scholarly journals Brain and Muscle Oxygen Saturation Combined with Kidney Injury Biomarkers Predict Cardiac Surgery Related Acute Kidney Injury

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1591
Author(s):  
Wiktor Szymanowicz ◽  
Ludmiła Daniłowicz-Szymanowicz ◽  
Wojtek Karolak ◽  
Maciej Michał Kowalik ◽  
Romuald Lango
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Oxygen Saturation ◽  
Cystatin C ◽  
Near Infrared ◽  
Kidney Injury ◽  
Tissue Oxygen Saturation ◽  
Muscle Oxygen ◽  
Patients At Risk ◽  
Novel Biomarkers

Background: Early identification of patients at risk for cardiac surgery-associated acute kidney injury (CS-AKI) based on novel biomarkers and tissue oxygen saturation might enable intervention to reduce kidney injury. Aims: The study aimed to ascertain whether brain and muscle oxygenation measured by near-infrared spectroscopy (NIRS), in addition to cystatin C and NGAL concentrations, could help with CS-AKI prediction. Methods: This is a single-centre prospective observational study on adult patients undergoing cardiac surgery using cardiopulmonary bypass (CPB). Brain and muscle NIRS were recorded during surgery. Cystatin C was measured on the first postoperative day, while NGAL directly before and 3 h after surgery. Results: CS-AKI was diagnosed in 18 (16%) of 114 patients. NIRS values recorded 20 min after CPB (with cut-off value ≤ 54.5% for muscle and ≤ 62.5% for the brain) were revealed to be the most accurate predictors of CS-AKI. Preoperative NGAL ≥ 91.5 ng/mL, postoperative NGAL ≥ 140.5 ng/mL, and postoperative cystatin C ≥ 1.23 mg/L were identified as independent and significant CS-AKI predictors. Conclusions: Brain and muscle oxygen saturation 20 min after CPB could be considered early parameters possibly related to CS-AKI risk, especially in patients with increased cystatin C and NGAL levels.

scholarly journals Use of cerebral oxygen saturation and hemoglobin concentration to predict acute kidney injury after cardiac surgery

2017 ◽  
Vol 46 (3) ◽  
pp. 1130-1137 ◽  
Author(s):  
Canan Balci ◽  
Engin Haftaci ◽  
Atike Tekeli Kunt
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Oxygen Saturation ◽  
Near Infrared ◽  
Artery Bypass ◽  
Kidney Injury ◽  
Hemoglobin Concentration ◽  
Cerebral Oximetry ◽  
Cerebral Oxygen Saturation ◽  
Cerebral Oxygen

Objective Acute kidney injury (AKI) is a common complication after cardiac surgery and is associated with significant morbidity and mortality. Near infrared spectroscopy (NIRS) is a noninvasive technique for real-time measurement of cerebral tissue oxygenation. The purpose of the present study was to evaluate the correlation of AKI with hemoglobin and regional cerebral oxygen saturation (rScO2) measured intraoperatively and postoperatively in patients undergoing cardiac surgery. Methods We retrospectively analyzed the prospectively collected data of 45 adult patients with normal renal function who underwent isolated coronary artery bypass grafting (CABG) from January 2014 to May 2014. Kidney injury was assessed according to the Acute Kidney Injury Network criteria. rScO2 and hemoglobin were measured every hour intraoperatively and for the first 24 hours postoperatively. Results The hemoglobin concentration and rScO2 were significantly lower in patients with than without AKI, and no linear trends were observed. No exact cut-off values were obtained. Conclusion This retrospective study shows that a lower rScO2 and hemoglobin concentration are correlated with AKI after CABG in patients with no peripheral vascular disease or recent myocardial infarction. We suggest that cerebral oximetry alone may predict postoperative AKI well.

Regional thigh tissue oxygen saturation during cardiopulmonary bypass predicts acute kidney injury after cardiac surgery

2020 ◽  
Vol 23 (4) ◽  
pp. 315-320
Author(s):  
Kenjiro Sakaki ◽  
Tadashi Kitamura ◽  
Satoshi Kohira ◽  
Shinzo Torii ◽  
Toshiaki Mishima ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Oxygen Saturation ◽  
Kidney Injury ◽  
Tissue Oxygen Saturation ◽  
Tissue Oxygen

scholarly journals Postoperative kidney oxygen saturation as a novel marker for acute kidney injury after adult cardiac surgery

2019 ◽  
Vol 157 (6) ◽  
pp. 2340-2351.e3 ◽  
Author(s):  
Christian Ortega-Loubon ◽  
Manuel Fernández-Molina ◽  
Inmaculada Fierro ◽  
Pablo Jorge-Monjas ◽  
Yolanda Carrascal ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Oxygen Saturation ◽  
Kidney Injury ◽  
Adult Cardiac Surgery

scholarly journals The Relevance of Renal Oxygen Saturation Over Other Markers in Cardiac Surgery–Associated Acute Kidney Injury

2019 ◽  
Vol 33 (10) ◽  
pp. 2622-2623 ◽  
Author(s):  
Christian Ortega-Loubon ◽  
Manuel Fernández-Molina ◽  
Pablo Jorge-Monjas ◽  
Inmaculada Fierro ◽  
Gonzalo Herrera-Calvo ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Oxygen Saturation ◽  
Kidney Injury ◽  
Renal Oxygen

scholarly journals Near-infrared spectroscopy monitoring tissue oxygen saturation after cardiac surgery

Critical Care ◽  
2009 ◽  
Vol 13 (Suppl 1) ◽  
pp. P239
Author(s):  
R Kopp ◽  
S Rex ◽  
K Dommann ◽  
G Schälte ◽  
G Dohmen ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Infrared Spectroscopy ◽  
Oxygen Saturation ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Tissue Oxygen Saturation ◽  
Tissue Oxygen

Acute Kidney Injury following Cardiac Surgery

2015 ◽  
pp. 451-480
Author(s):  
Bryan Romito ◽  
Joseph Meltzer
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Surgical Techniques ◽  
Kidney Injury ◽  
Renal Physiology ◽  
General Management ◽  
Novel Biomarkers ◽  
Short And Long Term ◽  
And Function

The primary goal of this chapter is to provide the reader with an overview of basic renal physiology and function and to review the identification, pathogenesis, and treatment of acute kidney injury following cardiac surgery. Particular focus will be directed toward the diagnostic criteria for acute kidney injury, short- and long-term impacts on patient outcomes, role of novel biomarkers, mechanisms of acute renal injury, general management principles, preventative strategies, and the influence of anesthetic and surgical techniques on its development. The content of this chapter will serve to underscore a particularly harmful but likely underappreciated problem affecting patients in the cardiothoracic critical care setting.

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