scholarly journals Surfactant-Laden Janus Droplets with Tunable Morphologies and Enhanced Stability for Fabricating Lens-Shaped Polymeric Microparticles

Micromachines ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 29
Author(s):  
Siyuan Xu ◽  
Takasi Nisisako
Keyword(s):  
Silicone Oil ◽  
Flow Focusing ◽  
Acrylate Monomer ◽  
Microfluidic Flow ◽  
Planar Convex ◽  
Improved Stability ◽  
Polymeric Microparticles ◽  
Glass Chip ◽  
Polymer Microparticles ◽  
Enhanced Stability

Janus droplets can function as excellent templates for fabricating physically and chemically anisotropic particles. Here, we report new surfactant-laden Janus droplets with curvature controllability and enhanced stability against coalescence, suitable for fabricating shape-anisotropic polymer microparticles. Using a microfluidic flow-focusing device on a glass chip, nanoliter-sized biphasic droplets, comprising an acrylate monomer segment and a silicone-oil (SO) segment containing a surfactant, were produced in a co-flowing aqueous polyvinyl alcohol (PVA) solution. At equilibrium, the droplets formed a Janus geometry based on the minimization of interfacial energy, and each of the two Janus segments were uniform in size with coefficient-of-variation values below 3%. By varying the concentration of the surfactant in the SO phase, the curvature of the interface between the two lobes could be shifted among concave, planar, and convex shapes. In addition, the Janus droplets exhibited significantly improved stability against coalescence compared with previously reported Janus droplets carrying no surfactant that coalesced rapidly. Finally, via off-chip photopolymerization, concave-convex, planar-convex, and biconvex lens-shaped particles were fabricated.

scholarly journals Preparation of Monodisperse Biodegradable Polymer Microparticles Using a Microfluidic Flow‐Focusing Device for Controlled Drug Delivery

Small ◽  
2009 ◽  
Vol 5 (13) ◽  
pp. 1575-1581 ◽  
Author(s):  
Qiaobing Xu ◽  
Michinao Hashimoto ◽  
Tram T. Dang ◽  
Todd Hoare ◽  
Daniel S. Kohane ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biodegradable Polymer ◽  
Controlled Drug Delivery ◽  
Flow Focusing ◽  
Microfluidic Flow ◽  
Polymer Microparticles

Formation of Polyacrylamide and PEGDA Hydrogel Particles in a Microfluidic Flow Focusing Droplet Generator

2018 ◽  
Vol 63 (9) ◽  
pp. 1328-1333
Author(s):  
D. V. Nozdriukhin ◽  
N. A. Filatov ◽  
A. A. Evstrapov ◽  
A. S. Bukatin
Keyword(s):  
Droplet Generator ◽  
Flow Focusing ◽  
Hydrogel Particles ◽  
Microfluidic Flow

scholarly journals Asynchronous generation of oil droplets using a microfluidic flow focusing system

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Peter Thurgood ◽  
Sara Baratchi ◽  
Aram Arash ◽  
Elena Pirogova ◽  
Aaron R. Jex ◽  
...  
Keyword(s):  
Flow Focusing ◽  
Oil Droplets ◽  
Microfluidic Flow

scholarly journals Breakup Dynamics of Semi-dilute Polymer Solutions in a Microfluidic Flow-focusing Device

Micromachines ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 406
Author(s):  
Chun-Dong Xue ◽  
Xiao-Dong Chen ◽  
Yong-Jiang Li ◽  
Guo-Qing Hu ◽  
Tun Cao ◽  
...  
Keyword(s):  
Relaxation Time ◽  
Polymer Solutions ◽  
Newtonian Fluids ◽  
Droplet Microfluidics ◽  
Droplet Generation ◽  
Flow Focusing ◽  
Polymeric Fluids ◽  
Practical Applications ◽  
Dilute Polymer Solutions ◽  
Microfluidic Flow

Droplet microfluidics involving non-Newtonian fluids is of great importance in both fundamental mechanisms and practical applications. In the present study, breakup dynamics in droplet generation of semi-dilute polymer solutions in a microfluidic flow-focusing device were experimentally investigated. We found that the filament thinning experiences a transition from a flow-driven to a capillary-driven regime, analogous to that of purely elastic fluids, while the highly elevated viscosity and complex network structures in the semi-dilute polymer solutions induce the breakup stages with a smaller power-law exponent and extensional relaxation time. It is elucidated that the elevated viscosity of the semi-dilute solution decelerates filament thinning in the flow-driven regime and the incomplete stretch of polymer molecules results in the smaller extensional relaxation time in the capillary-driven regime. These results extend the understanding of breakup dynamics in droplet generation of non-Newtonian fluids and provide guidance for microfluidic synthesis applications involving dense polymeric fluids.

Preparation of All-Trans-Retinoic Acid-Loaded mPEG-PLGA Nanoparticles Using Microfluidic Flow-Focusing Device for Controlled Drug Delivery

NANO ◽  
2020 ◽  
Vol 15 (08) ◽  
pp. 2050101
Author(s):  
Mojdeh Safari ◽  
Amir Amani ◽  
Tajudeen Adebileje ◽  
Jafar Ai ◽  
Seyed Mahdi Rezayat ◽  
...  
Keyword(s):  
Particle Size ◽  
Retinoic Acid ◽  
Plga Nanoparticles ◽  
Process Conditions ◽  
Flow Focusing ◽  
Flow Rates ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Microfluidic Flow ◽  
Minimum Particle Size

In recent years, microfluidic devices present unique advantages for the development of a new generation of nanoparticle synthesis method compared to bulk methods. In this study, we report a microfluidic flow-focusing method for the production of all trans retinoic acid (ATRA)-loaded methoxy poly(ethylene glycol)-poly(lactide-coglycolide) (mPEG-PLGA) nanoparticles (NPs). Box–Behnken experimental design (BBD) was applied to optimize of formulation ingredients and process conditions with minimum particle size, maximum drug loading% (DL%) and encapsulation efficiency% (EE%). Polymer concentration, drug concentration and flow rates of solvent (S) and antisolvent (AS) were selected as independent variables. Based on optimization strategy, minimum particle size achieved shows average (SD) particle size of [Formula: see text][Formula: see text]nm with DL of [Formula: see text][Formula: see text]wt.% and EE of [Formula: see text][Formula: see text]wt.%, respectively. While maximum DL has been reported to be [Formula: see text][Formula: see text]wt.% with particle size of [Formula: see text][Formula: see text]nm and EE of [Formula: see text][Formula: see text]wt.%, respectively. Moreover, the results have shown that the AS/S ratio represents the most significant effect on particle size. Indeed, increasing the AS flow rate directly results in generating smaller particles. The AS/S ratio represents the least significant effect on DL%, such that, at fixed flow rates, higher DL was observed at high concentration of drug and lower concentration of polymer. In conclusion, optimization of the ATRA-loaded mPEG-PLGA NPs by BBD yielded in a favorable drug carrier for ATRA that could provide a new treatment modality for different malignancies.

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