Hormonal biochemical monitoring at bull-producers of different breeds in the conditions of the Central Black Economic District

2022 ◽  
pp. 100-107
Author(s):  
A. Abilov ◽  
M. Dunin ◽  
I. Pridanova ◽  
S. Ushakov ◽  
B. Seidakhmetov
Keyword(s):  
Mineral Metabolism ◽  
Serum Cortisol ◽  
Black Soil ◽  
Comparative Aspect ◽  
White Breed ◽  
The Difference ◽  
Time Of Year ◽  
Cholesterol Precursor ◽  
Age Range ◽  
First Time

Purpose: To conduct a comprehensive monitoring of bulls of different breeds in the summer in a comparative perspective to the study of protein-lipid and mineral metabolism, as well as to determine hormonal status on the content of endogenous hormones: testosterone, estradiol, cortisol and serum thyroxine per day taking seed.Materials and methods. For the first time in a Chernozem region of the Russian Federation (Voronezh region) was carried out comprehensive monitoring of bulls of red-motley Holstein (n = 16), Red-and-White (n = 8) and Simmental (n = 6) rocks in the same time of year (summer) of the protein-lipid and mineral metabolism, as well as the level of endogenous hormone (testosterone, estradiol, cortisol, thyroxine) and their cholesterol precursor in comparative aspect, immediately after taking the seed. Age range bulls ranged from 2 to 11 years. General monitoring was conducted on 23 indices of blood serum 3 rocks. The studies were conducted by modern methods, using modern equipment and reagents.Results. At Red Pied Holsteins an increase of total protein 100.45 g / L versus 92 g / l in normal (above the norm of 9.2%, as compared with red and White breed at the level of 11.3%). A similar increase in concentration in the blood of Holstein bulls red-White breed recorded on globulins, 68.87 g / l to 63 g / l in normal (above the norm of 9.3%), and with respect to the red-and-White breed 17, 6%. Also notes the high content of AST bulls red-motley Holstein against the red-and-White 18%, but within the reference range. Condition protein and lipid metabolism in sires only differed in content of creatinine, which amounted to 165.04 micromol / l against 163 mmol / l in normal, 1.6% higher as compared to the red and white breed this index was higher 18.7%. According to the content of testosterone highest rate was observed in bulls red-White breed 54.73 ± 9.51 nmol / l, is 10.2% more than in bulls red checkered-Holstein and 12.45% compared with Simmental breed. Similarly, in terms of serum cortisol - 355.60 ± 39.2 nmol / l in the red-bulls White breed that more than 2-fold compared with bulls Red Pied Holstein and Simmental. The difference is statistically significant at P ≤ 0,01. According to the content of estradiol relatively low levels recorded in the bulls of red-motley breed - 0.265 nmol / L vs. 0.301 nmol / L in red bulls-motley Holstein, and 0.332 nmol / L - Simmental, is lower by 13.6% and 25 , 3%, respectively.Conclusion. It was found that substantially all of the studied parameters in bulls 3 breeds are at reference values, and this gives grounds to assume that all of these breeds are well adapted to the conditions of Black Soil.

Strategies for Oral Delivery of Metal-Saturated Lactoferrin

2019 ◽  
Vol 20 (11) ◽  
pp. 1046-1051 ◽  
Author(s):  
Przemysław Gajda-Morszewski ◽  
Klaudyna Śpiewak-Wojtyła ◽  
Maria Oszajca ◽  
Małgorzata Brindell
Keyword(s):  
Biological Activity ◽  
Oral Delivery ◽  
Therapeutic Potential ◽  
Structure And Function ◽  
The Difference ◽  
And Function ◽  
First Time

Lactoferrin was isolated and purified for the first time over 50-years ago. Since then, extensive studies on the structure and function of this protein have been performed and the research is still being continued. In this mini-review we focus on presenting recent scientific efforts towards the elucidation of the role and therapeutic potential of lactoferrin saturated with iron(III) or manganese(III) ions. The difference in biological activity of metal-saturated lactoferrin vs. the unmetalated one is emphasized. The strategies for oral delivery of lactoferrin, are also reviewed, with particular attention to the metalated protein.

Nokhri, Ger, and the Art of Separation in the Hebrew Bible

2018 ◽  
Author(s):  
Adi Ophir ◽  
Ishay Rosen-Zvi
Keyword(s):  
Hebrew Bible ◽  
Biblical Literature ◽  
The Difference ◽  
First Time

This chapter traces the developments of various terms denoting “others” in biblical literature. In much of the biblical corpus, Israel is still one goy among many, and the difference between it and its Others is neither binary nor stable. After a brief analysis of the dynamics of familial and ethnwic separations in Genesis and Exodus, this chapter concentrates on the priestly and Deuteronomistic modes of separating peoples, examines the novelty and limitedness of the Deuteronomistic legislation, where the nokhri (stranger) is systematically contrasted for the first time with the Israelite (referred to as “your brother”), and follows the various modes of separations and their rationales.

scholarly journals Generational Differences in Support and Care of Individuals Diagnosed With Severe Mental Illness

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 94-94
Author(s):  
Deborah Finkel ◽  
Per Bulöw ◽  
Pia Bulöw ◽  
Monika Wilińska ◽  
Cristina Joy Torgé ◽  
...  
Keyword(s):  
Social Support ◽  
Mental Illness ◽  
Severe Mental Illness ◽  
Social Services ◽  
Generational Differences ◽  
System A ◽  
Care Systems ◽  
The Difference ◽  
Changes Over Time ◽  
Age Range

Abstract As part of the process of de-institutionalizing the Swedish mental health care system, a reform was implemented in 1995 moving responsibility for social support for people with severe mental illness (SMI) from the county to social services in the municipalities. In many ways, older people with SMI were neglected in this changing landscape of psychiatric care. To investigate possible generational differences in support experiences, two nonoverlapping cohorts were created from surveys conducted every fifth year between 1996 and 2011 in one middle-sized municipality in the south of Sweden, aiming to detect the needs for social support. Cohort 1 includes everyone detected at the 1996 survey aged 65 and 79 years (N = 92). Cohort 2 includes individuals first detected at the 2011 survey who were aged 65 to 79 (N = 104). Results indicates significant differences between the two cohorts in diagnosis, reflecting changes over time in diagnostic tendencies. Cohort 1 was on average 10 years older than Cohort 2, even within the restricted age range. After correcting for age, there were no differences between the two cohorts in education, functioning (CAN and GAF), or marital status. Although Cohort 1 experienced more days of institutionalization than Cohort 2 (median = 424.5 days vs. 382 days), the difference was not statistically significant. Cohort 2 had significantly higher additional subsidies and disposable income, as well as significantly higher income from other sources after retirement. Results indicate the changing demands that older adults with SMI will place on care systems.

scholarly journals Intravenous Immunoglobulin Treatment in Kawasaki Disease Decreases the Incidence of Myopia

2021 ◽  
Vol 10 (7) ◽  
pp. 1381
Author(s):  
Hun-Ju Yu ◽  
Meng-Ni Chuang ◽  
Chiao-Lun Chu ◽  
Pei-Lin Wu ◽  
Shu-Chen Ho ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Intravenous Immunoglobulin ◽  
Systemic Vasculitis ◽  
Age Distribution ◽  
Population Based ◽  
Research Database ◽  
Ocular Manifestations ◽  
Missing Data Treatment ◽  
The Difference ◽  
Age Range

Kawasaki disease (KD) is a systemic vasculitis that primarily affects children under the age of 5 years old. The most significant complication is coronary artery lesions, but several ocular manifestations have also been reported. Recently, one study revealed an increasing incidence of myopia among KD patients. Therefore, the aim of this study was to assess the difference in myopic incidence between Kawasaki disease (KD) patients treated with aspirin and intravenous immunoglobulin (IVIG). Materials and methods: We carried out a nationwide retrospective cohort study by analyzing the data of KD patients (ICD-9-CM code 4461) from Taiwan’s National Health Insurance Research Database (NHIRD) during the period of 1996–2013. Results: A total of 14,102 diagnosed KD were found in Taiwan during the study period. After excluded missing data, treatment strategy and age distribution, a total of 1446 KD patients were enrolled for analysis including 53 of which received aspirin (without IVIG) and 1393 of which were treated with IVIG. Patients who had myopia, astigmatism, glaucoma, cataract, etc. prior to their KD diagnosis were excluded. The age range was 0 to 6 years old. According to the cumulative curves, our results demonstrated that the myopic incidence in the IVIG group was significantly lower than the aspirin group (hazard ratio: 0.59, 95% confidence intervals: 0.36~0.96, p = 0.02). Treatment with IVIG for KD patients may have benefit for myopia control. Conclusion: Compared to aspirin, IVIG may decrease the myopic risk in KD patients. However, it needs further investigation including clinical vision survey of myopia due to the limitations of this population-based study.

Speech Methodologies in Cleft Palate Assessment: A Pilot Project to Compare Two Phonetically Different Sentence Sets

2013 ◽  
Vol 20 (1) ◽  
pp. 49-72
Author(s):  
Jennie Smith ◽  
Tim Pring ◽  
Debbie Sell
Keyword(s):  
Cleft Palate ◽  
Pilot Project ◽  
Wilcoxon Test ◽  
Consecutive Series ◽  
Video Recordings ◽  
Significant Difference ◽  
The Difference ◽  
Audio Video ◽  
Age Range ◽  
The Impact

Objective: To investigate the impact of the phonetic content of two sentence sets on speech outcomes, specifically the effects of nasal phonemes. Method: Audio-video recordings of a consecutive series of 15 participants (age range 4–22 years), with cleft palate (syndromic or non-syndromic), with and without velopharyngeal dysfunction were taken. Participants repeated Sentence Set 1 (with nasals across sentences) and Sentence Set 2 (without nasals except the three nasal target sentences) during a routine speech recording. Two experienced Specialist Speech and Language Therapists, blinded to the study’s purpose, analyzed participants’ speech using the Cleft Audit Protocol for Speech-Augmented (CAPS-A). On day 1, recordings included Sentence Set 1. On day 2, 23 days later, recordings included Sentence Set 2. Main results: The difference between Sentence Set 1 and Sentence Set 2 ‘total scores’ (sum of scores on all CAPS-A parameters) was significant. The Pearson Product Moment showed high correlation. A Wilcoxon test revealed a significant difference between Sets 1 and 2 on the hypernasality parameter, and this alone accounted for the significant difference in total scores. Conclusion: The inclusion or exclusion of nasal consonants in the sentence set significantly affected perceptual ratings of hypernasality but none of the other CAPS-A parameters, highlighting the need for further investigation into perceptual nasality ratings.

Species diversity and abundance of Dacus (Diptera: Tephritidae) in five ecosystems of Penang, West Malaysia

1982 ◽  
Vol 72 (4) ◽  
pp. 709-716 ◽  
Author(s):  
Tan Keng-Hong ◽  
Lee Soo-Lam
Keyword(s):  
Species Diversity ◽  
Capsicum Annuum ◽  
Fruits And Vegetables ◽  
Methyl Eugenol ◽  
Dacus Dorsalis ◽  
The Difference ◽  
Vegetable Farm ◽  
First Time

AbstractDacus dorsalis Hend. infested eleven, D. cucurbitae Coq. five and D. umbrosus F. two of the eighteen common fruits and vegetables grown in Penang, West Malaysia. D. tau (Wlk.) infested bacang (Mangifera foetida), D. caudatus F. chilli (Capsicum annuum) and D. frauenfeldi Schin. water guava (Eugenia javanica), together with D. dorsalis. Pomelo (Citrus grandis) was found infested for the first time by D. cucurbitae. No flies were trapped using Capilure and trimedlure as baits. Cue-lure attracted D. caudatus, D. cucurbitae, D. frauenfeldi, D. occipitalis (Bez.) and D. tau. Methyl eugenol attracted D. dorsalis and D. umbrosus. Dorsalure was less attractive to D. caudatus and D. dorsalis than cue-lure and methyl eugenol, respectively, but it was equally attractive to D. frauenfeldi as cue-lure. Using traps baited with cue-lure or methyl eugenol in five ecosystems, the highest numbers of males of D. dorsalis, D. umbrosus, D. frauenfeldi and D. caudatus trapped were from a village, on a vegetable farm for D. cucurbitae, and D. occipitalis was only caught in a forest. Analysis showed that for each species of Dacus the difference between ecosystems was highly significant. The few examples caught in grassland were probably migrants.

Dose-window dependence on Si crystal orientation in separation by implanted oxygen substrate formation

2004 ◽  
Vol 19 (12) ◽  
pp. 3607-3613 ◽  
Author(s):  
H. Iikawa ◽  
M. Nakao ◽  
K. Izumi
Keyword(s):  
Experimental Data ◽  
Numerical Analysis ◽  
Crystal Orientation ◽  
Oxygen Ion ◽  
The Difference ◽  
First Time ◽  
Good Agreement

Separation by implemented oxygen (SIMOX)(111) substrates have been formed by oxygen-ion (16O+) implantation into Si(111), showing that a so-called “dose-window” at 16O+-implantation into Si differs from Si(100) to Si(111). In SIMOX(100), an oxygen dose of 4 × 1017/cm2 into Si(100) is widely recognized as the dose-window when the acceleration energy is 180 keV. For the first time, our work shows that an oxygen dose of 5 × 1017/cm2 into Si(111) is the dose-window for the formation of SIMOX(111) substrates when the acceleration energy is 180 keV. The difference between dose-windows is caused by anisotropy of the crystal orientation during growth of the faceted buried SiO2. We also numerically analyzed the data at different oxidation velocities for each facet of the polyhedral SiO2 islands. Numerical analysis results show good agreement with the experimental data.

45° REFLECTOMETRY OF SEMICONDUCTOR QUANTUM WELLS

2001 ◽  
Vol 15 (17n19) ◽  
pp. 683-687
Author(s):  
A. SILVA-CASTILLO ◽  
F. PEREZ-RODRIGUEZ
Keyword(s):  
Quantum Well ◽  
Quantum Wells ◽  
Growth Direction ◽  
Angle Of Incidence ◽  
Near Surface ◽  
New Information ◽  
Difference Formula ◽  
Exciton Polaritons ◽  
The Difference ◽  
First Time

We have applied the 45° reflectometry for the first time to study exciton-polaritons in quantum wells. The 45° reflectometry is a new polarization-modulation technique, which is based on the measurement of the difference [Formula: see text] between the p-polarization reflectivity (Rp) and the squared s-polarization reflectivity [Formula: see text] at an angle of incidence of 45°. We show that [Formula: see text] spectra may provide qualitatively new information on the exciton-polariton modes in a quantum well. These optical spectra turn out to be very sensitive to the zeros of the dielectric function along the quantum-well growth direction and, therefore, allow to identify the resonances associated with the Z exciton-polariton mode. We demonstrate that 45° reflectometry could be a powerful tool for studying Z exciton-polariton modes in near-surface quantum wells, which are difficult to observe in simple spectra of reflectivity Rp

scholarly journals A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Wei Xu ◽  
Yu-Lin Chen ◽  
Ying Zhao ◽  
Li-Jie Wang ◽  
Jiu-Jun Li ◽  
...  
Keyword(s):  
School Performance ◽  
Young Patients ◽  
Median Dose ◽  
Toxic Dose ◽  
Adolescent Population ◽  
Urban Rural ◽  
The Difference ◽  
Abuse Treatment ◽  
First Time ◽  
At Risk Adolescents

Carbamazepine is known to produce the side effect of euphoria. As such, it lends itself to being a drug of abuse, particularly in the adolescent population. This retrospective study evaluated carbamazepine abuse, treatment course, and associated morbidity in Chinese adolescents. The median dose of carbamazepine resulting in overdose was 2,000 mg (800–5,000). Patients were largely from urban-rural fringe areas (76.47%, 52.94%) with school performance within the last 1/3 range and (52.94%) unsupervised by parents. 35.29% experienced an obvious sense of euphoria. All patients had nervous system symptoms, 6 (35.29%) cases developed coma (GCS < 8), and 5 (29.41%) cases experienced convulsion. Four cases were treated with hemodialysis. The incidence rate in young patients with repeat carbamazepine use and without the supervision of parents was higher than that in first-time users (5/7 versus 4/10), but the difference was not significant. The toxic dose of repeat users was 3428 ± 1035 mg, significantly higher than that of 1470 ± 646 mg in first-time users (P=0.001). Carbamazepine can produce a sense of euphoria, which is more likely to lead to its abuse and overdose in adolescents. To prevent carbamazepine abuse and overdose will be critical in educating at-risk adolescents and preventing associated morbidities in the future.

scholarly journals Efficacy of BRAF and MEK Inhibition in Patients with BRAF-Mutant Advanced Melanoma and Germline CDKN2A Pathogenic Variants

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2440
Author(s):  
Francesco Spagnolo ◽  
Bruna Dalmasso ◽  
Enrica Tanda ◽  
Miriam Potrony ◽  
Susana Puig ◽  
...  
Keyword(s):  
Real World ◽  
Response Rate ◽  
Suppressor Gene ◽  
Phase Iii ◽  
Clinical Activity ◽  
P Value ◽  
Pathogenic Variants ◽  
Phase Iii Trials ◽  
The Difference ◽  
First Time

Inherited pathogenic variants (PVs) in the CDKN2A tumor suppressor gene are among the strongest risk factors for cutaneous melanoma. Dysregulation of the p16/RB1 pathway may intrinsically limit the activity of MAPK-directed therapy due to the interplay between the two pathways. In our study, we assessed, for the first time, whether patients with germline CDKN2A PVs achieve suboptimal results with BRAF inhibitors (BRAFi)+/−MEK inhibitors (MEKi). We compared the response rate of nineteen CDKN2A PVs carriers who received first-line treatment with BRAFi+/−MEKi with an expected rate derived from phase III trials and “real-world” studies. We observed partial response in 16/19 patients (84%), and no complete responses. The overall response rate was higher than that expected from phase III trials (66%), although not statistically significant (p-value = 0.143; 95% CI = 0.60–0.97); the difference was statistically significant (p-value = 0.019; 95% CI = 0.62–0.97) in the comparison with real-world studies (57%). The clinical activity of BRAFi+/−MEKi in patients with germline CDKN2A PV was not inferior to that of clinical trials and real-world studies, which is of primary importance for clinical management and genetic counseling of this subgroup of patients.

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