scholarly journals Implementation of molecular genetic tests in the diagnostics of thyroid cancer: own research

2021 ◽  
pp. 9-16
Author(s):  
O. P. Nechay ◽  
O. A. Tovkai ◽  
V. O. Palamarchuk ◽  
N. I. Belemets ◽  
S. І. Nikolayenko ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Molecular Genetic ◽  
Prognostic Significance ◽  
Pathogenic Mutation ◽  
Endocrine Surgery ◽  
Pathogenic Mutations ◽  
Endocrine Organs ◽  
Group 2 ◽  
Group 1

Aim — to investigate the significance of BRAFV600E, NRAS, KRAS, HRAS, RET/PTC (RET/PTC1 and RER/PTC3), PAX8/PPARg mutations for the development and course of thyroid cancer with the determination of a significant predictor mutation. Materials and methods. The analysis included 63 selected case histories of patients who, at the preoperative stage, underwent molecular genetic testing (MHT) of the thyroid gland (TG) masses and subsequently underwent surgical treatment in the surgical department of the Ukrainian Scientific and Practical Center for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues. The average age of the patients was 41.0 ± 1.8 years; from them 7men and56women. All patients underwent fine-needle aspiration puncture biopsy(FNAB) of thyroid nodules according to the standard method followed by a cytological conclusion in accordance with the Bethesda system.The Bethesda III category was revealed in 3 patients (4.8 %), Bethesda IV — 13 patients (20.6 %), Bethesda V — 12 patients (19.0 %), Bethesda VI in 35 (55.6 %) patients. The pathogenic mutations were detected in 47 (74.6 %) patients (group 1), among them two mutations were simultaneously found in two subjects. In 16 cases (25.4 %), no pathogenic mutation was found at all (group 2). Results. The genes that occurred most often were BRAFV600E — in 35 patients (55.6 %), NRAS — in 11 patients (17.5 %), KRAS — in 3 patients (4.8 %). In case of thyroid cancerdiagnosis, pathogenic mutations were found in 38 (79.1 %) subjects. The BRAFV600E gene mutation was observed when establishing a cytological conclusion classified as Bethesda III—V in 28.9 %, and in Bethesda V and in 77.1 %. Accordingly, the sensitivity of the test was low — 0.646, specificity — 0.733. The high prognostic significance of a positive result(PPV) value (from 0.784 to 0.943) indicated the likelihood of detecting thyroid cancer. This assumption confirms the calculation of the c-square criterion with the Yates correction, which is 5.207 (p = 0.023). The use of this test for the presence of the NRAS gene to detect thyroid cancer was ineffective, the value of the c -square criterion with Yates correction = 0.009 (p = 0.927). The incidence of thyroid cancer in group 1 in the cytological class Bethesda III—V was higher than in group 2, but it did not differ significantly between the groups. The aggressiveness of thyroid cancer in patients of group 1 with a positive MHT result did not have significant differences compared with the results obtained in group 2 (39.5 % and 33.3 %, respectively). Conclusions. The use of the kit for the determination of MHTmade it possible to identify pathogenic mutations in the genes BRAFV600E, NRAS, KRAS in 79.1 % of cases. The presence of these genes in combination with the analysis of cytomorphological findings classified according to the Bethesda III—V system did not increase the detection of thyroid cancer in the studied patients. The BRAFV600E gene, which was observed in 64.6 % of cases (PPV from 0.784 to 0.943), was a significant predictor among the studied candidate genes for establishing the diagnosis of thyroid cancer. Detection of a pathogenic mutation in patients with thyroid cancer did not indicate in favour of its aggressive course.

scholarly journals SELECTION AND DETERMINATION OF THE OPTIMAL CONCENTRATION OF THE PLATELET AGGREGATION INDUCER IN INTENSIVE THERAPY OF PATIENTS WITH COVID-19 INFECTION

2021 ◽  
Vol 20 (3) ◽  
pp. 16-24
Author(s):  
A.V. Marochkov ◽  
◽  
◽  
A.L. Lipnitski ◽  
A.G. Starovoitov ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Intensive Therapy ◽  
Prognostic Significance ◽  
Area Under The Curve ◽  
Chi Square ◽  
Coronavirus Infection ◽  
High Concentrations ◽  
Group 2 ◽  
Group 1

The change in platelet function that occurs in patients during treatment for a new coronavirus infection can be determined using the platelet aggregation method. Objectives. To determine optimal inducer of platelet aggregation and to assess its prognostic significance in intensive therapy of patients with COVID-19 infection. Material and methods. 34 patients with new coronavirus infection were included in group 1, and 30 healthy women were included in group 2. The study of platelet aggregation was carried out by the turbidimetric method with AP2110 analyzer (SOLAR, Results. The area under the aggregation curve was statistically significantly greater in patients in group 1 when using an ADP inducer at a dose of 0.3 μg/ml (69.1 (27.3; 164.4) unit in comparison with 55.3 (31.5; 68.2) units in group 2, p<0.001). When using an ADP inducer in high concentrations of 1.25 and 2.5 μg/ml and an adrenaline inducer in concentrations of 2.5 and 5 μM, the area under the curve in patients with COVID-19 infection was statistically significantly lower compared to group 2. The area under the aggregation curve according to the Hosmer-Lemeshov criterion has been found to be an independent predictor of death in the intensive care unit (Chi-square=5.074, p=0.06 for ADP 0.3 μg/ml and Chi square=15.121, p=0.057 for ADP 0.6 μg/ml). Conclusions. A comparative analysis of platelet aggregation using inducers of ADP, adrenaline and collagen has shown that in patients with new coronavirus infection, the degree of coagulation imbalance should be determined according to the indications obtained with an ADP inducer at a dose of 0.3 and 0.6 μg/ml.

Abstract 1756: Determination of the Mechanism of Elevated Left Ventricular Filling Pressures with Exercise: A Simultaneous Echocardiographic-Catheterization Study

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Wissam A Jaber ◽  
Barry A Borlaug ◽  
Margaret M Redfield ◽  
Pui W Lee ◽  
Steve R Ommen ◽  
...  
Keyword(s):  
Exercise Group ◽  
Left Ventricular ◽  
Filling Pressure ◽  
Ventricular Relaxation ◽  
Rate Table ◽  
Group 2 ◽  
Exercise Induced ◽  
Ventricular Filling ◽  
Group 1

Background: Exercise normally enhances LV relaxation with minimal change in filling pressure (P). We hypothesize that exercise in hypertensive (HTN) patients increases LV diastolic P through a direct effect on relaxation and ventricular-vascular coupling. Methods: Patients (n=21) with HTN, normal EF, and no coronary disease underwent simultaneous micromanometer LV P and echo-Doppler measurements at rest and with low level supine exercise (12 bicycle; 9 arm weight). Continuous volume (V) was obtained from mitral Doppler inflow and end-diastolic (ED) and end-systolic (ES) V from 2-D echo. Relaxation-corrected LV diastolic P was used for PV relationship P = α.e β*V ; to account for covariance in α and β, LV capacitance (EDV 20 = Ln[20mmHg/α]/β) was reported. Single beat method was used for LV ES elastance (Ees). Group 1 did not increase mean LV diastolic P (mDP) with exercise, Group 2 increased mDP >6mmHg. Results: LV diastolic P and arterial and LV ES elastance increased with exercise; EDV was stable; EDV 20 decreased. Compared to Group 1, Group 2 had a greater exercise-induced increase in afterload, associated with increase in LV minimal P and impaired augmentation of relaxation rate (Table & Figure ). Conclusions: In patients with HTN, impairment of ventricular relaxation plays a major role in causing LV filling P increase with exercise, which is related to ventricular-vascular coupling.

Determination of alpha 2-macroglobulin-trypsin complex with a new synthetic substrate.

1989 ◽  
Vol 35 (11) ◽  
pp. 2169-2172 ◽  
Author(s):  
K Kuroiwa ◽  
S Nakatsuyama ◽  
K Katayama ◽  
T Nagasawa
Keyword(s):  
Healthy Subjects ◽  
Colorimetric Assay ◽  
Colorimetric Method ◽  
Pancreatic Disease ◽  
Chromogenic Substrate ◽  
Standard Curve ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Abstract We have developed a colorimetric assay for quantifying alpha 2-macroglobulin-trypsin complex (alpha 2M-TRY) in human serum, based on use of a new chromogenic substrate D-gamma-tert-butyloxy-Glu-Gly-Arg-3-carboxy-4-hydroxyanilide dihydrochloride (PS-3001). Within-run CVs by this assay were 4.76%, 1.57%, and 0.83% for trypsin complex concentrations of 3.1, 12.2, and 48.1 U/L, respectively (n = 10 each). Between-day CVs were 5.38%, 3.12%, and 2.20% at each concentration, respectively (n = 7). Mean analytical recoveries of alpha 2M-TRY added to serum were 100%, 105%, and 101% for 9.2, 15.1, and 46.3 U/L, respectively (n = 2). The standard curve obtained was linear up to 330 U/L. We applied this method to the study of alpha 2M-TRY activity in sera from 97 healthy subjects (group 1), from 27 patients with acute pancreatitis (group 2), and from 25 patients with other chylopoietic diseases (group 3); results ranged from 0 to 1.2 U/L (mean = 0.5, SD = 0.3), from 1.2 to 77.4 U/L (mean = 14.6, SD = 19.0), and from 0 to 1.3 U/L (mean = 0.4, SD = 0.3), respectively. Concentrations of enzymatically active alpha 2M-TRY were significantly greater in sera from group 2 than in groups 1 and 3. The determination of serum alpha 2M-TRY activity by this simple, rapid, colorimetric method may be useful for the diagnosis and evaluation of pancreatic disease.

scholarly journals Effect of the first and second postpartum partial milking on blood serum calcium concentration in dairy cows

2014 ◽  
Vol 59 (No. 3) ◽  
pp. 128-133
Author(s):  
E.G. Salgado-Hernández ◽  
A. Aparicio-Cecilio ◽  
F.H. Velásquez-Forero ◽  
D.A. Castillo-Mata
Keyword(s):  
Blood Serum ◽  
Dairy Cows ◽  
Serum Calcium ◽  
Metabolic Disorders ◽  
Calcium Concentration ◽  
Atomic Absorption Spectrophotometry ◽  
Serum Calcium Concentration ◽  
Group 2 ◽  
Group 1

Parturient paresis and subclinical hypocalcemia are frequent metabolic disorders in dairy cows postpartum. The aim of this study was to determine the effect of postpartum partial milking in the first two milkings on blood serum calcium concentration in dairy cows. Twenty multiparous Holstein dairy cows were randomized into two groups. Cows of group 1 (n = 10) were partially milked at the first and second milking postpartum. Cows of group 2 (n = 10) were completely milked. Blood samples were collected from all animals 5&ndash;7 days before calving, within 30 min after calving, and 4, 8, 12, 16, 20, 24, 28, and 32 h after calving for determination of serum calcium (Ca), phosphorus (P), and magnesium (Mg) concentrations. Colostrum production was registered and sampled in the first and second milking. Concentration of Ca in colostrum was determined by atomic absorption spectrophotometry. Serum Ca and P concentrations decreased in both groups after parturition (P &lt; 0.05) and remained low during 32 h postpartum with no difference observed between groups (P &gt; 0.05). Serum concentrations of Mg were stable in all samples and no statistical difference was observed between groups (P &gt; 0.05). Colostrum production was higher in completely milked cows only in the first postpartum milking (P &lt; 0.05), but there was no difference between groups at the second milking. Total Ca secretion in colostrum was higher in the complete milking group at the first and second postpartum milking. Colostrum Ca secretion increased at the second milking with respect to the first one in both groups (P &lt; 0.05). There was no correlation between serum Ca and colostrum Ca (P &gt; 0.05). In this study, the partial milking of colostrum in the first and second milking postpartum did not prevent subclinical hypocalcemia in dairy cows. &nbsp;

Clinical study of thyroid cancer among a pediatric population born after Chernobyl (first report)

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 6069-6069
Author(s):  
M. B. Gorobeiko ◽  
O. S. Larin ◽  
S. M. Cherenko
Keyword(s):  
Thyroid Cancer ◽  
Surgical Treatment ◽  
Pediatric Population ◽  
Polluted Area ◽  
Follicular Variant ◽  
Regional Metastases ◽  
Radiation Induced ◽  
The Mean ◽  
Group 2 ◽  
Group 1

6069 Background: To evaluate the clinical and patologic results of surgical treatment of children born after Chernobyl and to compare these findings with well-known data of the group of patients who were children at the time of Chernobyl. To compare the clinical and pathologic features of thyroid cancer of children born after the Chernobyl versus those born prior to 1986. Methods: Comparison of clinical and pathologic result of surgical treatment of 141 patients born after Chernobyl (Group 1) and 589 patients (Group 2) aged 0–18 at the time of the disaster (1986) among the single institution clinical cohort within years 1995–2005. Results: In Group 1 there were 31 cancers (22%) vs. 243 (41%) in Group 2 (p<0.05 between Group 1 and Group 2). The rate of extrathyroid invasion was 69% vs. 36% (p<0.05 between Group 1 and Group 2). In Group 1, 17/21(80%) patients with extrathyroid invasion were found to have regional neck metastases (8 unilateral, 9 bilateral).The mean age in this subgroup was 13.4 ± 2.11 years but in the “benign subgroup” of Group 1 the mean age is 16.2 ± 0.77 years.In Group 2, 49/88 (55%) patients with extrathyroid invasion only had regional metastases. The mean age in this subgroup is 31.1 ± 4.7 years (p<0.05 between Group 1 and Group 2). We found cancer multifocality in 1 patient (3%, Group 1) vs. 55 (23%, Group 2).There were 19 cases (13.5%) of atypical adenomas in Group 1 vs. 46 (8%) in Group 2 (p<0.05 between Group 1 and Group 2). Histological types: solid follicular variant of papillary carcinoma (typical for radiation-induced children carcinomas with short latency) was found in 3 cases in Group 1 (9.5%) vs. 76 (31%) in the Group 2 (p<0.05 between Group 1 and Group 2). There was only one case of follicular thyroid cancer in Group 1 (3%) vs. 9% in Group 2. We did not find any relationship of cases of cancer in Group 1 to the Chernobyl-polluted area (only 3 patients − 10% from the nearest to Chernobyl regions) vs. 192 patients (80%) in Group 2 (p<0.05 between Group 1 and Group 2). Among patients with tumors of uncertain malignant potential 9 patients (6%) were from Chernobyl-polluted area vs.72% in Group 2 (p<0.05 between Group 1 and Group 2). Conclusions: Our data demonstrates higher likelihood of aggressive well-differentiated thyroid cancer among a pediatric population independently from Chernobyl irradiation and connected with another etiological factors of genesis of tumor.The solid-follicular variant of papillary cancer and multifocality are typical for radiation-induced carcinoma in children. No significant financial relationships to disclose.

Prognostic significance of magnetic resonance imaging in the acute phase of cervical spine injury

1992 ◽  
Vol 76 (2) ◽  
pp. 218-223 ◽  
Author(s):  
Dale M. Schaefer ◽  
Adam E. Flanders ◽  
Jewell L. Osterholm ◽  
Bruce E. Northrup
Keyword(s):  
Cervical Spine ◽  
Mr Imaging ◽  
Prognostic Significance ◽  
Spinal Segment ◽  
Content Type ◽  
Group 3 ◽  
Group 2 ◽  
Fine Print ◽  
Group 1

✓ Fifty-seven patients with acute cervical spine injuries and associated major neurological deficit were examined within 2 weeks of injury by magnetic resonance (MR) imaging. All patients had abnormal scans, indicating intramedullary lesions. This study was undertaken to determine if the early MR imaging pattern had a prognostic relationship to the eventual neurological outcome. Three different MR imaging patterns were observed in these patients: 21 patients had patterns characteristic of intramedullary hematoma (Group 1); 17 had intramedullary edema over more than one spinal segment, but no hemorrhage (Group 2); and 19 had restricted zones of intramedullary edema involving one spinal segment or less (Group 3). The neurological state was determined using standard motor index scores at admission and at follow-up examination. Characteristically, the patients in Group 1 had admission motor scores significantly lower than the other two groups. At follow-up examination, the median percent motor recovery was 9% for Group 1, 41% for Group 2, and 72% for Group 3. These studies suggest that the MR imaging pattern observed in the acutely injured human spinal cord has a prognostic significance in the final outcome of the motor system. It is only when an accurate prognosis can be given at the outset that useful treatment data might be collected for homogeneous injury groups, and accurately based long-term planning made for the best patient care.

scholarly journals The Comparative Analysis of the Influence of Traditional Education and Distance Learning by the Results of the Discipline “Internal Medicine” in Graduate Students

2020 ◽  
Vol 5 (6) ◽  
pp. 323-328
Author(s):  
H. Taktashov ◽  
◽  
N. Hrona ◽  
Ya. Voloshyn ◽  
O. Homozova ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Academic Performance ◽  
Distance Learning ◽  
Comparative Analysis ◽  
Graduate Students ◽  
Traditional Education ◽  
Group 2 ◽  
Academic Year ◽  
Group 1

The introduction of distance learning was the feature of teaching students during the last third of 2019-2020 academic year in the conditions of quarantine measures for SARS-COV-2. Partly traditional and partly distance learning fragmentariness of this academic year of different students’ groups allows substantiating the possibility and necessity of the comparative assessment and comparison of the results of these teaching approaches. The purpose of the study was to assess the features of the influence of traditional education and distance learning on the graduate students’ performance in “Internal Medicine” based on the results of the state exam. Materials and methods. The study of the results of the final exam of the 6th year students of the Medical University of the IV level of accreditation was carried out. The examination for distance students was held using “Standardized patient” model which was in the form of the situational task based on a real clinical case with laboratory instrumental data in the subdisciplines of Internal Medicine (“cardiology”, “pulmonology”, “gastroenterology”, “endocrinology”, “nephrology”, “rheumatology”, “hematology”). We identified 2 main groups for the comparative analysis. Group I consisted of 110 students who studied during the autumn and early spring terms in the context of traditional education with practical training of full value. Group II included 55 students who were taught in the form of distance learning using such educational platform and resources as Google Classroom, Google Meet during the spring term. Statistical processing of obtained results was carried out using the Statistica-Stat-Soft, USA and Microsoft Excel software package. Results and discussion. The analysis revealed the small differences in the levels of current academic performance in the subject of Internal Medicine in the context of distance learning in relation to the traditional one. When comparing the results of the two training forms we noted prevailing results of qualitative progress with the most pronounced differences in the subdisciplines “cardiology”, “gastroenterology”, in Group 1 and they reliably depended on the academic ranking in the discipline. The nature of the decline in the levels of general and high-quality academic performance based on the exam results with the most pronounced differences in the subdisciplines “rheumatology” and “gastroenterology” did not correlate with the academic ranking indicators of the current training in Group 2. When analyzing the structure of standardized exam questions, the highest efficiency of the answers was demonstrated basing on the skills of “Diagnosis of the leading syndrome”, and “Determination of a preliminary clinical diagnosis”, “Determination of the plan of examination, prognosis and prevention” in the general discipline and, especially, in such subdisciplines as “cardiology”, “gastroenterology”, “nephrology” in both groups, and, with Group 1 predominating. The lowest rates of the answers of Group 2 were recorded for the skills “Treatment, management tactics”, “Evaluation of laboratory and instrumental methods of examination” in the discipline in general and to a greater extent in the subdisciplines “gastroenterology”, “endocrinology”, “rheumatology”. Conclusion. The study showed a negative tendency of the peculiarities of the influence of the distance learning form on the current and final academic performance in the absence of the possibility of mastering theoretical material during direct work with the patient. The use of distance learning is possible as an addition to the traditional one in the blended learning and is promising in the implementation of high-tech informative methods to improve the quality of self-preparation of students for classroom studies

scholarly journals Does Unilateral Thyroid Cancer Affect The Malignant Risk Of Contralateral Thyroid Nodules?-A Retrospective Cohort Study

2020 ◽  
Author(s):  
Huan Liu ◽  
Jun Jin ◽  
Qiao Chen ◽  
Zhongmin Li
Keyword(s):  
Clinical Trial ◽  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Control Group ◽  
Clinical Trial Registration ◽  
Significant Difference ◽  
Group 2 ◽  
Experimental Group ◽  
Group 1

Abstract BackgroundThe incidence of thyroid nodules increased significantly, but the mortality rate of thyroid cancer remained stable or even decreased. However, surgical treatment of thyroid nodules is more aggressive, including the number and scope of surgery. the purpose of our study was to evaluate whether unilateral thyroid nodules affect the malignancy risk of contralateral thyroid nodules. Methods We conducted a retrospective study on all patients with thyroid nodules in a tertiary hospital within one year. Unilateral and bilateral thyroid nodules were the control group and the experimental group, respectively. Based on the TI-RADS grades, the experimental group and the control group were divided into two subgroups. We used chi-square test or Fisher's exact test to evaluate whether there were statistical differences in the incidence and pathological types of thyroid cancer between the experimental group and the control group. Results Our study showed that there was no significant difference in malignant risk between the experimental group 1 and the control group 1, and the experimental group 2 and the control group 2 (20%vs35%, p=0.724, 63.16%vs76.32%, p=0.297, respectively). Both the a-side thyroid of the experimental group and the control group were papillary thyroid carcinoma, including micropapillary thyroid carcinoma, and there was no difference in the proportion of micropapillary thyroid carcinoma (p = 0.200, 0.620, respectively). Conclusions There is no evidence that bilateral thyroid nodules affect each other in terms of malignant risk, that is, in bilateral thyroid nodules, unilateral thyroid cancer does not change the malignant risk of contralateral thyroid nodules.This study has been registered with the Chinese Clinical Trial Registry, clinical trial registration number: ChiCTR2000038611, registration time: 2020-09-26.

scholarly journals Natural sepiolite efficiency in reducing 137Cs transfer and deposition into meat and edible organs of broiler chickens

2011 ◽  
Vol 27 (2) ◽  
pp. 183-188 ◽  
Author(s):  
D. Vitorovic ◽  
G. Vitorovic ◽  
B. Mitrovic ◽  
V. Andric
Keyword(s):  
Broiler Chickens ◽  
Protective Action ◽  
Total Activity ◽  
Control Group ◽  
Standard Diet ◽  
Percentage Reduction ◽  
Group 2 ◽  
137Cs Deposition ◽  
Group 1

The objectives of the present study were to examine the level of radiocesium deposit in meat and edible organs of broiler chickens as well as to investigate efficiency of natural sepiolite in reducing 137Cs deposition in meat, liver and gizzard of alimentary contaminated broiler chickens. Broiler chickens (six weeks of age) were fed with the standard diet and each broiler was given a single oral dose of 137Cs, total activity of 3750 Bq. The broilers were divided into two groups (10 broilers per group). The group 1 was control (received only radiocesium). The broilers of the group 2, in addition to radiocesium received natural sepiolite solution (2 g sepiolite per bird). After 24 hours, all broilers, from each group, were stunned and killed. The samples of meat, (breast and legs), liver and gizzard were taken from each broiler, for gamma spectrometry determination of radiocesium activity. After 24 hours of contamination, 56 % of introduced 137Cs radioactivity was deposited in the meat (breast and legs muscles), 1 % in the liver and 2,4 % in the gizzard of broiler chickens 42 days of age. Natural sepiolite demonstrated insufficient protective action. Compared to the control group, percentage reduction (decreasing percentage) of 137Cs deposition in meat was 16%, in liver 5% and in gizzard 12%.

Epicardial obesity as a significant preclinical predictor of atherosclerosis of brachiocephalic arteries

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Ott ◽  
G.A Chumakova
Keyword(s):  
Cardiometabolic Risk ◽  
Subclinical Atherosclerosis ◽  
Prognostic Significance ◽  
Clinical Manifestations ◽  
Area Under The Curve ◽  
Visceral Obesity ◽  
Threshold Value ◽  
Group 2 ◽  
Brachiocephalic Arteries ◽  
Group 1

Abstract   Obesity is one of the significant factors of cardiovascular risk. Nowadays it is understood that it is visceral obesity (VO), which has metabolic activity due to the synthesis of adipokines, that determines cardiometabolic risk. The effect of epicardial obesity (EO), as a variant of VO on the formation of cardiometabolic risk (in particular coronary atherosclerosis) is being actively studied. The role of EO in the development of atherosclerosis of other localizations has been little studied. Objective To study the predictor value of EO as well as traditional criteria for obesity: body mass index (BMI) and waist circumference (WC) for the formation of atherosclerosis of brachiocephalic arteries (BCA). Materials and methods The study included 140 men 45.2±4.3 years old with arterial hypertension (AH) of the 1–3 degree and the absence of clinical manifestations and anamnesis of atherosclerosis of any localizations with a BMI of 20–35 kg /m2 and abdominal obesity according to WC ≥94 cm. Patients were divided into two groups depending on the thickness of the epicardial adipose tissue (EAT) measured behind the free wall of the right ventricle by echocardiography. Group 1 consisted of 60 patients with epicardial obesity (EAT ≥7 mm), group 2 included patients without epicardial obesity (EAT &lt;7 mm). Subclinical atherosclerosis of BCA was evaluated in all subjects using duplex brachiocephalic arteries (BCA). Results When assessing the thickness of the intima-media of the carotid arteries (TIM), a subclinical marker of BCA atherosclerosis, higher average TIM values in group 1 (EAT ≥7 mm) were revealed (1.09±0.34 mm versus 0.74±0, 05 mm in group 2 (EAT &lt;7 mm) (p=0.0001). Prevalence of subclinical BCA atherosclerosis from (20–45%) in group 1 patients was found in 57%, in group 2 only 4% (p=0.01). In the first group, hemodynamically significant asymptomatic BCA stenosis (50–65%) was found in 8% of patients. No hemodynamically significant BCA stenosis was detected in the second group. Using ROC analysis, the threshold value of EAT (9.25 mm) was obtained as a risk factor for hemodynamically significant stenoses of BCA (50% or more) with high prognostic significance (the area under the curve was 0.92). Using multivariate analysis of variance, the effect of various criteria of obesity on the formation of BCA atherosclerosis was studied. As a result of the analysis it was revealed that only EAT (p=0.02) influenced the development of BCA atherosclerosis (TIM more than 1.3 mm). WC and BMI did not affect the development of BCA subclinical atherosclerosis (p=0.21; p=0.24, respectively). Conclusions EO (EAT ≥7 mm) is an early marker of BCA subclinical atherosclerosis in contrast to the traditional criteria for obesity (BMI, WC). Patients with EAT of 9.25 mm or more need additional examinations and the appointment of pharmacotherapy aimed at the prevention of secondary complications. Funding Acknowledgement Type of funding source: None

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