Oxidative metabolism and glycolysis in benign brain tumors

1987 ◽  
Vol 67 (3) ◽  
pp. 336-340 ◽  
Author(s):  
Terry Lichtor ◽  
George J. Dohrmann
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Oxidative Metabolism ◽  
Glucose Utilization ◽  
Content Type ◽  
Human Brain Tumors ◽  
Elevated Glucose ◽  
Slow Growing

✓ Glucose utilization in vivo and hexokinase activity and mitochondrial oxygen consumption in vitro were measured in a series of human brain tumors. Several relatively slow-growing tumors appeared to have depressed electron-transport activities coupled with a compensatory elevated glucose utilization. These data suggest that a decrease in oxidative metabolism and a corresponding increase in glycolysis are not necessarily correlated with malignancy in certain human brain tumors.

Cell kinetics studies of human brain tumors by in vitro labeling using anti-BUdR monoclonal antibody

1988 ◽  
Vol 69 (3) ◽  
pp. 371-374 ◽  
Author(s):  
Takafumi Nishizaki ◽  
Tetsuji Orita ◽  
Masahide Saiki ◽  
Yasuhiro Furutani ◽  
Hideo Aoki
Keyword(s):  
Monoclonal Antibody ◽  
Brain Tumors ◽  
Human Brain ◽  
Intravenous Infusion ◽  
Reproductive Age ◽  
Proliferative Potential ◽  
Human Brain Tumor ◽  
Human Brain Tumors

✓ Since the development of a specific monoclonal antibody against the thymidine analogue bromodeoxyuridine (BUdR), many investigators have used intravenous infusion of BUdR to estimate the proliferative potential of human brain tumors. However, side effects such as the induction of cell mutation, latent virus promotion, or inhibition of cytodifferentiation cannot be ignored, and thus many workers hesitate to use it in patients, especially those with hepatic disease or of reproductive age. Furthermore, if BUdR remains in the deoxyribonucleic acid of tumor cells after injection, analysis of the effect of chemical and radiation therapy may not be evaluated correctly. In this report, in vitro BUdR labeling with an anti-BUdR antibody is compared with the in vivo methods described by previous authors. This method appears to be useful for determining the S-phase fraction of human brain tumor. It was more rapid, and was simple, safe, and reproducible as compared to the intravenous infusion method.

In vivo and in vitro NMR of human brain tumors

1997 ◽  
pp. 439-440
Author(s):  
V. Tugnoli ◽  
M. R. Tosi ◽  
A. Bertoluzza ◽  
G. Barbarella ◽  
R. Ricci
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors

Demonstration of an astrocyte-specific cerebroprotein by an immunofluorescence study of human brain tumors

1970 ◽  
Vol 33 (3) ◽  
pp. 281-286 ◽  
Author(s):  
Philippe Benda ◽  
Takesada Mori ◽  
William H. Sweet
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Ganglion Cells ◽  
Fluorescent Antibody ◽  
Fluorescent Antibody Technique ◽  
Antibody Technique ◽  
Content Type ◽  
Human Brain Tumors ◽  
Tay Sachs Disease ◽  
Cell Processes

✓ Specimens of 16 human brain tumors were studied by the indirect fluorescent-antibody technique to reveal the localization of the particular cerebroprotein found in strikingly increased amounts in human glial tumors as well as in the brain of a patient with Tay-Sachs disease. The cerebro-protein fraction named “10B” by Bogoch was found exclusively in reactive astrocytes, both in astrocytomas and in glioblastomas multiforme. Both the cytoplasm and the cell processes fluoresced upon exposure to antiserum to the “10B” proteins of Tay-Sachs disease. Fluorescence of fibrillary astrocytes located in white matter at some distance from a tumor might be related to discrete edematous changes or constitute an early step in the transition of normal glia to reactive or neoplastic astrocytes. There was no such staining of frankly neoplastic cells or of normal ganglion cells.

Chemosensitivity of Malignant Human Brain Tumors in vitro

2015 ◽  
pp. 157-166
Author(s):  
R. Sch�nmayr ◽  
J. C. Tonn ◽  
K. H. Link ◽  
H. P. Kraemer
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Human Brain Tumors

Expression of Vascular Endothelial Growth Factor in Human Brain Tumors In Vivo

Brain Tumor ◽  
1996 ◽  
pp. 237-245 ◽  
Author(s):  
Kiyonobu Ikezaki ◽  
Ken Samoto ◽  
Takanori Inamura ◽  
Tadahisa Shono ◽  
Masashi Fukui ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Brain Tumors ◽  
Human Brain ◽  
Vascular Endothelial ◽  
Human Brain Tumors ◽  
Endothelial Growth Factor

In vivo CT measurement of blood-brain transfer constant of iopamidol in human brain tumors

1992 ◽  
Vol 14 (2) ◽  
Author(s):  
W.T. Ivan Yeung ◽  
Ting-Yim Lee ◽  
RolandoF. Del Maestro ◽  
Roman Kozak ◽  
Thomas Brown
Keyword(s):  
Brain Tumors ◽  
Human Brain ◽  
Transfer Constant ◽  
Human Brain Tumors ◽  
Blood Brain ◽  
Ct Measurement

ATPase in human brain tumors

1970 ◽  
Vol 33 (2) ◽  
pp. 167-171 ◽  
Author(s):  
Edward R. Laws ◽  
John S. O'Connor
Keyword(s):  
Central Nervous System ◽  
Brain Tumors ◽  
Human Brain ◽  
Content Type ◽  
Human Brain Tumors ◽  
The Central Nervous System ◽  
Transport Atpases ◽  
Energy Dependent ◽  
And Control ◽  
Fine Print

✓ The energy-dependent membrane transport ATPases have been quantitatively determined in 59 human brain tumors and control cerebral cortex. The values for total ATPase were significantly decreased in the 11 types of brain tumors tested, while in the glioma group there was a consistent further decrease in ATPase with increasingly malignant types. The findings suggest that a deficiency in ATPase is a characteristic of neoplasia in the central nervous system.

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