scholarly journals Acute Kidney Injury due to Rhabdomyolysis

2016 ◽  
Vol 11 (1) ◽  
pp. 93-95
Author(s):  
Tania Mahbub ◽  
Ferdous Jahan ◽  
Dewan Masudul Haque ◽  
Md Nizam Uddin Chowdhury
Keyword(s):  
Acute Kidney Injury ◽  
Muscle Injury ◽  
Kidney Injury ◽  
Armed Forces ◽  
Clinical Syndrome ◽  
College Hospital ◽  
Medical College ◽  
High Rise ◽  
Dark Colour ◽  
Common Clinical Presentation

Rhabdomyolysis was first described as crush syndrome, during the London blitz of world war-ll. lt is a common clinical syndrome resulting from muscle injury there after release of toxic cellular component especially myoglobin. Muscle injury may results from a variety of causes. Most common clinical presentation of rhabdomyolysis is triad of myalgia, weakness and dark colour urine. But presentation may be varied. Very often it causes acute kidney injury and demands renal replacement therapy. Acute Renal Failure (ARF) is usually associated with very high rise of Creatinine Kinase(CK) >10,000 u/L1. In this series, there are few cases with rhabdomyolysis who were admitted and treated in Dhaka Medical College Hospital (DMCH) during July 2010 to April 2011. These cases of rhabdomyolysis normally developed acute kidney injury who were managed with dialysis support.Journal of Armed Forces Medical College Bangladesh Vol.11(1) 2015: 93-95

scholarly journals Acute Kidney Injury in Patients of Intensive Care Unit

2017 ◽  
Vol 8 (1) ◽  
pp. 38-44
Author(s):  
Nazneen Mahmood ◽  
Md Fazlur Rahman ◽  
Md Mostafizur Rahman ◽  
SM Hossain Shahid ◽  
Md Mahmudur Ahman Siddiqui
Keyword(s):  
Intensive Care Unit ◽  
Acute Kidney Injury ◽  
Intensive Care ◽  
Kidney Injury ◽  
Type I ◽  
College Hospital ◽  
Cross Sectional ◽  
Female Ratio ◽  
Failure Group ◽  
Medical College

Background: Acute Kidney Injury (AKI) is a common complication in patients admitted to the intensive care unit (ICU) and numerous causes are responsible for its development. The aim of the present study is to assess the incidence, risk factors, and outcome of patients who develop AKI in our ICU.Methodology: This study was conducted by the Department of Nephrology, Anwer Khan Modern Medical College Hospital (AKMMCH), a tertiary level center of Dhaka, during the period of January 2015 to December 2015. This is a Cross Sectional Descriptive type of Observational study on patients of Acute Kidney Injury (AKI) admitted to Intensive Care Unit (ICU) of AKMMCH.Result: A total number of 271 patients were admitted. Out of 271 patients, 59 (21.77%) patients with AKI who met our study requirements were included in the study and were evaluated. Among 59 patients 32 (54.23%) were males and 27 (45.77%) were females, with a male to female ratio of 1.19:1. The cause of admission were Diabetes mellitus with complication 11 (18.64%), Hepato-renal syndrome 10 (16.94%), Malignancy 7 (11.86%), Septicaemia 6 (10.18% ), Pneumonia 6 (10.18%), Intra-uterine death (IUD) 5 (8.48%) and others (Acute Myocardial Infarction, Non ST segment Elevated MI, Cerebro Vascular Disease, Gullain Burre Syndrome, Laparatomy, Type I and Type II Respiratory failure) 14 (23.72%). According to RIFLE's criteria most of the patients were from Injury group 32 (54.23%). Next to this, was Risk group 17 (28.83%) and in Failure, Loss and ESRD group were 7 (11.86%), 1(1.69%) and 2 (3.39%) accordingly. Regarding biochemical abnormality, mean Serum creatinine was 3.68 ± 2.15 and that of Urine output, HbA1C and HCO3 level ( in ABG ) were 4.57 ± 8.89, 6.91±1.4 and 17.14 ± 3.8 respectively. Out of 59 patients 10 (16.95%) needed Haemodialysis. According to RIFLE's criteria 7 (70%) were from Failure group, 1 patient from Loss group and 2 from ESRD group who received haemodialysis. 72.88% (43) patients improved, out of which 57.62% (34) got discharged from ICU after full recovery. 6.48% (4) patients expired and 3.38% (2) turned into ESRD and advised for regular haemodialysis.Conclusion: The incidence of AKI is high in patients admitted to ICU, and the development of AKI is associated with poor outcome and reduced survival. AKI significantly increases the duration of ICU stay, and this is likely to add to the healthcare burden. Age, gender or the presence of comorbidities do not appear to influence the incidence of AKI in our ICU patients.Anwer Khan Modern Medical College Journal Vol. 8, No. 1: Jan 2017, P 38-44

scholarly journals Assessment of urinary interleukin-18 in the early post-burn period to predict acute kidney injury of various degrees of burn patients

2022 ◽  
Author(s):  
Sharif Qamar Uddin ◽  
M. Nazrul Islam ◽  
M. Nizamuddin Chowdhury ◽  
Nizam Uddin Ahmed Chowdhury ◽  
Mohammad Zahir Uddin ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Predictive Value ◽  
Kidney Injury ◽  
Study Data ◽  
Burn Patients ◽  
Interleukin 18 ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Sensitivity Specificity

Background: Early detection of acute kidney injury (AKI) in burn-injured patients can help modify the treatment to prevent progression of acute renal failure and reduce the need for renal replacement therapy. The aim of the study was to evaluate urinary interleukin-18 in the early post-burn period to predict the AKI for the various degrees of burn patients.Methods: This prospective observational study was conducted in the department of nephrology, Dhaka medical college in collaboration with burn and plastic surgery unit of the same medical college hospital, from July 2017 to June 2018 for a period of one year. The 48 burn patients (Age>18 years) who attended in the burn unit of Dhaka medical college, Dhaka of both sexes were enrolled in this study. Data were analyzed by using SPSS 22.0. A value of p<0.05 was considered statistically significant for all tests.Results: In this study, mean age of the burn patients was 32.41±10.59 years. Male female ratio was 3.36:1. Urinary IL-18 in diagnosis of AKI showed accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 93.8%, 91.7%, 94.4%, 84.6% and 97.1% respectively. AUC for urinary IL-18 at admission was 0.968 (CI, 0.921-1.000) and AUC for serum creatinine at admission was 0.937 (CI, 0.871-1.000). Conclusions: According to Kappa value, AUC and sensitivity and specificity urinary IL-18 is a good biomarker in predicting of early AKI in burn patients.

scholarly journals Acute kidney injury is a common complication after acute stroke in Mymensingh Medical College Hospital

2016 ◽  
Vol 44 (2) ◽  
pp. 82-86
Author(s):  
Nitai Chandra Ray ◽  
Md Ayub Ali Chowdhury ◽  
Ashutosh Saha Roy ◽  
Md Abdul Muqueet ◽  
Binoy Paul ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Stroke ◽  
Kidney Injury ◽  
Developed Countries ◽  
Common Complication ◽  
Stroke Patients ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Significant Burden

Stroke represents a continuously evolving medical and social problem, being the third leading cause of death after heart disease and cancer in developed countries. Acute kidney injury (AKI) may develop as a possible complication after acute stroke. Insufficient care of acute stroke patients is an important factor behind it. It may be associated with a significant burden of morbidity and mortality. This cross sectional observational study was conducted in Mymensingh Medical College & Hospital, Mymensingh from July 2012 to June 2014. A total of 240 patients with newly detected acute stroke confirmed by CT scan of brain were included in this study. According to this study, 15.42% of acute stroke patients developed AKI. Majority (54.05%) of the AKI patients were in >60 years age group. 17.93 % of male patients developed AKI and 11.58% of female patients developed AKI. So, AKI was a common complication after acute stroke. Early diagnosis and management of AKI may be an important part of management of these stroke patients.Bangladesh Med J. 2015 May; 44 (2): 82-86

scholarly journals Postpartum Acute Kidney Injury - a Study at Faridpur Medical College Hospital

2021 ◽  
Vol 15 (2) ◽  
pp. 62-64
Author(s):  
Swapan Kumar Mondal ◽  
Ananta Kumar Biswas ◽  
Swapna Biswas Joy ◽  
MM Shahin Ul Islam ◽  
Bablu Kumar Pal ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Laboratory Data ◽  
Kidney Injury ◽  
Developed Countries ◽  
Medical College Hospital ◽  
Contributing Factors ◽  
College Hospital ◽  
Timely Initiation ◽  
Mortality And Morbidity ◽  
Medical College

Postpartum Acute Kidney Injury (AKI) is one of the serious complications of pregnancy and is associated with high mortality and morbidity. Although Postpartum AKI has decreased markedly in developed countries in the last 50 years, but it is a challenging health problem in pregnant women, specially in the developing countries like Bangladesh. Aim of this study was to determine the contributing factors and outcome of postpartum AKI. This observational study was conducted in the department of nephrology, Faridpur Medical College Hospital from January 2018 to December 2019. During that study period thirty two patients with postpartum AKI were admitted in the above mentioned department. Demographic, clinical and laboratory data of those patients were recorded. Mean age of patients was 25.3 ± 4.2 years, and the 72% patients underwent cesarean section. Oliguria was the main presentation (91%). Puerperal sepsis (38%), postpartum hemorrhage (22%), and Eclampsia (16%) were the common contributing factors. Hemodialysis was required for most of the patients (75%). Therefore early diagnosis, identification and treatment of cause, timely initiation of renal replacement therapy is mandatory. Faridpur Med. Coll. J. 2020;15(2): 62-64

scholarly journals Rhabdomyolysis induced acute kidney injury following physical exertion and severe hypercalcaemia in recovery phase-a case report

2015 ◽  
Vol 9 (2) ◽  
pp. 107-111
Author(s):  
Azizun Nessa ◽  
Md Fazlul Hoque ◽  
Md Amzad H Fakir ◽  
AKM Mijanur Rahman
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Physical Exertion ◽  
Armed Forces ◽  
Recovery Phase ◽  
Medical College ◽  
Specialized Centre ◽  
Threatening Condition ◽  
Life Threatening ◽  
Severe Hypercalcaemia

In military profession, acute kidney injury (AKI) due to rhabdomyolysis is not uncommon because of its nature of job. This life threatening condition needs early aggressive management in a specialized centre to restore normal renal function. Here we report a case of rhabdomyolysis due to physical exertion who developed acute kidney injury and required haemodialysis. Patient developed hypercalcaemia in his recovery phase which was successfully managed. DOI: http://dx.doi.org/10.3329/jafmc.v9i2.21849 Journal of Armed Forces Medical College Bangladesh Vol.9(2) 2013

scholarly journals Aetiology and outcome of Hypernatremia in Post Diarrhoeal Acute Kidney Injury in Children– An Experience in Dhaka Medical College Hospital

2017 ◽  
Vol 8 (2) ◽  
pp. 224-227
Author(s):  
Shireen Afroz ◽  
Tahmina Ferdous ◽  
Tania Sharmin ◽  
Nasir Hossain
Keyword(s):  
Acute Kidney Injury ◽  
Serum Sodium ◽  
Winter Season ◽  
Kidney Injury ◽  
Medical College Hospital ◽  
College Hospital ◽  
Oral Rehydration ◽  
Medical College ◽  
Life Threatening

Background : Hypernatremia (serum sodium 150mmol/L) is one of the most life-threatening complications of childhood diarrhoea, Acute kidney injury(AKI) when associated with hypernatremia results increased mortality and long term morbidity.Objectives : Our objective was to find out the aetiology and outcome of hypernatremia in post diarrhoeal AKI in children in a teaching hospital in Bangladesh.Methods : This prospective observational study was conducted over 06 months in the Paediatric Nephrology Department of Dhaka Medical College Hospital. A total of 15 children withpost diarrhoeal AKI withhypernatremia were evaluated.AKI staging was done by pRIFLE criteria. Hypernatremia was classified into mild, moderate and severe gradings. All patients were treated conservatively and with Intermittent Peritoneal Dialysis (IPD) as needed. Fluid adjustment was done according to serum sodium level.At the end of the study, samples were divided in to survive and death groups depending on outcome.Results : Age of the children ranged from 2 months to 18months. Ninety three percent cases were under 1 year.Forty seven percent patients were in Failure stage of AKI, 47%in Injury and 1 patient in Risk stage.Out of 15 cases 93% had severe hypernatremia. In 67% casesthe causes of hypernatremia were intake of concentrated oral rehydration solution (ORS) and found more in winter season. Regardless of cause overall 47% survived with normal renal functions and 53% died.Conclusion : Intake of concentrated ORS and diarrhoea during winter seasona are the most important cause of hypernatremia in infancy. Hypernatremia with AKI stage III (Failure) had poorest outcome.Northern International Medical College Journal Vol.8(2) January 2017: 224-227

scholarly journals Determinants of Outcomes of Acute Kidney Injury: Clinical Predictors and Beyond

2021 ◽  
Vol 10 (6) ◽  
pp. 1175
Author(s):  
Emaad M. Abdel-Rahman ◽  
Faruk Turgut ◽  
Jitendra K. Gautam ◽  
Samir C. Gautam
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Disease ◽  
Kidney Injury ◽  
Complete Recovery ◽  
Severe Form ◽  
Clinical Syndrome ◽  
Current Evidence ◽  
Clinical Predictors ◽  
End Stage

Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid impairment of kidney function. The incidence of AKI and its severe form AKI requiring dialysis (AKI-D) has been increasing over the years. AKI etiology may be multifactorial and is substantially associated with increased morbidity and mortality. The outcome of AKI-D can vary from partial or complete recovery to transitioning to chronic kidney disease, end stage kidney disease, or even death. Predicting outcomes of patients with AKI is crucial as it may allow clinicians to guide policy regarding adequate management of this problem and offer the best long-term options to their patients in advance. In this manuscript, we will review the current evidence regarding the determinants of AKI outcomes, focusing on AKI-D.

scholarly journals The impact of biomarkers of acute kidney injury on individual patient care

2019 ◽  
Vol 35 (8) ◽  
pp. 1295-1305 ◽  
Author(s):  
Jay L Koyner ◽  
Alexander Zarbock ◽  
Rajit K Basu ◽  
Claudio Ronco
Keyword(s):  
Acute Kidney Injury ◽  
Patient Care ◽  
Kidney Injury ◽  
Clinical Syndrome ◽  
Functional Markers ◽  
Close Monitoring ◽  
Clinical Implementation ◽  
Care Bundles ◽  
Increased Risk ◽  
The Impact

Abstract Acute kidney injury (AKI) remains a common clinical syndrome associated with increased morbidity and mortality. In the last several years there have been several advances in the identification of patients at increased risk for AKI through the use of traditional and newer functional and damage biomarkers of AKI. This article will specifically focus on the impact of biomarkers of AKI on individual patient care, focusing predominantly on the markers with the most expansive breadth of study in patients and reported literature evidence. Several studies have demonstrated that close monitoring of widely available biomarkers such as serum creatinine and urine output is strongly associated with improved patient outcomes. An integrated approach to these biomarkers used in context with patient risk factors (identifiable using electronic health record monitoring) and with tests of renal reserve may guide implementation and targeting of care bundles to optimize patient care. Besides traditional functional markers, biochemical injury biomarkers have been increasingly utilized in clinical trials both as a measure of kidney injury as well as a trigger to initiate other treatment options (e.g. care bundles and novel therapies). As the novel measures are becoming globally available, the clinical implementation of hospital-based real-time biomarker measurements involves a multidisciplinary approach. This literature review discusses the data evidence supporting both the strengths and limitations in the clinical implementation of biomarkers based on the authors’ collective clinical experiences and opinions.

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