scholarly journals Rhabdomyolysis induced acute kidney injury following physical exertion and severe hypercalcaemia in recovery phase-a case report

2015 ◽  
Vol 9 (2) ◽  
pp. 107-111
Author(s):  
Azizun Nessa ◽  
Md Fazlul Hoque ◽  
Md Amzad H Fakir ◽  
AKM Mijanur Rahman
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Physical Exertion ◽  
Armed Forces ◽  
Recovery Phase ◽  
Medical College ◽  
Specialized Centre ◽  
Threatening Condition ◽  
Life Threatening ◽  
Severe Hypercalcaemia

In military profession, acute kidney injury (AKI) due to rhabdomyolysis is not uncommon because of its nature of job. This life threatening condition needs early aggressive management in a specialized centre to restore normal renal function. Here we report a case of rhabdomyolysis due to physical exertion who developed acute kidney injury and required haemodialysis. Patient developed hypercalcaemia in his recovery phase which was successfully managed. DOI: http://dx.doi.org/10.3329/jafmc.v9i2.21849 Journal of Armed Forces Medical College Bangladesh Vol.9(2) 2013

scholarly journals Acute Kidney Injury due to Rhabdomyolysis

2016 ◽  
Vol 11 (1) ◽  
pp. 93-95
Author(s):  
Tania Mahbub ◽  
Ferdous Jahan ◽  
Dewan Masudul Haque ◽  
Md Nizam Uddin Chowdhury
Keyword(s):  
Acute Kidney Injury ◽  
Muscle Injury ◽  
Kidney Injury ◽  
Armed Forces ◽  
Clinical Syndrome ◽  
College Hospital ◽  
Medical College ◽  
High Rise ◽  
Dark Colour ◽  
Common Clinical Presentation

Rhabdomyolysis was first described as crush syndrome, during the London blitz of world war-ll. lt is a common clinical syndrome resulting from muscle injury there after release of toxic cellular component especially myoglobin. Muscle injury may results from a variety of causes. Most common clinical presentation of rhabdomyolysis is triad of myalgia, weakness and dark colour urine. But presentation may be varied. Very often it causes acute kidney injury and demands renal replacement therapy. Acute Renal Failure (ARF) is usually associated with very high rise of Creatinine Kinase(CK) >10,000 u/L1. In this series, there are few cases with rhabdomyolysis who were admitted and treated in Dhaka Medical College Hospital (DMCH) during July 2010 to April 2011. These cases of rhabdomyolysis normally developed acute kidney injury who were managed with dialysis support.Journal of Armed Forces Medical College Bangladesh Vol.11(1) 2015: 93-95

scholarly journals Rhabdomyolysis-Induced Acute Kidney Injury in Diabetic Emergency: Underdiagnosed and an Important Association to Be Aware of

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Ami Amin ◽  
Bhavika Gandhi ◽  
Steven Torre ◽  
Alireza Amirpour ◽  
Jennifer Cheng ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Diabetic Ketoacidosis ◽  
Clinical Manifestations ◽  
Kidney Injury ◽  
Clinical Syndrome ◽  
Dark Urine ◽  
Threatening Condition ◽  
Hyperosmolar Hyperglycemic State ◽  
Life Threatening ◽  
Electrolyte Abnormalities

Rhabdomyolysis is a potentially life-threatening clinical syndrome associated with muscle injury which can cause a leakage of intracellular contents, manifested from the range of being asymptomatic to a life-threatening condition causing acute kidney injury and severe electrolyte abnormalities. Rhabdomyolysis has been associated with both diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic nonketotic syndrome, though there is an increased association with rhabdomyolysis and acute kidney injury with hyperosmolar nonketonic state compared with patients with diabetic ketoacidosis. Common clinical manifestations are muscle pain, dark urine, and generalized weakness. The causes of rhabdomyolysis are broadly categorized into three groups: traumatic, nontraumatic exertional, and nontraumatic nonexertional. Here, we present a case of rhabdomyolysis-induced acute kidney injury in a patient with hyperosmolar hyperglycemic state. The patient was discharged on insulin and needed intermittent dialysis for two months. Our case highlights the importance of the rare association of rhabdomyolysis causing acute kidney injury in a diabetic emergency.

scholarly journals Interpretable and Continuous Prediction of Acute Kidney Injury in the Intensive Care

2021 ◽  
Author(s):  
Iacopo Vagliano ◽  
Oleksandra Lvova ◽  
Martijn C. Schut
Keyword(s):  
Machine Learning ◽  
Acute Kidney Injury ◽  
Intensive Care ◽  
Recurrent Neural Networks ◽  
Kidney Injury ◽  
Predictive Performance ◽  
Continuous Model ◽  
Machine Learning Model ◽  
Threatening Condition ◽  
Life Threatening

Acute kidney injury (AKI) is a common and potentially life-threatening condition, which often occurs in the intensive care unit. We propose a machine learning model based on recurrent neural networks to continuously predict AKI. We internally validated its predictive performance, both in terms of discrimination and calibration, and assessed its interpretability. Our model achieved good discrimination (AUC 0.80-0.94). Such a continuous model can support clinicians to promptly recognize and treat AKI patients and may improve their outcomes.

scholarly journals Aetiology and outcome of Hypernatremia in Post Diarrhoeal Acute Kidney Injury in Children– An Experience in Dhaka Medical College Hospital

2017 ◽  
Vol 8 (2) ◽  
pp. 224-227
Author(s):  
Shireen Afroz ◽  
Tahmina Ferdous ◽  
Tania Sharmin ◽  
Nasir Hossain
Keyword(s):  
Acute Kidney Injury ◽  
Serum Sodium ◽  
Winter Season ◽  
Kidney Injury ◽  
Medical College Hospital ◽  
College Hospital ◽  
Oral Rehydration ◽  
Medical College ◽  
Life Threatening

Background : Hypernatremia (serum sodium 150mmol/L) is one of the most life-threatening complications of childhood diarrhoea, Acute kidney injury(AKI) when associated with hypernatremia results increased mortality and long term morbidity.Objectives : Our objective was to find out the aetiology and outcome of hypernatremia in post diarrhoeal AKI in children in a teaching hospital in Bangladesh.Methods : This prospective observational study was conducted over 06 months in the Paediatric Nephrology Department of Dhaka Medical College Hospital. A total of 15 children withpost diarrhoeal AKI withhypernatremia were evaluated.AKI staging was done by pRIFLE criteria. Hypernatremia was classified into mild, moderate and severe gradings. All patients were treated conservatively and with Intermittent Peritoneal Dialysis (IPD) as needed. Fluid adjustment was done according to serum sodium level.At the end of the study, samples were divided in to survive and death groups depending on outcome.Results : Age of the children ranged from 2 months to 18months. Ninety three percent cases were under 1 year.Forty seven percent patients were in Failure stage of AKI, 47%in Injury and 1 patient in Risk stage.Out of 15 cases 93% had severe hypernatremia. In 67% casesthe causes of hypernatremia were intake of concentrated oral rehydration solution (ORS) and found more in winter season. Regardless of cause overall 47% survived with normal renal functions and 53% died.Conclusion : Intake of concentrated ORS and diarrhoea during winter seasona are the most important cause of hypernatremia in infancy. Hypernatremia with AKI stage III (Failure) had poorest outcome.Northern International Medical College Journal Vol.8(2) January 2017: 224-227

scholarly journals Cardiogenic shock and acute kidney injury: the rule rather than the exception

2020 ◽  
Author(s):  
N Ghionzoli ◽  
C Sciaccaluga ◽  
GE Mandoli ◽  
G Vergaro ◽  
F Gentile ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiogenic Shock ◽  
Severe Depression ◽  
Kidney Injury ◽  
Cardiorenal Syndrome ◽  
Current Evidence ◽  
Evidence Based ◽  
Threatening Condition ◽  
Life Threatening ◽  
Worse Prognosis

Abstract Cardiogenic shock (CS) is a life-threatening condition of poor end-organ perfusion, caused by any cardiovascular disease resulting in a severe depression of cardiac output. Despite recent advances in replacement therapies, the outcome of CS is still poor, and its management depends more on empirical decisions rather than on evidence-based strategies. By its side, acute kidney injury (AKI) is a frequent complication of CS, resulting in the onset of a cardiorenal syndrome. The combination of CS with AKI depicts a worse clinical scenario and holds a worse prognosis. Many factors can lead to acute renal impairment in the setting of CS, either for natural disease progression or for iatrogenic causes. This review aims at collecting the current evidence-based acknowledgments in epidemiology, pathophysiology, clinical features, diagnosis, and management of CS with AKI. We also attempted to highlight the major gaps in evidence as well as to point out possible strategies to improve the outcome.

scholarly journals Preventive strategies for acute kidney injury in cancer patients

2020 ◽  
Author(s):  
Laura Cosmai ◽  
Camillo Porta ◽  
Marina Foramitti ◽  
Valentina Perrone ◽  
Ludovica Mollica ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Cancer Patients ◽  
Kidney Injury ◽  
Clinical Approach ◽  
Related Risk ◽  
Threatening Condition ◽  
Huge Impact ◽  
Life Threatening ◽  
History Of

Abstract Acute kidney injury (AKI) is a common complication of cancer that occurs in up to 50% of neoplastic patients during the natural history of their disease; furthermore, it has a huge impact on key outcomes such as overall prognosis, length of hospitalization and costs. AKI in cancer patients has different causes, either patient-, tumour- or treatment-related. Patient-related risk factors for AKI are the same as in the general population, whereas tumour-related risk factors are represented by compression, obstruction, direct kidney infiltration from the tumour as well by precipitation, aggregation, crystallization or misfolding of paraprotein (as in the case of multiple myeloma). Finally, treatment-related risk factors are the most common observed in clinical practice and may present also with the feature of tumour lysis syndrome or thrombotic microangiopathies. In the absence of validated biomarkers, a multidisciplinary clinical approach that incorporates adequate assessment, use of appropriate preventive measures and early intervention is essential to reduce the incidence of this life-threatening condition in cancer patients.

Severe hypercalcaemia and acute kidney Injury in a patient with sarcoidosis

2019 ◽  
Author(s):  
Emily Whiles ◽  
Hareesh Joshi ◽  
Arun P Perumalthiagarajan ◽  
Amina Mohammed ◽  
Samson O Oyibo ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Severe Hypercalcaemia

The association between neutrophil-to-lymphocyte ratio and contrast-induced acute kidney injury in patients with carotid artery stenting

Vascular ◽  
2021 ◽  
pp. 170853812110125
Author(s):  
Altuğ Ösken ◽  
Ahmet Öz ◽  
Muhammed Keskin ◽  
Evliya Akdeniz ◽  
Hasan Şahan ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Carotid Artery ◽  
Carotid Artery Stenting ◽  
Kidney Injury ◽  
Fold Increase ◽  
Multivariate Regression Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Life Threatening ◽  
Prolonged Hospital

Objectives Contrast-induced acute kidney injury (CI-AKI) is a life-threatening complication that leads to comorbidities and prolonged hospital stay lengths in the setting of peripheral interventions. The presence of some CI-AKI risk factors has already been investigated. In this study, we evaluated the predictors of CI-AKI after carotid artery stenting. Methods A total of 389 patients with 50% to 99% carotid artery stenosis who underwent carotid artery stenting were included in this study. Patients were grouped according to CI-AKI status. Results CI-AKI developed in 26 (6.6%) patients. Age, baseline creatinine level, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were higher and estimated glomerular filtration rate, haemoglobin and lymphocyte count were lower in CI-AKI patients. In the multivariate regression analysis, the neutrophil-to-lymphocyte ratio triggered a 1.39- to 2.63-fold increase in the risk of CI-AKI onset ( p < 0.001). Conclusions The neutrophil-to-lymphocyte ratio may be a significant predictor of CI-AKI in patients with carotid artery stenting and higher neutrophil-to-lymphocyte ratio values may be independently associated with CI-AKI.

scholarly journals Rhabdomyolysis and severe biphasic disturbance of calcium homeostasis secondary to COVID-19 infection

2021 ◽  
Vol 14 (5) ◽  
pp. e239611
Author(s):  
Adrian Po Zhu Li ◽  
Stephen Thomas ◽  
Refik Gokmen ◽  
Dulmini Kariyawasam
Keyword(s):  
Acute Kidney Injury ◽  
Creatine Kinase ◽  
Calcium Homeostasis ◽  
Kidney Injury ◽  
Severe Hypercalcaemia ◽  
Severe Hypocalcaemia

We report a case of severe hypercalcaemia secondary to rhabdomyolysis in a woman with COVID-19 (SARS CoV-2) infection. The patient presented with myalgia and anuria with an acute kidney injury requiring haemodialysis. Creatine kinase peaked at 760 000 IU/L. A biphasic calcaemic response was observed with initial severe hypocalcaemia followed by severe, symptomatic hypercalcaemia, persistent despite haemodialysis. Control of the calcium levels was achieved by continuous haemofiltration.

scholarly journals Gene Microarray Integrated with High-Throughput Proteomics for the Discovery of Transthyretin in Rhabdomyolysis-Induced Acute Kidney Injury

2017 ◽  
Vol 43 (4) ◽  
pp. 1673-1688 ◽  
Author(s):  
Ou Li ◽  
Xiaodong Geng ◽  
Qian Ma ◽  
Weiwei Wang ◽  
Ran Liu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Western Blotting ◽  
Kidney Injury ◽  
Physical Exertion ◽  
Renal Tissue ◽  
Gene Microarray ◽  
Absolute Quantitation ◽  
Gene And Protein Expression ◽  
Isobaric Tagging

Background/Aims: Rhabdomyolysis, one of the leading causes of acute kidney injury (AKI), develops after trauma, drug toxicity, infections, burns, and physical exertion. The aim of this study was to investigate differences in gene and protein expression to elucidate the pathogenesis of rhabdomyolysis (RM)-induced AKI. Methods: In this study, we used glycerol induced renal injury as a model of RM-induced AKI. Affymetrix U133 plus 2.0 microarrays were used to perform gene microarray analysis. Isobaric tagging with related and absolute quantitation (iTRAQ) labeling mass spectrometry (MS) was applied to screen and identify differentially expressed proteins between RM-induced AKI and normal murine renal tissue. Verification experiments included immunohistochemistry (IHC), real-time PCR, Western blotting, and the measurement of ATP and ROS production. HK-2 cells were incubated in vitro with ferrous myoglobin and pcDNA-TTR, followed by assays to detect cell proliferation, ROS and apoptosis. Results: According to gene microarray and iTRAQ-MS analysis, we screened 17 common elements. After multiple analyses, we selected transthyretin (TTR) as our focus and investigated TTR in the kidney. Verification experiments with IHC confirmed differential expression levels of TTR proteins. Furthermore, Western blotting showed a stepwise decrease in TTR in AKI renal tissues. Cell-based experiments showed that overexpression of TTR could improve HK-2 cell viability and inhibit apoptosis. TTR reduced apoptosis by decreasing the accumulation of reactive oxygen species (ROS). Conclusion: This study reports a possible mechanism for RM-induced AKI and suggests that reductions in TTR could increase the generation of ROS and induce apoptosis. TTR may be a potentially valuable target for RM-induced AKI.

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