scholarly journals Dosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application

2021 ◽  
Vol 11 (21) ◽  
pp. 9823
Author(s):  
Sergio Mingo Barba ◽  
Francesco Schillaci ◽  
Roberto Catalano ◽  
Giada Petringa ◽  
Daniele Margarone ◽  
...  
Keyword(s):  
Experimental Data ◽  
Laser Plasma ◽  
Irradiation Time ◽  
Transmission Efficiency ◽  
Ion Beams ◽  
Proton Beams ◽  
Short Irradiation Time ◽  
Intermediate Energies ◽  
Proton Source ◽  
Sample Irradiation

ELIMED has been developed and installed at ELI beamlines as a part of the ELIMAIA beamline to transport, monitor, and use laser-driven ion beams suitable for multidisciplinary applications, including biomedical ones. This paper aims to investigate the feasibility to perform radiobiological experiments using laser-accelerated proton beams with intermediate energies (up to 30 MeV). To reach this goal, we simulate a proton source based on experimental data like the ones expected to be available in the first phase of ELIMED commissioning by using the G4-ELIMED application (an application based on the Geant4 toolkit that simulates the full ELIMED beamline). This allows the study of transmission efficiency and the final characteristics of the proton beam at the sample irradiation point. The Energy Selector System is used as an active energy modulator to obtain the desired beam features in a relatively short irradiation time (around 6 min). Furthermore, we demonstrate the capability of the beamline to filter out other ion contaminants, typically co-accelerated in a laser-plasma environment. These results can be considered as a detailed feasibility study for the use of ELIMED for various user applications such as radiobiological experiments with ultrahigh dose rate proton beams.

A Caged E3 Ligase Ligand for PROTAC-Mediated Protein Degradation with Light

2019 ◽  
Author(s):  
Cyrille Kounde ◽  
Maria M. Shchepinova ◽  
Edward Tate
Keyword(s):  
Protein Degradation ◽  
Irradiation Time ◽  
E3 Ligase ◽  
Von Hippel Lindau ◽  
Short Irradiation ◽  
Short Irradiation Time ◽  
Spatiotemporal Control

A caging group has been appended to a widely used Von Hippel Lindau (VHL) E3 ligase ligand for targeted protein degradation with PROTACs. Proteolysis is triggered only after a short irradiation time allowing spatiotemporal control of the protein’s fate.

The study of the refractive scattering of 6Li and 6He on carbon target with the S-matrix approach

2021 ◽  
Vol 36 (36) ◽  
Author(s):  
Liyuan Hu ◽  
Yushou Song ◽  
Yingwei Hou ◽  
Huilan Liu ◽  
Gongming Yu
Keyword(s):  
Experimental Data ◽  
Elastic Scattering ◽  
Forward Direction ◽  
Matrix Approach ◽  
Carbon Target ◽  
Intermediate Energies ◽  
S Matrix ◽  
Bombarding Energy

In this paper, the S-matrix parametrization is adopted to analyze the refractive scattering of [Formula: see text] at intermediate energies systematically and that of [Formula: see text] at 230 MeV. For [Formula: see text], the experimental data containing the Fraunhofer oscillations and the rainbow falloff are reproduced very well by adjusting parameters. The S-matrix parameters and the rainbow angles show evident tendencies as the bombarding energy increases, which are comparable with those of [Formula: see text] elastic scattering on carbon target. For [Formula: see text], the experimental data in the forward direction are reproduced successfully by slightly adjusting the parameters used in the calculation of [Formula: see text] at 210 MeV. The calculated results show that the [Formula: see text] scattering exhibits a comparable transparency with that of [Formula: see text] at intermediate energies.

scholarly journals In-beam tests of a PET demonstrator (LAPD) for hadrontherapy beam ballistic control: data comparison to Geant4 Monte-Carlo predictions

2020 ◽  
Vol 225 ◽  
pp. 09005
Author(s):  
Sébastien Binet ◽  
Arthur Bongrand ◽  
Emmanuel Busato ◽  
Christophe Insa ◽  
Daniel Lambert ◽  
...  
Keyword(s):  
Experimental Data ◽  
Monte Carlo ◽  
Mechanical Characteristics ◽  
Ion Beams ◽  
Cancer Treatments ◽  
Control Data ◽  
Data Comparison ◽  
Large Acceptance ◽  
Ballistic Control

This paper describes a small prototype of an in beam PET like detector, named ”Large Acceptance Pixelized Detector” (LAPD), developed to test technical concepts for the ion range control in the context of cancer treatments using proton or ion beams. The mechanical characteristics of this detector together with the read-out electronics are first presented. Then, results of a first experiment, performed on a 65 MeV proton beamline, are reported. Finally, we discuss the ability of Geant4 Monte-Carlo to reproduce the experimental data.

scholarly journals Quasi-monoenergetic proton beams by laser-plasma X-rays

2014 ◽  
Vol 508 ◽  
pp. 012003
Author(s):  
D Delle Side ◽  
J Krása ◽  
V Nassisi ◽  
L Velardi
Keyword(s):  
Laser Plasma ◽  
X Rays ◽  
Proton Beams

scholarly journals Beam and target optimization for energy production in accelerator driven systems

2019 ◽  
Vol 204 ◽  
pp. 04001
Author(s):  
Mihaela Paraipan ◽  
Anton A. Baldin ◽  
Elina G. Baldina ◽  
Serguey I. Tyutyunikov
Keyword(s):  
Energy Efficiency ◽  
Metal Oxide ◽  
Energy Production ◽  
Ion Beams ◽  
Target Structure ◽  
Safe Operation ◽  
Proton Beams ◽  
Driven Systems ◽  
Accelerator Driven Systems ◽  
Different Levels

The new concept of light nuclear beams instead of proton beams for ADS is substantiated. The influence of the target structure on the energy efficiency of 0.5-4 GeV proton beams and 0.25 – 0.5 AGeV light ion beams is studied. The target consists of rods with different composition (metal, oxide, carbide) and different levels of enrichment in order to implement the target with a criticality coefficient of 0.96 -0.97, which ensures safe operation. The cooling with different metals (lead, lead-bismuth eutectic - LBE, and sodium) is compared. The use of converters from very light materials (lithium, beryllium, carbon) and their influence on the neutron spectrum and energy released are analysed.

Laser-plasma ion beams-experiments towards charge transfer x-ray laser

1993 ◽  
Author(s):  
J. R. Crespo López-Urrutia ◽  
E. E. Fill ◽  
R. Bruch ◽  
D. Schneider
Keyword(s):  
Charge Transfer ◽  
Laser Plasma ◽  
Ion Beams ◽  
X Ray

Fast Ignition With Laser-Driven Ion Beams: Progress On Ignitor Beam Development Based On A New Relativistic Laser-Plasma Regime

CLEO: 2013 ◽  
2013 ◽  
Author(s):  
J. C. Fernández ◽  
B. J. Albright ◽  
D. Gautier ◽  
C. E. Hamilton ◽  
B. M. Hegelich ◽  
...  
Keyword(s):  
Laser Plasma ◽  
Fast Ignition ◽  
Ion Beams

HOW TO CALIBRATE THE TIME SCALE OF EMISSION OF INTERMEDIATE MASS FRAGMENTS

2005 ◽  
Vol 14 (03) ◽  
pp. 353-357 ◽  
Author(s):  
J. WILCZYŃSKI ◽  
E. DE FILIPPO ◽  
A. PAGANO ◽  
F. AMORINI ◽  
A. ANZALONE ◽  
...  
Keyword(s):  
Experimental Data ◽  
Time Scale ◽  
Time Sequence ◽  
Intermediate Mass ◽  
Intermediate Energies

In order to obtain information on the time sequence and time scale of the production of intermediate mass fragments (IMF) in nucleus-nucleus collisions at intermediate energies it is proposed to analyze correlations between relative velocities of IMF's with respect to projectile-like fragments (PLF) and target-like fragments (TLF). Experimental data on the production of IMF's in the 124 Sn +64 Ni reaction, taken with the CHIMERA multidetector array at 35 MeV/nucleon, have been analyzed with the proposed method.

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