scholarly journals Large-Scale Regeneration Patterns of Pinus nigra Subsp. salzmannii: Poor Evidence of Increasing Facilitation Across a Drought Gradient

Forests ◽  
2013 ◽  
Vol 5 (1) ◽  
pp. 1-20 ◽  
Author(s):  
Pedro Tíscar ◽  
Juan Linares
Keyword(s):  
Large Scale ◽  
Pinus Nigra ◽  
Scale Regeneration

scholarly journals Current Proteomic and Metabolomic Knowledge of Zygotic and Somatic Embryogenesis in Plants

2021 ◽  
Vol 22 (21) ◽  
pp. 11807
Author(s):  
Janet Juarez-Escobar ◽  
Esaú Bojórquez-Velázquez ◽  
Jose M. Elizalde-Contreras ◽  
José A. Guerrero-Analco ◽  
Víctor M. Loyola-Vargas ◽  
...  
Keyword(s):  
Somatic Embryogenesis ◽  
Large Scale ◽  
Research Effort ◽  
Zygotic Embryogenesis ◽  
Potential Contribution ◽  
In Vitro Techniques ◽  
Current State ◽  
Scale Regeneration ◽  
State Of Research

Embryogenesis is the primary developmental program in plants. The mechanisms that underlie the regulation of embryogenesis are an essential research subject given its potential contribution to mass in vitro propagation of profitable plant species. Somatic embryogenesis (SE) refers to the use of in vitro techniques to mimic the sexual reproduction program known as zygotic embryogenesis (ZE). In this review, we synthesize the current state of research on proteomic and metabolomic studies of SE and ZE in angiosperms (monocots and dicots) and gymnosperms. The most striking finding was the small number of studies addressing ZE. Meanwhile, the research effort focused on SE has been substantial but disjointed. Together, these research gaps may explain why the embryogenic induction stage and the maturation of the somatic embryo continue to be bottlenecks for efficient and large-scale regeneration of plants. Comprehensive and integrative studies of both SE and ZE are needed to provide the molecular foundation of plant embryogenesis, information which is needed to rationally guide experimental strategies to solve SE drawbacks in each species.

3-D Visualization of Municipal Regeneration using ArcScene

2017 ◽  
Author(s):  
Melissa Fedrigo
Keyword(s):  
Physical Environment ◽  
Large Scale ◽  
3D Visualization ◽  
Business Owners ◽  
Visualization Tool ◽  
Area Of Interest ◽  
Scale Regeneration

This presentation illustrates the use of ArcScene as a 3-D visualization tool in the context of prospective changes to the physical environment of a small municipal community. Before large-scale regeneration is agreed on or fully implemented in a municipality, there is an emphasis on the appearance of the area of interest over the course of the implementation. This presentation will discuss the benefits and limitations of 3D visualization for pre-construction, during, and post-construction presentation to municipal residents, members of council and impacted business owners.

scholarly journals Natural Large-Scale Regeneration of Rib Cartilage in a Mouse Model

2015 ◽  
Vol 30 (2) ◽  
pp. 297-308 ◽  
Author(s):  
Marissa K Srour ◽  
Jennifer L Fogel ◽  
Kent T Yamaguchi ◽  
Aaron P Montgomery ◽  
Audrey K Izuhara ◽  
...  
Keyword(s):  
Mouse Model ◽  
Large Scale ◽  
Rib Cartilage ◽  
Scale Regeneration

scholarly journals Poly(ADP-Ribose) Polymerase-3 Regulates Regeneration in Planarians

2020 ◽  
Vol 21 (3) ◽  
pp. 875
Author(s):  
Paul G. Barghouth ◽  
Peter Karabinis ◽  
Andie Venegas ◽  
Néstor J. Oviedo
Keyword(s):  
Large Scale ◽  
Molecular Mechanisms ◽  
Evolutionary Conservation ◽  
Covalent Attachment ◽  
Post Translational Modification ◽  
Cellular Events ◽  
Adult Body ◽  
Scale Regeneration ◽  
The Central Nervous System ◽  
Transcription And Replication

Protein ADP-ribosylation is a reversible post-translational modification (PTM) process that plays fundamental roles in cell signaling. The covalent attachment of ADP ribose polymers is executed by PAR polymerases (PARP) and it is essential for chromatin organization, DNA repair, cell cycle, transcription, and replication, among other critical cellular events. The process of PARylation or polyADP-ribosylation is dynamic and takes place across many tissues undergoing renewal and repair, but the molecular mechanisms regulating this PTM remain mostly unknown. Here, we introduce the use of the planarian Schmidtea mediterranea as a tractable model to study PARylation in the complexity of the adult body that is under constant renewal and is capable of regenerating damaged tissues. We identified the evolutionary conservation of PARP signaling that is expressed in planarian stem cells and differentiated tissues. We also demonstrate that Smed-PARP-3 homolog is required for proper regeneration of tissues in the anterior region of the animal. Furthermore, our results demonstrate, Smed-PARP-3(RNAi) disrupts the timely location of injury-induced cell death near the anterior facing wounds and also affects the regeneration of the central nervous system. Our work reveals novel roles for PARylation in large-scale regeneration and provides a simplified platform to investigate PARP signaling in the complexity of the adult body.

scholarly journals Planning Urban Manufacturing, Industrial Building Typologies, and Built Environments: Lessons From Inner London

2021 ◽  
Vol 6 (3) ◽  
pp. 350-367
Author(s):  
Jessica Ferm ◽  
Dimitrios Panayotopoulos-Tsiros ◽  
Sam Griffiths
Keyword(s):  
Urban Form ◽  
Large Scale ◽  
Unintended Consequences ◽  
Industrial Building ◽  
Land Uses ◽  
Economic Diversity ◽  
Mixed Use ◽  
Scale Regeneration ◽  
Large Plot ◽  
Post Industrial

Despite concerns about the loss of industry, industrial land, and buildings in high-value post-industrial cities, there is concurrently a renewed enthusiasm around the potential of “new” urban manufacturing and its contribution to the socio-economic diversity of cities. Yet, little is known about how planning policy can best support the retention and growth of urban manufacturing. To advance this agenda, this article proposes that we need a better understanding of industrial building typologies and resultant urban form. Using concepts developed by Julienne Hanson to analyse residential morphologies undergoing transformation under modernism, we apply these concepts to investigate the industrial, mixed-use contexts in two areas of London with concentrations of urban manufacturing—Hackney Mare Street and Old Kent Road. The research presented examines how both areas have evolved historically to produce distinctive urban tissues and a range of industrial building typologies. The article reveals that, despite territorial similarities in the late 19th century, the mixed land uses and smaller plot sizes of Hackney Mare Street have allowed for a more resilient development pattern, whereas the greater separation of land uses, large plot sizes, and inward-facing development in the Old Kent Road has facilitated its reimagination for large-scale regeneration. We conclude that greater attention needs to be paid to the relationship between urban manufacturing and built urban form if policies that aim to protect or support the revival of manufacturing in cities are to avoid negative unintended consequences.

scholarly journals Sox9+ messenger cells orchestrate large-scale skeletal regeneration in the mammalian rib

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Stephanie T Kuwahara ◽  
Maxwell A Serowoky ◽  
Venus Vakhshori ◽  
Nikita Tripuraneni ◽  
Neel V Hegde ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Hedgehog Signaling ◽  
Large Scale ◽  
Callus Formation ◽  
Editorial Note ◽  
Scale Regeneration ◽  
Regenerative Ability ◽  
Skeletal Regeneration ◽  
Large Bone ◽  
Unknown Signal

Most bones in mammals display a limited capacity for natural large-scale repair. The ribs are a notable exception, yet the source of their remarkable regenerative ability remains unknown. Here, we identify a Sox9-expressing periosteal subpopulation that orchestrates large-scale regeneration of murine rib bones. Deletion of the obligate Hedgehog co-receptor, Smoothened, in Sox9-expressing cells prior to injury results in a near-complete loss of callus formation and rib bone regeneration. In contrast to its role in development, Hedgehog signaling is dispensable for the proliferative expansion of callus cells in response to injury. Instead, Sox9-positive lineage cells require Hh signaling to stimulate neighboring cells to differentiate via an unknown signal into a skeletal cell type with dual chondrocyte/osteoblast properties. This type of callus cell may be critical for bridging large bone injuries. Thus despite contributing to only a subset of callus cells, Sox9-positive progenitors play a major role in orchestrating large-scale bone regeneration.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (<xref ref-type="decision-letter" rid="SA1">see decision letter</xref>).

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