scholarly journals Anaplastic carcinoma of the thyroid - clinicomorphological spectrum and review of literature

1970 ◽  
Vol 1 (1) ◽  
pp. 45-48 ◽  
Author(s):  
A Ghosh ◽  
N Nepal ◽  
MD Gharti ◽  
S Basnet ◽  
M Baxi ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Spindle Cell ◽  
Neck Mass ◽  
Anaplastic Thyroid Carcinoma ◽  
Anaplastic Carcinoma ◽  
High Power Field ◽  
The Mean ◽  
Cell Variant ◽  
Thyroid Malignancies ◽  
Atypical Mitosis

Background: Thyroid cancer is fairly common. The worldwide annual incidence ranges from 0.5 to 10 cases per 100,000 people. Anaplastic thyroid carcinoma, comprising less than 10% of all thyroid carcinomas, remains one of the most virulent of all cancers in humans with a 10 year survival rate of only 0.1 %. In the present study we looked into the clinical, cytological and histological spectrum of anaplastic carcinoma and compared our experience with recent literature. Materials and Methods: This was a hospital based retrospective study from January 2000 to November 2010. Clinical, cytological and histopathological data of all the diagnosed anaplastic thyroid carcinoma cases were reviewed and analyzed. Results: Of the 59 thyroid malignancies diagnosed in the same period, 7 cases were anaplastic carcinoma. The mean age was 63 years and was predominantly found in females. All of the cases presented with a neck mass that lasted for a mean of 5.7 months. The mean tumor size was 14.9 cm and the most common sub-type was the spindle cell type. Atypical mitosis of more than 5 per high power field and necrosis was noted in all cases. Conclusion: Due to the markedly aggressive nature of this tumor and its association with areas of endemic thyroid disease, early diagnosis and aggressive therapy is essential, especially in the Himalayan and Sub-Himalayan belt. Keywords: Anaplastic carcinoma; Thyroid carcinoma; Spindle cell variant DOI: 10.3126/jpn.v1i1.4451 Journal of Pathology of Nepal (2011) Vol.1, 45-48

scholarly journals Spindle cell variant of medullary thyroid carcinoma: a clinicopathologic study of four cases

2021 ◽  
Author(s):  
Yan Xia Wang ◽  
Shoujing Yang
Keyword(s):  
Thyroid Carcinoma ◽  
Spindle Cell ◽  
Regional Lymph Node ◽  
Fibrous Stroma ◽  
Immunohistochemical Markers ◽  
Clinicopathologic Study ◽  
Regional Lymph Node Dissection ◽  
Special Morphology ◽  
Cell Variant ◽  
Thyroid Malignancies

Abstract BackgroundMedullary thyroid carcinoma (MTC) is a malignant tumor derived from C cells. It accounts for about 10% of all thyroid malignancies. More than 14 histological variants have been described. Among them, spindle cell variant is extremely rare.Case presentationHere we describe 4 cases of spindle cell variant of MTC collected from 2012 to 2019. Ultrasound showed solid and hypoechoic nodules. Three patients underwent total thyroidectomy and regional lymph node dissection, and 1 patient underwent thyroid mass resection. Histologically, the tumors showed spindle shaped cells in bundles or interlaced arrangement, separated by hyalinised fibrous stroma that contained amyloid deposits. Immunohistochemistry showed that the tumor cells were positive for calcitonin, chromogranin A, synaptophysin, CD56, and TTF-1, but negative for other lineage-specific markers.ConclusionsWe report 4 rare cases of spindle cell variant of MTC. Due to its rarity and special morphology, the diagnosis of spindle cell variant MTC relies on its morphology and immunohistochemical markers to avoid misdiagnosis.

Mediastinal seminoma presenting as a neck mass falsely diagnosed as anaplastic thyroid carcinoma: A case report

2018 ◽  
Vol 47 (4) ◽  
pp. 334-336 ◽  
Author(s):  
Khaled Murshed ◽  
Issam Al-Bozom ◽  
Surjith Vattoth ◽  
Mohammed Akhtar
Keyword(s):  
Case Report ◽  
Thyroid Carcinoma ◽  
Neck Mass ◽  
Anaplastic Thyroid Carcinoma ◽  
Mediastinal Seminoma

Does Surgery Improve the Survival of Patients with Advanced Anaplastic Thyroid Carcinoma?

1998 ◽  
Vol 118 (5) ◽  
pp. 728-731
Author(s):  
WEN-TSOUNG LU ◽  
Jen-Der Lin ◽  
Hong-So Huang ◽  
Tzu-Chieh Chao
Keyword(s):  
Thyroid Carcinoma ◽  
Distant Metastases ◽  
Anaplastic Thyroid Carcinoma ◽  
Disease Group ◽  
Localized Disease ◽  
The Mean ◽  
Group 2 ◽  
Nonsurgical Patients ◽  
Head Neck ◽  
Group 1

Anaplastic thyroid carcinoma is one of the most lethal neoplasms, with poor prognosis being reported by most authors. The benefits of surgery for most cases of advanced disease remain controversial. In this study we asked the following question: Does surgical intervention alter outcomes for patients with advanced anaplastic thyroid carcinoma? Forty-six patients with advanced anaplastic thyroid carcinoma were analyzed. There were 20 patients with advanced localized disease (group 1), 15 of whom received surgery. Of the other 26 patients with evidence of distant metastases (group 2), 13 received surgery. For group 1 patients, the mean survival was 12.8 months versus 8.6 months in the surgical and nonsurgical subgroups ( p = 0.46). For group 2 patients, the mean survival was 3.5 months versus 2.8 months in the surgical and nonsurgical subgroups ( p = 0.72). These data suggest that surgery does not improve survival for patients with advanced anaplastic thyroid carcinoma. In conclusion, the mean survival showed no significant differences between surgical and nonsurgical patients ( p = 0.43). This study suggests that surgical resection does not improve the survival of patients with advanced anaplastic thyroid carcinoma. (Otolaryngol Head Neck Surg 1998;118:728–31.)

scholarly journals Extensive Neck Haematoma as an Extremely Rare Presentation of Thyroid Carcinoma: A Case Report

2020 ◽  
Vol 4 (3) ◽  
pp. 226
Author(s):  
Lo Ren Hui ◽  
Fairuz Mohd Ibrahim ◽  
Khairudin Abdullah ◽  
Nasriah Ahmad ◽  
Fazilah Hassan ◽  
...  
Keyword(s):  
Case Report ◽  
Thyroid Carcinoma ◽  
Airway Obstruction ◽  
Upper Airway ◽  
Health Sciences ◽  
Neck Mass ◽  
Anaplastic Thyroid Carcinoma ◽  
Upper Airway Obstruction ◽  
Rare Presentation ◽  
Fast Growing

Anaplastic thyroid carcinoma (ATC) is uncommon but deadly. It is typically presented with fast growing neck mass, hoarseness or dysphagia. We report an extremely rare presentation of ATC in an elderly lady, with expanding ecchymosis involving laryngopharynx, neck and upper chest region, which causing upper airway obstruction. The rarity of presentation and the management dilemma were discussed.International Journal of Human and Health Sciences Vol. 04 No. 03 July’20 Page : 226-228

Hepatic Metastases from the Spindle Cell Variant of Medullary Thyroid Carcinoma

2001 ◽  
Vol 45 (6) ◽  
pp. 1022-1026 ◽  
Author(s):  
Carolina Ibarrola de Andrés ◽  
Victor Manuel Castellano Megías ◽  
Claudio Ballestin Carcavilla ◽  
Nuria Alberti Masgrau ◽  
Andrés Perez Barrios ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Spindle Cell ◽  
Hepatic Metastases ◽  
Medullary Thyroid ◽  
Cell Variant

Cytogenetic tetraclonality in a rare spindle cell variant of an anaplastic carcinoma of the thyroid

2001 ◽  
Vol 125 (2) ◽  
pp. 163-166 ◽  
Author(s):  
Silvia Bol ◽  
Gazanfer Belge ◽  
Brita Thode ◽  
Ulrich Bonk ◽  
Sabine Bartnitzke ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Anaplastic Carcinoma ◽  
Cell Variant

scholarly journals Anaplastic Carcinoma Thyroid in a Young Child – an Extremely Rare Occurrence

2018 ◽  
Vol 61 (4) ◽  
pp. 150-152
Author(s):  
Suresh Chandra Sharma ◽  
Pirabu Sakthivel ◽  
Sarath Raveendran ◽  
Chirom Amit Singh ◽  
Tripti Nakra ◽  
...  
Keyword(s):  
Young Child ◽  
Thyroid Carcinoma ◽  
Anaplastic Thyroid Carcinoma ◽  
Anaplastic Carcinoma ◽  
Differential Diagnoses ◽  
Rare Occurrence ◽  
Histopathological Features ◽  
Neck Masses ◽  
Emergency Tracheostomy ◽  
Thyroid Swelling

Anaplastic thyroid carcinoma (ATC), one of the most aggressive malignancies, is extremely rare in childhood. We present a case of 5-yearold child who presented with rapidly progressing thyroid swelling and stridor, for which she underwent emergency tracheostomy and biopsy. Histopathological features were suggestive of ATC and the patient died within two months after diagnosis. ATC, though very rare in childhood, should be kept in the differential diagnoses of rapidly enlarging neck masses in children. To the best of our knowledge, this is the youngest case of ATC reported in literature.

scholarly journals Etiopathogenesis of Differentiated Thyroid Carcinomas

2016 ◽  
Vol 4 (3) ◽  
pp. 517-522
Author(s):  
Tanja Makazlieva ◽  
Olivija Vaskova ◽  
Venjamin Majstorov
Keyword(s):  
Thyroid Carcinoma ◽  
Epidemiological Studies ◽  
Genetic Alterations ◽  
Anaplastic Thyroid Carcinoma ◽  
Epigenetic Alterations ◽  
Thyroid Carcinomas ◽  
Etiological Factors ◽  
Appropriate Treatment ◽  
Poorly Differentiated ◽  
Thyroid Malignancies

INTRODUCTION: Thyroid malignomas are a heterogeneous group of neoplasm consisting of most frequent differentiated encountered carcinomas, papillary and follicular thyroid carcinoma, then medullary thyroid carcinoma originating from neuroendocrine calcitonin-producing C-cells and rare forms of thyroid lymphomas arising from intrathyroidal lymphatic tissue, thyroid sarcomas and poorly differentiated anaplastic thyroid carcinoma. There are increasing numbers of epidemiological studies and publications that have suggested increased incidence rate of thyroid carcinomas. We have read, analysed and compare available reviews and original articles investigating different etiological factors in the development of thyroid carcinomas through Google Scholar and PubMed Database.DISCUSSION: Aetiology involved in the development of thyroid carcinomas is multifactorial and includes external influences, as well as constitutional predispositions and genetic etiological factors. The actual effect of environmental and constitutional factors is on promoting genetic and epigenetic alterations which result in cell proliferation and oncogenesis. Until now are identified numerous genetic alterations, assumed to have an important role in oncogenesis, with MAPK and PI3K-AKT as crucial signalling networks regulating growth, proliferation, differentiation and cell survival/apoptosis. CONCLUSION: This new molecular insight could have a crucial impact on diagnosis and also on improving and selecting an appropriate treatment to the patients with thyroid malignancies.

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