scholarly journals PErsonalized Treatment by Real-time assessment (PETRA): A web-application for personalized diaries in psychiatric care

2022 ◽  
Author(s):  
Fionneke Bos ◽  
Lino von Klipstein ◽  
Ando C. Emerencia ◽  
Erwin Veermans ◽  
Tom Verhage ◽  
...  
Keyword(s):  
Real Time ◽  
Development Process ◽  
Psychiatric Care ◽  
Psychiatric Treatment ◽  
Clinical Care ◽  
Ease Of Use ◽  
Personalized Treatment ◽  
Web App ◽  
User Friendly ◽  
Time Assessment

Background: Smartphone self-monitoring through ecological momentary assessment (EMA) provides insights into the daily lives of people in psychiatric treatment and has the potential to improve their care. Currently, no clinical tools are available that help clients and clinicians with creating personalized EMA diaries and interpreting the gathered data. Integration of EMA in treatment is therefore difficult.Objective: To develop a web-based application for personalized EMA in routine psychiatric care, in close collaboration with all stakeholders (i.e., clients, clinicians, researchers, and software developers). Methods: We engaged 52 clients with mood, anxiety, and/or psychotic disorders and 45 clinicians (psychiatrists, psychologists, and psychiatric nurses) in interviews, focus groups, and usability sessions. We used human-centered design principles to determine important requirements for the web-app and designed high-fidelity prototypes that were continuously reevaluated and adapted. Results: The iterative development process resulted in PETRA (PErsonalized Treatment by Real-time Assessment), which is a scientifically grounded web-app for the integration of personalized EMA in clinical care. PETRA includes a decision aid to support clients and clinicians with constructing personalized EMA diaries, an EMA diary item repository, a text-message-based diary delivery system, and a feedback module for visualizing the gathered EMA data. PETRA is integrated in electronic health record (EHR) systems to ensure ease-of-use and sustainability, and adheres to privacy regulations.Conclusions: PETRA was built to fulfill the needs of clients and clinicians for a user-friendly and personalized EMA tool embedded in routine psychiatric care. PETRA is unique in this co-development process, its extensive yet user-friendly personalization options, its integration in EHR systems, its transdiagnostic focus, and its strong scientific foundation in the design of EMA diaries and feedback. The clinical effectiveness of integrating personalized diaries via PETRA into care awaits further research. As such, PETRA paves the way for a systematic investigation into the utility of personalized EMA for routine mental health care.

scholarly journals Software Architecture of a Fog Computing Node for Industrial Internet of Things

Sensors ◽  
2021 ◽  
Vol 21 (11) ◽  
pp. 3715
Author(s):  
Ioan Ungurean ◽  
Nicoleta Cristina Gaitan
Keyword(s):  
Internet Of Things ◽  
Real Time ◽  
Development Process ◽  
Fog Computing ◽  
Low Latency ◽  
Practical Implementation ◽  
Industrial Internet Of Things ◽  
Industrial Internet ◽  
Starting Point ◽  
Hard Real Time

In the design and development process of fog computing solutions for the Industrial Internet of Things (IIoT), we need to take into consideration the characteristics of the industrial environment that must be met. These include low latency, predictability, response time, and operating with hard real-time compiling. A starting point may be the reference fog architecture released by the OpenFog Consortium (now part of the Industrial Internet Consortium), but it has a high abstraction level and does not define how to integrate the fieldbuses and devices into the fog system. Therefore, the biggest challenges in the design and implementation of fog solutions for IIoT is the diversity of fieldbuses and devices used in the industrial field and ensuring compliance with all constraints in terms of real-time compiling, low latency, and predictability. Thus, this paper proposes a solution for a fog node that addresses these issues and integrates industrial fieldbuses. For practical implementation, there are specialized systems on chips (SoCs) that provides support for real-time communication with the fieldbuses through specialized coprocessors and peripherals. In this paper, we describe the implementation of the fog node on a system based on Xilinx Zynq UltraScale+ MPSoC ZU3EG A484 SoC.

scholarly journals Broccoli Fluorets: Split Aptamers as a User-Friendly Fluorescent Toolkit for Dynamic RNA Nanotechnology

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3178 ◽  
Author(s):  
Morgan Chandler ◽  
Tatiana Lyalina ◽  
Justin Halman ◽  
Lauren Rackley ◽  
Lauren Lee ◽  
...  
Keyword(s):  
Real Time ◽  
Logic Gates ◽  
Rna Aptamers ◽  
One Pot ◽  
Rna Nanotechnology ◽  
Close Proximity ◽  
Direct Tracking ◽  
Displacement Approach ◽  
User Friendly ◽  
In Cells

RNA aptamers selected to bind fluorophores and activate their fluorescence offer a simple and modular way to visualize native RNAs in cells. Split aptamers which are inactive until the halves are brought within close proximity can become useful for visualizing the dynamic actions of RNA assemblies and their interactions in real time with low background noise and eliminated necessity for covalently attached dyes. Here, we design and test several sets of F30 Broccoli aptamer splits, that we call fluorets, to compare their relative fluorescence and physicochemical stabilities. We show that the splits can be simply assembled either through one-pot thermal annealing or co-transcriptionally, thus allowing for direct tracking of transcription reactions via the fluorescent response. We suggest a set of rules that enable for the construction of responsive biomaterials that readily change their fluorescent behavior when various stimuli such as the presence of divalent ions, exposure to various nucleases, or changes in temperature are applied. We also show that the strand displacement approach can be used to program the controllable fluorescent responses in isothermal conditions. Overall, this work lays a foundation for the future development of dynamic systems for molecular computing which can be used to monitor real-time processes in cells and construct biocompatible logic gates.

Piezoresistive Polymer-Based Materials for Real-Time Assessment of the Stump/Socket Interface Pressure in Lower Limb Amputees

2017 ◽  
Vol 17 (7) ◽  
pp. 2182-2190 ◽  
Author(s):  
Armando Ferreira ◽  
Vitor Correia ◽  
Emilia Mendes ◽  
Claudia Lopes ◽  
Jose Filipe Vilela Vaz ◽  
...  
Keyword(s):  
Real Time ◽  
Lower Limb ◽  
Interface Pressure ◽  
Socket Interface ◽  
Lower Limb Amputees ◽  
Time Assessment
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