scholarly journals The Association between Anemia and Parkinson’s Disease: A Nested Case-Control Study Using a National Health Screening Cohort

2021 ◽  
Vol 11 (5) ◽  
pp. 623
Author(s):  
Ji Hee Kim ◽  
Jae Keun Oh ◽  
Jee Hye Wee ◽  
Chan Yang Min ◽  
Dae Myoung Yoo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
National Health ◽  
Smoking Status ◽  
Multiple Logistic Regression Analysis ◽  
Fasting Blood Glucose ◽  
National Sample ◽  
Case Control ◽  
Region Of Residence ◽  
Nested Case Control

(1) Background: Controversy exists regarding the relationship between anemia and Parkinson’s disease (PD). This study aimed to evaluate the risk of PD related to anemia in the Korean population. (2) Methods: The Korean National Health Insurance Service-National Sample Cohort, which includes adults over 40 years of age, was assessed from 2002 to 2015. A total of 5844 PD patients were matched by age, sex, income, and region of residence with 23,376 control participants at a ratio of 1:4. The analyzed covariates included age, sex, blood pressure, fasting blood glucose, obesity, smoking status, and alcohol consumption. A multiple logistic regression analysis was conducted for case-control analyses. (3) Results: The adjusted odds ratio (OR) for the risk of PD associated with anemia was 1.09 after adjusting for potential confounders (95% confidence interval (CI) 1.01–1.18, p = 0.030). Among men younger than 70 years, the adjusted OR of PD was 1.34 (95% CI 1.13–1.60, p = 0.001). (4) Conclusions: Our findings suggest that anemia may increase the risk of PD, particularly in men younger than 70 years. Further research is required to elucidate the causal relationship between these two diseases.

Association Between Thyroid Diseases and Parkinson’s Disease: A Nested Case-Control Study Using a National Health Screening Cohort

2020 ◽  
pp. 1-10
Author(s):  
Ji Hee Kim ◽  
Heui Seung Lee ◽  
Jun Hyong Ahn ◽  
Jae Keun Oh ◽  
In Bok Chang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
National Health ◽  
National Sample ◽  
Thyroid Diseases ◽  
Control Group ◽  
Region Of Residence ◽  
Pituitary Thyroid Axis ◽  
Nested Case Control ◽  
Levothyroxine Treatment

Background: Although the dopaminergic system is interconnected with the hypothalamic-pituitary-thyroid axis, few studies have explained the causal relationship between thyroid disease and Parkinson’s disease (PD). Objective: The goal of this study was to investigate the association between thyroid diseases and PD in Korean residents. Methods: The Korean National Health Insurance Service-National Sample Cohort, which includes individuals aged ≥40 years, was assessed from 2002 to 2015. A total of 5,586 PD patients were matched by age, sex, income, and the region of residence with 22,344 control participants at a ratio of 1:4. In the PD and control groups, previous histories of levothyroxine treatment, goiter, hypothyroidism, thyroiditis, and hyperthyroidism were investigated. Results: The rates of levothyroxine treatment for more than 3 months, hypothyroidism, and hyperthyroidism were higher in the PD group than the control group (3.2%, 3.8%, and 2.8% vs. 2.5%, 2.9%, and 1.9%, respectively, p <  0.05). The adjusted odds ratios (ORs) in model 2, which was adjusted for all potential confounders, for hypothyroidism and hyperthyroidism in the PD group were 1.25 (95% confidence interval (CI) 1.01–1.55, p = 0.044) and 1.37 (95% CI 1.13–1.67, p = 0.002), respectively. In subgroup analyses, the association between hypothyroidism and PD was maintained in men older than 70 years and the association between hyperthyroidism and PD was maintained in women younger than 70 years. Conclusion: Both hyperthyroidism and hypothyroidism were associated with higher risk of PD, particularly for women younger than 70 years and men older than 70 years, respectively.

scholarly journals Risk of neurodegenerative dementia in asthma patients: a nested case–control study using a national sample cohort

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e030227 ◽  
Author(s):  
So Young Kim ◽  
Chanyang Min ◽  
Dong Jun Oh ◽  
Hyo Geun Choi
Keyword(s):  
Case Control Study ◽  
Previous History ◽  
National Sample ◽  
Case Control ◽  
Region Of Residence ◽  
Neurodegenerative Dementia ◽  
Icd 10 ◽  
History Of ◽  
Nested Case Control ◽  
Control Study

ObjectivesThis study investigated the risk of neurodegenerative dementia following asthma.DesignA nested case–control studySettingThe ≥60-year-old population was selected from the Korean Health Insurance Review and Assessment Service – National Sample Cohort from 2002 to 2013.Participants and interventionsThe 11 442 dementia cases were matched with 45 768 control cases for age, sex, income, region of residence, hypertension, diabetes and dyslipidaemia. Asthma was classified using International Classification of Disease-10 (ICD-10) codes (J45 and J46) and medication history. Dementia was identified based on ICD-10 codes (G30 and F00).Primary and secondary outcome measuresThe ORs of a previous history of asthma in patients with dementia were analysed using conditional logistic regression analysis stratified for age, sex, income, region of residence, hypertension, diabetes and dyslipidaemia. Subgroup analysis was performed according to age and sex.ResultsOverall, 22.6% (2587/11 442) and 22.3% (10 229/45 768) of the cases in the dementia and control groups, respectively, had a previous history of asthma. The OR for asthma in the dementia group was not higher than that in the control group (adjusted OR=0.97, 95% CI 0.92 to 1.02, p=0.207). All age and sex subgroups demonstrated consistent results.ConclusionsAsthma was not related to an increased risk of dementia.

scholarly journals Prodromal symptoms and early detection of Parkinson's disease in general practice: a nested case-control study

2014 ◽  
Vol 31 (4) ◽  
pp. 373-378 ◽  
Author(s):  
A. O. A. Plouvier ◽  
R. J. M. G. Hameleers ◽  
E. A. J. van den Heuvel ◽  
H. H. Bor ◽  
T. C. Olde Hartman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
General Practice ◽  
Early Detection ◽  
Case Control Study ◽  
Case Control ◽  
Prodromal Symptoms ◽  
Nested Case Control ◽  
Control Study

scholarly journals Skin Cancer May Delay Onset but Not Progression of Parkinson's Disease: A Nested Case-Control Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Abhimanyu Mahajan ◽  
Martina Chirra ◽  
Alok K. Dwivedi ◽  
Andrea Sturchio ◽  
Elizabeth G. Keeling ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Skin Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Use of non-steroidal anti-inflammatory drugs and risk of Parkinson's disease: nested case-control study

BMJ ◽  
2011 ◽  
Vol 342 (jan20 1) ◽  
pp. d198-d198 ◽  
Author(s):  
J. A. Driver ◽  
G. Logroscino ◽  
L. Lu ◽  
J. M. Gaziano ◽  
T. Kurth
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Nested Case Control ◽  
Control Study

β-Adrenoceptor Drugs and Parkinson’s Disease: A Nationwide Nested Case–Control Study

CNS Drugs ◽  
2020 ◽  
Vol 34 (7) ◽  
pp. 763-772
Author(s):  
Sibylle de Germay ◽  
Cécile Conte ◽  
Olivier Rascol ◽  
Jean-Louis Montastruc ◽  
Maryse Lapeyre-Mestre
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Association between Temporomandibular Joint Disorder and Parkinson’s Disease

2021 ◽  
Vol 11 (6) ◽  
pp. 747
Author(s):  
Hyo-Geun Choi ◽  
Joo-Heung Yoon ◽  
Tae-Hwan Chung ◽  
Chanyang Min ◽  
Dae-Myoung Yoo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Temporomandibular Disorder ◽  
Fasting Blood Glucose ◽  
Population Data ◽  
Population Based ◽  
Large Set ◽  
Joint Disorder ◽  
Korean National Health Insurance ◽  
Nested Case Control

This study performed two different analyses using a large set of population data from the Korean National Health Insurance Service Health Screening Cohort to evaluate the interactional association between temporomandibular disorder (TMD) and Parkinson’s disease (PD). Two nested case–control population-based studies were conducted on 514,866 participants. In Study I, 4455 participants with TMD were matched with 17,820 control participants, with a ratio of 1:4. In Study II, 6076 participants with PD were matched with 24,304 control participants, with a ratio of 1:4. Obesity, smoking, alcohol consumption, systolic, diastolic blood pressure, fasting blood glucose level, and total cholesterol were adjusted. The adjusted odds ratio (OR) for TMD was 1.43 (95% confidence interval (CI) = 1.02–2.00) in PD patients compared to non-PD patients in Study I (p < 0.001). The adjusted OR for PD was 1.56 (95% CI = 1.13–2.15) in TMD patients compared to non-TMD patients in Study II (p = 0.007). This study demonstrated that patients with TMD have a significantly higher risk of developing PD and, conversely, those with PD have a significantly higher risk of developing TMD.

Non-motor features of Parkinson’s disease in a nested case–control study of US men

2018 ◽  
Vol 89 (12) ◽  
pp. 1288-1295 ◽  
Author(s):  
Katherine C Hughes ◽  
Xiang Gao ◽  
Jessica M Baker ◽  
Christopher Stephen ◽  
Iris Y Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Rapid Eye Movement Sleep ◽  
Sleep Behaviour ◽  
Nested Case Control ◽  
Control Study ◽  
Smell Identification

BackgroundSeveral non-motor features may individually contribute to identify prodromal Parkinson’s disease (PD), but little is known on how they interact.MethodsWe conducted a case–control study nested within the Health Professionals Follow-up Study in a large cohort of men age 40–75 at recruitment in 1986. Cases (n=120) had confirmed PD, were<85 in January 2012, returned a 2012 questionnaire with questions on probable rapid eye movement sleep behaviour disorder (RBD) and constipation sent to all cohort participants and completed in 2014 the Brief Smell Identification Test and a questionnaire assessing parkinsonism and other non-motor PD features (including depressive symptoms, excessive daytime sleepiness, impaired colour vision and body pain). Controls (n=6479) met the same criteria as cases, except for the PD diagnosis.ResultsConcurrent constipation, probable RBD and hyposmia were present in 29.3% of cases and 1.1% of controls, yielding an age-adjusted OR of 160(95%CI 72.8to353) for three features versus none. The odds of PD increased exponentially with additional non-motor features (OR for 6–7 features versus none: 1325; 95%CI333to5279). Among men without PD, the number of non-motor features was associated with odds of parkinsonism (OR for 6–7 features versus none: 89; 95%CI21.2to375). We estimated that in a population with a prodromal PD prevalence of 2%, concurrent constipation, probable RBD and hyposmia would have a maximum sensitivity of 29% and a positive predictive value (PPV) of 35%. The PPV could increase up to 70% by including additional features, but with sharply decreased sensitivity.ConclusionsConcurrent constipation, probable RBD and hyposmia are strongly associated with PD. Because these features often precede motor symptoms and their co-occurrence could provide an efficient method for early PD identification.

Recurrent falls in Parkinson’s disease after one year of follow-up: A nested case-control study

2016 ◽  
Vol 65 ◽  
pp. 17-24 ◽  
Author(s):  
Tatjana Gazibara ◽  
Darija Kisic Tepavcevic ◽  
Marina Svetel ◽  
Aleksandra Tomic ◽  
Iva Stankovic ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Control Study ◽  
Case Control ◽  
Recurrent Falls ◽  
One Year ◽  
Nested Case Control ◽  
Control Study
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