Functional Status of the Children with Cerebral PalsyAnd Their Mothers’ Psychological Status: A Cross-sectional Study

Objective: The aims of this study were to assess the demographic characteristics and functional status of children with cerebral palsy (CP) and to evaluate the psychological status of their mothers.Results: A total of 101 patients were included in the study (%57,4% boys, %42,6% girls). Their mean age was 6,79±4,48 (1,5-18) years. Mothers’ mean age was 33,31±7,72 (20-53) years. The neurologic classification were as follows: diplegia 27,7%, tetraplegia 45,5%, hemiplegia 19,8%, dyskinetic or ataxic 6,9%. The GMFCS levels were as follows: level 1 11,9%, level 2 14,9%, level 3 17,8%, level 4 25.7%, level 5 29,7%. SCL-90-R outcomes were as follows: 38,6% somatization, 18,8% anxiety, 37,6% obsessive-compulsive, 36,6% depression, 32,7% interpersonal-sensitivity, 21,8% eating-sleeping disorder. We didn’t detect any significant correlation between the GMFCS levels of children and mothers’ physicological status. Childrens’ low WeeFIM scores were related with anxiety, obsessive-compulsive, depression, interpersonalsensitivity, paranoid ideation and eating-sleeping disorder. (p=0,009, p=0,017, p=0,009, P=0,0001, p=0,021, p=0,001 respectively). The presence of chronic disease was related with somatization, anxiety and depression (p=0,001, p=0,024, p=0,008 respectively). The presence of pain was related with somatization (p=0,0001).Conclusion: Lower WeeFIM scores of children with CP and chronic disease and pain presence in their mothers were detected as the factors that negatively affect psychological status of mothers.International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 17-23

Selective Fasciectomy in Dupuytren’s Contracture: An Experience of A Specialized Tertiary Hospital in Bangladesh

Background: Dupuytren’s disease is a benign yet disabling, irreversible, progressive fibroproliferative condition affecting the palm and fingers, leading to flection contracture of metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints.Objective: To evaluate results of selective fasciectomy to correct the deformity of MCP and PIP joints and observe the complications.Methods: This crosssectional study was done on 30 patients of Dupuytren’s contracture treated by selective fasciectomy, between January 2015 and December 2018, in Department of Orthopaedic Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Selective fasciectomy was done under brachial plexus block, tourniquet control and loupe magnification. Brunner zigzag incision was used. Indications for surgery was MCP flection contracture more than 30⁰ and any degree of PIP flection contracture. Postoperatively hand was immobilised in extension of MCP and PIP joints for 2 weeks and then active and passive movements were encouraged and intermittent splinting for 10 weeks (only at night in last 6 weeks).Results: Among 30 patients, 24 (80%) patients were male, 6 (20%) were female; mean age was 62 years (56-74 years). 12 (40%) cases were bilateral, ring and little fingers involvement were seen in most cases (92%). Mean MCP correction was 53⁰ and mean PIP correction was 34⁰ (p<0.001). There were 3 digital nerve injuries peroperatively which were repaired/reconstructed and protective sensation regained in repaired nerve area at 1 year and 3 (10%) marginal skin loss postoperatively which healed secondarily. Superficial wound infection developed in 3 (10%) patients which healed on dressing and antibiotics. Complex regional pain syndrome developed in 2 (6.66%) patients which were mild and resolved on conservative management. 3 (10%) patients developed scar sequilae which were mild and resolved on conservative treatment. Radial digital artery injury was observed in 1 (3.33%); however, no ischaemic insult was observed postoperatively. 2 (6.66%) patients developed recurrence of the disease who were more than 70 years old; however, they declined further intervention.Conclusion: Selective fasciectomy is an easy and effective procedure with less complication to correct the deformities and improve the gripstrength significantly in Dupuytren’s contracture patients.International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 41-46

Relationship Between Functional Activity And Nutritional Status, Manual Ability And Intelligence In Children With Cerebral Palsy

International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 30-35

Molecular Biomarkers for Diagnosis of Oral Cancer: An Overview

Oral cancer is one of the six leading cancers in the world and is a constant threat to the health sector in developing countries as well as developed ones. Late presentation, due to lack of awareness and invasive incisional biopsy is the crucial factor for this. Nowadays, scientists are trying to find out an easy and reliable method of early diagnosis of oral cancer and molecular biomarkers might be very helpful for that. This review was aimed to evaluate the published literature on molecular biomarkers which are related to oral cancer. For this, advanced searching was applied by specific keywords in PubMed-Medline resource database and found 12466 publications were clinical trials on humans. Then after applying all inclusion criteria, 19 articles were included finally in the review. This paper uncovered that recognition of biomarkers will be useful for the early detection of oral cancer and their prognosis after treatment. We can suggest that p53, EGFR, miR-34a, miR-143 estimation is important to decide the conceivable risk of oral malignant growth advancement in the speculated oral lesion and after the curative procedure EGFR, Podoplanin and miR-21can aid us regarding the prognosis of patient.International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 11-16

Global Warming and Greenhouse Gases: A Major Public Health Issue in Todays’ World

not availableInternational Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 3-5

Seroprevalence, clinical profile and knowledge, attitudes, and practices (KAPs) of brucellosis in North India in patients with pyrexia of unknown origin and chronic joint pain

Introduction: Brucellosis is a significant but lesser-known cause of pyrexia of unknown origin (PUO) in India. Studies documenting the prevalence of Brucellosis in different parts of India are sparse and few. Clinicians thus usually don’t consider it in their differential diagnosis. This study assesses its prevalence in two groups: febrile patients with unknown etiology and individuals presenting with arthritis and/or joint pains. Knowledge, Attitude, and Practices (KAP) among clinicians about the disease was evaluated.Materials and Methods: This is a prospective study conducted at a tertiary care center of North India catering to urban, semi-urban, and rural populace. Ninety-two patients with fever of unknown origin, arthralgia, or similar constitutional symptoms were recruited in this study. Detailed clinical history was elicited from all patients as per predesigned proforma and a rigorous physical examination was conducted. Following primary screening to rule out malaria, enteric fever, and leptospirosis, secondary screening for Brucellosis was done by Rapid Screen Test (PUO screen) and IgM and IgG ELISA. A predesigned survey was used for assessing KAP among clinicians about Brucellosis.Results: Brucella infection was diagnosed in 27 (29.3%) cases. The most common symptoms among the patients apart from fever were arthralgia (77.8%), fatigue (70.8%), pallor (66.1%), headache (59.2%), backache (53.8%) and cough (33.3%). PUO screen is a specific test for brucellosis but lacks sensitivity. It detects acute cases but misses chronic cases. IgM ELISA being more sensitive should be used for confirmation. Low ODs point to chronic brucellosis which was confirmed by IgG ELISA. Normal CRP levels in patients with PUO and chronic joint pains should point to brucellosis. KAP revealed that 25% to 50% of doctors considered Brucella in their differential diagnosis of acute and chronic fever respectively while 10% Orthopedics considered it in cases of arthralgia.Conclusion: Our results highlight the significance of Brucella as a cause of PUO and arthralgia. Brucellosis is an underrecognized but important cause of pyrexia of unknown origin and chronic joint pain. It should be actively suspected, diagnosed, and treated.International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 80-88

Conducting a FIMA Lifesaver Course in the COVID-19 Setting by IMAM in Malaysia

Every year, the Federation of Islamic Medical Association (FIMA) conducts a basic life support (BLS) course for the public, not just in one, but in several countries. It is held in mosques as a method of raising awareness on the importance of BLS among the public, apart from highlighting the function of a mosque as a place of obtaining knowledge. Traditionally, it was conducted as face-to-face training. However, with the 2019 novel coronavirus pandemic, the training was changed to a hybrid method to balance between the needs to teach BLS skills to the public and the necessity of avoiding the spread of infection. This article discussed the Islamic Medical Association of Malaysia (IMAM)’s experience in organizing a mass BLS course for public in the midst of the COVID-19 pandemic while utilising a small mosque as a hub of learning.International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 6-10

Evaluation of Liquid Based Cytology (LBC) and Conventional Pap’s Smear Test as Methods of Cervical Cancer Screening

Background: Cervical cancer screening can actually prevent most cervical cancers and also facilitates early detection which allows fruitful treatment.Objective: To evaluate and compare the efficacy of Liquid-based cytology (LBC) with conventional Pap smear test.Methods: This crosssectional study was conducted between March 2015 and June 2017. A total of 72 women participated in this study attending the Out-Patient Department (OPD) of Gynaecology (Colposcopy Clinic) of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, for VIA test. The smears prepared by the conventional Pap smear method and Liquid-based cytology method were observed by two independent observers in Department of Pathology of the same institution.Results: The mean age of the patients was 40.22±12.29 years. Considering histopathology as gold standard, in conventional Pap smear preparation our data suggested its sensitivity 87.5%, specificity 92.2%, accuracy 91.7%, positive predictive value 58.3% and negative predictive value 98.3%. In contrast, in Liquid-based cytology, we found its sensitivity 75.0%, specificity 90.6%, accuracy 88.9%, positive predictive value 50.0% and negative predictive value 96.7%.Conclusion: LBC has practical advantages over conventional preparation by producing monolayer of cells, smaller area to screen, reproducibility and availability of doing adjunct molecular techniques from residual sample. However, conventional preparation shows better sensitivity and positive predictive value and almost similar specificity, negative predictive value and accuracy with LBC.International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 36-40

Manifestations of Polycystic Ovary Syndrome are Similar Regardless of the Degree of Menstrual Cycle Variation

Background: Menstrual irregularities may predict over adverse consequences in polycystic ovary syndrome (PCOS).Objective: To observe the relation of variants of menstrual cycles with clinical and biochemical features of PCOS.Methods: This cross-sectional study encompassed 200 PCOS women diagnosed by Rotterdam criteria and 120 age-matched healthy controls. Subgroups were classified according to menstrual cycle length as: polymenorrheic (<21 days), eumenorrheic (21-35 days), oligomenorrheic (36 days-3 months) and amenorrheic (>3 months). Glucose was measured by glucose oxidase, lipid by glycerol phosphate dehydrogenenase-peroxidase and all hormones by chemiluminescent immuno-assay method.Results: Around 86% of PCOS patients had menstrual irregularity, among which 75% had oligomenorrhea followed by amenorrhea (9%) and polymenorrhea (2%). All the subgroups of PCOS patients (polymenorrhea excluded from further analyses) had significantly poor metabolic manifestations than the control namely insulin resistance (IR), impaired glycaemic status, general and central obesity, metabolic syndrome and dyslipidaemia. Acanthosis nigricans (AN), hyperandrogenemia (HA) and IR had significant predictive association with PCOS patients with both irregular [OR (95% CI)- AN: 21.994 (6.427, 75.267), p<0.001; HA: 27.735 (8.672, 88.704), p<0.001; IR: 7.268 (2.647, 19.954), p<0.001] and regular cycle [AN: 16.449 (3.830, 70.643), p<0.001; HA: 24.635 (6.349, 95.590), p<0.001; IR: 6.071 (1.658, 22.234), p=0.006] in reference to control group. None of the variables had significant predictive associations with irregular cycle in reference to regular cycle in patients with PCOS.Conclusion: Oligomenorrhea was the most common variant of menstrual irregularity in PCOS patients. All menstrual variants including eumenorrhea had similar manifestations in PCOS women, but poorer than controls.International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 96-103

Effect of comorbidities and polypharmacy on fall risk among older adults

Introduction: Fall is considered by far one of the leading causes of morbidity and mortality in the elderly population. Fall is almost always multifactorial. This study looks into the relation between different comorbidities, polypharmacy and falls.Methods: A descriptive and prospective study, the study population comprised 150 elderly patients aged > 60 years old, males and females, patients with previous history of falls are excluded. Comorbidity burden, polypharmacy and risk of falls were assessed.Results and Discussion: There was a significant positive correlation between Number of comorbidities, medications and risk of falls and there was a significant association between high risk of falls and presence of DM, PVD, OLD CVA and UI. Also, there was a significant positive correlation between age and risk of falls.Conclusion: Multiple comorbidities, polypharmacy and increasing age increase risk of falls.International Journal of Human and Health Sciences Vol. 06 No. 01 January’22 Page: 75-79