scholarly journals A Sulfated-Polysaccharide Fraction from Seaweed Gracilaria birdiae Prevents Naproxen-Induced Gastrointestinal Damage in Rats

Marine Drugs ◽  
2012 ◽  
Vol 10 (12) ◽  
pp. 2618-2633 ◽  
Author(s):  
Renan Silva ◽  
Ana Santana ◽  
Nathalia Carvalho ◽  
Talita Bezerra ◽  
Camila Oliveira ◽  
...  
2016 ◽  
Vol 152 ◽  
pp. 140-148 ◽  
Author(s):  
Willer M. Sousa ◽  
Renan O. Silva ◽  
Francisco F. Bezerra ◽  
Rudy D. Bingana ◽  
Francisco Clark N. Barros ◽  
...  

Marine Drugs ◽  
2011 ◽  
Vol 9 (11) ◽  
pp. 2188-2200 ◽  
Author(s):  
Renan Oliveira Silva ◽  
Geice Maria Pereira dos Santos ◽  
Lucas Antonio Duarte Nicolau ◽  
Larisse Tavares Lucetti ◽  
Ana Paula Macedo Santana ◽  
...  

2014 ◽  
Vol 66 (8) ◽  
pp. 1161-1170 ◽  
Author(s):  
Tarcisio V. Brito ◽  
José P. R. P. Neto ◽  
Rafael S. Prudêncio ◽  
Jalles A. Batista ◽  
José S. C. Júnior ◽  
...  

2012 ◽  
Vol 27 (2) ◽  
pp. 287-292 ◽  
Author(s):  
Bartolomeu W.S. Souza ◽  
Miguel A. Cerqueira ◽  
Ana I. Bourbon ◽  
Ana C. Pinheiro ◽  
Joana T. Martins ◽  
...  

2012 ◽  
Vol 35 (1) ◽  
pp. 93-100 ◽  
Author(s):  
Luciano de Sousa Chaves ◽  
Lucas Antonio Duarte Nicolau ◽  
Renan Oliveira Silva ◽  
Francisco Clark Nogueira Barros ◽  
Ana Lúcia Ponte Freitas ◽  
...  

2013 ◽  
Vol 23 (2) ◽  
pp. 320-328 ◽  
Author(s):  
Samara R.B. Damasceno ◽  
Jocélia C. Rodrigues ◽  
Renan O. Silva ◽  
Lucas A.D. Nicolau ◽  
Luciano S. Chaves ◽  
...  

2011 ◽  
Vol 60 (12) ◽  
pp. 1121-1130 ◽  
Author(s):  
Edfranck de Sousa Oliveira Vanderlei ◽  
Ianna Wivianne Fernandes de Araújo ◽  
Ana Luíza Gomes Quinderé ◽  
Bruno Pedrosa Fontes ◽  
Ygor Raphael Gomes Eloy ◽  
...  

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2055 ◽  
Author(s):  
Leticia Castelo Branco Peroba Oliveira ◽  
Moacir Fernandes Queiroz ◽  
Gabriel Pereira Fidelis ◽  
Karoline Rachel Teodosio Melo ◽  
Rafael Barros Gomes Câmara ◽  
...  

The genus Gracilaria synthesizes sulfated polysaccharides (SPs). Many of these SPs, including those synthesized by the edible seaweed Gracilaria birdiae, have not yet been adequately investigated for their use as potential pharmaceutical compounds. Previous studies have demonstrated the immunomodulatory effects of sulfated galactans from G. birdiae. In this study, a galactan (GB) was extracted from G. birdiae and evaluated by cell proliferation and antioxidant tests. GB showed no radical hydroxyl (OH) and superoxide (O2−) scavenging ability. However, GB was able to donate electrons in two further different assays and presented iron- and copper-chelating activity. Urolithiasis affects approximately 10% of the world’s population and is strongly associated with calcium oxalate (CaOx) crystals. No efficient compound is currently available for the treatment of this disease. GB appeared to interact with and stabilize calcium oxalate dihydrate crystals, leading to the modification of their morphology, size, and surface charge. These crystals then acquired the same characteristics as those found in healthy individuals. In addition, GB showed no cytotoxic effect against human kidney cells (HEK-293). Taken together, our current findings highlight the potential application of GB as an antiurolithic agent.


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