal foetus associated with a large placenta with cystic changes. The incidence of a normal diploid foetus and a partial molar placenta is extremely rare. Here we report a case of partial molar pregnancy in which a normal appearing foetus with diploid karyotype coexist. In this case a 24yr old primigravida at 20 week 3days gestation presented with 3-4 episodes of vaginal bleeding and generalised swelling of body since one month. On evaluation she was found to have moderate anaemia, proteinuria, raised serum β hcg and USG showed a single live foetus with thickened cystic placenta covering the internal os. After counselling patient was put up for hysterotomy. The product of conception and placenta were sent for histopathology and karyotyping which confirmed partial hydatidiform mole with trisomy 21 foetus. Patient had uneventful post op period and was followed up with serial β hcg measurement which fell to undetectable levels within two months. 

scholarly journals Partial hydatidiform mole and coexistent live fetus: a case report and review of the literature

Open Medicine ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 843-846
Author(s):  
Chengying Zeng ◽  
Yanbi Chen ◽  
Lijuan Zhao ◽  
Bo Wan
Keyword(s):  
Case Report ◽  
Pregnant Woman ◽  
Peripheral Blood ◽  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Molar Pregnancy ◽  
Review Of The Literature ◽  
Partial Hydatidiform Mole ◽  
Normal Fetus ◽  
Live Fetus

AbstractTwin pregnancy of a hydatidiform mole with a coexistent live fetus is very rare, and complete molar pregnancy is involved in most cases. A partial molar pregnancy almost always ends in miscarriage due to a triploid fetus. Here, we report a case of a 32-year-old Chinese woman with ultrasound diagnosis of a partial molar pregnancy. Amniocentesis suggested mosaicism, but the fetus was morphologically normal. The woman chose to continue the pregnancy after fully understanding the risk. The infant was delivered prematurely, and the presence of a large single placenta with molar changes. The baby’s peripheral blood chromosomes were diploid, and the pregnant woman had no serious complications. The diagnosis, management, and monitoring of this condition will remain challenging because of its rarity. Partial hydatidiform mole combined with pregnancy can result in delivering of a normal fetus and live birth under proper management.

scholarly journals Viable Intrauterine Pregnancy and Coexisting Molar Pregnancy in a Bicornuate Uterus: A Rare Presentation

2016 ◽  
Vol 6 ◽  
pp. 26 ◽  
Author(s):  
Kavitha Krishnamoorthy ◽  
Sabrina Gerkowicz ◽  
Usha Verma
Keyword(s):  
Vaginal Bleeding ◽  
Hydatidiform Mole ◽  
Molar Pregnancy ◽  
Intrauterine Pregnancy ◽  
Rare Presentation ◽  
Bicornuate Uterus ◽  
First Case ◽  
Dilation And Curettage ◽  
Β Hcg ◽  
The Right

A complete hydatidiform mole with a viable coexisting fetus (CMCF) is a rare occurrence. Similarly, Mullerian anomalies such as a bicornuate uterus are uncommon variants of normal anatomy. We report a case of a 40-year-old female with a known bicornuate uterus presenting at 13 weeks gestation with vaginal bleeding. Ultrasound findings showed a healthy viable pregnancy in the right horn with complete molar pregnancy in the left horn. After extensive counseling, the patient desired conservative management, however, was unable to continue due to profuse vaginal bleeding. The patient underwent suction dilation and curettage under general anesthesia and evacuation of the uterine horns. Postoperatively, the patient was followed until serum beta-human chorionic gonadotropin (β-hCG) level dropped to <5 mU. This is the first case of a CMCF reported in a bicornuate uterus, diagnosed with the use of ultrasound imaging.

scholarly journals Delivery of Euthyroid Baby following Hyperthyroidism in Twin Gestation with Coexisting Complete Hydatidiform Mole

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Rishi Raj ◽  
Edilfavia Mae Uy ◽  
Matthew Hager ◽  
Kamyar Asadipooya
Keyword(s):  
Twin Pregnancy ◽  
Molecular Mimicry ◽  
Rare Complication ◽  
Hydatidiform Mole ◽  
Gestational Trophoblastic Disease ◽  
Thyroid Stimulating Hormone ◽  
Dose Titration ◽  
Molar Pregnancy ◽  
Trophoblastic Disease ◽  
Normal Fetus

Context. Gestational trophoblastic disease (GTD) is a rare complication of pregnancy, ranging from molar pregnancy to choriocarcinoma. Twin pregnancies with GTD and coexisting normal fetus are extremely rare with an estimated incidence of 1 case per 22,000–100,000 pregnancies. Molecular mimicry between human chorionic gonadotrophin (hCG) and thyroid-stimulating hormone (TSH) leads to gestational trophoblastic hyperthyroidism (GTH) which is further associated with increased maternal and fetal complications. This is the first reported case in literature describing the delivery of a baby with biochemical euthyroid status following a twin pregnancy with hydatidiform mole (HM) associated with gestational trophoblastic hyperthyroidism (GTH). Case Description. A 24-year-old G4 P3 Caucasian female with twin gestation was admitted to hospital for gestation trophoblastic hyperthyroidism. She was later diagnosed to have twin pregnancy with complete mole and coexisting normal fetus complicated by gestational trophoblastic hyperthyroidism (GTH). Despite the risk associated with the continuation of molar pregnancy, per patient request, pregnancy was continued till viability of the fetus. The patient underwent cesarean section due to worsening preeclampsia and delivered a euthyroid baby at the 24th week of gestation. Conclusions. Twin pregnancy with gestational trophoblastic disease and coexisting normal fetus is associated with high risk of hyperthyroidism, and careful monitoring of the thyroid function test along with dose titration of thionamides is of utmost importance throughout the gestation. If normal thyroid hormone levels are maintained during the pregnancy, euthyroidism could be successfully achieved in the baby.

scholarly journals Expectant Management of a Twin Pregnancy with Complete Hydatidiform Mole and Coexistent Normal Fetus

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Colin Johnson ◽  
Caroline Davitt ◽  
Rachel Harrison ◽  
Meredith Cruz
Keyword(s):  
Twin Pregnancy ◽  
Hydatidiform Mole ◽  
Expectant Management ◽  
Fetal Monitoring ◽  
Molar Pregnancy ◽  
Complete Hydatidiform Mole ◽  
Normal Fetus ◽  
Healthy Female ◽  
Negative Woman ◽  
Inpatient Management

Twin pregnancies complicated by complete hydatidiform mole coexisting with a viable fetus are rare and may result in significant complications. We describe the expectant management and our surgical approach in a 27-year-old Rh-negative woman presenting with recurrent episodes of vaginal bleeding and a twin pregnancy consisting of a molar pregnancy coexisting with a normal fetus. Inpatient management was undertaken with close maternal and fetal monitoring until cesarean delivery of a healthy female infant and histopathologically confirmed complete hydatidiform molar pregnancy (karyotype 46XX) at 34 weeks with no evidence of malignancy.

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