scholarly journals An Insight into the Role of Postmortem Immunohistochemistry in the Comprehension of the Inflammatory Pathophysiology of COVID-19 Disease and Vaccine-Related Thrombotic Adverse Events: A Narrative Review

2021 ◽  
Vol 22 (21) ◽  
pp. 12024
Author(s):  
Chiara Stassi ◽  
Cristina Mondello ◽  
Gennaro Baldino ◽  
Luigi Cardia ◽  
Alessio Asmundo ◽  
...  

On 11 March 2020, the World Health Organization (WHO) declared a pandemic due to the spread of COVID-19 from Wuhan, China, causing high mortality rates all over the world. The related disease, which mainly affects the lungs, is responsible for the onset of Diffuse Alveolar Damage (DAD) and a hypercoagulability state, frequently leading to Severe Acute Respiratory Syndrome (SARS) and multiorgan failure, particularly in old and severe-critically ill patients. In order to find effective therapeutic strategies, many efforts have been made aiming to shed light on the pathophysiology of COVID-19 disease. Moreover, following the late advent of vaccination campaigns, the need for the comprehension of the pathophysiology of the fatal, although rare, thrombotic adverse events has become mandatory as well. The achievement of such purposes needs a multidisciplinary approach, depending on a correct interpretation of clinical, biochemical, biomolecular, and forensic findings. In this scenario, autopsies have helped in defining, on both gross and histologic examinations, the main changes to which the affected organs undergo and the role in assessing whether a patient is dead “from” or “with” COVID-19, not to mention whether the existence of a causal link exists between vaccination and thrombotic adverse events. In the present work, we explored the role of postmortem immunohistochemistry, and the increasingly used ancillary technique, in helping to understand the mechanism underlying the pathophysiology of both COVID-19 disease and COVID-19 vaccine-related adverse and rare effects.

Author(s):  
SWAGATIKA PRIYADARSINI ◽  
ROHIT SINGH ◽  
ARUN SOMAGOND ◽  
PUJA MECH

Coronavirus disease is the current cause of global concern. The massive outbreak of COVID-19 has led the World Health Organization (WHO) to declare this as a pandemic situation. The Severe Acute Respiratory Syndrome Coronavirus-2 (SARSCoV-2) is responsible for COVID-19 leading to acute respiratory distress and substantial mortality in humans. However, the first laboratory confirmation of SARS-CoV-2 in a pet dog in Hong Kong has shown the possibility of human-to-animal transmission (zooanthroponotic) of the virus. Thereafter, many animals including cat, tiger, lion and mink have also been reported to acquire the virus in several countries. In this situation the role of veterinarian assumes important in treating the animals, helping in food security, disease diagnosis, surveillance and boosting the economy of livestock stakeholders at the grassroot level. In the absence of any selective vaccine or drug against SARS-CoV-2, the world is anticipated to triumph over this pandemic with collaborative, multisectoral, and transdisciplinary approach linking human, animal and environmental health. This article gives an insight into the confirmed SARS-CoV-2 outbreaks in animals, including the factors behind the shuffling of the virus among variety of species and also emphasizes on the role of veterinarian in managing and safeguarding public health so as to pave the way for adopting one health approach in order to conserve biodiversity.


Author(s):  
Lara Bittmann

On December 31, 2019, WHO was informed of cases of pneumonia of unknown cause in Wuhan City, China. A novel coronavirus was identified as the cause by Chinese authorities on January 7, 2020 and was provisionally named "2019-nCoV". This new Coronavirus causes a clinical picture which has received now the name COVID-19. The virus has spread subsequently worldwide and was explained on the 11th of March, 2020 by the World Health Organization to the pandemic.


Coronaviruses ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 49-56
Author(s):  
Gaurav M. Doshi ◽  
Hemen S. Ved ◽  
Ami P. Thakkar

The World Health Organization (WHO) has recently announced the spread of novel coronavirus (nCoV) globally and has declared it a pandemic. The probable source of transmission of the virus, which is from animal to human and human to human contact, has been established. As per the statistics reported by the WHO on 11th April 2020, data has shown that more than sixteen lakh confirmed cases have been identified globally. The reported cases related to nCoV in India have been rising substantially. The review article discusses the characteristics of nCoV in detail with the probability of potentially effective old drugs that may inhibit the virus. The research may further emphasize and draw the attention of the world towards the development of an effective vaccine as well as alternative therapies. Moreover, the article will help to bridge the gap between the new researchers since it’s the current thrust area of research.


2021 ◽  
Vol 29 (Supplement_1) ◽  
pp. i45-i46
Author(s):  
A Peletidi ◽  
R Kayyali

Abstract Introduction Obesity is one of the main cardiovascular disease (CVD) risk factors.(1) In primary care, pharmacists are in a unique position to offer weight management (WM) interventions. Greece is the European country with the highest number of pharmacies (84.06 pharmacies per 100,000 citizens).(2) The UK was chosen as a reference country, because of the structured public health services offered, the local knowledge and because it was considered to be the closest country to Greece geographically, unlike Australia and Canada, where there is also evidence confirming the potential role of pharmacists in WM. Aim To design and evaluate a 10-week WM programme offered by trained pharmacists in Patras. Methods This WM programme was a step ahead of other interventions worldwide as apart from the usual measuring parameters (weight, body mass index, waist circumference, blood pressure (BP)) it also offered an AUDIT-C and Mediterranean diet score tests. Results In total,117 individuals participated. Of those, 97.4% (n=114), achieved the programme’s aim, losing at least 5% of their initial weight. The mean % of total weight loss (10th week) was 8.97% (SD2.65), and the t-test showed statistically significant results (P<0.001; 95% CI [8.48, 9.45]). The programme also helped participants to reduce their waist-to-height ratio, an early indicator of the CVD risk in both male (P=0.004) and female (P<0.001) participants. Additionally, it improved participants’ BP, AUDIT-C score and physical activity levels significantly (P<0.001). Conclusion The research is the first systematic effort in Greece to initiate and explore the potential role of pharmacists in public health. The successful results of this WM programme constitute a first step towards the structured incorporation of pharmacists in public’s health promotion. It proposed a model for effectively delivering public health services in Greece. This study adds to the evidence in relation to pharmacists’ CVD role in public health with outcomes that superseded other pharmacy-led WM programmes. It also provides the first evidence that Greek pharmacists have the potential to play an important role within primary healthcare and that after training they are able to provide public health services for both the public’s benefit and their clinical role enhancement. This primary evidence should support the Panhellenic Pharmaceutical Association, to “fight” for their rights for an active role in primary care. In terms of limitations, it must be noted that the participants’ collected data were recorded by pharmacists, and the analysis therefore depended on the accuracy of the recorded data, in particular on the measurements or calculations obtained. Although the sample size was achieved, it can be argued that it is small for the generalisation of findings across Greece. Therefore, the WM programme should be offered in other Greek cities to identify if similar results can be replicated, so as to consolidate the contribution of pharmacists in promoting public health. Additionally, the study was limited as it did not include a control group. Despite the limitations, our findings provide a model for a pharmacy-led public health programme revolving around WM that can be used as a model for services in the future. References 1. Mendis S, Puska P, Norrving B, World Health Organization., World Heart Federation., World Stroke Organization. Global atlas on cardiovascular disease prevention and control [Internet]. Geneva: World Health Organization in collaboration with the World Heart Federation and the World Stroke Organization; 2011 [cited 2018 Jun 26]. 155 p. Available from: http://www.who.int/cardiovascular_diseases/publications/atlas_cvd/en/ 2. Pharmaceutical Group of the European Union. Pharmacy with you throughout life:PGEU Annual Report [Internet]. 2015. Available from: https://www.pgeu.eu/en/library/530:annual-report-2015.html


2020 ◽  
Vol 14 (4) ◽  
pp. 193-197
Author(s):  
Alan Glasper

In light of the emergence in China of COVID-19, the novel corona virus, emeritus professor Alan Glasper, from the University of Southampton discusses the role of the World Health Organization and other public health institutions in responding to potential new global pandemics and deliberates on the role of NHS staff in coping with infectious disease in clinical environments.


2018 ◽  
Vol 9 (2) ◽  
pp. 165-170
Author(s):  
Husni Husni

One of the effects is not maintaining hygiene during menstruation is able to hitkankes Rahim neck (cervical). Based on data from the World Health Organization (WHO),cervical cancer is the second most cancer in women aged 15-45 years after breast cancer. Noless than 500,000 new cases with 280,000 patient deaths occur each year worldwide.Indonesia was ranked first by the victims died at least 555 women per day and 200,000women annually. This study aims to determine the correlation between knowledge andattitude towards personal hygiene during menstruation action at SMAN 2 Bengkulu City. Thisresearch is descriptive analytic. The number of respondents 84 people with a samplingtechnique that stratified random sampling. Presentation of data is done by using a frequencydistribution table. The collection of data taken using a questionnaire. The data were analyzedusing univariate and bivariate analysis with Chi-Square.The results showed that therespondents are classified as good knowledge of (54.8%), attitude unfavorabel or does notsupport (53.6%), and the biggest acts (52.4%) is good. From the bivariate analysis were foundno correlation between knowledge against acts of personal hygiene during menstruation (p =0.794), and no relation attitude towards personal hygiene actions during menstruation (p =0.975).Required role of schools, educators, parents to be more proactive in enhancingknowledge and useful information about the process of menstruation and how to maintainhygiene during menstruation.


2014 ◽  
Vol 18 (1) ◽  
pp. 405-424
Author(s):  
Pia Acconci

The World Health Organization (who) was established in 1946 as a specialized agency of the United Nations (un). Since its establishment, the who has managed outbreaks of infectious diseases from a regulatory, as well as an operational perspective. The adoption of the International Health Regulations (ihrs) has been an important achievement from the former perspective. When the Ebola epidemic intensified in 2014, the who Director General issued temporary recommendations under the ihrs in order to reduce the spread of the disease and minimize cross-border barriers to international trade. The un Secretary General and then the Security Council and the General Assembly have also taken action against the Ebola epidemic. In particular, the Security Council adopted a resolution under Chapter vii of the un Charter, and thus connected the maintenance of the international peace and security to the health and social emergency. After dealing with the role of the who as a guide and coordinator of the reaction to epidemics, this article shows how the action by the Security Council against the Ebola epidemic impacts on the who ‘authority’ for the protection of health.


2020 ◽  
pp. 281-288
Author(s):  
Marcella Longo ◽  
Cristiana Valerio

Chronic diseases are the main cause of death and hospitalizations in the world. In 2005 World Health Organization estimated that over 60% of all annual deaths were due to chronic diseases, even with a high neconomic impact. For these reasons chronic illness care is one of the most difficult challenge for the health service: the management of chronic patients needs a different set-ting, as compared with the “hospital – based model” used for acute conditions. In this work, we described the first data of a Hub cardiology out-patient clinic of Azienda Socio Sanitaria Milano Nord, of Lombardia region. Between August 1, 2015 and August 31, 2016, we evaluated 2956 clinical examinations and 4364 instrumental tests. The five main diagnoses were: hypertension (25%), diabetes (17%), chronic coronary syndromes (12%), atrial fibrillation (14%), chronic heart failure (4%). Our results show the high volume of activities of cardiology service and demonstrate the important role of territorial cardiology for chronic cardiovascular disease management.


Author(s):  
Farzana Nazera ◽  
Assoc. Prof. Dr. Valliappan Raju

Counterfeit medicine is a dangerous problem in Bangladesh which make the country's healthcare system in more challenging. For a developing nation like Bangladesh, it is hard to find a perfect solution to curb this problem. According to the World Health Organization (2021), awareness is the key to prevent innocent patient from taking counterfeit medicine. Due to knowledge gap, it's hard for patients to detect the authenticity of medicine because it requires knowledge of medicinal formulation. Physicians of Bangladesh could play a vital role in preventing this counterfeit medicine problem by establishing guidance co-operation relationship with the patients. The study made a literature review of the concept of counterfeit medicine, conducted a bibliometric analysis of counterfeit medicine on Scopus database and provided a relationship flow diagram of prospective guidance relationship between physicians and patients. The study concluded that, this consultation service should be offered by the physicians to the patients and the study expected that, the patient willingly accepts it for getting the safeguard against counterfeit medicine. Keywords: Bibliometric Analysis, Physicians, Patients, Counterfeit Medicine, Bangladesh


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