scholarly journals Very High CA125 due to Non-neoplastic Lesion of Ovary

2014 ◽  
Vol 7 (2) ◽  
pp. 52-54
Author(s):  
KDB Bista
Keyword(s):  
Tumor Marker ◽  
Pelvic Inflammatory Disease ◽  
Young Woman ◽  
Inflammatory Disease ◽  
Abdominal Tuberculosis ◽  
Ca 125 ◽  
Ovarian Malignancy ◽  
Obstetrics And Gynaecology ◽  
Neoplastic Lesion ◽  
Very High

High CA-125 levels have been strongly associated with ovarian malignancy. But due to nonspecific nature of this tumor marker it has been found to be raised to high levels above 1000u/Ml even in some non neoplastic conditions which have to be kept in mind. A young woman was found to have very high Ca125 levels of 3500u/Ml after rupture of endometrioma. Endometrioma, pelvic inflammatory disease, abdominal tuberculosis are some of the nonneoplastic conditions associated with very high levels of Ca125. DOI: http://www.dx.doi.org/10.3126/njog.v7i2.11146   Nepal Journal of Obstetrics and Gynaecology / Vol 7 / No. 2 / Issue 14 / July-Dec, 2012 / 52-54

CA 125 in Benign Gynecological Conditions

1998 ◽  
Vol 13 (4) ◽  
pp. 231-237 ◽  
Author(s):  
H. Meden ◽  
A. Fattahi-Meibodi
Keyword(s):  
Tumor Marker ◽  
Ectopic Pregnancy ◽  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Cirrhosis Of The Liver ◽  
Ca 125 ◽  
Ovarian Cysts ◽  
Gynecological Tumors ◽  
Ovarian Abscess

The tumor marker CA 125 was initially thought to be specific for ovarian malignancies. Subsequently it was found to be raised in a variety of benign conditions, including pregnancy, pelvic inflammatory disease, tuberculosis and cirrhosis of the liver. With respect to gynecological tumors, CA 125 may be elevated in benign ovarian cysts, tubo-ovarian abscess, endometriosis, hyperstimulation syndrome, ectopic pregnancy and fibroids. These results demonstrate that CA 125 is a marker of non-specific peritoneal conditions.

scholarly journals Mesothelin versus Ca125 in Screening the Ovarian Malignancy

2016 ◽  
pp. 107
Author(s):  
Meliana Jayasaputra ◽  
Freddy W Wagey ◽  
Max R Rarung
Keyword(s):  
Tumor Marker ◽  
Sensitivity And Specificity ◽  
Cross Sectional Study ◽  
Ca 125 ◽  
Ovarian Malignancy ◽  
Roc Curve Analysis ◽  
Cross Sectional ◽  
Auc Value ◽  
Spss Software ◽  
Higher Sensitivity

Objective: To determine the sensitivity and specificity of mesothelin compared with Ca-125 as a tumor marker in predicting ovarian malignancy. Method: The cross sectional study design with diagnostic tests was conducted in 30 samples of patients undergoing elective laparotomy due to ovarian tumor. We compared the sensitivity and specificity between mesothelin and Ca-125, then the data were analyzed using SPSS software version 22.0. Result: According to the ROC curve analysis, optimal sensitivity and specificity value of mesothelin was 63.2% and 54.5% at a cut-off point of 0.45 pg/ml; or 42.1% and 72.7% at a cut-off point of 0.55 pg/ml. While the value of both optimal sensitivity and specificity of Ca-125 was 73.7% and 63.6% at a cut-off point of 46.63 U/ml. Conclusion: Mesothelin and Ca-125 are not different significantly for the AUC value of 50%. Due to higher sensitivity and specificity of Ca-125 than mesothelin, Ca-125 is still used as tumor marker for screening the ovarian malignancy. [Indones J Obstet Gynecol 2016; 4-2: 107-110] Keywords: Ca-125, mesothelin, ovarian malignancy

High CA 125 in a Case of Abdominal Tuberculosis mimicking Ovarian Malignancy

2016 ◽  
Vol 3 (1) ◽  
pp. 51-52
Author(s):  
Iqbal Tintoiya ◽  
Nimisha Srivastava ◽  
Pratima Thamke
Keyword(s):  
Abdominal Tuberculosis ◽  
Ca 125 ◽  
Ovarian Malignancy

scholarly journals DIAGNOSTIC VALUE OF CA-125 IN PATIENTS WITH EPITHELIAL OVARIAN CANCER AT THE DR. SOETOMO GENERAL HOSPITAL SURABAYA IN 2016

2019 ◽  
Vol 25 (2) ◽  
pp. 145
Author(s):  
Kintan Putri ◽  
Betty Agustina Tambunan ◽  
Willy Sandhika
Keyword(s):  
Ovarian Cancer ◽  
Positive Predictive Value ◽  
Epithelial Ovarian Cancer ◽  
Tumor Marker ◽  
General Hospital ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Diagnostic Value ◽  
Ca 125 ◽  
Ovarian Malignancy

Ovarian cancer is the fourth cancer with most incidence in Indonesian female with 10.238 cases in 20141. Tumor marker CA-125 is assosciated with ovarian cancer, importantly epithelial ovarian cancer. This study aims to find out diagnostic value (sensitivity, specificity, positive predictive value, negative predictive value) of CA-125 among patients with epithelial ovarian cancer in Dr. Soetomo General Hospital Surabaya in 2016. This study used analytic cross sectional method and was performed by evaluating medical records of patients suspected for ovarian malignancy in Dr. Soetomo General Hospital Surabaya in 2016. There were total 97 patients found fit for criteria of inclusion in this study. Tissue histopathological examination confirmed 66 patients have epithelial ovarian malignancy and 31 patients do not. Samples distributed using 35 U/ml as CA-125 upper limit, TP: 54.64%, FP: 19.59%, FN: 13.40%, dan TN: 12.37%. Diagnostic value obtained as follows: sensitivity 80.30%, spesificity 38.71%, positive predictive value 73.61%, negative predictive value 48%, and accuracy 67.01%. Tumor marker associated with ovarian cancer CA-125 has found high in sensitivity but low in specificity among patients with epithelial ovarian cancer in Dr. Soetomo General Hospital Surabaya in 2016.

Serum CA-125 in the diagnosis of acute pelvic inflammatory disease

1994 ◽  
Vol 44 (1) ◽  
pp. 53-57 ◽  
Author(s):  
J. Mozas ◽  
J.A. Castilla ◽  
P. Jimena ◽  
T. Gil ◽  
M. Acebal ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Ca 125 ◽  
Acute Pelvic Inflammatory Disease

scholarly journals A diagnostic approach for differentiating abdominal tuberculosis from ovarian malignancy: a case series and literature review

2019 ◽  
Vol 13 (S11) ◽  
Author(s):  
Moh Nailul Fahmi ◽  
Annisaa Pelita Harti
Keyword(s):  
Ovarian Cancer ◽  
Extrapulmonary Tuberculosis ◽  
Clinical Manifestations ◽  
Case Series ◽  
Abdominal Tuberculosis ◽  
Diagnostic Approach ◽  
Ca 125 ◽  
Imaging Features ◽  
Ovarian Malignancy ◽  
Cancer Antigen 125

Abstract Background Abdominal tuberculosis is an uncommon variant of extrapulmonary tuberculosis. It accounts for 3.5% of extrapulmonary tuberculosis. Diagnosis of abdominal tuberculosis is still a challenge due to its non-specific symptoms. Abdominal tuberculosis and ovarian cancer may show similar symptoms, laboratory and imaging features. The goal of our report is to emphasize for the need of a diagnostic approach based on clinical manifestations, laboratory, imaging findings, and additional tests for considering a diagnosis of abdominal tuberculosis rather than ovarian cancer. Case presentation We report 3 cases of abdominal tuberculosis in our Onco-gynaecology Division, Department of Obstetrics and Gynaecology, Sardjito Hospital, Yogyakarta, Indonesia in 2018 which were previously diagnosed as ovarian malignancy and managed surgically. All of our patients experienced abdominal pain and enlargement but only two of them had significant weight loss. The general symptoms were typically found in onco-gynaecology patients, especially in those with ovarian malignancy. Ultrasound examination showed multilocular masses, 2 of them with solid parts and ascites. Cancer antigen 125 (CA-125) levels were found increasing in those three patients. All of them were treated surgically and diagnosis of abdominal tuberculosis was established through the histopathological result of tissue biopsy. Based on our cases and literature, we consider the need of a diagnostic approach to differentiate abdominal tuberculosis from ovarian malignancy, an attempt to avoid unnecessary invasive procedures that put burden risk for the patients. Conclusion Minimally invasive tests to establish the diagnosis of abdominal tuberculosis should be optimized to reduce the burden risk of laparotomy. Careful diagnostic steps should be followed to avoid wrong diagnosis.

scholarly journals Pelvic Inflammatory Disease: Possible Catches and Correct Management in Young Women

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Chiara Di Tucci ◽  
Daniele Di Mascio ◽  
Michele Carlo Schiavi ◽  
Giorgia Perniola ◽  
Ludovico Muzii ◽  
...  
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Young Women ◽  
Inflammatory Disease ◽  
Transvaginal Ultrasound ◽  
Correct Diagnosis ◽  
Pelvic Mass ◽  
Treatment Decision ◽  
Ca 125 ◽  
Fertility Sparing ◽  
The Right

The incidence of adnexal masses increases exponentially with age and the most frequent causes in young women are physiologic cysts and pelvic abscesses with pelvic inflammatory disease (PID). Clinical examination can direct physicians to an appropriate management of adnexal mass, but the role of transvaginal ultrasound is crucial for diagnosis and treatment decision, even if it sometimes can be misleading, especially in young women. Ca 125, blood count, and CRP are useful to clarify suspected etiology of a pelvic mass, but specificity and positive predictive value are low because elevation of laboratory tests may occur in several benign conditions. In our work we present four cases of suspected pelvic masses. Despite guidelines for management of PID, the right timing to switch to surgical therapy is not clear. Therefore, the treatment decision should be based on a careful evaluation of various parameters such as signs symptoms and above all age. Moreover, we believe that, for a correct diagnosis and for the best fertility sparing treatment, it is also extremely important to refer to a gynecological oncology unit with an expert surgeon.

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