scholarly journals The Relevance of Fetal Abdominal Subcutaneous Tissue Recording in Predicting Perinatal Outcome of GDM Pregnancies: A Retrospective Study

2020 ◽  
Vol 9 (10) ◽  
pp. 3375
Author(s):  
Friederike Weschenfelder ◽  
Nadin Baum ◽  
Thomas Lehmann ◽  
Ekkehard Schleußner ◽  
Tanja Groten
Keyword(s):  
Gestational Age ◽  
Predictive Power ◽  
Neonatal Outcome ◽  
Subcutaneous Tissue ◽  
Mode Of Delivery ◽  
Abdominal Circumference ◽  
Large For Gestational Age ◽  
Maternal Body Mass Index ◽  
Clinical Parameters ◽  
Ultrasound Parameters

Guidelines on the management of gestational diabetes (GDM) instruct physicians to involve ultrasound-based monitoring of fetal growth in addition to blood glucose. So far, glucose control besides clinical parameters like maternal body mass index (BMI) and gestational weight gain have been shown to predict neonatal outcome. We aimed to evaluate the discriminative ability of fetal abdominal subcutaneous tissue (FAST) in addition to standard ultrasound parameters like abdominal circumference (AC) and estimated fetal weight (EFW) for perinatal complications like large for gestational age (LGA), hypoglycemia, hyperbilirubinemia, mode of delivery and admission to neonatal intensive care unit (NICU). Ultrasound data and neonatal outcome was collected of 805 GDM cases from 2012 to 2016: 3205 FAST, 3195 AC-measurements and 3190 EFW calculations were included. AC, EFW and FAST increased linear with gestational age. Combining ultrasound and clinical parameters improved predictive power for LGA. In the subgroup where fetuses grow with an AC > 75th additional adding of FAST to standard ultrasound parameters increased predictive power for hypoglycemia. Our results confirm inclusion of ultrasound parameters to be beneficial in monitoring GDM pregnancies. Additional FAST determination revealed to be of potential clinical relevance in the subgroup AC > 75th percentile.

scholarly journals Perinatal Asphyxia Among Neonates Admitted Jimma Medical Center, Jimma, Ethiopia

2020 ◽  
Vol 7 ◽  
pp. 2333794X2098130
Author(s):  
Ebissa Bayana Kebede ◽  
Adugna Olani Akuma ◽  
Yonas Biratu Tarfa
Keyword(s):  
Gestational Age ◽  
Medical Center ◽  
Perinatal Asphyxia ◽  
Mode Of Delivery ◽  
Large For Gestational Age ◽  
Systematic Sampling ◽  
P Value ◽  
Health Extension Workers ◽  
Severe Problem ◽  
Prolonged Labor

Background: Perinatal asphyxia is a severe problem which causes serious problem in neonates in developing countries. This study is aimed to determine magnitude of perinatal asphyxia and its associated factors. Methods: A cross-sectional study design was conducted among neonates admitted over a period of 4 years on 740 samples. Systematic sampling method was employed to get required samples from log book. Epi-data 3.1 is used for data entry and the entered data was exported to SPSS Version 23 for analysis. Bivariable and multiple variable logistic regressions analysis were applied to see the association between dependent and independent variables. Finally, P-value <.05 at 95% CI was declared statistically significant. Results: The main significant factor associated to perinatal asphyxia were prolonged labor ( P = .04, AOR = 1.68 95%CI: [1.00, 2.80]), being primipara ( P = .003, AOR = 2.06, 95%CI: [1.28, 3.30]), Small for Gestational Age (SGA) ( P = .001, AOR = 4.35, 95%CI: [1.85, 10.19]), Large for Gestational Age ( P = .001, AOR = 16.75, 95%CI: [3.82, 73.33]) and mode of delivery. Conclusion: The magnitude of perinatal asphyxia was 18%. Prolonged labor, parity, birth size, mode of delivery, and APGAR score at 1st minute were significantly associated with perinatal asphyxia. So, Nurses, Midwives, Medical Doctors, and health extension workers have to engage and contribute to on how to decrease the magnitude of perinatal asphyxia.

Abdominal Circumference Alone versus Estimated Fetal Weight after 24 Weeks to Predict Small or Large for Gestational Age at Birth: A Meta-Analysis

2017 ◽  
Vol 34 (11) ◽  
pp. 1115-1124 ◽  
Author(s):  
José Yordan ◽  
Bradley Holbrook ◽  
Pranita Nirgudkar ◽  
Ellen Mozurkewich ◽  
Nathan Blue
Keyword(s):  
Gestational Age ◽  
Meta Analysis ◽  
Screening Method ◽  
Case Series ◽  
Fetal Weight ◽  
Abdominal Circumference ◽  
Large For Gestational Age ◽  
Predictive Values ◽  
Sensitivity Specificity ◽  
Estimated Fetal Weight

Objective We compared the sensitivity and specificity of abdominal circumference (AC) alone versus estimated fetal weight (EFW) to predict small for gestational age (SGA) or large for gestational age (LGA) at birth. Study Design We searched the literature for studies assessing an ultrasonographic AC or EFW after 24 weeks to predict SGA or LGA at birth. Case series or studies including anomalous fetuses or multiple gestations were excluded. We computed the sensitivity, specificity, and positive and negative predictive values of any AC or EFW cutoff analyzed by at least two studies. Results We identified 2,460 studies, of which 40 met inclusion criteria (n = 36,519). Four studies assessed AC alone to predict SGA (n = 5,119), and six assessed AC to predict LGA (n = 6,110). Sixteen assessed EFW to predict SGA (n = 13,825), and 22 evaluated EFW to predict LGA (n = 18,896). To predict SGA, AC and EFW < 10th percentile have similar ability to predict SGA. To predict LGA, AC cutoffs were comparable to all EFW cutoffs, except that AC > 35 cm had better sensitivity. Conclusion After 24 weeks, AC is comparable to EFW to predict both SGA and LGA. In settings where serial EFWs are inaccessible, a simpler screening method with AC alone may suffice.

scholarly journals Maternal Body Mass Index and Ethnicity in Relation to The Adverse Outcomes of Large for Gestational Age and Gestational Diabetes Mellitus in a Retrospective Cohort of Australian Pregnant Women.

2021 ◽  
Author(s):  
Catherine Knight-Agarwal ◽  
Jani Rati ◽  
Meisa Al-Foraih ◽  
Dionne Eckley ◽  
Carrie Ka Wai Lui ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Body Mass Index ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Body Mass ◽  
Gestational Age ◽  
Retrospective Cohort ◽  
Adverse Outcomes ◽  
Large For Gestational Age ◽  
Maternal Body Mass Index

Abstract Background: The prevalence of maternal overweight and obesity has been increasing. This research explored the association between maternal body mass index and ethnicity in relation to the adverse outcomes of large for gestational age and gestational diabetes mellitus. Method: A retrospective cohort study was undertaken with 27 814 Australian women of various ethnicities, who gave birth to a singleton infant between 2008 and 2017. Variables were examined using logistic regression. Results: A significantly higher proportion of large for gestational age infants were born to overweight and obese women compared to those who were classified as underweight and healthy weight. Asian-born women with a body mass index of ≥ 40kg/m2 had an adjusted odds ratio of 9.926 (3.859 - 25.535) for birthing a large for gestational age infant whereas Australian-born women had an adjusted odds ratio of 2.661 (2.256 - 3.139) for the same outcome. Women born in Australia were at high risk of birthing a large for gestational age infant in the presence of insulin controlled gestational diabetes mellitus, but this risk was not significant for those with the diet-controlled type. Asian-born women did not present an elevated risk of birthing a large for gestational infant, in either the diet controlled, or insulin controlled gestational diabetes mellitus groups. Conclusion: Large for gestational age and gestational diabetes mellitus are adverse pregnancy outcomes that can lead to significant maternal and neonatal morbidity. Women who are overweight or obese, and considering a pregnancy, are encouraged to seek culturally appropriate nutrition and weight management advice during the periconception period.

Characterization of Stem Cells and Immune Cells in Preterm and Term Mother’s Milk

2019 ◽  
Vol 35 (3) ◽  
pp. 528-534 ◽  
Author(s):  
Shujuan Li ◽  
Lan Zhang ◽  
Qi Zhou ◽  
Siyuan Jiang ◽  
Yi Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Human Milk ◽  
Gestational Age ◽  
Immune Cells ◽  
Immune Cell ◽  
Mode Of Delivery ◽  
Maternal Body Mass Index ◽  
Hemopoietic Stem Cells ◽  
Mature Milk ◽  
Cellular Components

Background: Human milk is known to be rich in cellular components, including stem cells and immune cells. However, the dynamics of these cellular components at different lactation stages, and the differences between milk for preterm and term infants, are poorly understood. Research aim: To identify changes in the cellular components of human milk at different lactation stages, and to explore the associations of these changes with maternal and infant characteristics. Methods: Forty mothers of newborns of different gestational ages were enrolled. Colostrum, transitional, and mature milk samples were collected. Stem cell and immune cell molecule markers were detected using flow cytometry. Pluripotent genes (SOX2, NANOG, OCT4, and KLF4) were detected via quantitative real-time PCR. Results: Human milk contained some stem cells but more immune cells. The percentages of hemopoietic stem cells were significantly higher in mature milk than in colostrum, and the percentages of total immune cells were lower in mature milk than in colostrum. The percentages of hemopoietic stem cells in colostrum and transitional milk were influenced by gestational age. Some minor differences in the cell composition of human milk could be explained by maternal body mass index, the mode of delivery, and parity. Conclusion: Our results again confirmed that human milk contains stem cells. Additionally, the percentages of hemopoietic stem cells and major immune cells changed dynamically at different lactation stages and were associated with gestational age at delivery.

31 Fetal abdominal circumference growth velocity as a predictor of neonatal outcome and birth weight in appropriate-for-gestational-age neonates

2016 ◽  
Vol 6 (3) ◽  
pp. 192-193
Author(s):  
Manouk Hendrix ◽  
Sander Van Kuijk ◽  
Desire Kramer ◽  
Danilo Gavilanes ◽  
Marc Spaanderman ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Growth Velocity ◽  
Neonatal Outcome ◽  
Abdominal Circumference ◽  
Appropriate For Gestational Age

Predictive Value of Fetal Abdominal Circumference in Diagnosing Large for Gestational Age Infants [9D]

2019 ◽  
Vol 133 (1) ◽  
pp. 44S-44S
Author(s):  
Rohini Kopparam ◽  
Kathy Matthews ◽  
Rana Khan ◽  
Tracy B. Grossman ◽  
Shari Ellen Gelber
Keyword(s):  
Gestational Age ◽  
Predictive Value ◽  
Abdominal Circumference ◽  
Large For Gestational Age

scholarly journals Comparison of ultrasound parameters for diagnosis of IUGR

2018 ◽  
Vol 7 (2) ◽  
pp. 596
Author(s):  
Pardeshi Yogeshwari Gangadhar ◽  
Nancy S. Pillai
Keyword(s):  
Gestational Age ◽  
Head Circumference ◽  
Abdominal Circumference ◽  
Medical Sciences ◽  
Accuracy Rate ◽  
Femur Length ◽  
Active Approach ◽  
Obstetrics And Gynaecology ◽  
Sensitivity Specificity ◽  
Ultrasound Parameters

Background: An active approach to the diagnosis of IUGR should be undertaken so that the foetus can be closely monitored and when indicated, be promptly delivered.Methods: Study was conducted at Department of Obstetrics and Gynaecology, Pushpagiri Institute of Medical Sciences, Thiruvalla. All pregnant women whose gestational ages were assessed by ultrasonography in 1st trimester was included in the study. An ultrasonographic biometric evaluation was done between 22-24 weeks and repeated at 32-34 weeks of gestational age and their ratios compared, using standard formulae.Results: We has observed that at 22-24 weeks of gestational age abdominal circumference (AC) has a better sensitivity, specificity, NPV and PPV when compared with femur length (FL), head circumference (HC), FL/AC and HC/AC. AC has got lowest FP and FN with a highest accuracy rate of 83% as compared to FL, HC, FL/AC and HC/AC at 22-24 weeks of gestational age. At 32-34 weeks of gestational age AC remains better in sensitivity, specificity, NPV, PPV, FP and FN values as compared to FL, HC, FL/AC and HC/AC.Conclusions: AC has a better sensitivity, specificity, NPV and PPV for diagnosis of IUGR when compared with FL, HC, FL/AC and HC/AC. AC has got lowest FP and FN with a highest accuracy rate at both 22-24 weeks of gestational age and 32-34 weeks of gestational age. The sensitivity, specificity and accuracy of AC is more at 32-34 weeks of gestation than at 22-24 weeks for diagnosis of IUGR.

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