scholarly journals Association between Temporomandibular Joint Disorder and Parkinson’s Disease

2021 ◽  
Vol 11 (6) ◽  
pp. 747
Author(s):  
Hyo-Geun Choi ◽  
Joo-Heung Yoon ◽  
Tae-Hwan Chung ◽  
Chanyang Min ◽  
Dae-Myoung Yoo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Temporomandibular Disorder ◽  
Fasting Blood Glucose ◽  
Population Data ◽  
Population Based ◽  
Large Set ◽  
Joint Disorder ◽  
Korean National Health Insurance ◽  
Nested Case Control

This study performed two different analyses using a large set of population data from the Korean National Health Insurance Service Health Screening Cohort to evaluate the interactional association between temporomandibular disorder (TMD) and Parkinson’s disease (PD). Two nested case–control population-based studies were conducted on 514,866 participants. In Study I, 4455 participants with TMD were matched with 17,820 control participants, with a ratio of 1:4. In Study II, 6076 participants with PD were matched with 24,304 control participants, with a ratio of 1:4. Obesity, smoking, alcohol consumption, systolic, diastolic blood pressure, fasting blood glucose level, and total cholesterol were adjusted. The adjusted odds ratio (OR) for TMD was 1.43 (95% confidence interval (CI) = 1.02–2.00) in PD patients compared to non-PD patients in Study I (p < 0.001). The adjusted OR for PD was 1.56 (95% CI = 1.13–2.15) in TMD patients compared to non-TMD patients in Study II (p = 0.007). This study demonstrated that patients with TMD have a significantly higher risk of developing PD and, conversely, those with PD have a significantly higher risk of developing TMD.

scholarly journals The Association between Anemia and Parkinson’s Disease: A Nested Case-Control Study Using a National Health Screening Cohort

2021 ◽  
Vol 11 (5) ◽  
pp. 623
Author(s):  
Ji Hee Kim ◽  
Jae Keun Oh ◽  
Jee Hye Wee ◽  
Chan Yang Min ◽  
Dae Myoung Yoo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
National Health ◽  
Smoking Status ◽  
Multiple Logistic Regression Analysis ◽  
Fasting Blood Glucose ◽  
National Sample ◽  
Case Control ◽  
Region Of Residence ◽  
Nested Case Control

(1) Background: Controversy exists regarding the relationship between anemia and Parkinson’s disease (PD). This study aimed to evaluate the risk of PD related to anemia in the Korean population. (2) Methods: The Korean National Health Insurance Service-National Sample Cohort, which includes adults over 40 years of age, was assessed from 2002 to 2015. A total of 5844 PD patients were matched by age, sex, income, and region of residence with 23,376 control participants at a ratio of 1:4. The analyzed covariates included age, sex, blood pressure, fasting blood glucose, obesity, smoking status, and alcohol consumption. A multiple logistic regression analysis was conducted for case-control analyses. (3) Results: The adjusted odds ratio (OR) for the risk of PD associated with anemia was 1.09 after adjusting for potential confounders (95% confidence interval (CI) 1.01–1.18, p = 0.030). Among men younger than 70 years, the adjusted OR of PD was 1.34 (95% CI 1.13–1.60, p = 0.001). (4) Conclusions: Our findings suggest that anemia may increase the risk of PD, particularly in men younger than 70 years. Further research is required to elucidate the causal relationship between these two diseases.

scholarly journals Prevalence of temporomandibular joint disorder in people with Parkinson’s disease in a public university hospital

Revista CEFAC ◽  
2019 ◽  
Vol 21 (3) ◽  
Author(s):  
Renato Mariano da Silva ◽  
Vilma Lucia dos Santos ◽  
Taysa Vannoska de Almeida Silva ◽  
Carla Cabral dos Santos Accioly Lins
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Oral Health ◽  
Temporomandibular Joint ◽  
Temporomandibular Disorders ◽  
Temporomandibular Disorder ◽  
Public University ◽  
University Hospital ◽  
Temporomandibular Joint Disorder ◽  
Joint Disorder

ABSTRACT Objective: to evaluate the prevalence of temporomandibular joint disorder in people with Parkinson’s disease in a public university hospital, and relate it to sociodemographic factors, general health and oral health self-report, and phase and time of illness. Methods: the Research Diagnostic Criteria for Temporomandibular Disorders were used. The sample was classified according to the diagnosis of temporomandibular disorder and associated with the variables. The odds ratio of Chi-square was applied with a 95% confidence interval and a level of significance set at p<0.05. Results: 110 people presented with Parkinson's disease were assessed. The prevalence of temporomandibular disorder was 35%, being more frequent among males (58%), in elderly people (53%), in phase 2 of the disease (61%), click (37%) being the predominant clinical indication. Of the variables analyzed, only gender and self-perception of oral health showed to be associated with temporomandibular disorders. Conclusion: the presence of temporomandibular disorder has been observed in people with Parkinson's disease, and the fact of being male and reporting moderate oral health seen as associated factors.

scholarly journals Decreased Risk of Parkinson’s Disease After Rheumatoid Arthritis Diagnosis: A Nested Case-Control Study with Matched Cases and Controls

2021 ◽  
pp. 1-12
Author(s):  
Jonas Bacelis ◽  
Michele Compagno ◽  
Sonia George ◽  
Andrew Pospisilik ◽  
Patrik Brundin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Risk Reduction ◽  
Odds Ratio ◽  
Later Life ◽  
Population Based ◽  
National Patient ◽  
Nested Case Control

Background: Rheumatoid arthritis (RA) and the genetic risk landscape of autoimmune disorders and Parkinson’s disease overlap. Additionally, anti-inflammatory medications used to treat RA might influence PD risk. Objective: To use a population-based approach to determine if there is an association between pre-occurring rheumatoid arthritis (RA) and later-life risk of Parkinson’s disease (PD). Methods: The study population was 3.6 million residents of Sweden, who were alive during part or all of the follow-up period; 1997–2016. We obtained diagnoses from the national patient registry and identified 30,032 PD patients, 8,256 of whom each was matched to ten controls based on birth year, sex, birth location, and time of follow-up. We determined the risk reduction for PD in individuals previously diagnosed with RA. We also determined if the time (in relation to the index year) of the RA diagnosis influenced PD risk and repeated the analysis in a sex-stratified setting. Results: Individuals with a previous diagnosis of RA had a decreased risk of later developing PD by 30–50% compared to individuals without an RA diagnosis. This relationship was strongest in our conservative analysis, where the first PD diagnosis occurred close to the earliest PD symptoms (odds ratio 0.47 (CI 95% 0.28–0.75, p = 0.0006); with the greatest risk reduction in females (odds ratio 0.40 (CI 95% 0,19 –0.76, p = 0.002). Discussion: Our findings provide evidence that individuals diagnosed with RA have a significantly lower risk of developing PD than the general population. Our data should be considered when developing or repurposing therapies aimed at modifying the course of PD.

Migraine is related to an increased risk of Parkinson’s disease: A population-based, propensity score-matched, longitudinal follow-up study

Cephalalgia ◽  
2016 ◽  
Vol 36 (14) ◽  
pp. 1316-1323 ◽  
Author(s):  
Hsin-I Wang ◽  
Yu-Chun Ho ◽  
Ya-Ping Huang ◽  
Shin-Liang Pan
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Survival Rate ◽  
Propensity Score ◽  
Population Based ◽  
Free Survival ◽  
Follow Up Study ◽  
Increased Risk ◽  
Migraine Group

Background The association between migraine and Parkinson’s disease (PD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether migraineurs are at a higher risk of developing PD. Methods A total of 41,019 subjects aged between 40 and 90 years with at least two ambulatory visits with a diagnosis of migraine in 2001 were enrolled in the migraine group. A logistic regression model that included age, sex, pre-existing comorbidities and socioeconomic status as covariates was used to compute the propensity score. The non-migraine group consisted of 41,019 propensity score-matched, randomly sampled subjects without migraine. The PD-free survival rate were estimated using the Kaplan–Meier method. Stratified Cox proportional hazard regression was used to estimate the effect of migraine on the risk of developing PD. Results During follow-up, 148 subjects in the migraine group and 101 in the non-migraine group developed PD. Compared to the non-migraine group, the hazard ratio of PD for the migraine group was 1.64 (95% confidence interval: 1.25–2.14, p = 0.0004). The PD-free survival rate for the migraine group was significantly lower than that for the non-migraine group ( p = 0.0041). Conclusions This study showed an increased risk of developing PD in patients with migraine.

scholarly journals Trend of recognizing depression symptoms and antidepressants use in newly diagnosed Parkinson's disease: Population‐based study

2021 ◽  
Author(s):  
Khalid Orayj ◽  
Tahani Almeleebia ◽  
Easwaran Vigneshwaran ◽  
Sultan Alshahrani ◽  
Sirajudeen. S. Alavudeen ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Population Based ◽  
Depression Symptoms ◽  
Newly Diagnosed ◽  
Population Based Study

Association Between Thyroid Diseases and Parkinson’s Disease: A Nested Case-Control Study Using a National Health Screening Cohort

2020 ◽  
pp. 1-10
Author(s):  
Ji Hee Kim ◽  
Heui Seung Lee ◽  
Jun Hyong Ahn ◽  
Jae Keun Oh ◽  
In Bok Chang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
National Health ◽  
National Sample ◽  
Thyroid Diseases ◽  
Control Group ◽  
Region Of Residence ◽  
Pituitary Thyroid Axis ◽  
Nested Case Control ◽  
Levothyroxine Treatment

Background: Although the dopaminergic system is interconnected with the hypothalamic-pituitary-thyroid axis, few studies have explained the causal relationship between thyroid disease and Parkinson’s disease (PD). Objective: The goal of this study was to investigate the association between thyroid diseases and PD in Korean residents. Methods: The Korean National Health Insurance Service-National Sample Cohort, which includes individuals aged ≥40 years, was assessed from 2002 to 2015. A total of 5,586 PD patients were matched by age, sex, income, and the region of residence with 22,344 control participants at a ratio of 1:4. In the PD and control groups, previous histories of levothyroxine treatment, goiter, hypothyroidism, thyroiditis, and hyperthyroidism were investigated. Results: The rates of levothyroxine treatment for more than 3 months, hypothyroidism, and hyperthyroidism were higher in the PD group than the control group (3.2%, 3.8%, and 2.8% vs. 2.5%, 2.9%, and 1.9%, respectively, p <  0.05). The adjusted odds ratios (ORs) in model 2, which was adjusted for all potential confounders, for hypothyroidism and hyperthyroidism in the PD group were 1.25 (95% confidence interval (CI) 1.01–1.55, p = 0.044) and 1.37 (95% CI 1.13–1.67, p = 0.002), respectively. In subgroup analyses, the association between hypothyroidism and PD was maintained in men older than 70 years and the association between hyperthyroidism and PD was maintained in women younger than 70 years. Conclusion: Both hyperthyroidism and hypothyroidism were associated with higher risk of PD, particularly for women younger than 70 years and men older than 70 years, respectively.

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