scholarly journals Identification of carbendazim carcinogenicity: experimental study in cba mice СВА мice

2019 ◽  
Vol 87 (3) ◽  
pp. 18-23 ◽  
Author(s):  
V.S. Lisovska ◽  
N.M. Nedopytanska ◽  
O.V. Reshavska ◽  
N.V. Tereschenko ◽  
E.A. Bahlii

ABSTRACT. Introduction. Carbendazim is a systemic benzimidazole fungicide rated as a possible human carcinogen. In Ukraine, over 20 carbendazim-based preparative forms of fungicides, predominantly generics, are registered, therefore, oncogenicity study of carbendazim from different manufacturers is of immediate interest. Objective of the paper is to identify carcinogenicity of 98 % technical carbendazim under conditions of chronic experiment in mice Methods. A total of 280 male and 280 female CBA mice were included in the study. Carbendazim was intragastrically administered in these animals for 18 months 5 times per week via a gastric tube at the doses of 0, 5, 25 and 75 mg/kg body weight as 0, 0.1, 0.5 and 1.5 % ex tempore prepared a suspension. Dead as well as sacrificed animals according to the experimental schedule were subjected to autopsy. Carcinogenicity was assessed using direct effect parameters — tumour ratio and their latent period. Results and Discussion. Clinical parameters of the condition of experimental animals, survival and incidence of premalignancy did not differ from those in the control animals. The main cause of death in animals throughout the study were non-specific intercurrent diseases developed with approximately the same rate in the experimental and control group. Tumour incidence (n = 37) in experimental and control groups did not statistically differ and complied with the spontaneous level in CBA mice. Conclusion. Incidence of tumours, their histological structure, location and latent period in experimental animals on carbendazim at the dose of 5, 25 and 75 mg/kg did not differ from those in the control group. Thus, the experimental study of carbendazim in CBA mice after intragastric administration for 78 weeks did not reveal the carcinogenic potential of the substance. Key Words: pesticides, carbendazim, carcinogenicity, mice.

2018 ◽  
Vol 6 (1) ◽  
pp. 34
Author(s):  
Tawali Tawali

This research is aimed to find out the effect of definitions toward students’ vocabulary mastery: it was an experimental study at the second grade student of MTs NW Haqqul Yaqin Sayang- sayang. The subject of this research was the second grade of MTs NW Haqqul Yaqin Sayang- sayang.The research was used experimental method with quantitative approach. The population of this research consist of 55 students, and the sample is 29 for experimental group while 26 for control group. The technique of collecting data was used definition for experimental group and matching word with antonym for control group. The data was collected by using post-test only and the data was analyzed by t-test formula. Based on data analysis the mean score of experimental group was 76,4 and control group was 69,23, beside of that standard deviation for experimental group was 114,28 and for control group was 113,09 and the value of t-test was 2,44 and t-table was 2,000. Degree of freedom is 53 with significant level 0,05. It means that the value of t-test was higher than t-table (t-test ˃ t-table). The alternative hypothesis (Ha) was accepted and null hypothesis (Ho) was rejected. Thus, the conclusion of this research was there was an effect of definition toward students’ vocabulary mastery: an experimental study at the second grade students of MTs NW Haqqul Yaqin Sayang-sayang.


2021 ◽  
Vol 9 (04) ◽  
pp. 464-467
Author(s):  
Ngozi a ◽  
◽  
N. Omeke ◽  
Haruna M. Ndahi ◽  
◽  
...  

Given the medicinal importance of the avocado plant in alternative medicine,the present study aimed to study the effect of the phytochemical content of P. americana leaf extract on the hematological system of albino rats. Albino rats were obtained andclustered into sixgroups,with five rats per groupsimultaneously were assigned experimental and control. The rats in the experimental group were administered with varying doses of the prepared aqueous extract of P. americanawithin the period of the study. The rats in the control group were administered with other substances such as water and feed for the study period.The hematological system of the experimental animal was assessed after the administration of the extract, and it was observed that the aqueous extract of P. americana leaf recorded no significant adverse effect on the hematology system of the experimental study animal.


1999 ◽  
Vol 42 (3) ◽  
pp. 281-294
Author(s):  
Y. Toukourou ◽  
K.-J. Peters

Abstract. Title of the paper: Impaet of feed restriction on the growth performance of goat kids The influence of differential feeding levels on growth performance in 72 goat kids "Bunte Deutsche Edelziege" during the pre-weaning period was examined. The 72 animals were assigned to a control group and two experimental groups that received respectively 20% and 40% less milk/less concentrate compared to the control (fed at 2.4 times energy demand for maintenance). The experimental gained animals significantly less relative to the control group. However, during the subsequent realimentation period when all animals were fed at a energy level of 2.4 times maintenance same treatment, the daily weight gain among the kids was in inverse proportion to the level ofmilk deprivation in the pre-weaning phase. The rapid growth among the experimental animals was such that the initial differences in body weight between the experimental and control groups were fully compensated. Growth performance of kids with respect to different levels of concentrated feed was less clear cut and d.ffered significantly only behveen the group that received the lowest feed level relative to all the other groups.


2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Christopher Vunni Draiko ◽  
Khemika Yamarat ◽  
Alessio Panza ◽  
Judith Draleru ◽  
Martin Taban ◽  
...  

This study aimed to examine the effects of the Helping Babies Breathe (HBB) training interventions program on the knowledge, psychomotor skills, and competency of health workers in managing birth asphyxia and reducing mortality of newborns experiencing asphyxia within 24 hours. This study used pre- and post-test design (quasi experimental study). Purposive sampling was employed, and a computer-generated number was used to select the participants. Health workers from Juba Teaching Hospital comprised the intervention group. They were evaluated before and after the training from February to June 2017. A post training skill and competency evaluation was performed using a NeoNatalie newborn simulator and was repeated after three months of implementation for intervention and control group. Seventy health workers were enrolled; 40 were in the intervention group and 30 in the control group. Early newborn mortality due to asphyxia within 24 hours in intervention and control measure at pre and post implementation showed a significant reduction within the intervention than the control. Knowledge, psychomotor and competency of health care workers improved immediately after training and early newborn mortality reduced by half at the end of three months. It is recommended that training of health workers on HBB should be scaled up in most of the health facilities in South Sudan.


2021 ◽  
Author(s):  
Anis Pourdavarani ◽  
Jamileh Farokhzadian ◽  
Mansooreh Azizzadeh Forouz ◽  
Sedigheh Khodabandeh Shahraki

Abstract Background: Anxiety and depression are the most common psychological disorders in the aging period. One of the ways to deal with anxiety and depression and increase happiness in the elderly is to train positive thinking. Therefore, the present study aimed to investigate positive thinking skills training on anxiety and happiness in the elderly.Methods: In this quasi-experimental study, 48 elderly people referred to two comprehensive health service centers in Kerman in southeastern Iran were selected by convenience sampling method and randomly assigned into intervention groups (n = 24) and control (n = 24). The data collection tools included the Beck Anxiety Inventory and the Oxford Happiness Inventory. Questionnaires were filled out before the intervention, then positive thinking training was held in eight sessions of 90 minutes. After training program, the was conducted one month after it, the follow-up tools.Results: The results showed that the mean score of anxiety before positive thinking training was (13.58 ± 8.61) and (19.25± 11.67) in the intervention and the control group, respectively. After positive thinking training, the mean scores were (4.50 ±4.07) and (15.54±9.04) in the intervention and control group, respectively. After the intervention, which significantly reduced anxiety the intervention, group (t= 8.10, P<0.001). The mean score of happiness before the test was (26.58±12.40) and (37.91 ± 5.57) in the intervention and control groups, respectively. However, the posttest happiness scores of the intervention and control groups were (62.91± 4.66) and (35.62 ±10.62), respectively. The results showed that implementing positive thinking training increased happiness significantly (t=-4.08, P<0.001).Conclusion: Since positive thinking training effect reducing anxiety and increasing happiness in the elderly. Due to the growing trend of the elderly population, the positive thinking training approach can be used as a suitable, cost-effective, and efficient method in reducing anxiety and increasing happiness in the elderly.


2021 ◽  
Author(s):  
Christoph Kulgemeyer ◽  
Jörg Wittwer

Online explanation videos on platforms like YouTube are popular among students and serve as an important resource for both distance learning and regular science education. Despite their immense potential, some of the explainer videos for physics include problematic explanation approaches, possibly fostering misconceptions. However, some of them manage to achieve good ratings on YouTube. A possible reason could be that explainer videos with misconceptions foster an “illusion of understanding”—the mistaken belief that a topic has been understood. In particular, misconceptions close to everyday experiences might elicit greater interest and appear more convincing than scientifically correct explanations. This experimental study was conducted to research this effect. Physics learners (N = 149), with a low prior knowledge enrolled in introductory university courses on primary education, were randomly assigned to experimental and control groups. While the experimental group watched a video introducing the concept of force relying on misconceptions, the control group watched the scientifically correct video. Both videos were comparable in terms of comprehensibility and duration. In the posttest, the experimental group believed that the video was scientifically correct, well-explained, and that they do not require further instruction to understand the concept—indicators of an illusion of understanding. The video including misconceptions was perceived as better understandable than the scientifically correct video (d = 0.62*). The experimental group was significantly more convinced by the misconception after watching the video than the control group (d = 1.86**). They learnt more erroneous knowledge about the misconception than the control group about the scientifically correct concept (Cohen’s q = 0.37*). We argue that this might become problematic (a) in physics instruction because students who have watched a misleading video might regard further teaching in school as irrelevant, and (b) learners might tend to rate videos including misconceptions better on an online platform like YouTube.


2017 ◽  
Vol 3 (1) ◽  
pp. 17
Author(s):  
Atayewa Merjen Gurbangeldiyewna ◽  
Hermayawati Hermayawati

The objectives of the study are to find out the ability of the students in writing descriptive text both before and after the treatment either at control group or experiment group; to find out the effectiveness of Interactive Media for teaching writing descriptive text; to find out what writing elements that received significant improvement after being taught by Interactive Media. This research was conducted using experimental study to overcome students’ problem in learning English especially writing skill. The researcher used two classes as the subject: XI MIPA-1 as the experiment group and XI MIPA-4 as control group. Those MIPA classes belong to Argo Mulyo High School /SMA N 1 Sedayu, Argomulyo, Bantul.The experimental class was taught the descriptive text by using Interactive Media in the form of Macromedia Flash while control groupwas taught by using non-computer based lessons. Total sample of both classes were 60 students. The research was conducted within quasi-experiment study which used pre-post tests design of experiment and control groups. The researcher used this method in order to find out whether computer-based instruction/Interactive Media could make significant improvement on the students’ descriptive writing skill. Such effectiveness was seen from difference of means between pre-post of both control and experiment groups and its t-test score at the degree of significancy. The t-test was higher than the t-table, Interactive Media then was proved significancy in improving the students’ writing descriptive text skill. The students’ writing was analyzed and scored based on rubrics postulated by Brown and Bailey including paragraph organization, its content, language structure, vocabulary and mechanics. The experiment shows that the t-test was (3.16) which is higher than t-table (2.000). The aspects of wtiting that has significant improvement were content, organization, structure, vocabulary - means pre-test of experimental group = 76.5 and control group = 70.8 increased into, experimental group = 87.22 and control group = 78.8 during post test with standard deviation of experimental group = 7.7 and control group = 9.97. Since there was a significant improvement of students’ writing skill by using Interactive Media, this research then confirms that Interactive Media is effective for teaching writing at SMA level.


2019 ◽  
pp. 105984051987164 ◽  
Author(s):  
Mohd Said Nurumal ◽  
Siti Hajar Mohd Zain ◽  
Mohamad Haniki Nik Mohamed ◽  
Shefaly Shorey

Preventing smoking among adolescents is critical. This study evaluated the effectiveness of the Smoking Prevention Education Program among nonsmoking adolescents. A quasi-experimental study design was used. Data were collected from Year 5 students ( n = 140) from four government primary schools in the Kuantan and Pahang districts of Malaysia. The participating schools were randomly assigned into the intervention and control groups. Questionnaires and exhaled carbon monoxide (CO) levels were used to collect data at the baseline and at 3 months postintervention. At 3 months postintervention, the percentage of nonsmokers remained 100% in the intervention group, while 2.9% of the participants in the control group reported to have smoked in past 7 days. Comparatively, the mean scores of attitudes, subjective norms, and nonsmoking intentions of the intervention group improved significantly. The intervention was effective in preventing smoking initiations among Malaysian adolescents; however, further evaluation of this intervention is needed among varied populations.


Author(s):  
R. Suvitha ◽  
K. Kanchana ◽  
T. Nirmala

A quasi experimental study to evaluate the efficacy of sesame oil on radiation induced xerostomia among patients with head and neck cancer. Non randomized quasi experimental pretest posttest control group design was adopted in this study. By using purposive sampling technique, 26 samples were selected based on inclusion criteria, 13 in experimental and 13 in control group. The demographic variables, clinical profile of the samples were collected, the level of Xerostomia was assessed by modified GRIX questionnaire in both experimental and control group. Intervention was given to experimental group and routine treatment was given to control group. It was identified that the mean level of Xerostomia among head and neck cancer patient in the experimental and control group was 51.08 and 30.4 respectively with mean difference of 20.54. Likewise the standard deviation of the experimental and control group was 4.63 and 4.92 respectively. The calculated ‘t’ value 10.96 was greater than the table value of 2.06 at 0.05 level of significance. Hence, it was concluded that sesame oil mouth rinsing is an effective method to reduce the radiation induced Xerostomia among patient with head and neck cancer.


2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Zahra Saberi Louyeh ◽  
Mahin Naderifar ◽  
Hamed Faghihi ◽  
Brenda S. Lessen Knoll ◽  
Nasrin Mahmoodi

Background: Premature babies face nutritional problems caused by underdevelopment and lack of coordination between sucking, swallowing, and breathing. Appropriate early interventions are needed to promote the nutritional adequacy of these infants. Objectives: This study was designed to compare the effect of breast milk odor and incubator cover on the nutritional adequacy of premature infants. Methods: A quasi-experimental study was conducted on 105 preterm infants aged 28 - 33 weeks who were admitted to the Neonatal Intensive Care Unit (NICU) of Ali Ibn Abi Taleb Hospital in Zahedan in 2018. The subjects were selected via convenience sampling and randomized into three groups: breast milk odor (BMO), incubator cover (IC), and control. Infants in the IC group were placed in an incubator for two hours before feeding. In the BMO group, a gauze soaked with breast milk was placed 1.5 cm away from the infant’s nose in the incubator, and a prescribed amount of milk was given by a syringe to the infant through the mouth. The amount of milk that the baby orally received in the first 10 min (nutritional adequacy) was recorded by a camera, and the results were compared in the three groups. Results: One-way analysis of variance showed a statistically significant difference between the control group and the two groups of incubator cover and breast milk odor (P < 0.001) such that nutritional adequacy was lower in the control group than in the two other groups. Conclusions: Both the smell of breast milk and incubator cover improved the nutritional adequacy of premature infants and enabled them to orally receive more breast milk.


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