scholarly journals Therapeutic effectiveness of modern antihelminthic drugs for geese capillariasis

2019 ◽  
Vol 21 (93) ◽  
pp. 41-45
Author(s):  
V. О. Yevstafieva ◽  
V. I. Yeresko
Keyword(s):  
Experimental Testing ◽  
Experimental Studies ◽  
Therapeutic Effectiveness ◽  
Parasitic Diseases ◽  
Years Of Experience ◽  
Control Groups ◽  
Domestic Production ◽  
Control And Prevention ◽  
And Control ◽  
Effective Drugs

Many years of experience in fighting and preventing of helminthiasis in waterfowl shows that the successful elimination of parasitic diseases is possible under the conditions of a complex of organizational and economic, veterinary and sanitary and special anti-parasitic measures, which must necessarily include deworming of poultry. The purpose of the work was to study the effectiveness of modern antihelminthic drugs for the spontaneous capillariasis geese. Experimental testing of antihelminthic preparations of domestic production was performed: piperazine 45% (DR – piperazine adipinat), 22% phenzole (DR – fenbendazole) and brovadazole plus (DR – piperazine adipinat, phenbendazole). The efficacy of the drugs was determined by the results of helminthic autopsy and coproscopicof the geese of the experimental and control groups. The main indicators of the action of drugs were extensiveness and intensive. It was established that according to the results of helminthocoproscopic investigations, the most effective drugs for capillariasis geese were phenzole 22% and brovadazole plus, their effectiveness at day 15 of the experiment was 100.0%. Efficiency (EE and IE) of piperazine 45% was slightly lower and at day 5 of treatment, according to the results of the coproscopy, was 40.0% and 65.0% respectively, for 10 days – 70.0% and 76.0%, for 15 days – 70% , 0 and 82.0%. At the same time, according to the results of helminthic autopsy geese in the process of their treatment, the effectiveness of the preparations of phenzole 22% and piperazine 45% were lower. EI of experimental geese for 15 days with the use of phenzole 22% was 40.0%, and II decreased from 21.20 ± 1.16 to 2.00 ± 1.00 ex./head. In the application of piperazine, 45% of the experimental poultry EI for 15 days reached 60.0%, II decreased from 22.40 ± 1.12 to 3.67 ± 0.58 ex./head. Extens- and intensefficiency of piperazine 45% was 40.0 and 86.0%, phenzole 22% – 60.0 and 92.0%, respectively. It was determined that the most effective preparation for geese capillariasis is brovadazole plus (EE, IE – 100.0%), which is confirmed by the results of coproscopic studies and helminthic autopsy. Based on the data obtained, confirmed by experimental studies, we recommend the use of the drug brovadazol plus in the control and prevention of capillariasis geese.

Relative Effectiveness of Certain Drugs Against Shock Produced in Mice From Tourniquet and Burn Trauma

1956 ◽  
Vol 185 (1) ◽  
pp. 195-200 ◽  
Author(s):  
R. Carl Millican ◽  
Edward F. Stohlman
Keyword(s):  
Relative Effectiveness ◽  
Plasma Cholinesterase ◽  
Therapeutic Effectiveness ◽  
Burn Shock ◽  
Bacterial Polysaccharide ◽  
Control Groups ◽  
Positive Effects ◽  
Simultaneous Comparisons ◽  
Human Plasma Cholinesterase ◽  
And Control

The therapeutic effectiveness of chlorpromazine, dibenamine, l-norepinephrine, 1-ethylsulfonyl-4-ethyl-piperazine hydrochloride, serotonin, ascorbic acid, human plasma cholinesterase and a bacterial polysaccharide (Piromen), has been studied in experimental tourniquet and burn shock in mice. Employing survival as an indication of therapeutic effect, simultaneous comparisons were made of the survival of groups of animals receiving these agents in saline and control groups receiving saline alone. Chlorpromazine pretreatment (8–20 mg/kg) produced reproducible positive effects on survival whether given alone or in conjunction with saline replacement therapy. Dibenamine pretreatment (5–25 mg/kg) produced positive effects on survival but this response was not always reproducible. No beneficial effect was demonstrable following administration of the remainder of these agents when compared to control groups given saline alone.

scholarly journals Comparison of the effectiveness of feminist therapy with sex therapy Based CBT on sexual intimacy in Betrayed Women

2021 ◽  
Vol 3 (1) ◽  
pp. 01-04
Author(s):  
Bafandegan Vahid
Keyword(s):  
Experimental Studies ◽  
Sex Therapy ◽  
Control Group ◽  
Feminist Therapy ◽  
Sexual Intimacy ◽  
Control Groups ◽  
The People ◽  
Post Test ◽  
And Control ◽  
Experimental Group

The Present Study Aims to Comparison of the effectiveness of feminist therapy (FT) with sex therapy on sexual intimacy in female. This Study Was Typed of Experimental Studies with pre- test and Post-Test with Control Group. The Study Consisted of All woman Referred to the Counselling Centres in university Neyshabur City. A Sample of 36 People Was Selected Then Randomly Assigned to Two Experimental Groups and One Control Groups. The people inventory sexual intimacy Botlani (SII) Was Used for Data Collection Then Based on 12 Meetings 90 Minutes for the Experiment Groups. The Pre-Test and Post-Test Scores Were Analysed Using a Manova Test in the SPSS 20 Software. According to the Results of Showed feminist Therapy More Effect Than Other Experimental Group and Control Group (p≤0.001) so sex Therapy More Effect Than Control Group in Variable (p≤0.001). The conclusion is that the feminist therapy approach can be used to increase sexual intimacy in developing Muslim societies.

scholarly journals Comparison of the Effectiveness of Feminist Therapy with Sex Therapy Based Cbt on Sexual Intimacy in Betrayed Women

2021 ◽  
pp. 1-4
Author(s):  
Bafandegan Vahid ◽  
◽  
Bagherpour Zahra ◽  
Keyword(s):  
Experimental Studies ◽  
Sex Therapy ◽  
Control Group ◽  
Feminist Therapy ◽  
Sexual Intimacy ◽  
Control Groups ◽  
The People ◽  
Post Test ◽  
And Control ◽  
Experimental Group

The Present Study Aims to Comparison of the effectiveness of feminist therapy (FT) with sex therapy on sexual intimacy in female. This Study Was Typed of Experimental Studies with pre-test and Post-Test with Control Group. The Study Consisted of All woman Referred to the Counselling Centres in university Neyshabur City. A Sample of 36 People Was Selected Then Randomly Assigned to Two Experimental Groups and One Control Groups. The people inventory sexual intimacy Botlani (SII) Was Used for Data Collection Then Based on 12 Meetings 90 Minutes for the Experiment Groups. The PreTest and Post-Test Scores Were Analysed Using a Manova Test in the SPSS 20 Software. According to the Results of Showed feminist Therapy More Effect Than Other Experimental Group and Control Group (p≤0.001) so sex Therapy More Effect Than Control Group in Variable (p≤0.001). The conclusion is that the feminist therapy approach can be used to increase sexual intimacy in developing Muslim societies

Design, numerical simulation and experimental testing of a controlled electrical actuation system in a real aircraft morphing wing model

2015 ◽  
Vol 119 (1219) ◽  
pp. 1047-1072 ◽  
Author(s):  
R. M. Botez ◽  
M. J. Tchatchueng Kammegne ◽  
L. T. Grigorie
Keyword(s):  
Experimental Testing ◽  
Experimental Studies ◽  
Morphing Wing ◽  
Theoretical Simulation ◽  
Actuation Mechanism ◽  
Wing Model ◽  
Actuation System ◽  
Structural Rigidity ◽  
Bench Testing ◽  
And Control

AbstractThe paper focuses on the modelling, simulation and control of an electrical miniature actuator integrated in the actuation mechanism of a new morphing wing application. The morphed wing is a portion of an existing regional aircraft wing, its interior consisting of spars, stringers, and ribs, and having a structural rigidity similar to the rigidity of a real aircraft. The upper surface of the wing is a flexible skin, made of composite materials, and optimised in order to fulfill the morphing wing project requirements. In addition, a controllable rigid aileron is attached on the wing. The established architecture of the actuation mechanism uses four similar miniature actuators fixed inside the wing and actuating directly the flexible upper surface of the wing. The actuator was designed in-house, as there is no actuator on the market that could fit directly inside our morphing wing model. It consists of a brushless direct current (BLDC) motor with a gearbox and a screw for pushing and pulling the flexible upper surface of the wing. The electrical motor and the screw are coupled through a gearing system. Before proceeding with the modelling, the actuator is tested experimentally (stand alone configuration) to ensure that the entire range of the requirements (rated or nominal torque, nominal current, nominal speed, static force, size) would be fulfilled. In order to validate the theoretical, simulation and standalone configuration experimental studies, a bench testing and a wind-tunnel testing of four similar actuators integrated on the real morphing wing model are performed.

Nursing care of diabetic foot based on nanosilver antibacterial dressings

2020 ◽  
Vol 10 (8) ◽  
pp. 1265-1270
Author(s):  
Shenghua Cao ◽  
Xiaoqian Wu ◽  
Jianling Zhao ◽  
Xinhong Jia
Keyword(s):  
Diabetic Foot ◽  
Intervention Group ◽  
Control Group ◽  
Diabetic Foot Ulcers ◽  
Control Groups ◽  
Nano Silver ◽  
Control And Prevention ◽  
Time Required ◽  
Time Of Admission ◽  
And Control

To investigate the control and prevention of diabetic foot infection with nano-silver antibacterial dressings and the difficulty of nursing. Sixty patients with diabetic foot, treated at our hospital between January 2017 to January 2018, were randomly assigned to intervention and control groups (n = 30 per group). Blood glucose was strictly controlled in both groups. After debridement, the ulcerated feet of the intervention and control groups were wrapped with nanosilver antibacterial and Vaseline dressings, respectively. The degree of pain and the severity and areas of ulcers were evaluated at the time of admission and after four weeks of treatment. The time required for ulcers to heal was assessed and the number of dressing changes were counted. The two groups were compared in terms of ease of care. Although treatment improved the Wagner grade in both groups, the improvement was significantly better in the intervention group than in the control group (P < 0.05). Moreover, treatment reduced ulcerated areas in both groups, with significantly smaller ulcerated areas in the intervention group than in the control group (P < 0.05). The intervention group had significantly lower visual analog scores (VAS) than the control group (P < 0.05), although treatment lowered VAS in both groups. Ulcers healed significantly sooner and dressings were changed less frequently in the intervention group than in the control group (P < 0.05). The nursing difficulty of the intervention group was significantly lower than that of the control group. Nanosilver antibacterial dressings can promote healing, reduce ulcerated areas, improve Wagner classification, and reduce the frequency of dressing changes in patients with diabetic foot ulcers. At the same time, the use of nano-silver can reduce the difficulty of patient care.

scholarly journals Indirect Allorecognition of Donor Class I and II Major Histocompatibility Complex Peptides Promotes the Development of Transplant Vasculopathy

2001 ◽  
Vol 12 (11) ◽  
pp. 2500-2506 ◽  
Author(s):  
KARL L. WOMER ◽  
JAMES R. STONE ◽  
BARBARA MURPHY ◽  
ANIL CHANDRAKER ◽  
MOHAMED H. SAYEGH
Keyword(s):  
Chronic Rejection ◽  
Experimental Studies ◽  
Class Ii ◽  
Class I ◽  
Control Groups ◽  
Definitive Evidence ◽  
Hla Dq ◽  
Indirect Allorecognition ◽  
And Control

Abstract. Recent clinical and experimental evidence suggests that indirect allorecognition may promote the development of chronic rejection, but definitive experimental studies are lacking. To study the contribution of indirect allorecognition to chronic rejection, naïve Lewis (RT11) rats were immunized with synthetic Wistar Furth (WF) class II-RT1u.D (HLA-DR—like) or -RT1u.B (HLA-DQ—like) or class I-RT1u.A (HLA-A—like) peptides emulsified in complete Freund's adjuvant 7 d before transplantation (n = 5 to 7/group). Experimental and control animals then acted as recipients of fully mismatched WF vascularized cardiac allografts. Recipients received immunosuppression in the form of cyclosporine at a tapering dose that allows for long-term allograft survival. Animals were sacrificed at either 3 or 6 mo, with allograft arterial luminal occlusion scored on elastin stains by a blinded observer. At 3 mo, mean vessel scores were significantly higher in the RT1u.A-immunized versus class II—immunized and control groups (P < 0.05). By 6 mo, there was progression of chronic allograft vasculopathy and a significantly higher mean vessel score in the RT1u.A- and RT1u.D-immunized versus RT1u.B and control groups (P < 0.05). In vitro studies show evidence of shifting MHC allopeptide immunogenicity. It was concluded that T cells primed by specific donor class I and II MHC allopeptides promote the development of chronic vascularized allograft rejection. These novel observations provide definitive evidence of a link between indirect allorecognition and the development and progression of chronic rejection.

scholarly journals Comparative Efficiency of Sepranol and Cefamethrin Use in Postpartum Acute Endometritis in Cows

2020 ◽  
Vol 11 (2) ◽  
pp. 1874-1878 ◽  
Author(s):  
Samat R. Yusupov ◽  
Sergey Yu. Smolentsev ◽  
Zoya G. Churina ◽  
Galiya R. Yusupova ◽  
Alfis R. Hasanov ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Experimental Studies ◽  
Reproductive Function ◽  
Reproductive Organs ◽  
Natural Resistance ◽  
Collective Farm ◽  
Control Groups ◽  
Comparative Efficiency ◽  
Comparative Aspect ◽  
And Control

In the recent times, postpartum inflammatory diseases of the reproductive organs in cows are considered as a typical infectious pathology. The main reason is an increase in the pathogenicity of conditionally pathogenic micro flora against the weakening of the natural resistance of the animal. The postpartum acute endometritis is diagnosed as the most common among the postpartum inflammatory diseases.  It is observed in 22.5...38.4% of calving cows. The aim of the work was to study the effectiveness of preparations of plant based Sepranol and Cefamethrin in the pharmacotherapy of­ postpartum acute endometritis in cows. Experimental studies were carried out on the basis of the SEC collective farm Niva of Medvedevsky district of the Mari El Republic. The clinical­ evaluation of therapeutic efficacy of the proposed drugs in­ combination with other therapeutic methods were carried out in a comparative aspect in scientific and economic experiment with the separation of cows according to the principle of analogues into experimental and control groups under the same conditions of their feeding­, keeping, and exploitation. The main criterion for assessing the therapeutic effectiveness of the­ tested drugs was the restoration of their reproductive function in experimental animals in the shortest time possible. Studies have shown that for postpartum acute endometritis, the use of complex treatment with­ Сefamethrin at a dose of 80 ml intrauterine with a 48-hour interval before­ recovery allowed­ to obtain a therapeutic effect up to 96%, reduce the number of infertility days,­ and increase the fertility percentage.

scholarly journals COULD THE INTESTINAL EPITHELIAL ALTERATIONS PROMOTED BY ROUX-EN-Y GASTRIC BYPASS EXPLAIN HIGHER TENDENCY FOR COLONIC DISEASES IN BARIATRIC PATIENTS?

2020 ◽  
Vol 33 (4) ◽  
Author(s):  
Eduardo WENDLER ◽  
Osvaldo MALAFAIA ◽  
Bruno Luiz ARIEDE ◽  
Jurandir Marcondes RIBAS-FILHO ◽  
Nicolau Gregori CZECZKO ◽  
...  
Keyword(s):  
Experimental Studies ◽  
Nuclear Staining ◽  
Intestinal Epithelial ◽  
Ascending Colon ◽  
Control Groups ◽  
Ki 67 ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Bariatric Patients ◽  
And Control

ABSTRACT Background: Intestinal diversions have revolutionized the treatment of morbid obesity due to its viability and sustained response. However, experimental studies suggest, after these derivations, a higher risk of colon cancer. Aim: To analyze the histological and immunohistological changes that the jejunojejunal shunt can produce in the jejunum, ileum and ascending colon. Method: Twenty-four male Wistar rats were randomly divided into two groups, control (n=12) and experiment (n=12) and subdivided into groups of four. Nine weeks after the jejunojejunal shunt, segmental resection of the excluded jejunum, terminal ileum and ascending colon was performed. Histological analysis focused on the thickness of the mucosa, height of the villi, depth of the crypts and immunohistochemistry in the expression of Ki-67 and p53. Results: Significant differences were found between the experiment and control groups in relation to the thickness of the mucosa in the jejunum (p=0.011), in the ileum (p<0.001) and in the colon (p=0.027). There was also a significant difference in relation to the height of the villus in the ileum (p<0.001) and the depth of the crypts in the jejunum (p0.001). The results indicated that there is a significant difference between the groups regarding the expression of Ki-67 in the colon (p<0.001). No significant differences were found between the groups regarding the expression of Ki-67 in the jejunum and ileum. In the P53 evaluation, negative nuclear staining was found in all cases. Conclusion: The jejunojejunal deviation performed in the Roux-in-Y gastrojejunal bypass, predispose epithelial proliferative effects, causing an increase in the thickness of the mucosa, height of the villi and depth of the crypts of the jejunum, ileum and ascending colon.

scholarly journals Tissue-specific modification of selenium concentration by acute and chronic dexamethasone administration in mice

1997 ◽  
Vol 78 (3) ◽  
pp. 501-508 ◽  
Author(s):  
Chiho Watanabe ◽  
Choong-Yong Kim ◽  
Hiroshi Satoh
Keyword(s):  
Drinking Water ◽  
Glutathione Peroxidase ◽  
Adult Male ◽  
Experimental Studies ◽  
Selenium Concentration ◽  
Treated Group ◽  
Control Group ◽  
Control Groups ◽  
The Difference ◽  
And Control

Several clinical reports have shown changes in plasma Se concentration with corticosteroid treatments, but the results have been inconsistent. Few experimental studies have been done on this subject. In the present study the effect of dexamethasone (DEX) treatment on Se concentrations and activities of Se-dependent glutathione peroxidase (EC1.11.1.9; SeGPx) were examined in adult male ICR mice. In the first experiment, DEX was given via drinking water containing 5 or 50 mg DEX/I. At 1 or 3 weeks of DEX treatment, mice were dissected and the Se concentrations as well as SeGPx activities in various tissues, including plasma, were determined. At 1 week the DEX-treated groups had significantly lower hepatic Se concentrations and significantly higher plasma and cerebral concentrations than the control group. The DEX-treated groups showed lower SeGPx activities in the hepatic cytosol and higher SeGPx activities in the plasma than the saline (9 g NaCl/l)-treated group, in parallel with the changes in Se concentrations. At 3 weeks, neither hepatic nor plasma Se concentrations showed a significant change. In the second experiment, mice were injected subcutaneously with DEX and, thereafter, mice were food-deprived. The DEX-injected groups had higher plasma Se concentrations. A similar finding was obtained also when the DEX- or saline-injected mice were not food-deprived. Thus, the difference between the DEX-treated and control groups was possibly caused by redistribution of tissue Se. These results suggested that the effects of DEX on Se concentrations were tissue dependent and that the higher plasma Se observed in DEX-treated groups might be explained by the release of tissue Se into plasma as plasma SeGPx.

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

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