scholarly journals An Observational Study to Assess Outcome of NSTEMI Patients with Raised Serum Uric Acid Level in a Tertiary Care Hospital of Bangladesh

2020 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Normal Serum ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Level Group

Background: Non-ST segment elevation myocardial infarction (NSTEMI) is the commonest form of ACS and a leading global cause of premature morbidity and mortality. Evidences link serum uric acid with short and long-term major adverse outcomes (MACE) in patients with NSTEMI. Objective: To see in-hospital outcome of NSTEMI patients with raised serum uric acid level. Methodology: This cross-sectional observational study was conducted in the Department of Cardiology, Sylhet MAG Osmani Medical College Hospital, Sylhet during the period from July, 2017 to June, 2019. Fifty NSTEMI patients with raised serum uric acid (>7mg/dl in male; >6mg/dl in female) level (Group A) and fifty NSTEMI patients with normal serum uric acid level (group B) admitted within 24 hours of symptom onset were consequently enrolled. In-hospital complications and mortality were recorded while continuing standard treatment for the event. Results: The mean age was 60.82 (SD 9.62) years in group A and 49.90 (SD 10.40) years in group B. The mean age of the patients of group A was significantly higher than patients of Group B (p<0.001). Male preponderance was in both groups (84.0% versus 80.0%; p=0.603). Diabetes mellitus (52.0% versus 22.0%; p=0.002), hypertension (78.0% versus 52.0%; p=0.039) and dyslipidaemia (48.0% versus 12.0%; p<0.001) were more frequent in group A than that of group B. But smoking status (70.0% versus 66.0%; p=0.668), family history of CAD (10.0% versus 26.0%; p=0.476) did not differ significantly. Killip class did not differ significantly between group A and group B (p=0.127). In-hospital mortality was 5 (10.0%) patients in group A and 2 (4.0%) patients in group B; did not reach the level of significance (p>0.05) and complications such as post MI angina, cardiogenic shock, acute left ventricular failure, re-infarction, sinus tachycardia, sinus bradycardia, atrial flutter, atrial fibrillation, bundle branch block, ventricular tachycardia, ventricular fibrillation did not differ significantly between the two groups (p>0.05). Conclusion: There is no significant difference between in-hospital outcome (mortality and complications) of NSTEMI patients with raised and normal serum uric acid level.

scholarly journals Effects of Hyperuricemia on Fetal Outcome in Preeclamptic Patients

2019 ◽  
Vol 9 (2) ◽  
pp. 117-120
Author(s):  
Nusrat Mahjabeen ◽  
Sk Zinnat Ara Nasreen ◽  
Ferdousi Begum ◽  
Faryl Mustary
Keyword(s):  
Uric Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Fetal Outcome ◽  
Group A ◽  
Group B

Background: A raised serum uric acid is recognized as an unfavourable fetal outcome of pre-eclampsia. The objective of this study was to determine the relationship between hyperuricemia and fetal outcome in preeclamptic patients. Methods: This observational study was carried out in the Department of Gynecology and Obstetrics of BIRDEM General Hospital from July 2015 to June 2016. Fifty pre eclamptic pregnant women with hyperuricemia (group A) and 50 preeclamptic pregnant women with normal serum uric acid level (group B) were taken as study subjects. Data were analyzed by SPSS where p value less than 0.05 was considered significant. Results: Mean age of the patients was 25.88 ± 4.52 years and 24.30 ± 5.09 years in group A and group B respectively. Mean serum uric acid level was 7.19±0.62 mg/dl in group A and 4.83±0.73 mg/dl in group B. Maximum (66%) patients were primigravida in group A and 34% in group B. In this study, intra-uterine death (IUD) occurred in 4 (8%) cases in group A and in 1 (2%) case in group B, intra-uterine growth retardation (IUGR) was 20 (40%) cases in group A and 4 (8%) cases in group B, low birth weight was in 38 (76%) cases in group A and 21(42%) cases in group B. Occurrence of IUGR and low birth weight was significantly higher in group A than group B. APGAR score was significantly lower in group A (5.10±1.61) than that of group B (6.36±1.32). Neonatal intensive care unit (NICU) referral was more in group A (60%) than group B (20%). Conclusion: It can be concluded that hyperuricemia is a predictor of poor fetal outcome in pre-eclamptic women. Birdem Med J 2019; 9(2): 117-120

scholarly journals Effect of raised serum uric acid level on perinatal and maternal outcome in cases of pregnancy-induced hypertension

2017 ◽  
Vol 10 (2) ◽  
pp. 58 ◽  
Author(s):  
Qumrun Nassa Ahmed ◽  
Farhana Dewan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Pregnancy Induced Hypertension ◽  
Maternal Complications ◽  
Induced Hypertension ◽  
Group A ◽  
Group B

<p>The aim of this study was to find out the effects of raised serum uric acid level on perinatal and maternal outcome in cases of pregnancy-induced hypertension. One hundred pregnant women with gestational period beyond 28 weeks with pregnancy-induced hypertension-preeclampsia and eclampsia were included in this study and divided into two groups. Group A (n=65) patients with a serum uric acid level &gt;6 mg/dL was compared to Group B (n=35) patients with a uric acid level &lt;6 gm/dL. It revealed that high uric acid level in patients with pregnancy-induced hypertension was a risk factor for several maternal complications like postpartum hemorrhage (Group A, 17.4%; Group B, 22.6%), postpartum eclampsia (Group A, 10.1%; Group B, 9.7%), abruptio placentae (Group A, 8.7%; Group B, 6.4%), HELLP syndrome (Group A, 2.9%; Group B, 0%) and pulmonary edema (Group A, 4.3%; Group B, 0%). In case of perinatal outcome, the birth weight, intrauterine growth retardation, intrauterine death, stillbirth and neonatal death rate were worse in Group A 1.9 kg, 66.7, 19, 7 and 8% in comparison to Group B, where those were 2.1, 13, 6, 2, and 2% respectively. In conclusion, high uric acid in blood in patient with hypertensive disorders in pregnancy is a risk factor for several maternal complications.</p>

A STUDY OF SERUM URIC ACID LEVELS IN PREECLAMPSIA

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Sushma Goad ◽  
Anita Verma ◽  
Subhash Chandra
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Age Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Level Elevation ◽  
The Mean

Background: To Study Serum Uric Acid level elevation in Hypertensive Disorders of Pregnancy. Methods: 50 Patients diagnosed as having Pre-eclampsia with age between 18-37 years and 50 controls with similar age group. Results: The mean serum uric acid level in control group was 3.41 ± 0.62 and in patient 7.01 ± 0.58 which was statistically significant (p =0.001). Conclusion: Serum uric acid levels were significantly higher in preeclampsia could be a useful indicator of fetal complication in preeclampsia patients. Keywords: serum uric acid, preeclampsia, laboratory.

scholarly journals Serum uric acid level in type 2 diabetes mellitus

2019 ◽  
Vol 6 (4) ◽  
pp. 1265
Author(s):  
D. Vasantha Kalyani ◽  
M. Ilamaran ◽  
P. Suresh Kumar ◽  
Saranya Nagalingam
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
The Mean ◽  
Artery Disease

Background: Diabetes mellitus is the most important risk factor associated with two to four fold increased incidence of coronary artery disease. The major risk factors for CAD are hypercholesterolemia, hypertension, diabetes mellitus, and cigarette smoking Objectives: To study the level of serum uric acid in type 2 diabetes mellitus and the correlation between elevated serum uric acid level and the component of metabolic syndrome like obesity, hypertension, dyslipidemia.Methods: The study was done as descriptive analytical study among the diabetic patients in a tertiary care setting during the period January 2018 to February 2019. The inclusion and exclusion criteria were clearly defined and the study participants were recruited for the study after getting the informed consent. The socio demographic profile, clinical and laboratory data were collected from the blood sample obtained from the patients with the standardized procedures. Data was entered in Microsoft excel spread sheet and analyzed statistically using SPSS statistical software. Student ‘t’ test and Chi-square test values were applied for significance.Results: Serum uric acid in the study population and control varied from 3.0 to 8.1 and 2.7 to 5.5 mg/dl respectively. The mean and standard deviation of uric acid among cases was 5.08±1.42 while in control it was 3.55±0.62 respectively. The serum uric acid level of diabetics was very much elevated compare with controls and it was highly significant. Significant correlation was noticed between serum uric acid and BMI as well as WHR. Elevated uric acid levels were significantly noticed among those with hypertension, dyslipidemia, coronary artery disease and chronicity of the diabetes.Conclusions: Uric acid was significantly elevated in diabetic population and the mean value of serum uric acid level was higher in longer duration of diabetes, hypertension, dyslipidemia, central obesity which are the components of metabolic syndrome.

scholarly journals Relationship Between Uric Acid Level and Blood Pressure in T2DM Patient Attending in BIRDEM General Hospital

2018 ◽  
Vol 9 (2) ◽  
pp. 49-53
Author(s):  
S Ferdous ◽  
K Begum ◽  
MA Muttalib
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Stone Formation ◽  
Serum Uric Acid Level ◽  
High Serum ◽  
Normal Serum ◽  
Significant Difference

Hyperuricemia is associated with higher mortality in patients suffering from hypertension, coronary heart disease, cerebrovascular events, metabolic syndrome, insulin resistance, gout and renal stone formation and it is more in individuals with diabetes. The prevalence of hyperuricemia is high in T2DM. The aim of the present study was to assess the relationship between hyperuricemia and blood pressure in T2DM subjects and thus to help the clinician for early diagnosis, treatment and to prevent further complications. Total 350 study subjects were enrolled for this study; among them 203 were T2DM with normal level of serum uric acid level and 147 were T2DM with high serum uric acid level. It was observed that systolic blood pressure was significantly higher (134.5±9.6 mm of Hg) in T2DM with hyperuricemia (p<0.001) than T2DM with normal serum uric acid level (123.3±10.9 mm of Hg). On the other hand diastolic blood pressure was significantly higher (87.1±5.9 mm of Hg) in T2DM with hyperuricemia (p<0.001) than T2DM with normal serum uric acid level (79.6±8.3 mm of Hg). Age (years) showed no significant difference between T2DM with serum uric acid<7 mg/dl and T2DM with serum uric acid>7 mg/dl (p<0.05). In our study it was revealed that males were in greater risk of developing hyperuricemia. BMI was significantly (p<0.001) greater in T2DM subjects who had normal serum uric acid level (27.9±3.8) than with those who had serum uric acid>7 mg/dl (24.4±3.83). No significant differences were found in FBS, blood sugar 2 hours after breakfast, HbA1C, serum creatinine and blood urea between groups.Bangladesh J Med Biochem 2016; 9(2): 49-53

scholarly journals Estimation of Serum Uric Acid in Cases of Hyperuriceamia and Gout

2011 ◽  
Vol 51 (181) ◽  
Author(s):  
R K Pokharel ◽  
BK Yadav ◽  
B Jha ◽  
K Parajuli
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Relevant Information ◽  
University Teaching ◽  
Acute Gout ◽  
College Hospital ◽  
The Mean

Introduction: Gout is crystal deposit arthritis and is an ancient disease. The biologic precursor to gout is hyperuricaemia. The prevalence of hyperuricaemia and gout has an increasing trend all over the world including the developing countries. The purpose of this study is to estimate serum uric acid level in hyperuricaemic and gout patients attending a medical college hospital. Methods: A consecutive 150 hyperuricaemics and 150 gout patients attending Tribhuwan University Teaching Hospital from June to September 2005 were included in this study. The serum uric acid level was measured by the enzymatic (PAP- Uricase) method. The patients with acute gout were interviewed and relevant information was obtained. Results: Males comprised 84 % of gout cases. Hyperuricaemia was common in both sexes. The mean age for gout was 47.49 and 56.65 years in males and females respectively. The mean age for the first gout attack was 42.1 ± 14.0 years. Family history was positive in 22 % of cases. The overall mean serum uric acid level in hyperuricaemics was 7.2 ± 0.7 mg/dL and 8.4 ± 1.1 mg/dL in acute gout (p 0.0001). The mean serum uric acid level was signifi cantly (p 0.0001) high among males both at the asymptomatic phase and at acute gout. Gout was more common in non-vegetarians (95 %) and alcoholics (65.3 %). Serum uric acid level was inversely related with the amount of daily water intake (p 0.0001). Conclusions: Serum uric acid level is signifi cantly high among the male gouty arthritic patients. However, it is also high among asymptomatic hyperuricaemic cases of both sexes.  Keywords: asymptomatic hyperuricaemia, gout, serum uric acid level.

scholarly journals Serum uric acid level in acute ischemic stroke in eastern India

2017 ◽  
Vol 5 (6) ◽  
pp. 2353 ◽  
Author(s):  
Bijaya Kumar Behera ◽  
Pankaj Kumar Hui ◽  
Roniya Simethy
Keyword(s):  
Uric Acid ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Serum Uric Acid ◽  
Scale Score ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Diabetic Patients ◽  
The Mean

Background: Present study was done to estimate the level of serum uric acid in acute ischemic stroke and to find out whether it is protective against or increases the risk for ischemic stroke and its effect on stroke outcome.Methods: A total of 100 patients and 100 controls were taken randomly. Risk factors of stroke were considered such as hypertension, diabetes, adverse lipid profile, smoking and obesity. Serum uric acid level was measured in both cases and controls. Modified National Institute of Health (NIH) stroke scale score was calculated at the time of admission and discharge. Statistical analysis was done using SPSS 21.0 software.Results: Out of 100 patients studied 65 were males and 35 were females. The mean serum uric acid level in stroke cases was 6.11±1.47 where as it was 4.85±1.12 in controls. SUA levels was higher among males than females. The mean SUA in hypertensive subjects (6.58±1.33) was significantly higher than in normotensive subjects (5.23±1.42). There was statistically significant difference between SUA levels in diabetic (6.66±1.26) and non-diabetic patients (5.63±1.49). Mean SUA among overweight patients was (7.0±1.16) where as it was (5.22±1.23) in patients with normal weight. The mean SUA in smokers (6.33±1.38) was higher than that in non-smokers (6.02±1.51). There was significant positive correlation between SUA an NIH stroke scale score(P<0.05). SUA levels were significantly higher in patients who succumbed as compared to those who were discharged from hospital.Conclusions: SUA can be used as a marker for increased of stroke. Higher SUA is associated with a bad prognosis.

scholarly journals Relation Of Serum Uric Acid Concentrations With Etiology And Severity In Patients With Cirrhosis Of Liver

2021 ◽  
Vol 5 (2) ◽  
pp. 01-06
Author(s):  
Rashedul Hasan ◽  
Projesh Kumar Roy ◽  
Masudur Rahman Khan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Liver Enzymes ◽  
Serum Uric Acid Level ◽  
Female Ratio ◽  
Positive Correlation ◽  
The Mean ◽  
Cirrhosis Of Liver

Background: Hyperuricemia is now an established factor to cause oxidative stress, insulin resistance and systemic inflammation. So it is likely that hyperuricemia might be involved in hepatic necro-inflammation and destruction which are the common underlying pathophysiology of cirrhosis. On the other hand, as uric acid is the end product of cellular degradation, increased hepatocyte destruction due to any etiology increases the level of serum uric acid which might further aggravate hepatic necro-inflammation, cirrhosis & complications. Objectives: To assess serum uric acid concentrations in patients of cirrhosis of liver and its relation with cirrhosis of different etiology, disease severity and liver enzymes. Materials and Methods: This cross sectional observational study was carried out in the Department of Gastroenterology, BSMMU, Bangladesh during the period of September 2015 to October 2016. A total of 220 diagnosed cases of cirrhosis of liver due to any cause from inpatient & outpatient Department of Gastroenterology of Banghabandhu Sheikh Mujib Medical University were enrolled as the study population. Serum uric acid level was measured in each patient and its relationship with different etiology of cirrhosis, severity of cirrhosis and liver enzymes were assessed. Results: The mean age was found to be 47.8 ± 14.6 years and male: female ratio was 1.9:1. Majority patients (52.3%) belonged to CTP Class C. The mean (±SD) value of serum uric acid was 6.19 (±3.25mg/dl) and hyperuricemia (>7 mg/dl) was detected in 27.73% patients. Among all etiologies of CLD, the higher mean (±SD) level of serum uric acid was found in NAFLD (19.54 ±2.20 mg/dl). There was positive correlation of serum uric acid with liver enzymes. Conclusion: Mean serum uric acid level increased gradually as the cirrhotic patients progressed to higher CTP classes & there was positive correlation of serum uric acid with liver enzymes. It requires further large scale multicenter studies with increased sample size & prolong follow-up to establish serum uric acid as a risk factor of CLD.

scholarly journals Influence of serum estradiol on serum uric acid level in pre and postmenopausal women.

2019 ◽  
Vol 26 (09) ◽  
pp. 1587-1591
Author(s):  
Rahat Naseem ◽  
Sardar Muhammad Al-Fareed Zafar ◽  
Samia Jawed ◽  
Saima Mukhtar ◽  
Farhat Ijaz ◽  
...  
Keyword(s):  
Uric Acid ◽  
Postmenopausal Women ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Assay Method ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Estradiol ◽  
The Mean

Background: Hyperuricemia develops when serum uric acid level exceeds the normal value. Estrogen may influence the level of serum uric acid. Postmenopausal females have a remarkable reduction in its level, so serum estradiol is studied in relation to serum uric acid levels in pre and post-menopausal women. Objective: To find out the relationship of serum Estradiol with serum uric acid level in premenopausal and postmenopausal women in local population. Study Design: Case control study. Setting: This study was conducted in Lady Aitchison Hospital Lahore. Period: March 2017- August 2017. Material and Methods: 134 females were enrolled in total and were grouped in to two. Group A comprised of premenopausal and Group B included postmenopausal females. After complete history and general physical examination, 5 ml venous blood sample under aseptic measures was taken. Serum uric acid was measured by enzymatic and serum estradiol by Enzyme-linked immunosorbent assay method. Results: The mean age of pre and postmenopausal women was 32 and 57 ± 7 years, with significantly lower in premenopause. The mean serum E2 was 91.86 ± 26.71 mg/dL in premenopause and 22.04 ± 9.28 mg/dL in postmenopause, with significantly lower mean in postmenopause. Mean serum uric acid was statistically higher in postmenopause that was 6.04 ± 0.58 mg/dL, when compared to premenopause that was 4.22 ± 0.90 mg/dL. Conclusion: Serum uric acid levels increased due to decreased serum estradiol in postmenopausal women as compared to premenopausal women.

Significance of high-normal serum uric acid level as a risk factor for arterial stiffness in healthy Korean men

2012 ◽  
Vol 17 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Jin Young Shin ◽  
Hye Ree Lee ◽  
Jae Yong Shim
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Arterial Stiffness ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Healthy Subjects ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Confounding Factors ◽  
The Mean

A high serum uric acid (SUA) level is a known risk factor for cardiovascular disease. However, little is known about the relationship between arterial stiffness and uric acid in healthy subjects with a normal SUA level. We assessed whether a high-normal uric acid level increased arterial stiffness by measuring brachial–ankle pulse wave velocity (ba-PWV) in healthy subjects. Among 779 subjects who visited the health promotion center, 393 men and 234 women with normal SUA levels (male: 3.5–8.0 mg/dl, female: 2.5–5.4 mg/dl) were divided into quartiles: in men, Q1 ( n = 90, 3.5–4.3 mg/dl), Q2 ( n = 94, 4.4–5.1 mg/dl), Q3 ( n = 106, 5.2–5.9 mg/dl) and Q4 ( n = 103, 6.0–8.0 mg/dl); in women, Q1 ( n = 57, 2.5–3.6 mg/dl), Q2 ( n = 49, 3.7–4.1 mg/dl), Q3 ( n = 61, 4.2–4.6 mg/dl) and Q4 ( n = 67, 4.7–5.4 mg/dl). The mean values of ba-PWV increased gradually by SUA quartile. The men’s SUA had an independent, positive association with ba-PWV after correcting for age, glucose, body mass index, blood pressure, resting heart rate, high-sensitivity C-reactive protein (hs-CRP), high-density lipoprotein (HDL)-cholesterol and triglyceride ( R2 = 0.39, adjusted R2 = 0.37, p < 0.001). The odds ratios (95% CI) for high ba-PWVs (> 75th percentile, 1473 cm/s) in men were 1.89 (0.69–5.20, Q2), 2.36 (1.10–5.08, Q3), and 2.91 (1.39–6.11, Q4), after adjusting for confounding factors ( p < 0.001). In women, SUA showed no independent association with ba-PWV ( p = 0.186). After adjusting for confounding factors, the mean ba-PWV values of Q3 (1418 cm/s) and Q4 (1421 cm/s) in men were higher than those of Q1 (1355 cm/s) ( p < 0.05). Above the SUA level of 5.2 mg/dl, arterial stiffness was increased in healthy Korean men.

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