Magnetic Nanoclusters for T2 MR Imaging in Cancer using Xenograft Mice Model

2020 ◽  
Vol 3 (1) ◽  
pp. 1-7
Author(s):  
Jooyeon Kim ◽  
◽  
Giljae Lee ◽  
Jingyu Kim ◽  
◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Cytotoxicity Test ◽  
Resonance Imaging ◽  
Mice Model ◽  
Related Research ◽  
Magnetic Nanoclusters ◽  
Cell Survival Rate ◽  
Xenograft Mice Model ◽  
Xenograft Mice

In this study, we tried to develop nanoprobe for molecular magnetic resonance (MR) imaging using magnetic nanoclusters (MNC). MNCs for magnetic resonance imaging were synthesized by thermal decomposition. The size of the synthesized MNC was confirmed to be 73 ± 32.4 nm. Cytotoxicity test of the synthesized MNCs showed that the cell state of about 80% or more did not change in all the treatment ranges and cell survival rate was high even though the MNCs were injected. MNC was injected intravenously into the tail vein of nude mice. As a result, it was found that enhancement of the contrast was confirmed in xenograft mice model using MNC. These results will contribute to clinical application and related research through magnetic nanocluster in the future.

scholarly journals A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging

2021 ◽  
Vol 22 (9) ◽  
pp. 4586
Author(s):  
Marta Orts-Arroyo ◽  
Amadeo Ten-Esteve ◽  
Sonia Ginés-Cárdenas ◽  
Isabel Castro ◽  
Luis Martí-Bonmatí ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Lesion Detection ◽  
Resonance Imaging ◽  
X Ray Diffraction ◽  
Functional Images ◽  
High Relaxivity ◽  
Contrast Enhanced ◽  
Phantom Studies

The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)2(H2O)6](ClO4)3·2H2O (1) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase. 1 has been characterized through UV-vis, IR, SEM-EDAX, and single-crystal X-ray diffraction techniques, and its magnetic and relaxometric properties have been investigated by means of SQUID magnetometer and MR imaging phantom studies, respectively. On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast-enhanced magnetic resonance imaging.

Magnetic resonance imaging—guided percutaneous fenestration of a cervical intradural cyst

2003 ◽  
Vol 99 (3) ◽  
pp. 313-315 ◽  
Author(s):  
Shinobu Takahashi ◽  
Shigehiro Morikawa ◽  
Masaaki Egawa ◽  
Yasuo Saruhashi ◽  
Yoshitaka Matsusue
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Complete Disappearance ◽  
Resonance Imaging ◽  
Content Type ◽  
Local Anesthetic Agent ◽  
Intradural Extramedullary ◽  
Severe Exercise ◽  
Exercise Induced ◽  
High Cervical

✓ The authors describe the case of a high cervical, intradural extramedullary cyst located anterior to the spinal cord in a 13-year-old boy. The lesion was fenestrated percutaneously by using real-time magnetic resonance (MR) imaging guidance and a local anesthetic agent. The patient's symptom, severe exercise-induced headache, immediately resolved after treatment. Nine months later, complete disappearance of the cyst was confirmed on MR imaging and computerized tomography myelography. Magnetic resonance imageing—guided fenestration can be considered a minimally invasive option for intradural cystic lesions.

scholarly journals Co-Treatment with the Epigenetic Drug, 3-Deazaneplanocin A (DZNep) and Cisplatin after DZNep Priming Enhances the Response to Platinum-Based Therapy in Chondrosarcomas

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4648
Author(s):  
Eva Lhuissier ◽  
Juliette Aury-Landas ◽  
Marion Lenté ◽  
Karim Boumediene ◽  
Catherine Baugé
Keyword(s):  
Tumor Volume ◽  
Mice Model ◽  
Antitumoral Effect ◽  
Viable Cells ◽  
Epigenetic Drug ◽  
Xenograft Mice Model ◽  
Xenograft Mice ◽  
Tumoral Cells

Background: We have previously shown that 3-Deazaneplanocin A (DZNep) induces apoptosis in chondrosarcomas. Herein, we tested whether the combination of this epigenetic drug to a standard anticancer therapy may enhance the response to each drug in these bone tumors. Methods: Two chondrosarcoma cell lines (SW1353 and JJ012) were cultured in the presence of DZNep and/or cisplatin. Cell growth was evaluated by counting viable cells, and apoptosis was determined by Apo2.7 expression by flow cytometry. In vivo, the antitumoral effect of the DZNep/cisplatin combination was assessed through measurements of tumor volume of JJ012 xenografts in nude mice. Results: In vitro, the DZNep/cisplatin combination reduced cell survival and increased apoptosis compared to each drug alone in chondrosarcomas, but not in normal cells (chondrocytes). This enhancement of the antitumoral effect of the DZNep/cisplatin combination required a priming incubation with DZNep before the co-treatment with DZNep/cisplatin. Furthermore, in the chondrosarcoma xenograft mice model, the combination of both drugs more strongly reduced tumor growth and induced more apoptosis in tumoral cells than each of the drugs alone. Conclusion: Our results show that DZNep exposure can presensitize chondrosarcoma cells to a standard anticancer drug, emphasizing the promising clinical utilities of epigenetic-chemotherapeutic drug combinations in the future treatment of chondrosarcomas.

scholarly journals Using magnetic resonance imaging in animal models to guide drug development in multiple sclerosis

2013 ◽  
Vol 20 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Nabeela Nathoo ◽  
V Wee Yong ◽  
Jeff F Dunn
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Clinical Trials ◽  
Magnetic Resonance ◽  
Animal Models ◽  
Mr Imaging ◽  
Preclinical Studies ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
Potential Therapeutics

Major advances are taking place in the development of therapeutics for multiple sclerosis (MS), with a move past traditional immunomodulatory/immunosuppressive therapies toward medications aimed at promoting remyelination or neuroprotection. With an increase in diversity of MS therapies comes the need to assess the effectiveness of such therapies. Magnetic resonance imaging (MRI) is one of the main tools used to evaluate the effectiveness of MS therapeutics in clinical trials. As all new therapeutics for MS are tested in animal models first, it is logical that MRI be incorporated into preclinical studies assessing therapeutics. Here, we review key papers showing how MR imaging has been combined with a range of animal models to evaluate potential therapeutics for MS. We also advise on how to maximize the potential for incorporating MRI into preclinical studies evaluating possible therapeutics for MS, which should improve the likelihood of discovering new medications for the condition.

Physiological support and monitoring of critically ill patients during magnetic resonance imaging

1988 ◽  
Vol 68 (2) ◽  
pp. 246-250 ◽  
Author(s):  
Gene H. Barnett ◽  
Allan H. Ropper ◽  
Keith A. Johnson
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Critically Ill ◽  
Resonance Imaging ◽  
Monitoring Equipment ◽  
Mr Image ◽  
Content Type ◽  
Neurological Patients ◽  
Fine Print ◽  
Electrical Interference

✓ Magnetic resonance (MR) imaging has been largely restricted to patients who are neurologically and hemodynamically stable. The strong magnetic field and radiofrequency transmissions involved in acquiring images are potential sources of interference with monitoring equipment. A method of support and physiological monitoring of critically ill neurosurgical and neurological patients during MR imaging using a 0.6-tesla MR system is reported. This technique has not caused degradation of the MR image due to electrical interference. Adequate preparation and precautions allow many critically ill neurosurgical and neurological patients to safely undergo MR imaging.

Normal Magnetic Resonance Imaging Anatomy of the Capsular Ligamentous Supporting Structures of the Knee

2016 ◽  
Vol 67 (4) ◽  
pp. 356-367 ◽  
Author(s):  
Lana H. Gimber ◽  
Jolene C. Hardy ◽  
David M. Melville ◽  
Luke R. Scalcione ◽  
Andrew Rowan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Proximal Tibiofibular Joint ◽  
Imaging Findings ◽  
Resonance Imaging ◽  
Tibiofibular Joint ◽  
Anatomic Variants ◽  
Neurovascular Structures ◽  
Supporting Structures

Recognition of the normal magnetic resonance (MR) imaging appearances of the capsular ligaments of the knee is of great importance. These ligaments contribute to stability of the knee joint and are frequently injured. In this article, we describe the normal MR imaging anatomy of the capsular ligaments of the knee including the lateral and medial collateral ligamentous complexes, the extensor mechanism, and the supporting ligamentous structures of the proximal tibiofibular joint. Normal MR imaging findings and important anatomic variants of the neurovascular structures of the knee are also described.

Low Field Magnetic Resonance Imaging of Focal Hepatic Masses at 0.02 T

1989 ◽  
Vol 30 (6) ◽  
pp. 591-595
Author(s):  
L. Ekelund ◽  
L. Athlin
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Malignant Tumors ◽  
Signal To Noise Ratio ◽  
Malignant Neoplasms ◽  
Hepatic Hemangioma ◽  
Resonance Imaging ◽  
Benign Lesions ◽  
Low Field ◽  
Better Than

The diagnostic utility of extremely low field magnetic resonance (MR) imaging was evaluated in 25 patients with focal hepatic masses, including 17 with primary (n=7) or secondary (n= 10) malignant neoplasms and 8 with benign lesions (6 hemangiomas). The findings were compared with the results of computed tomography (CT). Out of 16 patients with malignant tumors demonstrated by both modalities, the diagnostic information from MR imaging was equal to or better than that from CT in 6 patients and inferior to CT in 10. Shortcomings of MR were mainly due to low signal-to-noise ratio and poor spatial resolution, resulting in an image quality inferior to that obtained at higher field strengths. Considering these facts, together with the long imaging times required, low field MR cannot be recommended for general use in the evaluation of hepatic masses. On the other hand, our results indicate that this technique may be useful in establishing the diagnosis of hepatic hemangioma.

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