scholarly journals Minimal invasive procedures for the treatment of genitourinary syndrome of menopause (GSM). Un update

2020 ◽  
Vol 19 (1) ◽  
pp. 35-44
Author(s):  
Dimitrios Zacharakis ◽  
Eleni Pitsouni ◽  
Themos Grigoriadis ◽  
Christos Kalantzis ◽  
Dimitrios Loutradis ◽  
...  
Keyword(s):  
High Intensity ◽  
Electromagnetic Waves ◽  
Platelet Rich Plasma ◽  
Vaginal Wall ◽  
Minimal Invasive ◽  
Long Term Results ◽  
Invasive Procedures ◽  
Genitourinary Syndrome Of Menopause ◽  
Age Related ◽  
Genitourinary Syndrome

Genitourinary syndrome of menopause (GSM) is a new term for a condition more renowned as atrophic vaginitis. It is used to describe a variety of menopausal symptoms and signs that are related to the physical changes of the vulva, vagina and lower urinary tract. The etiology of GSM is secondary to decreased levels of endogenous estrogens and represents a common but underreported condition. In this update we present novel minimal invasive procedures that may benefit GSM symptoms making particular focus on platelet-rich plasma (PRP) treatment, hyaluronic acid (HA) treatment and energy-based devices (CO2 laser, YAG laser, radiofrequency device and high intensity focused ultrasounds). Currently, PRP has becoming popular as a non-operative treatment option for GSM symptoms. The principle underlying PRP treatment has to do with its ability to reproduce natural mechanisms of cell regeneration through the sequential secretion of numerous growth factors. Moreover, HA has been widely used as an important ingredient in topical hydrating and lubricating gels or injected for conditions such as dyspareunia. Lately, it has also been used as a new tool to treat age-related fat lysis of the female genitalia and especially the labia majora. Τhe Energy based devices have been recently suggested for the management of GSM. They utilize technologies such as laser, electromagnetic waves and high intensity focused ultrasounds to focus energy in the vaginal wall heating the targeted tissue at various depths without causing any pain or needing a recovery time. These minimal invasive procedures appear to be promising options for the treatment of GSM symptoms. However, further studies are necessary to evaluate more thoroughly the effectiveness and safety of these procedure and assess medium and long term results.

scholarly journals Microablative Fractional Radiofrequency as a Therapeutical Option for Genitourinary Syndrome of Menopause: Perspectives

2021 ◽  
Vol 3 ◽  
Author(s):  
Márcia Farina Kamilos ◽  
Ana Paula Ferreira Costa ◽  
Ayane Cristine Alves Sarmento ◽  
José Eleutério ◽  
Ana Katherine Gonçalves
Keyword(s):  
Electromagnetic Waves ◽  
Energy Use ◽  
Therapeutic Option ◽  
Thermal Action ◽  
Functional Improvement ◽  
Elastic Fibers ◽  
Tissue Elasticity ◽  
Genitourinary Syndrome Of Menopause ◽  
Labia Minora ◽  
Genitourinary Syndrome

The genitourinary syndrome in menopause can occur at different stages of life, with different causes or triggering factors, such as prolonged use of antiestrogens, chemotherapy, radiotherapy, and extensive vaginal surgeries, which can alter vascularization, hydration, collagen quality, and tissue elasticity. Despite hormonal therapy being considered the best evidenced treatment for genitourinary syndrome of menopause (GSM), there are limitations concerning the latter. Thus, alternative, complementary, or even substitutive treatments have emerged, such as energy use, promoting thermal tissue stimulation to improve tropism. Due to its practicality and feasibility, the micro ablative fractional radiofrequency (MAFRF) has gained space among these energies. It uses high-frequency electromagnetic waves and promotes thermal micro points in the superficial and deep dermis. The safety of these energies limits thermal action laterality and depth. Laterally, it is essential for an adequate regenerative effect without scarring marks or sequelae; the appropriate depth is important for stimulating the obligatory tissue repair response with the production and reorganization of collagen, elastic fibers, increased vascularization and hydration, and the consequent improvement in tropism. In gynecology, the MAFRF is used with therapeutic indication and functional improvement; it is applied to the entire length of the vaginal walls, the vulvar vestibule, urethral meatus, labia minora, clitoris prepuce, labia majora, perineum, and perianal region. The MAFRF has been proved to be an effective and safe treatment for GSM, with long-lasting effects, significantly reducing symptoms and improving vaginal tropism. This review aims to analyze the MAFRF as a non-hormonal therapeutic option for GSM.

scholarly journals Non-Coding RNAs in the Transcriptional Network That Differentiates Skeletal Muscles of Sedentary from Long-Term Endurance- and Resistance-Trained Elderly

2021 ◽  
Vol 22 (4) ◽  
pp. 1539
Author(s):  
Paola De Sanctis ◽  
Giuseppe Filardo ◽  
Provvidenza Maria Abruzzo ◽  
Annalisa Astolfi ◽  
Alessandra Bolotta ◽  
...  
Keyword(s):  
Exercise Training ◽  
High Intensity ◽  
Vastus Lateralis ◽  
Mammalian Target Of Rapamycin ◽  
Differentially Expressed ◽  
Transcriptional Networks ◽  
Vastus Lateralis Muscle ◽  
Age Related ◽  
Wide Range ◽  
Non Coding Rnas

In a previous study, the whole transcriptome of the vastus lateralis muscle from sedentary elderly and from age-matched athletes with an exceptional record of high-intensity, life-long exercise training was compared—the two groups representing the two extremes on a physical activity scale. Exercise training enabled the skeletal muscle to counteract age-related sarcopenia by inducing a wide range of adaptations, sustained by the expression of protein-coding genes involved in energy handling, proteostasis, cytoskeletal organization, inflammation control, and cellular senescence. Building on the previous study, we examined here the network of non-coding RNAs participating in the orchestration of gene expression and identified differentially expressed micro- and long-non-coding RNAs and some of their possible targets and roles. Unsupervised hierarchical clustering analyses of all non-coding RNAs were able to discriminate between sedentary and trained individuals, regardless of the exercise typology. Validated targets of differentially expressed miRNA were grouped by KEGG analysis, which pointed to functional areas involved in cell cycle, cytoskeletal control, longevity, and many signaling pathways, including AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR), which had been shown to be pivotal in the modulation of the effects of high-intensity, life-long exercise training. The analysis of differentially expressed long-non-coding RNAs identified transcriptional networks, involving lncRNAs, miRNAs and mRNAs, affecting processes in line with the beneficial role of exercise training.

Vaginal Laser Therapy for Genitourinary Syndrome of Menopause – Systematic Review

Maturitas ◽  
2021 ◽  
Author(s):  
Eduard Mension ◽  
Inmaculada Alonso ◽  
Marta Tortajada ◽  
Isabel Matas ◽  
Sílvia Gómez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Laser Therapy ◽  
Genitourinary Syndrome Of Menopause ◽  
Genitourinary Syndrome

Long-term Results of Mucosal Advancement Flap Combined With Platelet-rich Plasma for High Cryptoglandular Perianal Fistulas

2014 ◽  
Vol 57 (2) ◽  
pp. 223-227 ◽  
Author(s):  
Kevin W. Göttgens ◽  
Wouter Vening ◽  
Stefan J. van der Hagen ◽  
Wim G. van Gemert ◽  
Reinier R. Smeets ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Advancement Flap ◽  
Long Term Results ◽  
Perianal Fistulas

Laser therapy for the genitourinary syndrome of menopause. A systematic review and meta-analysis

Maturitas ◽  
2017 ◽  
Vol 103 ◽  
pp. 78-88 ◽  
Author(s):  
Eleni Pitsouni ◽  
Themos Grigoriadis ◽  
Matthew E. Falagas ◽  
Stefano Salvatore ◽  
Stavros Athanasiou
Keyword(s):  
Systematic Review ◽  
Laser Therapy ◽  
Meta Analysis ◽  
Genitourinary Syndrome Of Menopause ◽  
Genitourinary Syndrome

“ADMINISTRATION OF PLATELET RICH PLASMA- A SHIFT IN ACCELERATED ORTHODONTICS– A REVIEW “

2021 ◽  
pp. 44-45
Author(s):  
Saraa Angel .L ◽  
Abhijeet Jaiswal
Keyword(s):  
Human Population ◽  
Orthodontic Treatment ◽  
Tooth Movement ◽  
Treatment Time ◽  
Platelet Rich Plasma ◽  
Invasive Procedures ◽  
Non Invasive ◽  
Surgical Methods ◽  
Accelerated Orthodontics ◽  
Economical Alternative

Increasing awareness towards self-appearance and aesthetics has led to increase in overall patients willing to undergo orthodontic treatment. Various surgical and non surgical methods have been tried to reduce the overall orthodontic treatment time. Painless, non invasive procedures are preferred over the traumatic methods. Platelet Rich Plasma (PRP) injection has recently gained popularity due to its safe , relatively painless and economical alternative in accelerating the tooth movement. This article briefs on the researches done in animal and human population so far using PRPand their cumulative effects on tooth movement.

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