scholarly journals Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice

2021 ◽  
Vol 22 (24) ◽  
pp. 13305
Author(s):  
Maren K. Schroeder ◽  
Bin Liu ◽  
Robert G. Hinshaw ◽  
Mi-Ae Park ◽  
Shuyan Wang ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Radiation Effects ◽  
Motor Coordination ◽  
Space Radiation ◽  
High Energy ◽  
High Energy Particle ◽  
Wild Type ◽  
Particle Radiation ◽  
Specific Effects

Space radiation presents a substantial threat to travel beyond Earth. Relatively low doses of high-energy particle radiation cause physiological and behavioral impairments in rodents and may pose risks to human spaceflight. There is evidence that 56Fe irradiation, a significant component of space radiation, may be more harmful to males than to females and worsen Alzheimer’s disease pathology in genetically vulnerable models. Yet, research on the long-term, sex- and genotype-specific effects of 56Fe irradiation is lacking. Here, we irradiated 4-month-old male and female, wild-type and Alzheimer’s-like APP/PS1 mice with 0, 0.10, or 0.50 Gy of 56Fe ions (1GeV/u). Mice underwent microPET scans before and 7.5 months after irradiation, a battery of behavioral tests at 11 months of age and were sacrificed for pathological and biochemical analyses at 12 months of age. 56Fe irradiation worsened amyloid-beta (Aβ) pathology, gliosis, neuroinflammation and spatial memory, but improved motor coordination, in male transgenic mice and worsened fear memory in wild-type males. Although sham-irradiated female APP/PS1 mice had more cerebral Aβ and gliosis than sham-irradiated male transgenics, female mice of both genotypes were relatively spared from radiation effects 8 months later. These results provide evidence for sex-specific, long-term CNS effects of space radiation.

scholarly journals Bisecting GlcNAc structure is implicated in suppression of stroma-dependent haemopoiesis in transgenic mice expressing N-acetylglucosaminyltransferase III

1998 ◽  
Vol 331 (3) ◽  
pp. 733-742 ◽  
Author(s):  
Masafumi YOSHIMURA ◽  
Yoshito IHARA ◽  
Tetsuo NISHIURA ◽  
Yu OKAJIMA ◽  
Megumu OGAWA ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Transgenic Mice ◽  
Stromal Cells ◽  
Bone Marrow Cells ◽  
Adherent Cell ◽  
Wild Type ◽  
Spleen Cells ◽  
Bisecting Glcnac ◽  
Marrow Cells

Several sugar structures have been reported to be necessary for haemopoiesis. We analysed the haematological phenotypes of transgenic mice expressing β-1,4 N-acetylglucosaminyltransferase III (GnT-III), which forms bisecting N-acetylglucosamine on asparagine-linked oligosaccharides. In the transgenic mice, the GnT-III activity was elevated in bone marrow, spleen and peripheral blood and in isolated mononuclear cells from these tissues, whereas no activity was found in these tissues of wild-type mice. Stromal cells after long-term cultures of transgenic-derived bone marrow and spleen cells also showed elevated GnT-III activity, compared with an undetectable activity in wild-type stromal cells. As judged by HPLC analysis, lectin blotting and lectin cytotoxicity assay, bisecting GlcNAc residues were increased on both blood cells and stromal cells from bone marrow and spleen in transgenic mice. The transgenic mice displayed spleen atrophy, hypocellular bone marrow and pancytopenia. Bone marrow cells and spleen cells from transgenic mice produced fewer haemopoietic colonies. After lethal irradiation followed by bone marrow transplantation, transgenic recipient mice showed pancytopenia compared with wild-type recipient mice. Bone marrow cells from transgenic donors gave haematological reconstitution at the same level as wild-type donor cells. In addition, non-adherent cell production was decreased in long-term bone marrow cell cultures of transgenic mice. Collectively these results indicate that the stroma-supported haemopoiesis is compromised in transgenic mice expressing GnT-III, providing the first demonstration that the N-glycans have some significant roles in stroma-dependent haemopoiesis.

scholarly journals Development of High Energy Particle Detector for the Study of Space Radiation Storm

2014 ◽  
Vol 31 (3) ◽  
pp. 277-283 ◽  
Author(s):  
Gyeong-Bok Jo ◽  
Jongdae Sohn ◽  
Cheong Rim Choi ◽  
Yu Yi ◽  
Kyoung-Wook Min ◽  
...  
Keyword(s):  
Space Radiation ◽  
High Energy ◽  
High Energy Particle ◽  
Particle Detector ◽  
Energy Particle

scholarly journals Hubble Space Telescope observations of Europa in and out of eclipse

2010 ◽  
Vol 9 (4) ◽  
pp. 265-271 ◽  
Author(s):  
W.B. Sparks ◽  
M. McGrath ◽  
K. Hand ◽  
H.C. Ford ◽  
P. Geissler ◽  
...  
Keyword(s):  
Hubble Space Telescope ◽  
Broad Band ◽  
Line Emission ◽  
Optical Emission ◽  
High Energy ◽  
High Energy Particle ◽  
Wide Field ◽  
Particle Radiation ◽  
Space Telescope ◽  
Solar Blind

AbstractEuropa is a prime target for astrobiology and has been prioritized as the next target for a National Aeronautics and Space Administration flagship mission. It is important, therefore, that we advance our understanding of Europa, its ocean and physical environment as much as possible. Here, we describe observations of Europa obtained during its orbital eclipse by Jupiter using the Hubble Space Telescope. We obtained Advanced Camera for Surveys Solar Blind Channel far ultraviolet low-resolution spectra that show oxygen line emission both in and out of eclipse. We also used the Wide-Field and Planetary Camera-2 and searched for broad-band optical emission from fluorescence of the surface material, arising from the very high level of incident energetic particle radiation on ices and potentially organic substances. The high-energy particle radiation at the surface of Europa is extremely intense and is responsible for the production of a tenuous oxygen atmosphere and associated FUV line emission. Approximately 50% of the oxygen emission lasts at least a few hours into the eclipse. We discuss the detection limits of the optical emission, which allow us to estimate the fraction of incident energy reradiated at optical wavelengths, through electron-excited emission, Cherenkov radiation in the ice and fluorescent processes.

Long term persistence of thyrotropin receptor antibodies in wild-type and transgenic mice in a Graves’ disease model

Thyroid ◽  
2012 ◽  
pp. 120410232313002
Author(s):  
Sandra M McLachlan ◽  
Holly Aliesky ◽  
Chun-Rong Chen ◽  
Basil Rapoport
Keyword(s):  
Transgenic Mice ◽  
Disease Model ◽  
Graves Disease ◽  
Thyrotropin Receptor ◽  
Wild Type ◽  
Thyrotropin Receptor Antibodies ◽  
Receptor Antibodies

The Drugs and Natural Antioxidants as the Components of Anti-radiation Countermeasures during Cosmic Flights

2017 ◽  
pp. 66-73 ◽  
Author(s):  
И. Ушаков ◽  
I. Ushakov ◽  
М. Васин ◽  
M. Vasin
Keyword(s):  
Solar Activity ◽  
Cosmic Rays ◽  
Radiation Effects ◽  
High Energy ◽  
Galactic Cosmic Rays ◽  
Stress Factors ◽  
Solar Cosmic Rays ◽  
Post Radiation ◽  
The Impact

Radiation situation for cosmonauts over long-term cosmic flights is caused by low-rate radiation of galactic cosmic rays and solar cosmic rays consisting of high-energy proton as well as heavy particles (Z>10) within 1-2 % that is exclusively a threat of stochastic radiation effects (small increase of cancer risk and decrease of mean life span) for men. During interplanetary expedition periods the small probability of raised solar activity there is a threat of exposure to astronauts at doses that cause deterministic radiation effects leading to the development of the disease as a clinical manifestation of radiation injuries,. In a similar scenario it is necessary to have available to cosmic ship anti-radiation countermeasures for cosmonaut protection. Among radioprotective equipment can be provided with radiation protective agents and partial shielding of body separate section providing the best condition for post-radiation repair of radiosensitive body tissues. Preparation B-190 (indralin) is the most perspective from a small numbers of other radioprotectors permitting for men administration. Besides high radioprotective efficacy and large broadness of protective action B-190 is well tolerated including the impact of extrem flight factors. Antiemetic agent latran (ondansetron) is most interesting among preparation for prophylaxis and reduction of prodromal radiation reaction. To accelerate post-radiation hematopoietic recovery after raised solar activity an administration of radiomitigators (riboxin et al.) is substantiated. Neupomax (neupogen) is recommended as a preparation for pathogenesis therapy of acute radiation syndrome. Possible consequences of long-term cosmic voyages for oxidative stress development are taken into consideration. On their basis of nNatural antioxidants, preparations and nutrients radiomodulators, fully qualitative nutrition including vegetable food enriched flavonoids, vitamins C, E and carotene potentially prevent a shorten of cosmonaut biological age induced by solar cosmic rays and galactic cosmic rays and stress factors of long-term cosmic voyages. Radiomodulators are low and non-toxic and have not side effects in recommended doses. Their radioprotective effect is directly induced by adaption reaction on cellular and organismic levels through gene expression modulation and in that way the increase of non-specific body tolerance. The implementation of radiomodulator action is possible through hormesis mechanism.

scholarly journals The long-term effects of space weather on satellite operations

2010 ◽  
Vol 28 (6) ◽  
pp. 1361-1367 ◽  
Author(s):  
D. T. Welling
Keyword(s):  
Background Radiation ◽  
High Energy ◽  
High Energy Particle ◽  
Solar Cycles ◽  
Long Term Effects ◽  
Radiation Background ◽  
Particle Exposure ◽  
Total Lifetime ◽  
The Impact

Abstract. Integrated lifetime radiation damage may cause spacecraft to become more susceptible to operational anomalies by changing material characteristics of electronic components. This study demonstrates and quantifies the impact of these effects by examining the National Oceanic and Atmospheric Administration (NOAA) National Geophysical Data Center (NGDC) satellite anomaly database. Energetic particle data from the Geostationary Operational Environmental Satellites (GOES) is used to construct the total lifetime particle exposure a satellite has received at the epoch of an anomaly. These values are compared to the satellite's chronological age and the average exposure per year (calculated over two solar cycles.) The results show that many anomalies occur on satellites that have received a total lifetime high-energy particle exposure that is disproportionate to their age. In particular, 10.8% of all events occurred on satellites that received over two times more 20 to 40 MeV proton lifetime particle exposure than predicted using an average annual mean. This number inflates to 35.2% for 40 to 80 MeV protons and 33.7% for ≥2 MeV electrons. Overall, 73.5% of all anomalies occurred on a spacecraft that had experienced greater than two times the expected particle exposure for one of the eight particle populations used in this study. Simplistically, this means that the long term radiation background exposure matters, and that if the background radiation is elevated during the satellite's lifetime, the satellite is likely to experience more anomalies than satellites that have not been exposed to the elevated environment.

P1-108: Effects of space radiation on hippocampal-dependent learning and neuropathology in wild-type and Alzheimer's disease transgenic mice

2013 ◽  
Vol 9 ◽  
pp. P190-P190 ◽  
Author(s):  
Juliet Moncaster ◽  
Mark Wojnarowicz ◽  
Srikant Sarangi ◽  
Andrew Fisher ◽  
Olga Minaeva ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Space Radiation ◽  
Wild Type ◽  
Dependent Learning

Amorphization of Zr3Al by 1-MeV electron radiation

1988 ◽  
Vol 46 ◽  
pp. 464-465
Author(s):  
J. Koike ◽  
P.R. Okamoto ◽  
L.E. Rehn ◽  
M. Meshii
Keyword(s):  
Room Temperature ◽  
Ion Irradiation ◽  
National Laboratory ◽  
High Energy ◽  
High Energy Particle ◽  
Nominal Composition ◽  
Electron Radiation ◽  
Energy Particle ◽  
Particle Radiation ◽  
Lattice Softening

A crystalline to amorphous transition during high energy particle radiation has been reported in various intermetallic compounds. Chemical disordering is known to precede amorphization, which takes place only below a certain temperature. In Zr3A1, chemical disordering has been observed during 1-MeV electron radiation at temperatures between 130 and 375K but no amorphization has been reported. A large decrease in shear modulus was also observed during chemical disordering of Zr3Al by 1-MeV Kr ion irradiation at room temperature, followed by amorphization. In the present work, the possibility of amorphization of Zr3Al by electron radiation was examined, and the lattice softening due to chemical disordering was studied with electron diffraction.An alloy with a nominal composition of Zr-25at%Al was furnished by Chalk River National Laboratory. It was annealed at 925°C for 2 weeks and subsequently sliced and jet-polished. Specimen was irradiated and examined at 52K with 1-MeV electrons in the Argonne-HVEM.

The influences of radiation effects on DC/RF performances of Lg=22 nm gate-all-around nanosheet field-effect transistor

2022 ◽  
Author(s):  
Yue Ma ◽  
Jinshun Bi ◽  
Sandip Majumdar ◽  
Safdar Mehmood ◽  
Lanlong Ji ◽  
...  
Keyword(s):  
Field Effect ◽  
Radiation Effects ◽  
Field Effect Transistor ◽  
Vertical Direction ◽  
High Energy ◽  
High Energy Particle ◽  
Lateral Direction ◽  
Effect Transistor ◽  
Rf Performances ◽  
Tcad Simulations

Abstract In this paper, we carried out detailed TCAD simulations to investigate the radiation effects, e.g., total ionizing dose (TID) and single-event effects (SEEs), on direct current (DC) and radio frequency (RF) characteristics of the gate-all-around (GAA) nanosheet field-effect transistor (FET). The simulation model used is composed of 7-layer stacked GAA nanosheet FET with Lg=22 nm, which was implemented in this study. The open current and the drain-induced barrier lowering of the device are ~ 3mA/μm and 47mV/V, respectively. The results indicate that the TID have little influence on the DC and RF characteristics when the transistor is working in an open state. During the SEEs simulation, we considered three incident directions for the high energy particle, including the lateral direction of the channels, the vertical direction of the channels and the top of the channels. The influence of the particle injecting along the lateral and vertical directions of the channels shows stronger relation with the distance from the incident point compared to the influence of the particle from the top. Besides, the general influence of the particle injecting along the lateral directions of the channels is higher than the other two directions. The total injected charge of the particle injecting along the lateral direction, along the vertical direction and from the top are 3 fC, 1.4 fC and 2.1 fC, respectively. As compared to the FinFET, the GAA nanosheet has superior RF performances and less sensitivity to TID effect. This work can provide a guideline for the GAA nanosheet devices in aerospace and avionic RF applications.

Sign in / Sign up

Export Citation Format

Share Document