Effect of Captopril on Blood Pressure, Total Body Sodium and Fluid Consumption of Genetically Hypertensive (GH) and Normotensive (N) Rats

Eighty per cent of rats surviving 8–12 weeks when given 1.75 or 2.0% sodium chloride solution in place of drinking water had at least 20 mm Hg elevation of systolic arterial blood pressure. Changes in tissue water and electrolytes were: a) a consistent increase in sodium, potassium, and chloride contents of aorta; b) an increase in sodium and extracellular water contents of muscle, more marked in skeletal than heart muscle; c) marked muscle potassium depletion in one series; and d) an increase in total body sodium and a tendency toward hypernatremia. At the time of sacrifice no consistent association was evident between blood pressure elevation and water and electrolyte changes.

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Exchangeable Sodium in Rats with Goldblatt Two-Kidney One-Clip Hypertension

Clinical Science ◽

10.1042/cs0630271 ◽

1982 ◽

Vol 63 (3) ◽

pp. 271-274 ◽

Cited By ~ 8

Author(s):

D. McAreavey ◽

W. B. Brown ◽

J. I. S. Robertson

Keyword(s):

Blood Pressure ◽

Chloride Solution ◽

Sodium Balance ◽

Left Renal Artery ◽

Sham Operation ◽

Exchangeable Sodium ◽

Body Sodium ◽

Significant Difference ◽

Total Body ◽

And Control

1. Exchangeable sodium (NaE) was measured serially in rats given a sodium-free diet to eat with sodium chloride solution (85 mmol/l) containing 22Na to drink. 2. After 15 days, nine rats had a left renal artery clip applied; nine had a sham operation. 3. There was no significant difference in NaE between the two groups during the 6 week period after clipping, at the end of which blood pressure was 189 ± 8 mmHg (mean ± sem) in the clipped group and 150 ± 2 mmHg in the sham-operated group (P < 0·001). 4. When the clips were removed blood pressure in the hypertensive group fell to 144 ± 4 mmHg. 5. On the first day after removal of the clip NaE was significantly lower in the clipped group than in the sham-operated group, but there were no significant differences thereafter. 6. Total body sodium (TBNa), measured at death, was consistently higher than NaE by a mean of 1·25 ± 0·08 mmol, in hypertensive and control rats alike. 7. We conclude that changes in sodium balance are not a necessary accompaniment of the development of hypertension in this two-kidney one-clip rat model.

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Blood volume, blood pressure and total body sodium: internal signalling and output control

Acta Physiologica ◽

10.1111/j.1748-1716.2008.01932.x ◽

2009 ◽

Vol 195 (1) ◽

pp. 187-196 ◽

Cited By ~ 36

Author(s):

P. Bie

Keyword(s):

Blood Pressure ◽

Blood Volume ◽

Output Control ◽

Body Sodium ◽

Volume Blood ◽

Total Body

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Blood Pressure in Genetically Hypertensive Rats

Hypertension ◽

10.1161/01.hyp.26.3.452 ◽

1995 ◽

Vol 26 (3) ◽

pp. 452-459 ◽

Cited By ~ 57

Author(s):

Anne O. Davidson ◽

Nicholas Schork ◽

Bryon C. Jaques ◽

Andrew W. Kelman ◽

Roger G. Sutcliffe ◽

...

Keyword(s):

Blood Pressure ◽

Hypertensive Rats ◽

Genetically Hypertensive Rats ◽

Genetically Hypertensive

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Steroids during development of genetic hypertension in rats of Lyon strain

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1989.257.2.h506 ◽

1989 ◽

Vol 257 (2) ◽

pp. H506-H510 ◽

Cited By ~ 1

Author(s):

M. Vincent ◽

C. E. Gomez-Sanchez ◽

A. Bataillard ◽

J. Sassard

Keyword(s):

Blood Pressure ◽

Urinary Excretion ◽

Male Rats ◽

Hydroxylase Activity ◽

Full Development ◽

Genetically Hypertensive Rats ◽

Low Blood Pressure ◽

Doc Concentration ◽

Low Levels ◽

Genetically Hypertensive

The urinary excretion and the plasma concentration of deoxycorticosterone (DOC), corticosterone, 18-hydroxy-DOC (18-OH-DOC), aldosterone, and 19-nor-DOC were measured by specific radioimmunoassays in genetically hypertensive (LH), normotensive (LN), and low blood pressure (LL) male rats of the Lyon strains at two ages that characterize the development of their systolic blood pressure (SBP). When compared with both LN and LL controls, 5-wk-old LH rats exhibited an increased urinary DOC and decreased urinary corticosterone excretions, which were significantly related to the SBP level (r' = 0.618 and -0.520; n = 23; P less than 0.01 for DOC and corticosterone, respectively). In addition, the adrenal synthesis of LH rats was found to rely on an increased 18-hydroxylase activity as indicated by elevated urinary 18-OH-DOC/corticosterone and aldosterone/corticosterone associated with a lower 11-beta-hydroxylase activity shown by the decreased urinary corticosterone/DOC. Twenty-wk-old LH rats with fully developed hypertension exhibited normal urinary excretion of steroids and a decrease in plasma DOC concentration, which negatively correlated with the SBP level (r' = -0.574; n = 25; P less than 0.01). In conclusion, the present study demonstrates that in the Lyon model of genetically hypertensive rats, compared with two genetically different control strains and maintained under physiological unstressed conditions, the development of hypertension is associated with an increased urinary excretion of DOC. After the full development of their hypertension, the mineralocorticoid synthesis in LH rats returns to normal or low levels which could, however, remain inappropriately high for their sodium body content.

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NE turnover in genetically hypertensive rats of Lyon strain. I. Brain nuclei

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1988.255.4.h729 ◽

1988 ◽

Vol 255 (4) ◽

pp. H729-H735 ◽

Cited By ~ 1

Author(s):

M. Sautel ◽

J. Sacquet ◽

M. Vincent ◽

J. Sassard

Keyword(s):

Blood Pressure ◽

Hypothalamic Nucleus ◽

Primary Role ◽

Hypertensive Rats ◽

Brain Areas ◽

Brain Nuclei ◽

Genetically Hypertensive Rats ◽

Low Blood Pressure ◽

Genetically Hypertensive

Several indirect evidences of alterations in the central catecholaminergic structures were obtained in genetically hypertensive rats. Because they could be of pathogenetic value, we measured, in the present work, the in vivo turnover (TO) of norepinephrine (NE) in brain areas of 5- and 22-wk-old genetically hypertensive (LH) rats of the Lyon strain, and their simultaneously selected normotensive (LN) and low blood pressure (LL) controls. Among the changes observed, the increased TO of NE in the A2 and A6 regions of 5-wk-old LH rats and its decrease in the posteroventral hypothalamic nucleus of 22-wk-old LH animals appeared likely to compensate for hypertension. On the contrary, the decreased TO of NE in the anterior hypothalamic nucleus observed at 5 wk and in the A6 and A1 areas at 22 wk of age in LH rats could participate in the development or the maintenance of hypertension. Above all, it was postulated that the increased TO of NE found in the A7 region of 5-wk-old LH rats could play a primary role in the pathogenesis of hypertension in the Lyon model.

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