Molecular Heterogeneity in Childhood Precursor B Acute Lymphoblastic Leukemia with Immunoglobulin Heavy Chain Gene in Germline Configuration

1995 ◽  
Vol 20 (1-2) ◽  
pp. 157-160
Author(s):  
J. Roman Gomez ◽  
P. Andres ◽  
M. J. Garcia ◽  
R. Flores ◽  
M. A. Jimenez ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Heavy Chain ◽  
Lymphoblastic Leukemia ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Molecular Heterogeneity ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene

scholarly journals Rearrangement of immunoglobulin heavy chain genes in T cell acute lymphoblastic leukemia

Blood ◽  
1985 ◽  
Vol 65 (3) ◽  
pp. 725-729 ◽  
Author(s):  
GR Kitchingman ◽  
U Rovigatti ◽  
AM Mauer ◽  
S Melvin ◽  
SB Murphy ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Heavy Chain ◽  
Germ Line ◽  
Lymphoblastic Leukemia ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Immunoglobulin Heavy Chain Genes

Abstract We studied the arrangement of the immunoglobulin heavy chain genes by Southern blot analysis of DNA freshly obtained from marrow blast cells of 14 children with T cell acute lymphoblastic leukemia (T-ALL) using probes to the C mu and JH gene segments: At least one of the C mu-gene alleles was rearranged in three cases. In two of these, one C mu gene had the germ-line configuration and one was rearranged, whereas both alleles were rearranged in the third case. In one case, a rearranged heavy chain gene hybridized to the C mu-region probe, but not to the JH probe, indicating that the entire JH region had been deleted. These results demonstrate that immunoglobulin heavy chain gene rearrangements are not restricted to B lineage lymphoproliferative diseases in humans.

scholarly journals Rearrangement of immunoglobulin heavy chain genes in T cell acute lymphoblastic leukemia

Blood ◽  
1985 ◽  
Vol 65 (3) ◽  
pp. 725-729
Author(s):  
GR Kitchingman ◽  
U Rovigatti ◽  
AM Mauer ◽  
S Melvin ◽  
SB Murphy ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Heavy Chain ◽  
Germ Line ◽  
Lymphoblastic Leukemia ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Immunoglobulin Heavy Chain Genes

We studied the arrangement of the immunoglobulin heavy chain genes by Southern blot analysis of DNA freshly obtained from marrow blast cells of 14 children with T cell acute lymphoblastic leukemia (T-ALL) using probes to the C mu and JH gene segments: At least one of the C mu-gene alleles was rearranged in three cases. In two of these, one C mu gene had the germ-line configuration and one was rearranged, whereas both alleles were rearranged in the third case. In one case, a rearranged heavy chain gene hybridized to the C mu-region probe, but not to the JH probe, indicating that the entire JH region had been deleted. These results demonstrate that immunoglobulin heavy chain gene rearrangements are not restricted to B lineage lymphoproliferative diseases in humans.

scholarly journals Primary Malignant Lymphoma of the Brain: Mutation Pattern of Rearranged Immunoglobulin Heavy Chain Gene

2002 ◽  
Vol 93 (12) ◽  
pp. 1308-1316 ◽  
Author(s):  
Sumio Endo ◽  
Shu-Jing Zhang ◽  
Takafumi Saito ◽  
Mitsuo Kouno ◽  
Toshihiko Kuroiwa ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Heavy Chain ◽  
Immunoglobulin Heavy Chain ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Immunoglobulin Heavy Chain Gene ◽  
Mutation Pattern ◽  
The Brain
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