scholarly journals The Role of Gut Microbial β-Glucuronidase in Estrogen Reactivation and Breast Cancer

2021 ◽  
Vol 9 ◽  
Author(s):  
Yue Sui ◽  
Jianming Wu ◽  
Jianping Chen
Keyword(s):  
Breast Cancer ◽  
Estrogen Metabolism ◽  
Research Gaps ◽  
Phase Ii Metabolism ◽  
The Past ◽  
Primary Products ◽  
Wide Range ◽  
Endogenous Compounds ◽  
Bile Excretion

Over the past decade, the gut microbiota has received considerable attention for its interactions with the host. Microbial β-glucuronidase generated by this community has hence aroused concern for its biotransformation activity to a wide range of exogenous (foreign) and endogenous compounds. Lately, the role of gut microbial β-glucuronidase in the pathogenesis of breast cancer has been proposed for its estrogen reactivation activity. This is plausible considering that estrogen glucuronides are the primary products of estrogens’ hepatic phase II metabolism and are subject to β-glucuronidase-catalyzed hydrolysis in the gut via bile excretion. However, research in this field is still at its very preliminary stage. This review outlines the biology of microbial β-glucuronidase in the gastrointestinal tract and elaborates on the clues to the existence of microbial β-glucuronidase–estrogen metabolism–breast cancer axis. The research gaps in this field will be discussed and possible strategies to address these challenges are suggested.

History and Morality

2020 ◽  
Author(s):  
Donald Bloxham
Keyword(s):  
Foreign Country ◽  
Moral Thought ◽  
Majority Opinion ◽  
The Past ◽  
Wide Range ◽  
Moral Judgements ◽  
Value Judgements ◽  
The Impact

Against majority opinion within his profession, Donald Bloxham argues that it is legitimate, often unavoidable, and frequently important for historians to make value judgements about the past. History and Morality draws on a wide range of historical examples, and its author’s insights as a practising historian. Examining concepts like impartiality, neutrality, contextualization, and the use and abuse of the idea of the past as a foreign country, Bloxham’s book investigates how the discipline has got to the point where what is preached can be so inconsistent with what is practised. It illuminates how far tacit moral judgements infuse works of history, and how strange those histories would look if the judgements were removed. Bloxham argues that rather than trying to eradicate all judgemental elements from their work historians need to think more consistently about how, and with what justification, they make the judgements that they do. The importance of all this lies not just in the responsibilities that historians bear towards the past—responsibilities to take historical actors on those actors’ own terms and to portray the impact of those actors’ deeds—but also in the role of history as a source of identity, pride, and shame in the present. The account of moral thought in History and Morality has ramifications far beyond the activities of vocational historians.

scholarly journals The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4576
Author(s):  
Hung-Yu Lin ◽  
Hui-Wen Ho ◽  
Yen-Hsiang Chang ◽  
Chun-Jui Wei ◽  
Pei-Yi Chu
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Regulatory Networks ◽  
Molecular Mechanisms ◽  
Drug Resistant ◽  
Therapeutic Targeting ◽  
The Past ◽  
Regulated Cell Death ◽  
Common Malignancy

Breast cancer (BC) is the most common malignancy among women worldwide. The discovery of regulated cell death processes has enabled advances in the treatment of BC. In the past decade, ferroptosis, a new form of iron-dependent regulated cell death caused by excessive lipid peroxidation has been implicated in the development and therapeutic responses of BC. Intriguingly, the induction of ferroptosis acts to suppress conventional therapy-resistant cells, and to potentiate the effects of immunotherapy. As such, pharmacological or genetic modulation targeting ferroptosis holds great potential for the treatment of drug-resistant cancers. In this review, we present a critical analysis of the current understanding of the molecular mechanisms and regulatory networks involved in ferroptosis, the potential physiological functions of ferroptosis in tumor suppression, its potential in therapeutic targeting, and explore recent advances in the development of therapeutic strategies for BC.

scholarly journals From Nursery to Nursing Home: Emerging Concepts in Clostridioides difficile Pathogenesis

2020 ◽  
Vol 88 (7) ◽  
Author(s):  
Alexander B. Smith ◽  
Joshua Soto Ocana ◽  
Joseph P. Zackular
Keyword(s):  
Pharmaceutical Drugs ◽  
Human Gastrointestinal Tract ◽  
Content Type ◽  
The Past ◽  
Clostridioides Difficile ◽  
Wide Range ◽  
Pediatric Populations ◽  
The Impact ◽  
Shed Light

ABSTRACT Clostridioides difficile is a Gram-positive, spore-forming, anaerobic bacterium that infects the human gastrointestinal tract, causing a wide range of disorders that vary in severity from mild diarrhea to toxic megacolon and/or death. Over the past decade, incidence, severity, and costs associated with C. difficile infection (CDI) have increased dramatically in both the pediatric and adult populations. The factors driving this rapidly evolving epidemiology remain largely unknown but are likely due in part to previously unappreciated host, microbiota, and environmental factors. In this review, we will cover the risks and challenges of CDI in adult and pediatric populations and examine asymptomatic colonization in infants. We will also discuss the emerging role of diet, pharmaceutical drugs, and pathogen-microbiota interactions in C. difficile pathogenesis, as well as the impact of host-microbiota interactions in the manifestation of C. difficile-associated disease. Finally, we highlight new areas of research and novel strategies that may shed light on this complex infection and provide insights into the future of microbiota-based therapeutics for CDI.

scholarly journals The Flame Retardancy of Polyethylene Composites: From Fundamental Concepts to Nanocomposites

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5157
Author(s):  
Erfan Rezvani Ghomi ◽  
Fatemeh Khosravi ◽  
Zahra Mossayebi ◽  
Ali Saedi Ardahaei ◽  
Fatemeh Morshedi Dehaghi ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Flame Retardancy ◽  
Cost Efficiency ◽  
Research Papers ◽  
The Past ◽  
Wide Range ◽  
Fire Retardance ◽  
Low Toxicity ◽  
Implementing Strategies

Polyethylene (PE) is one the most used plastics worldwide for a wide range of applications due to its good mechanical and chemical resistance, low density, cost efficiency, ease of processability, non-reactivity, low toxicity, good electric insulation, and good functionality. However, its high flammability and rapid flame spread pose dangers for certain applications. Therefore, different flame-retardant (FR) additives are incorporated into PE to increase its flame retardancy. In this review article, research papers from the past 10 years on the flame retardancy of PE systems are comprehensively reviewed and classified based on the additive sources. The FR additives are classified in well-known FR families, including phosphorous, melamine, nitrogen, inorganic hydroxides, boron, and silicon. The mechanism of fire retardance in each family is pinpointed. In addition to the efficiency of each FR in increasing the flame retardancy, its impact on the mechanical properties of the PE system is also discussed. Most of the FRs can decrease the heat release rate (HRR) of the PE products and simultaneously maintains the mechanical properties in appropriate ratios. Based on the literature, inorganic hydroxide seems to be used more in PE systems compared to other families. Finally, the role of nanotechnology for more efficient FR-PE systems is discussed and recommendations are given on implementing strategies that could help incorporate flame retardancy in the circular economy model.

scholarly journals International trade in services: The role of international shipping

2007 ◽  
Vol 59 (2-3) ◽  
pp. 376-399
Author(s):  
Ivana Popovic-Petrovic
Keyword(s):  
International Trade ◽  
Trade In Services ◽  
National Interests ◽  
Transportation Services ◽  
The Past ◽  
Wide Range ◽  
The World ◽  
Increasing Demand ◽  
Merchandise Trade

The General Agreement on Trade in Services (GATS) is one of the World Trade Organization's most important agreements. This accord is the first and only set of multilateral rules covering international trade in services. It is a framework for international trade in services and a legal basis for resolving conflicting national interests. For the past two decades, trade in services has grown faster than merchandise trade. Currently, they represent more than two thirds of the World Gross Domestic Product. As the term services covers a wide range of intangible and heterogeneous products and activities, there has been an increasing demand for detailed, relevant and internationally comparable statistical information on trade in services. In the last ten years, the share of transportation services in international trade in commercial services was steady and amounted to about one quarter.

scholarly journals Quality assurance in Irish schools: Inspection and school self-evaluation

2020 ◽  
Vol 68 (4) ◽  
pp. 161-180
Author(s):  
Gerry McNamara ◽  
Joe O’Hara ◽  
Martin Brown ◽  
Irene Quinn
Keyword(s):  
Quality Assurance ◽  
Public Sector ◽  
School Evaluation ◽  
School Inspection ◽  
The Public ◽  
Policy Actors ◽  
Self Evaluation ◽  
The Past ◽  
Wide Range

AbstractIn this paper, we provide an overview of the development of school inspection in Ireland over the past twenty years using the analytic and critical lens developed by Richard Boyle in partnership with the current authors. The paper is fundamentally a reflection on the nature, purpose and operation of evaluation in the Irish public sector through the lens of education. The paper provides a historical overview of developments in the linked areas of school evaluation and inspection, and goes on to explore how the implementation of this mode of quality assurance has influenced, and been influenced by, a wide range of policy actors. The argument made is that education has embedded a culture of evaluation in a unique yet systemically resonant manner and that a reflection on this reality will help illuminate our understanding of the role of evaluation across the public sector as a whole.

scholarly journals Exploring the Role of Nanoparticles in Enhancing Mechanical Properties of Hydrogel Nanocomposites

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 882 ◽  
Author(s):  
Josergio Zaragoza ◽  
Scott Fukuoka ◽  
Marcus Kraus ◽  
James Thomin ◽  
Prashanth Asuri
Keyword(s):  
Mechanical Properties ◽  
Elastic Moduli ◽  
Maximum Modulus ◽  
Polymer Particle ◽  
Particle Interactions ◽  
Polyacrylamide Hydrogels ◽  
The Past ◽  
Wide Range ◽  
Hydrogel Nanocomposites

Over the past few decades, research studies have established that the mechanical properties of hydrogels can be largely impacted by the addition of nanoparticles. However, the exact mechanisms behind such enhancements are not yet fully understood. To further explore the role of nanoparticles on the enhanced mechanical properties of hydrogel nanocomposites, we used chemically crosslinked polyacrylamide hydrogels incorporating silica nanoparticles as the model system. Rheological measurements indicate that nanoparticle-mediated increases in hydrogel elastic modulus can exceed the maximum modulus that can be obtained through purely chemical crosslinking. Moreover, the data reveal that nanoparticle, monomer, and chemical crosslinker concentrations can all play an important role on the nanoparticle mediated-enhancements in mechanical properties. These results also demonstrate a strong role for pseudo crosslinking facilitated by polymer–particle interactions on the observed enhancements in elastic moduli. Taken together, our work delves into the role of nanoparticles on enhancing hydrogel properties, which is vital to the development of hydrogel nanocomposites with a wide range of specific mechanical properties.

scholarly journals Taxanes for the Treatment of Metastatic Breast Cancer

2012 ◽  
Vol 6 ◽  
pp. BCBCR.S8205 ◽  
Author(s):  
W.J. Gradishar
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Metastatic Breast ◽  
Dose Schedule ◽  
Breast Cancer Treatment ◽  
Current Role ◽  
The Past ◽  
Stage Disease ◽  
Taxane Resistance

Taxanes have remained a cornerstone of breast cancer treatment over the past three decades, improving the lives of patients with both early- and late-stage disease. The purpose of this review is to summarize the current role of taxanes, including an albumin-bound formulation that enhances delivery of paclitaxel to tumors, in the management of metastatic breast cancer (MBC). Since the introduction of Cremophor EL-paclitaxel to the clinic in the mid-1990s, a substantial amount of investigation has gone into subjects such as formulation, dose, schedule, and taxane resistance, allowing physicians greater flexibility in treating patients with MBC. This review will also examine how the shrinking pool of taxane-naive patients, a result of the expansion of taxanes into the neoadjuvant and adjuvant settings, will respond to taxane retreatment for metastatic disease. Taxane treatment seems likely to continue to play an important role in the treatment of MBC.

scholarly journals A Review of the Potential Role of Human Cytomegalovirus (HCMV) Infections in Breast Cancer Carcinogenesis and Abnormal Immunity

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1842 ◽  
Author(s):  
Jürgen Geisler ◽  
Joel Touma ◽  
Afsar Rahbar ◽  
Cecilia Söderberg-Nauclér ◽  
Katja Vetvik
Keyword(s):  
Breast Cancer ◽  
Human Cytomegalovirus ◽  
Triple Negative ◽  
Breast Tumors ◽  
Active Role ◽  
Gene Products ◽  
Breast Cancers ◽  
Wide Range

Previously recognized classical human onco-viruses can regulate complex neoplastic events, and are estimated to play a role during carcinogenesis in 15–20% of cancer cases. Although the DNA and gene products of several viruses have been found in breast tumors, none of the classical onco-viruses have definitely been linked to the initiation of breast cancer. However, recent evidence shows that human cytomegalovirus (HCMV) gene products are found in >90% of tumors and metastases of breast cancers, and their increased expression can be correlated to a more aggressive breast cancer phenotype. Supporting the active role of HCMV in breast cancer, a specific HCMV strain, HCMV-DB, was recently shown to exert oncogenic transformational activity in breast epithelial cells in vitro, and to give rise to fast-growing, triple-negative breast tumors when injected into immune deficient mice. The same observation holds true for clinical studies implying increased HCMV protein expression in triple negative breast cancer biopsies. In addition to functionally being able to hijack tumor-promoting cellular events, HCMV is known to exhibit a wide range of immunosuppressive effects, which can have radical impact on the tumor microenvironment. HCMV infected cells can avoid recognition and elimination by the immune system by orchestrating polarization of immunosuppressive type II macrophages, preventing antigen presentation, by expressing T cell inhibitory molecules, and possibly, by the induction of regulatory T (Treg) cell responses. These actions would be especially deleterious for the antigenic activation and proliferation of tumor specific CD8+ cytotoxic T lymphocytes (CTLs), whose effector functions have recently been targeted by successful, experimental immunotherapy protocols. The recognition of alternative causes and drivers of breast cancer is a pivotal research topic for the development of diagnostics and novel, effective preventive and therapeutic strategies targeting both tumor cells and their microenvironments.

Conceptual metaphor theory

2008 ◽  
Vol 6 ◽  
pp. 168-184 ◽  
Author(s):  
Zoltán Kövecses
Keyword(s):  
Cognitive Linguistics ◽  
Standard Theory ◽  
Top Down ◽  
Conceptual Metaphor Theory ◽  
The Past ◽  
Cognitive Metaphor ◽  
Wide Range ◽  
Metaphor Theory ◽  
Basic Level

Despite its popularity in and outside cognitive linguistics, cognitive metaphor theory (CMT) has received a wide range of criticisms in the past two decades. Several metaphor researchers have criticized the methodology with which metaphor is studied (emphasizing concepts instead of words), the direction of analysis (emphasizing a top-down instead of a bottom-up approach), the category level of metaphor (claiming its superordinate status instead of basic level), the embodiment of metaphor (emphasizing the universal, mechanical, and monolithic aspects instead of nonuniversal, nonmechanical, and nonmonolithic aspects of embodiment), and its relationship to culture (emphasizing the role of universal bodily experience instead of the interaction of body and context). In the paper, I respond to this criticism largely based on my own research and propose a view on these issues that can successfully meet these challenges and that can be regarded as an alternative to the “standard theory.”

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