scholarly journals Congenital hypothyroidism screening with umbilical cord blood thyroid-stimulating hormone at birth and peripheral venous blood thyroid-stimulating hormone after 72 h at a hospital in suburban area of Chhattisgarh

2021 ◽  
Vol 8 (1) ◽  
pp. 38-41
Author(s):  
Bhalendu Pratap Singh ◽  
Naresh P Motwani ◽  
C Sudhakar ◽  
Uma Chaturvedi
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Congenital Hypothyroidism ◽  
Umbilical Cord Blood ◽  
Venous Blood ◽  
Thyroid Stimulating Hormone ◽  
Suburban Area ◽  
Peripheral Venous Blood ◽  
Stimulating Hormone

scholarly journals Umbilical Cord Blood Culture in General in the Diagnosis of Sageis Newborns

2020 ◽  
pp. 126-131
Author(s):  
Naredra P. Porval ◽  
Kanvikar Reshmi ◽  
D. B. Potdar ◽  
S. B. Karanjkar
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
High Risk ◽  
Blood Culture ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Neonatal Sepsis ◽  
Venous Blood ◽  
Peripheral Venous Blood

Worldwide neonatal sepsis is among the most frequent causes of neonatal death. Various studies have tried to establish the relationship between prevalence of neonatal septicemia risk factors and bacteriological profiling, low birth weight, prematurity, etc. Current study was aimed to compare early onset of neonatal sepsis (EONS) among primigravida and multigravida mothers using umbilical cord blood (UCB) and peripheral venous blood (PVB) samples. It was also aimed to establish the utilization of umbilical cord blood culture (UCBC) in comparison to peripheral venous blood culture (PVBC) in identifying EONS. In present study the blood samples were collected from high risk neonates for the clinical blood culture and screening. Among the 75 neonates in the study, 24 (32.0%) were observed to have sepsis screen positive. Study of high risk neonates umbilical cord blood culture (UCBC) positivity was 17.3% while Peripheral Venous blood culture positivity was 5.3%. Moreover,  in this study all risk factors like Prematurity, Low birth weights, Premature rupture of membrane, and birth asphyxia were significantly (p<0.05) associated with UCBC growth/positivity. Low birth weight (86%) was mostly reported in the high risk neonates with other associated sepsis factors. Similarly maternal fever and prolonged rupture of membrane was highly significantly (p<0.01) associated with UCBC positivity. Gram negative bacterias  were  more  commonly found,  such as Pseudomonas (5.3%), followed by E. coli (4%), and Klebsiella (2.7%) and gram positive Streptococcus sp. (2.7%), etc. From our analysis it can be said that the UCBC has strong diagnostic outcomes as compared to the PVBC for etiological evaluation of bacterial sepsis in neonates at high risk.

Is Umbilical Cord Blood Total Thyroxin Measurement Effective in Newborn Screening for Hypothyroidism?

2009 ◽  
Vol 16 (3) ◽  
pp. 119-123 ◽  
Author(s):  
M Abduljabbar ◽  
A Al Shahri ◽  
A Afifi
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Congenital Hypothyroidism ◽  
Umbilical Cord Blood ◽  
Newborn Infants ◽  
Early Discharge ◽  
Recall Rate ◽  
Thyroid Stimulating Hormone ◽  
Central Hypothyroidism ◽  
Discharge Policy

Objective To assess the performance of the use of umbilical cord blood for screening of primary congenital hypothyroidism in the Saudi Aramco Medical Services Organization newborn thyroid screening programme. Methods Umbilical cord blood total thyroxin (CB-TT4) was measured. In samples with low T4 concentrations, an additional measurement of cord blood thyroid-stimulating hormone was made. Results A total of 96,015 newborn infants were screened in the period January 1990-December 2007. Twenty-six cases of primary congenital hypothyroidism, six cases of transient hypothyroidism and 13 cases of central hypothyroidism were detected. This method of screening resulted in 100% sensitivity and 98% specificity (95% CI 84–100, and 95% CI 98–98.2, respectively). However, there was a high mean recall rate of 1.9%. Conclusion The use of CB-TT4 is a valid screening strategy for primary congenital hypothyroidism. It meets the metabolic screening demands of early discharge policy and guarantees screening all newborns delivered in the hospital.

scholarly journals Use of umbilical cord blood culture in the diagnosis of early onset neonatal sepsis among high risk mothers

2021 ◽  
Vol 12 (12) ◽  
pp. 78-84
Author(s):  
Maitreyi Ojha ◽  
Ashish Pradhan ◽  
Sudip Dutta ◽  
Anamika Jaiswal
Keyword(s):  
Blood Culture ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Neonatal Sepsis ◽  
Predictive Value ◽  
Early Onset ◽  
Venous Blood ◽  
Peripheral Vein ◽  
Peripheral Venous Blood

Background: Early onset neonatal sepsis (EONS) is one of the important causes of morbidity and mortality in neonates. Its early diagnosis and prompt treatment is essential and any delay in the diagnosis can have serious consequences including neonatal death. Blood culture is the gold standard test for diagnosis of neonatal sepsis. Umbilical cord blood culture (UCBC) is a painless procedure and technically less challenging. We conducted this study to evaluate use of UCBC for the diagnosis of EONS and compared it with the results of peripheral venous blood culture (PVBC) reports. Aims and Objectives: The aim of the study was to evaluate UCBC for the diagnosis of EONS and compared it with the results of PVBC reports. Materials and Methods: This was a hospital-based prospective cohort study consisting of 100 neonates who were at risk of EONS. The study was conducted in the Department of Pediatrics Sikkim Manipal Institute of Medical Sciences Gangtok between January 2018 and December 2019. Neonates found to be at risk of development of EONS were included in this study on the basis of a predefined inclusion and exclusion criteria. Immediately after birth blood samples were collected from both umbilical cord and peripheral vein and were sent to bacteriology lab. Sensitivity, specificity, positive predictive value, and negative predictive value of both the samples were analyzed. Results: Out of 100 neonates in 32 (32%) EONS could be confirmed with positive sepsis screening results and/or demonstration of organisms on blood culture. Among the 32 neonates with EONS, 17 were found to be premature. The mean gestational age of newborns with EONS was found to be 35.2 weeks. The umbilical blood culture was found to have sensitivity and specificity of 100% and 74.4%, respectively, whereas peripheral vein blood culture was found to have sensitivity and specificity of 77.7% and 72.5%, respectively. The most common organism grown in our study was Escherichia coli. Conclusion: UCBC is painless and technically less challenging method of blood sampling. It has been found to have a higher sensitivity as well specificity for the diagnosis of EONS as compared to peripheral venous blood sample.

scholarly journals Comparative assessment of umbilical cord blood with peripheral venous blood using hematological scoring system as an early predictive screening method for the detection of early-onset neonatal sepsis in the tertiary care center of Central India

2022 ◽  
Vol 13 (1) ◽  
pp. 118-122
Author(s):  
Sunil Arya ◽  
Gagandeep Shukla ◽  
Prachi Goyal ◽  
Urvashi Channa
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Scoring System ◽  
Venous Blood ◽  
Screening Method ◽  
Peripheral Venous Blood ◽  
Sepsis Screen

Background: Sepsis is one of the major causes of neonatal morbidity and mortality. Early recognition and diagnosis of early-onset neonatal sepsis (EONS) is difficult because of the variable and non-specific clinical presentation of this condition. Hence, there is a need for early predictive screening method for EONS. Aims and Objectives: To compare the umbilical cord blood Haematological Scoring System (HSS) with peripheral venous blood as an early predictive screening method for detection of EONS. Materials and Methods: 100 inborn neonates with two or more risk factors for EONS, chosen by sequential sampling method were included in this prospective analytical study. Blood samples were collected from the umbilical cord and peripheral vein analyzed for hematological parameters, sepsis screen, and peripheral smear for HSS of Rodwell et al., send for blood culture. Blood cultures were performed as gold standard for diagnosing neonatal sepsis and sepsis screen was done to corroborate the diagnosis of neonatal sepsis. Results: Of 100 neonates, 21 belongs to sepsis; 14 to probable sepsis; 65 to no sepsis. HSS in umbilical cord blood (UCB) had Sensitivity-74.28%, Specificity-92.30%, PPV-83.87%, NPV-86.95% and HSS in PVB had Sensitivity-62.85%, Specificity- 87.69%, PPV-75.86%, NPV-81.69%. Conclusion: HSS score in UCB can be used as a simple, quick, cost-effective, and readily available screening test with decent sensitivity and high specificity, for the detection of EONS.

Erythrocyte metabolism of umbilical cord blood and venous blood during delivery

1968 ◽  
Vol 21 (2) ◽  
pp. 175-179 ◽  
Author(s):  
Jan Lewandowski ◽  
Wirgiliusz Duda ◽  
Zdzisława Fabjanowska ◽  
Wanda Leyko
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Venous Blood ◽  
Erythrocyte Metabolism
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