Micro-Particle Image Velocimetry Investigation of Flow Fields of SonoVue Microbubbles Mediated by Ultrasound and Their Relationship With Delivery

Flow structures and pressure drops were investigated in rectangular serpentine micro-channels with miter bends which had hydraulic diameters of 0.209mm, 0.395mm and 0.549mm respectively. To evaluate the bend effect, the additional pressure drop due to the miter bend must be obtained. Three groups of micro-channels were fabricated to remove the inlet and outlet losses. A validated micro-particle image velocimetry (μPIV) system was used to achieve the flow structure in a serpentine micro-channel with hydraulic diameter of 0.173mm. The experimental results show the vortices around the outer and inner walls of the bend do not form when Re<100. Those vortices appear and continue to develop with the Re number when Re> 100-300, and the shape and size of the vortices almost remain constant when Re>1000. The bend loss coefficient Kb was observed to be related with the Re number when Re<100, with the Re number and channel size when Re>100. It almost keeps constant and changes in the range of ± 10% When Re is larger than some value in 1300-1500. And a size effect on Kb was also observed.

Download Full-text

Measurement of periodic micro flows using micro-particle image velocimetry with phase sampling

Microfluidics and Nanofluidics ◽

10.1007/s10404-012-1132-2 ◽

2013 ◽

Vol 15 (1) ◽

pp. 127-135 ◽

Cited By ~ 2

Author(s):

Wen-I Wu ◽

Daniel Ewing ◽

Chan Y. Ching ◽

P. R. Selvaganapathy

Keyword(s):

Particle Image Velocimetry ◽

Particle Image ◽

Micro Particle Image Velocimetry ◽

Image Velocimetry ◽

Phase Sampling ◽

Micro Flows

Download Full-text

Fluid Dynamic Analysis of the 50 cc Penn State Artificial Heart Under Physiological Operating Conditions Using Particle Image Velocimetry

Journal of Biomechanical Engineering ◽

10.1115/1.1798056 ◽

2004 ◽

Vol 126 (5) ◽

pp. 585-593 ◽

Cited By ~ 24

Author(s):

Pramote Hochareon ◽

Keefe B. Manning ◽

Arnold A. Fontaine ◽

John M. Tarbell ◽

Steven Deutsch

Keyword(s):

Particle Image Velocimetry ◽

Artificial Heart ◽

Particle Image ◽

Flow Fields ◽

Design Tool ◽

Operating Conditions ◽

Shear Rates ◽

Heart Chamber ◽

Image Velocimetry ◽

Penn State

In order to bridge the gap of existing artificial heart technology to the diverse needs of the patient population, we have been investigating the viability of a scaled-down design of the current 70 cc Penn State artificial heart. The issues of clot formation and hemolysis may become magnified within a 50 cc chamber compared to the existing 70 cc one. Particle image velocimetry (PIV) was employed to map the entire 50 cc Penn State artificial heart chamber. Flow fields constructed from PIV data indicate a rotational flow pattern that provides washout during diastole. In addition, shear rate maps were constructed for the inner walls of the heart chamber. The lateral walls of the mitral and aortic ports experience high shear rates while the upper and bottom walls undergo low shear rates, with sufficiently long exposure times to potentially induce platelet activation or thrombus formation. In this study, we have demonstrated that PIV may adequately map the flow fields accurately in a reasonable amount of time. Therefore, the potential exists of employing PIV as a design tool.

Download Full-text

A Review of Planar PIV Systems and Image Processing Tools for Lab-On-Chip Microfluidics

Sensors ◽

10.3390/s18093090 ◽

2018 ◽

Vol 18 (9) ◽

pp. 3090 ◽

Cited By ~ 1

Author(s):

Fahrettin Ergin ◽

Bo Watz ◽

Nicolai Gade-Nielsen

Keyword(s):

Image Processing ◽

Particle Image Velocimetry ◽

Particle Image ◽

Relevant Information ◽

Droplet Formation ◽

Field Investigation ◽

Cell Counting ◽

Lab On Chip ◽

Micro Particle Image Velocimetry ◽

Image Velocimetry

Image-based sensor systems are quite popular in micro-scale flow investigations due to their flexibility and scalability. The aim of this manuscript is to provide an overview of current technical possibilities for Particle Image Velocimetry (PIV) systems and related image processing tools used in microfluidics applications. In general, the PIV systems and related image processing tools can be used in a myriad of applications, including (but not limited to): Mixing of chemicals, droplet formation, drug delivery, cell counting, cell sorting, cell locomotion, object detection, and object tracking. The intention is to provide some application examples to demonstrate the use of image processing solutions to overcome certain challenges encountered in microfluidics. These solutions are often in the form of image pre- and post-processing techniques, and how to use these will be described briefly in order to extract the relevant information from the raw images. In particular, three main application areas are covered: Micro mixing, droplet formation, and flow around microscopic objects. For each application, a flow field investigation is performed using Micro-Particle Image Velocimetry (µPIV). Both two-component (2C) and three-component (3C) µPIV systems are used to generate the reported results, and a brief description of these systems are included. The results include detailed velocity, concentration and interface measurements for micromixers, phase-separated velocity measurements for the micro-droplet generator, and time-resolved (TR) position, velocity and flow fields around swimming objects. Recommendations on, which technique is more suitable in a given situation are also provided.

Download Full-text