scholarly journals Salivary Biomarkers of Stress, Anxiety and Depression

2021 ◽  
Vol 10 (3) ◽  
pp. 517
Author(s):  
Sylwia Chojnowska ◽  
Iwona Ptaszyńska-Sarosiek ◽  
Alina Kępka ◽  
Małgorzata Knaś ◽  
Napoleon Waszkiewicz
Keyword(s):  
Salivary Cortisol ◽  
Depressive Disorders ◽  
Immunoglobulin A ◽  
Strong Relationship ◽  
Fibroblast Growth Factor 2 ◽  
Stress Axis ◽  
Anxiety And Depression ◽  
Salivary Biomarkers ◽  
Appropriate Treatment ◽  
As Stress

Stress, anxiety and depressive disorders are often characterized by the activation of the stress axis, which results in similar symptoms at some point in these disorders. These disorders are closely related to each other—they occur simultaneously or follow one another. The diagnosis of stress, anxiety and depression is not a perfect procedure currently—it is based on patient observation and an interview with the patient and their family. There are no laboratory tests that would dispel the doubts of the doctor making the diagnosis and allow the appropriate treatment to be implemented as soon as possible. Therefore, this study will review the components of saliva that could be helpful in the quick diagnosis of stress, anxiety and/or depression. Such potential salivary biomarkers could also be useful in monitoring the effectiveness of pharmacological treatment prescribed by a psychiatrist. The following are promising salivary biomarkers of stress, anxiety or depression: cortisol, immunoglobulin A (sIgA), lysozyme, melatonin, α-amylase (sAA), chromogranin A (CgA) and fibroblast growth factor 2 (FGF-2). To the best valuable potential salivary markers of stress, we can include cortisol, lysozyme, sAA and CgA. To differentiate depression from stress, salivary cortisol and melatonin can be helpful. Fluctuations in the concentrations of the above-mentioned substances in saliva indicate a particularly strong relationship with typical human psychological problems, such as stress, depression or anxiety.

scholarly journals Salivary Biomarkers and Training Load During Training and Competition in Paralympic Swimmers

2018 ◽  
Vol 13 (7) ◽  
pp. 839-843 ◽  
Author(s):  
Ciara Sinnott-O’Connor ◽  
Thomas M. Comyns ◽  
Alan M. Nevill ◽  
Giles D. Warrington
Keyword(s):  
Stress Response ◽  
Stress Responses ◽  
Salivary Cortisol ◽  
Perceived Exertion ◽  
Immunoglobulin A ◽  
Training Load ◽  
Rating Of Perceived Exertion ◽  
Alpha Amylase ◽  
Salivary Biomarkers ◽  
Paralympic Games

Context: Stress responses in athletes can be attributed to training and competition, where increased physiological and psychological stress may negatively affect performance and recovery. Purpose: To examine the relationship between training load (TL) and salivary biomarkers immunoglobulin A (IgA), alpha-amylase (AA), and cortisol across a 16-wk preparation phase and 10-d competition phase in Paralympic swimmers. Methods: Four Paralympic swimmers provided biweekly saliva samples during 3 training phases—(1) normal training, (2) intensified training, and (3) taper—as well as daily saliva samples in the 10-d Paralympic competition (2016 Paralympic Games). TL was measured using session rating of perceived exertion. Results: Multilevel analysis identified a significant increase in salivary immunoglobulin A (sIgA: 94.98 [27.69] μg·mL−1), salivary alpha-amylase (sAA: 45.78 [19.07] μg·mL−1), and salivary cortisol (7.92 [2.17] nM) during intensified training concurrent with a 38.3% increase in TL. During the taper phase, a 49.5% decrease in TL from the intensified training phase resulted in a decrease in sIgA, sAA, and salivary cortisol; however, all 3 remained higher than baseline levels. A further significant increase was observed during competition in sIgA (168.69 [24.19] μg·mL−1), sAA (35.86 [16.67] μg·mL−1), and salivary cortisol (10.49 [1.89] nM) despite a continued decrease (77.8%) in TL from the taper phase. Conclusions: Results demonstrate that performance in major competition such as Paralympic games, despite a noticeable reduction in TL, induces a stress response in athletes. Because of the elevated stress response observed, modifications to individual postrace recovery protocols may be required to enable athletes to maximize performance across all 10 d of competition.

Investigation of the Relationship Between Occupational Stress and Temporomandibular Joint Disorders by Measuring Salivary Cortisol and Immunoglobulin a Levels in Students of Qom Dental School

2021 ◽  
Author(s):  
Yasamin Barakian ◽  
Samira Hajisadeghi ◽  
Elham Keykha ◽  
Abolfazl Mohammadbeigi ◽  
Alireza Karimi
Keyword(s):  
Temporomandibular Joint ◽  
Occupational Stress ◽  
Salivary Cortisol ◽  
Immunoglobulin A ◽  
Temporomandibular Joint Disorders ◽  
Dental School ◽  
P Value ◽  
Salivary Biomarkers ◽  
The Mean ◽  
The Relationship

Abstract Objectives Occupational stress is defined as a lack of coordination between job requirements and individual abilities. This stress relates to several salivary biomarkers. Stress plays an important role in creating temporomandibular disorder (TMD). In this study we aimed to investigate the relationship between stress and TMD by examining the occupational stress using dental environment stress (DES) questionnaire and measuring the stress markers in saliva including cortisol and immunoglobulin A in fourth to sixth year students of Qom Dental School. Methods In present study, 60 students participated. At first, a clinical examination was performed based on the RDC/TMD method to determine the temporomandibular joint status, then a DES questionnaire was completed to determine the occupational stress level and finally a sample of saliva was taken from the students and the amounts of salivary cortisol and IgA were measured by enzyme-linked immunosorbent assay (ELISA). Results The mean cortisol and IgA levels were 4.74 ± 2.80 ng/ml and 220.26 ± 121.22 µg/ml, respectively and the mean score of the DES questionnaire was 2.48 ± 0.58. In this study, 24 patients (40%) suffered from TMD. There was no correlation between cortisol and IgA levels with the DES score (p value > 0.05). There was no significant relationship between TMD and three variables of cortisol, IgA and DES scores (p value > 0.05). Conclusion Stress is one of the most important causes of TMD. Salivary biomarkers can be useful markers for determining stress in people with TMD but this issue was not confirmed in our study. Clinical relevance: In this study, no relationship was observed between TMD and occupational stress.

scholarly journals Mini-Review Article – Current Opinion on Salivary Biomarkers as a Measurement for Stress and Fatigue

2013 ◽  
Vol 6 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Ting Chun Yi ◽  
Shabbir Moochhala
Keyword(s):  
Salivary Cortisol ◽  
Immunoglobulin A ◽  
Individual Variability ◽  
Review Article ◽  
Salivary Amylase ◽  
Non Invasive ◽  
Salivary Peptide ◽  
Stress Research ◽  
Salivary Biomarkers ◽  
Salivary Immunoglobulin A

Salivary biomarkers have been increasingly popular in stress research as saliva is easily produced and collection is non-invasive and not limited by geographical distance or lack of infrastructure. Several salivary biomarkers have been utilized in stress research, for instance, salivary cortisol, salivary amylase and salivary immunoglobulin A. Despite being sensitive to changes in fatigue, they have limitations such as inter-individual variability, and interactions with other constituents that may confound the results. Recently, Hyperion Biotechnology has developed the Fatigue Biomarker Index (FBI), which is a measurement of the changes in concentration of salivary peptides with fatigue. The FBI has been shown to be an accurate and objective biomarker of fatigue, and has huge potential for use in various fields and industries. This article will review some of the previous and current salivary biomarkers of stress, as well as critically appraise the new salivary peptide test in terms of its accuracy, application and access.

The Relationship between Life Events and Personality Style to the Development of Depressive and Anxiety Disorders Among Adolescents

2020 ◽  
Vol 10 ◽  
Author(s):  
Noga Oschry-Bernstein ◽  
Netta Horesh-Reinman ◽  
Adar Avnon ◽  
Tomer Mevorach ◽  
Alan Apter ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Life Events ◽  
Depressive Disorders ◽  
Multinomial Logistic Regression ◽  
Statistical Correlation ◽  
Personality Characteristics ◽  
Dominant Factor ◽  
Anxiety And Depression ◽  
Unique Contribution ◽  
Early Trauma

Background:: The separateness of anxiety disorder and depressive disorder as two distinct disorders is often questioned. The aim of the current study is to examine whether there is a different profile of life events and personality characteristics for anxiety and depression disorders in adolescents. Methods:: One hundred forty-six adolescents participated in the study, 57 boys and 89 girls, ranging in age from 11-18 years (mean=15.08+1.97). The study group included 92 adolescents with a clinical diagnosis of depression or anxiety, and the comparison group included 54 teenagers with no known psychopathology. Results:: Multinomial logistic regression produced different predictive profiles for anxiety disorder and for depressive disorders. Life event variables, especially minor life events and early traumas, were found to be predictors for depression. Furthermore, interaction was found between early trauma and minor life events in the prediction of depression, such that the existence of trauma weakened the statistical correlation between minor life events and the onset of depression. In addition, contrary to the literature regarding adults, it was found that during adolescence personality variables have a unique contribution as predictive factors for vulnerability to the onset of anxiety and depression, thus reducing the significance of life events. Conclusion:: Our findings suggest that different profile of life events and personality characteristics can be identified for the two disorders. In addition, it appears that early traumas are a dominant factor that overshadows more recent life events at the onset of depression among adolescents.

The validity of diagnostic systems for common mental disorders: a comparison between the ID-CATEGO and the DSM-III systems

1990 ◽  
Vol 20 (1) ◽  
pp. 209-218 ◽  
Author(s):  
David Grayson ◽  
Keith Bridges ◽  
Diane Cook ◽  
David Goldberg
Keyword(s):  
Discriminant Analysis ◽  
Depressive Disorders ◽  
Common Mental Disorders ◽  
Latent Trait ◽  
Mental Illnesses ◽  
Anxiety And Depression ◽  
Multiple Discriminant Analysis ◽  
Diagnostic Systems ◽  
Scale Scores ◽  
Initial Scale

SYNOPSISIt is argued that latent trait analysis provides a way of examining the construct validity of diagnostic concepts which are used to categorize common mental illnesses. The present study adds two additional aspects of validity using multiple discriminant analysis applied to two widely used taxonomic systems. Scales of anxiety and depression derived from previous latent trait analyses are applied to individuals reaching criteria for ‘caseness’ on the ID-CATEGO system and the DSM-III system, both at initial diagnosis and six months later. The first multiple discriminant analysis is carried out on the initial scale scores, and the results are interpreted in terms of concurrent validity. The second analysis uses improvement scores on the two scales and relates to predictive validity. It is argued that the ID-CATEGO system provides a better classification for common mental illnesses than the DSM-III system, since it allows a better discrimination to be made between anxiety and depressive disorders.

scholarly journals Loneliness and Depression among Polish High-School Students

2021 ◽  
Vol 18 (4) ◽  
pp. 1706
Author(s):  
Beata Dziedzic ◽  
Paulina Sarwa ◽  
Ewa Kobos ◽  
Zofia Sienkiewicz ◽  
Anna Idzik ◽  
...  
Keyword(s):  
High School ◽  
High School Students ◽  
Depressive Disorders ◽  
Depression Scale ◽  
Young Person ◽  
Anxiety And Depression ◽  
School Students ◽  
Loneliness Scale ◽  
Emotional Loneliness ◽  
Anxiety Depression

Introduction: Having impaired relations and limited interpersonal contact is associated with a sense of loneliness, and can result in a number of mental disorders, including the development of depression. Approximately one in five adolescents in the world suffers from depression, and first episodes of such are occurring at increasingly young ages. Due to a lack of appropriate support from parents, teachers and the healthcare system, the young person feels alone when dealing with their problem. Aims: The aims of this study are to determine the prevalence of anxiety, depression, aggression and sense of loneliness among high school students, and to analyze a correlation between loneliness and depression. Materials and methods: The study was conducted on 300 high school students in Poland. The study material was collected using the Hospital Anxiety and Depression Scale (HADS-M) and De Jong Gierveld Loneliness Scale (DJGLS). Results: A feeling of loneliness correlated significantly with depressive disorders (p < 0.005), with the strongest effect between the total HADS-M score and the total loneliness scale score (r = 0.61). The overall presence of disorders as per HADS-M was found to be 23%, and borderline conditions were found in 19.3%. In 24% of the students, disorders were revealed on the anxiety subscale and in 46.3% on the aggression subscale. On DJGLS, a very severe sense of loneliness was observed in 6.67% of the subjects, and in 42.3% of them, a moderate feeling of loneliness was indicated. On the social loneliness subscale, a severe sense of loneliness was found in 22.7%, while on the emotional loneliness subscale, it was found in 16.7% of the subjects. Conclusions: In this study, a quarter of the student participants experienced anxiety and depression disorders. Students showing higher levels of anxiety, depression, and aggression also showed enhanced loneliness. Girls showed higher levels of anxiety, depression and aggression, as well as emotional loneliness.

scholarly journals Salivary Biomarkers in COVID-19 Patients: Towards a Wide-Scale Test for Monitoring Disease Activity

2021 ◽  
Vol 11 (5) ◽  
pp. 385
Author(s):  
Cecilia Napodano ◽  
Cinzia Callà ◽  
Antonella Fiorita ◽  
Mariapaola Marino ◽  
Eleonora Taddei ◽  
...  
Keyword(s):  
Real Time ◽  
Immunoglobulin A ◽  
Free Light Chains ◽  
Non Invasive ◽  
Salivary Biomarkers ◽  
Wide Scale ◽  
Scale Test ◽  
Control Disease ◽  
Rapid Laboratory ◽  
Operator Curve

The ongoing outbreak of coronavirus disease 2019 (COVID-19), which impairs the functionality of several organs, represents a major threat to human health. One of the hardest challenges in the fight against COVID-19 is the development of wide-scale, effective, and rapid laboratory tests to control disease severity, progression, and possible sudden worsening. Monitoring patients in real-time is highly demanded in this pandemic era when physicians need reliable and quantitative tools to prioritize patients’ access to intensive care departments. In this regard, salivary biomarkers are extremely promising, as they allow for the fast and non-invasive collection of specimens and can be repeated multiple times. Methods: We compare salivary levels of immunoglobulin A subclasses (IgA1 and IgA2) and free light chains (kFLC and λFLC) in a cohort of 29 SARS-CoV-2 patients and 21 healthy subjects. Results: We found that each biomarker differs significantly between the two groups, with p-values ranging from 10−8 to 10−4. A Receiving Operator Curve analysis shows that λFLC level is the best-suited candidate to discriminate the two groups (AUC = 0.96), with an accuracy of 0.94 (0.87–1.00 95% CI), a precision of 0.91 (0.81–1.00 95% CI), a sensitivity of 1.00 (0.96–1.00 95% CI), and a specificity of 0.86 (0.70–1.00 95% CI). Conclusion: These results suggest λFLC as an ideal indicator of patient conditions. This hypothesis is strengthened by the consideration that the λFLC half-life (approximately 6 h) is significantly shorter than the IgA one (21 days), thus confirming the potential of λFLC for effectively monitoring patients’ fluctuation in real-time.

Salivary Cortisol and Immunoglobulin A Responses During Golf Competition vs. Practice in Elite Male and Female Junior Golfers

2010 ◽  
Vol 24 (3) ◽  
pp. 852-858 ◽  
Author(s):  
Kwang-Jun Kim ◽  
Saejong Park ◽  
Kwang-Hoi Kim ◽  
Tae-Won Jun ◽  
Dong-Ho Park ◽  
...  
Keyword(s):  
Salivary Cortisol ◽  
Immunoglobulin A ◽  
Male And Female

Relaxation Increases Salivary Immunoglobulin a

1987 ◽  
Vol 61 (2) ◽  
pp. 623-629 ◽  
Author(s):  
Ronald G. Green ◽  
Marsha L. Green
Keyword(s):  
Immune System ◽  
Salivary Cortisol ◽  
Immunoglobulin A ◽  
High Stress ◽  
Relaxation Response ◽  
Control Group ◽  
Coping Skill ◽  
Relaxation Methods ◽  
Eyes Closed ◽  
Salivary Immunoglobulin A

While research indicates that high stress may be immunosuppressive, little is known about the effects of relaxation on the immune system. To determine whether relaxation is immunoenhancing, 50 volunteer college students were randomly assigned to one of four relaxation methods (Benson's relaxation response, guided visualization, massage, lying quietly with eyes closed, or a touching-control group). Salivary immunoglobulin A (S-IgA) and salivary Cortisol levels were recorded before and after one 20-min. relaxation session. Subjects in the relaxation response, visualization, and massage groups showed a significant increase in S-IgA concentrations from the before to the after relaxation samples. Also, post-relaxation S-IgA concentrations were significantly higher in the relaxation response, visualization, and massage groups than in the touching-control group. Salivary Cortisol did not change significantly. These data suggest that one component of the immune system, S-IgA, may be enhanced by the practice of a coping skill such as relaxation.

scholarly journals AB0177 ANXIETY-DEPRESSIVE SPECTRUM IN PATIENTS WITH RHEUMATOID ARTHRITIS AND ANKYLOSING SPONDILITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1114.2-1114
Author(s):  
M. Letaeva ◽  
M. Koroleva ◽  
J. Averkieva ◽  
O. Malyshenko ◽  
T. Raskina
Keyword(s):  
Rheumatoid Arthritis ◽  
Depressive Disorders ◽  
Depression Scale ◽  
Well Being ◽  
Depressive Syndrome ◽  
Depression Screening ◽  
Anxiety And Depression ◽  
Control Group ◽  
Subjective Well Being ◽  
Anxiety Depression

Objectives:to assess the frequency of occurrence of the anxiety-depressive spectrum in patients with rheumatoid arthritis and ankylosing spondylitis.Methods:A survey was conducted of 44 patients aged from 21 to 57 years (average age - 42.3 ± 6.7 years), who were treated at GAUZ KO OKGVV. All patients had a verified diagnosis of RA and AS according to the ACR criteria and received treatment with basic drugs. The control group consisted of 40 people comparable in age and sex, without concomitant pathology of RA and AS.The depression screening card, the subjective well-being scale, and the hospital anxiety and depression scale (HADS) were used to assess and detect anxiety-depressive syndrome. The assessment of the condition is carried out over the last 2 weeks, which corresponds to the temporary diagnostic criterion for depression.The Depression Screening Scale is a 35-item self-questionnaire that assesses 7 categories of signs: sleep and appetite disorders, anxiety, emotional instability, cognitive impairment, loss of self, guilt, and suicidal tendencies. A total score of 65 and above indicates a high likelihood of depression.The Subjective Well-Being Scale is a psychodiagnostic screening tool for measuring the emotional component of subjective well-being or emotional comfort.Hospital Anxiety and Depression Scale Zigmond A.S., Snaith R.P. was developed for the primary detection of depression and anxiety in a general medical practice. The HADS scale consists of 14 statements with 4 possible answers and includes two parts: anxiety and depression. The sum of points of 8 or more is regarded as “subclinically expressed anxiety / depression”, 11 or more points - “clinically expressed anxiety / depression”.Results:According to the results of the depression screening questionnaire, 34 (77.3%) patients with RA and AS showed signs of depression, while in the control group only 6 (15%) patients tested positive for the presence of depressive disorders. According to the data obtained when assessing the scale of well-being in the main group, 26 (59.1%) patients showed signs of emotional discomfort (the indicator was 80% or more), in the control group - in 6 (15%). Using the hospital scale of anxiety and depression HADS, anxiety-depressive syndrome was detected in 36 (81.8%) patients with RA and AS: 16 (44.4%) patients had anxiety, 20 (55.6%) - depression, of them, subclinically expressed anxiety and depression were observed in 10 (27.7%) and 12 (33.3%) people, respectively. Anxiety-depressive syndrome in the control group, according to the HADS questionnaire, was detected only in 8 (20%) patients, of whom 4 (10%) patients had subclinical anxiety and 4 (10%) had signs of depression. No clinically pronounced anxiety and depression were registered in the control group.Conclusion:In most patients with rheumatoid arthritis and ankylosing spondylitis, anxiety-depressive disorders have been identified, which can directly affect both the course of the disease itself and the development of various complications. Timely diagnosis of mental disorders and close cooperation of rheumatologists, psychiatrists and psychologists in the selection of adequate therapy can improve the course and prognosis of the disease.Disclosure of Interests:None declared

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