Effect of Live-Fire Training Drills on Firefighters’ Platelet Number and Function

2011 ◽  
Vol 15 (2) ◽  
pp. 233-239 ◽  
Author(s):  
Denise L. Smith ◽  
Steven J. Petruzzello ◽  
Eric Goldstein ◽  
Uzma Ahmad ◽  
Krishnarao Tangella ◽  
...  
Keyword(s):  
Platelet Number ◽  
And Function

Bleeding Time in Rats: A Comparison of Different Experimental Conditions

1982 ◽  
Vol 48 (01) ◽  
pp. 108-111 ◽  
Author(s):  
Elisabetta Dejana ◽  
Silvia Villa ◽  
Giovanni de Gaetano
Keyword(s):  
Platelet Function ◽  
Bleeding Time ◽  
Platelet Dysfunction ◽  
Experimental Conditions ◽  
Platelet Number ◽  
Coagulation Defects ◽  
Tail Tip ◽  
And Function ◽  
Storage Pool Disease ◽  
Type Of Anaesthesia

SummaryThe tail bleeding time (BT) in rats definitely varies according to the method applied. Of the various variables that may influence BT, we have evaluated the position (horizontal or vertical) of the tail, the environment (air or saline), the temperature (4°, 23° or 37° C) and the type of anaesthesia. Transection of the tail tip cannot be used to screen drugs active on platelet function since it is sensitive to coagulation defects. Template BT in contrast is not modified by heparin and is sensitive to defects of platelet number and function (“storage pool disease”, dipyridamole-like drugs, exogenous prostacyclin). In contrast the test fails to detect aspirin-induced platelet dysfunction. The evidence reported indicates that thromboxane A2-prostacyclin balance is not a factor regulating BT. Aspirin treatment however may be a precipitating factor when associated with other abnormalities of platelet function.Template BT is a valid screening test for platelet disorders and for antiplatelet drugs.

Thrombohaemorrhagic complications in 101 cases of myeloproliferative disorders: Relationship to platelet number and function

1983 ◽  
Vol 19 (11) ◽  
pp. 1593-1599 ◽  
Author(s):  
Tiziano Barbui ◽  
Sergio Cortelazzo ◽  
Piera Viero ◽  
Renato Bassan ◽  
Enrico Dini ◽  
...  
Keyword(s):  
Myeloproliferative Disorders ◽  
Platelet Number ◽  
And Function

Haemostatic Effects of Recombinant Human Erythropoietin in Chronic Haemodialysis Patients

1989 ◽  
Vol 61 (01) ◽  
pp. 117-121 ◽  
Author(s):  
Chris van Geet ◽  
Didier Hauglustaine ◽  
Luc Verresen ◽  
Marleen Vanrusselt ◽  
Jos Vermylen
Keyword(s):  
Platelet Count ◽  
Recombinant Human Erythropoietin ◽  
Bleeding Time ◽  
Chronic Haemodialysis ◽  
Recombinant Erythropoietin ◽  
The Third ◽  
Human Erythropoietin ◽  
Platelet Number ◽  
Almost All ◽  
And Function

SummaryRecombinant human erythropoietin was administered for up to 40 weeks to nine patients on chronic haemodialysis. From the third week of administration onwards, not only haemoglobin and haematocrit but also the platelet count rose, the latter, however, transiently. Subnormal platelet aggregation before therapy also improved transiently and in parallel with the erythropoietin dosage. The bleeding time normalized in almost all patients. There were no major side-effects. We conclude that recombinant erythropoietin improves haemostasis in chronic haemodialysis patients by increasing the haematocrit and in addition transiently enhances platelet number and function.

scholarly journals Defining the Thrombotic Risk in Patients with Myeloproliferative Neoplasms

2011 ◽  
Vol 11 ◽  
pp. 1131-1137 ◽  
Author(s):  
Fabrizio Vianello ◽  
Anna Battisti ◽  
Giuseppe Cella ◽  
Marina Marchetti ◽  
Anna Falanga
Keyword(s):  
Myeloid Leukemia ◽  
Myeloproliferative Neoplasms ◽  
Dynamic Interactions ◽  
Kinase Gene ◽  
Myeloid Metaplasia ◽  
Thrombotic Risk ◽  
Platelet Number ◽  
Tyrosine Kinase Gene ◽  
And Function ◽  
Plasma Markers

Polycythemia vera (PV) and essential thrombocythemia (ET) are two Philadelphia-negative myeloproliferative neoplasms (MPN) associated with an acquired mutation in theJAK2tyrosine kinase gene. There is a rare incidence of progression to myelofibrosis and myeloid metaplasia in both disorders, which may or may not precede transformation to acute myeloid leukemia, but thrombosis is the main cause of morbidity and mortality. The pathophysiology of thrombosis in patients with MPN is complex. Traditionally, abnormalities of platelet number and function have been claimed as the main players, but increased dynamic interactions between platelets, leukocytes, and the endothelium do probably represent a fundamental interplay in generating a thrombophilic state. In addition, endothelial dysfunction, a well-known risk factor for vascular disease, may play a role in the thrombotic risk of patients with PV and ET. The identification of plasma markers translating the hemostatic imbalance in patients with PV and ET would be extremely helpful in order to define the subgroup of patients with a significant clinical risk of thrombosis.

Disorders of platelet number and function

2010 ◽  
pp. 4506-4518
Author(s):  
Kathryn E. Webert ◽  
John G. Kelton
Keyword(s):  
Bone Marrow ◽  
Arachidonic Acid ◽  
Blood Vessel ◽  
Critical Role ◽  
Adenosine Diphosphate ◽  
Reticuloendothelial System ◽  
Glycoprotein Ib ◽  
Platelet Number ◽  
Key Features ◽  
And Function

Platelets are released from megakaryocytes in the bone marrow and circulate for 5 to 10 days before being cleared by the cells of the reticuloendothelial system. They play a critical role in haemostasis, with key features being (1) adhesion—when the wall of a blood vessel is damaged, platelets adhere to exposed collagen and other components of the subendothelium via the glycoprotein Ib receptor and other adhesive receptors; followed by (2) activation—release of thrombin, adenosine diphosphate, and arachidonic acid, which is converted by a cascade of enzymes into platelet activating agents including thromboxane A...

scholarly journals Genetic Techniques Used in the Diagnosis of Inherited Platelet Disorders

2019 ◽  
Vol 45 (07) ◽  
pp. 685-694 ◽  
Author(s):  
Andrew D. Mumford ◽  
Sarah K. Westbury
Keyword(s):  
Genetic Analysis ◽  
Genetic Disorders ◽  
Genetic Diagnosis ◽  
Inherited Disorders ◽  
Recent Advances ◽  
Platelet Number ◽  
Genetic Techniques ◽  
Platelet Disorders ◽  
And Function

AbstractRecent advances in genetic analysis are bringing huge benefits to patients with rare genetic disorders, including those with inherited disorders of platelet number and function. Modern clinical hematological practice now has a range of genetic techniques available to enable the precision diagnosis of inherited platelet disorders (IPDs). There are some features of this disparate group of inherited disorders that present specific challenges to establishing an accurate genetic diagnosis. This review aims to introduce the techniques that are relevant for the genetic diagnosis of IPDs and will discuss the key considerations necessary for their application to the clinic.

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