Role of bone morphogenetic proteins in periodontal tissue engineering: Relatively unexplored horizon

2021 ◽  
pp. 1-4
Author(s):  
Preeti Prakash Kale ◽  
Amit Mani ◽  
Raju Anarthe ◽  
Rachita Mustilwar
Keyword(s):  
Tissue Engineering ◽  
Bone Morphogenetic Proteins ◽  
Target Tissue ◽  
Signaling Mechanism ◽  
Tissue Scaffold ◽  
Periodontal Tissues ◽  
Bone Morphogenic Proteins ◽  
Formidable Challenge ◽  
Unique Nature ◽  
Potent Growth

Tissue engineering aims to reconstruct the natural target tissue by a combination of three key elements stem/progenitor cells (that will create the new tissue), signaling molecules (that instruct the cells to form the desired tissue) scaffold/extracellular matrix (to hold the cells). Regeneration of the periodontal tissues following destructive episodes of various forms of periodontitis is a formidable challenge to periodontologists. Bone morphogenic proteins have been considered as the most potent growth factors that can promote the bone regeneration. This review will emphasize on the unique nature of the tissue engineered bone morphogenic proteins molecules regarding their structure, classification, signaling mechanism, etc. which will further help in understanding their role and potential advances necessary to facilitate the process of regeneration in the field of periodontics.

scholarly journals Tissue Engineering, Morphogenesis, and Regeneration of the Periodontal Tissues By Bone Morphogenetic Proteins

1997 ◽  
Vol 8 (2) ◽  
pp. 154-163 ◽  
Author(s):  
Ugo Ripamonti ◽  
A. Hari Reddi
Keyword(s):  
Tissue Engineering ◽  
Molecular Biology ◽  
Bone Morphogenetic Proteins ◽  
Periodontal Ligament ◽  
Alveolar Bone ◽  
Periodontal Tissues ◽  
Collagenous Matrix ◽  
Furcation Defects ◽  
Osteogenic Protein

Tissue engineering is the emerging field of science developing techniques for fabrication of new tissues for replacement based on principles of cell and developmental biology and biomaterials. Morphogenesis is the cascade of pattern formation and the attainment of form of the various organs and the organism as a whole. The periodontium consists of the periodontal ligament, cementum, and alveolar bone. Bone has considerable potential for regeneration and therefore is a prototypic model for tissue engineering. The three main ingredients for tissue engineering are regulatory signals, responding stem cells, and extracellular matrix. Recent advances in molecular biology of the bone morphogenetic proteins (BMPs) have set the stage for tissue engineering of bone and related tissues, including the periodontium. Bone-derived BMPs, with a collagenous matrix as carrier, induced cementum and alveolar bone regeneration in surgically created furcation defects in the primate. It is noteworthy that there was morphogenesis of periodontal ligament and a faithful insertion of Sharpey's fibers into cementum. In the same furcation model, recombinant human osteogenic protein-1 (rhOP-1, also known as BMP-7), in conjunction with the collagenous carrier, induced extensive cementogenesis with insertion of Sharpey's fibers into the newly formed cementum. The observation that BMPs induce cementogenesis and periodontal ligament formation indicates that these proteins may have multiple functions in vivo not limited to cartilage and bone induction. The rapid advances in the molecular biology of BMPs and their receptors bode well for novel strategies to engineer the regeneration of the periodontal tissues.

Regenereation in periodontics

2018 ◽  
Author(s):  
Murtaza Kaderi ◽  
Mohsin Ali ◽  
Alfiya Ali ◽  
Tasneem Kaderi
Keyword(s):  
Tissue Engineering ◽  
Clinical Practice ◽  
Periodontal Disease ◽  
Disease Progression ◽  
Tissue Regeneration ◽  
Surgical Procedures ◽  
Periodontal Regeneration ◽  
Guided Tissue Regeneration ◽  
Periodontal Tissues ◽  
Extensive Documentation

The goals of periodontal therapy are to arrest of periodontal disease progression and to attain the regeneration of the periodontal apparatus. Osseous grafting and Guided tissue regeneration (GTR) are the two techniques with the most extensive documentation of periodontal regeneration. However, these techniques offer limited potential towards regenerating the periodontal tissues. Recent surgical procedures and application of newer materials aim at greater and more predictable regeneration with the concept of tissue engineering for enhanced periodontal regeneration and functional attachment have been developed, analyzed, and employed in clinical practice

scholarly journals Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Stefano Focaroli ◽  
Gabriella Teti ◽  
Viviana Salvatore ◽  
Isabella Orienti ◽  
Mirella Falconi
Keyword(s):  
Tissue Engineering ◽  
Bone Morphogenetic Proteins ◽  
Transforming Growth Factor ◽  
Cartilage Tissue Engineering ◽  
Biomechanical Properties ◽  
Alginate Beads ◽  
Cartilage Tissue ◽  
Self Healing ◽  
Tissue Replacement

Articular cartilage is a highly organized tissue with complex biomechanical properties. However, injuries to the cartilage usually lead to numerous health concerns and often culminate in disabling symptoms, due to the poor intrinsic capacity of this tissue for self-healing. Although various approaches are proposed for the regeneration of cartilage, its repair still represents an enormous challenge for orthopedic surgeons. The field of tissue engineering currently offers some of the most promising strategies for cartilage restoration, in which assorted biomaterials and cell-based therapies are combined to develop new therapeutic regimens for tissue replacement. The current study describes thein vitrobehavior of human adipose-derived mesenchymal stem cells (hADSCs) encapsulated within calcium/cobalt (Ca/Co) alginate beads. These novel chondrogenesis-promoting scaffolds take advantage of the synergy between the alginate matrix and Co+2ions, without employing costly growth factors (e.g., transforming growth factor betas (TGF-βs) or bone morphogenetic proteins (BMPs)) to direct hADSC differentiation into cartilage-producing chondrocytes.

scholarly journals A Novel Albumin-Based Tissue Scaffold for Autogenic Tissue Engineering Applications

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Pei-Shan Li ◽  
I. -Liang Lee ◽  
Wei-Lin Yu ◽  
Jui-Sheng Sun ◽  
Wann-Neng Jane ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Engineering Applications ◽  
Tissue Scaffold

scholarly journals Harnessing the Topography of 3D Spongy-Like Electrospun Bundled Fibrous Scaffold via a Sharply Inclined Array Collector

Polymers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1444 ◽  
Author(s):  
Sun Hee Cho ◽  
Jeong In Kim ◽  
Cheol Sang Kim ◽  
Chan Hee Park ◽  
In Gi Kim
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Three Dimensional ◽  
Living System ◽  
Pivotal Role ◽  
Skin Tissue ◽  
Target Tissue ◽  
Fibrous Scaffold ◽  
Electrospun Scaffolds ◽  
Directional Change

To date, many researchers have studied a considerable number of three-dimensional (3D) cotton-like electrospun scaffolds for tissue engineering, including the generation of bone, cartilage, and skin tissue. Although numerous 3D electrospun fibrous matrixes have been successfully developed, additional research is needed to produce 3D patterned and sophisticated structures. The development of 3D fibrous matrixes with patterned and sophisticated structures (FM-PSS) capable of mimicking the extracellular matrix (ECM) is important for advancing tissue engineering. Because modulating nano to microscale features of the 3D fibrous scaffold to control the ambient microenvironment of target tissue cells can play a pivotal role in inducing tissue morphogenesis after transplantation in a living system. To achieve this objective, the 3D FM-PSSs were successfully generated by the electrospinning using a directional change of the sharply inclined array collector. The 3D FM-PSSs overcome the current limitations of conventional electrospun cotton-type 3D matrixes of random fibers.

Tissue engineering

2013 ◽  
pp. 664-668
Author(s):  
Andrew McCaskie ◽  
Paul Genever ◽  
Cosimo De Bari
Keyword(s):  
Tissue Engineering ◽  
Host Tissue ◽  
Target Tissue ◽  
Cell Therapies ◽  
Cell Matrix ◽  
Wide Range ◽  
Regenerative Approach ◽  
Great Relevance ◽  
Functional Interface

The field of tissue engineering has developed rapidly over the last few decades and is of great relevance to musculoskeletal therapy and intervention. Tissue engineering strategies are often considered in a simplified form in terms of cells, scaffolds, and additional factors, although it should be noted that successful translation of such a strategy is more complex. There are many variations of usage and combination and it is not necessary for all three to be provided by the proposed treatment. However, the regenerative approach must produce both the quantity and quality of target tissue at the level of the cell, matrix, and environment. Moreover, the regenerated tissue must interact with the host tissue with a seamless biological and functional interface. Tissue engineering, regenerative medicine, and cell therapies have developed significantly over the last few decades and are applicable to a wide range of musculoskeletal applications. Many strategies have been identified that would potentially benefit patients but the future will require successful translation from the laboratory into clinical practice. It is important to identify clinical targets where there is both clinical need and an informed view that the approach is likely to be successful.

scholarly journals Biomaterial-Based Approaches for Regeneration of Periodontal Ligament and Cementum Using 3D Platforms

2019 ◽  
Vol 20 (18) ◽  
pp. 4364 ◽  
Author(s):  
Chan Ho Park
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Periodontal Ligament ◽  
State Of The Art ◽  
Tooth Root ◽  
Tissue Formation ◽  
Periodontal Tissue ◽  
Periodontal Tissues ◽  
Root Surfaces ◽  
Periodontal Ligaments

Currently, various tissue engineering strategies have been developed for multiple tissue regeneration and integrative structure formations as well as single tissue formation in musculoskeletal complexes. In particular, the regeneration of periodontal tissues or tooth-supportive structures is still challenging to spatiotemporally compartmentalize PCL (poly-ε-caprolactone)-cementum constructs with micron-scaled interfaces, integrative tissue (or cementum) formations with optimal dimensions along the tooth-root surfaces, and specific orientations of engineered periodontal ligaments (PDLs). Here, we discuss current advanced approaches to spatiotemporally control PDL orientations with specific angulations and to regenerate cementum layers on the tooth-root surfaces with Sharpey’s fiber anchorages for state-of-the-art periodontal tissue engineering.

The Role of Bone Morphogenetic Proteins in Tissue Engineering Particulate Bone Grafts

2014 ◽  
Vol 32 (4) ◽  
pp. 377-383 ◽  
Author(s):  
Ondine Patricia Lucaciu ◽  
Olga Soritau ◽  
Grigore Baciut ◽  
Dan Lucaciu ◽  
Mihaela Baciut ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Morphogenetic Proteins ◽  
Bone Grafts

The Application of Rapid Prototyping and Manufacturing for Anatomical Modelling in Medicine

2010 ◽  
Vol 6 ◽  
pp. 57-65 ◽  
Author(s):  
S. Singare ◽  
W. Ping ◽  
X. Guanghui
Keyword(s):  
Tissue Engineering ◽  
Rapid Prototyping ◽  
Computer Aided Design ◽  
Surgical Planning ◽  
Three Dimensional ◽  
Advanced Technology ◽  
Tissue Scaffold ◽  
Custom Implant ◽  
Rapid Prototyping And Manufacturing ◽  
High Level

This paper reviews the applications of advanced technology such as CT, reverse engineering (RE), computer aided design (CAD) and rapid prototyping (RP) in medicine. We described: 1) the use of RP and medical imaging in surgical planning; 2) the design process for the production of customized medical implants by rapid prototyping; and 3) the fabrication of three-dimensional scaffolds for tissue engineering of human liver. In order to examine the applicability and efficiency of the rapid prototyping technology, some case studies are presented, involving visualization and surgical planning; the design of custom implant for cranial reconstruction; and the use of RP in the production of tissue scaffold. From the results, it has been shown that RP can be applied with high level of accuracy in surgical planning, custom implant and tissue engineering.

Current Approaches of Bone Morphogenetic Proteins in Dentistry

2015 ◽  
Vol 41 (3) ◽  
pp. 337-342 ◽  
Author(s):  
Rosa-María Díaz-Sánchez ◽  
Rosa-María Yáñez-Vico ◽  
Ana Fernández-Olavarría ◽  
Regina Mosquera-Pérez ◽  
Alejandro Iglesias-Linares ◽  
...  
Keyword(s):  
Bone Morphogenetic Proteins ◽  
Specific Growth ◽  
Bone Matrix ◽  
Bone Lesions ◽  
Allogenic Bone ◽  
Bone Morphogenic Proteins ◽  
Alloplastic Materials ◽  
Bone Response ◽  
Near Future

Bone morphogenic proteins (BMPs) are a group of osteoinductive proteins obtained from nonmineralized bone matrix; they are capable of stimulating the differentiation of pluripotent mesenchymal cells to osteoprogenitor cells. They have become a likely treatment option, given their action on regeneration and remodeling of bone lesions and increasing the bone response around alloplastic materials. It may be feasible in the near future for BMPs to replace autologous and allogenic bone grafts. The application of specific growth factors for osteoinduction without using a bone graft constitutes a real impact on bone regeneration. The use of BMP is not only focused on osteogenic regeneration: There are a variety of studies investigating other properties, such as periodontal or dental regeneration from the conservative viewpoint. In this review, we will highlight the role of the BMP in bone, periodontal and dental regeneration.

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