scholarly journals Current Nanocarrier Strategies Improve Vitamin B12 Pharmacokinetics, Ameliorate Patients’ Lives, and Reduce Costs

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 743
Author(s):  
Marco Fidaleo ◽  
Stefano Tacconi ◽  
Carolina Sbarigia ◽  
Daniele Passeri ◽  
Marco Rossi ◽  
...  
Keyword(s):  
Side Effects ◽  
Vitamin B12 ◽  
Memory Performance ◽  
Oral Route ◽  
High Dose ◽  
Human Beings ◽  
Inborn Errors ◽  
Essential Nutrient

Vitamin B12 (VitB12) is a naturally occurring compound produced by microorganisms and an essential nutrient for humans. Several papers highlight the role of VitB12 deficiency in bone and heart health, depression, memory performance, fertility, embryo development, and cancer, while VitB12 treatment is crucial for survival in inborn errors of VitB12 metabolism. VitB12 is administrated through intramuscular injection, thus impacting the patients’ lifestyle, although it is known that oral administration may meet the specific requirement even in the case of malabsorption. Furthermore, the high-dose injection of VitB12 does not ensure a constant dosage, while the oral route allows only 1.2% of the vitamin to be absorbed in human beings. Nanocarriers are promising nanotechnology that can enable therapies to be improved, reducing side effects. Today, nanocarrier strategies applied at VitB12 delivery are at the initial phase and aim to simplify administration, reduce costs, improve pharmacokinetics, and ameliorate the quality of patients’ lives. The safety of nanotechnologies is still under investigation and few treatments involving nanocarriers have been approved, so far. Here, we highlight the role of VitB12 in human metabolism and diseases, and the issues linked to its molecule properties, and discuss how nanocarriers can improve the therapy and supplementation of the vitamin and reduce possible side effects and limits.

scholarly journals Role of Oxycodone Hydrochloride in Treating Radiotherapy-Related Pain

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yinxia Wang ◽  
Ligang Xing
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
Cancer Pain ◽  
Cancer Patients ◽  
Pain Control ◽  
Analgesic Drugs ◽  
Oxycodone Hydrochloride ◽  
Radiation Esophagitis

Radiotherapy is commonly used to treat cancer patients. Besides the curable effect, radiotherapy also could relieve the pain of cancer patients. However, cancer pain is gradually alleviated about two weeks after radiotherapy. In addition, cancer patients who receive radiotherapy may also suffer from pain flare or radiotherapy-induced side effects such as radiation esophagitis, enteritis, and mucositis. Pain control is reported to be inadequate during the whole course of radiotherapy (before, during, and after radiotherapy), and quality of life is seriously affected. Hence, radiotherapy is suggested to be combined with analgesic drugs in clinical guidelines. Previous studies have shown that radiotherapy combined with oxycodone hydrochloride can effectively alleviate cancer pain. In this review, we firstly presented the necessity of analgesia during the whole course of radiotherapy. We also sketched the role of oxycodone hydrochloride in radiotherapy of bone metastases and radiotherapy-induced oral mucositis. Finally, we concluded that oxycodone hydrochloride shows good efficacy and tolerance and could be used for pain management before, during, and after radiotherapy.

scholarly journals The role of erenumab in the treatment of migraine

2020 ◽  
Vol 13 ◽  
pp. 175628642092711 ◽  
Author(s):  
Anna P. Andreou ◽  
Matteo Fuccaro ◽  
Giorgio Lambru
Keyword(s):  
Clinical Trials ◽  
Side Effects ◽  
European Medicines Agency ◽  
Human Antibody ◽  
Subcutaneous Injections ◽  
Calcitonin Gene ◽  
The Us ◽  
Different Doses

Calcitonin gene related peptide (CGRP) monoclonal antibodies (mAbs) have been the first class of specifically developed preventive treatments for migraine. Clinical trials data suggest superiority of the CGRP mAbs to placebo in terms of prevention of migraine symptoms, migraine-specific quality of life and headache related disability. Treatment-related side effects overall did not differ significantly from placebo and discontinuation rate due to side effects has been low across the clinical trials, perhaps in view of their peripheral mode of action. Along with their route and frequency of administration, these novel class of drugs may constitute an improvement compared with the established arsenal of migraine treatments. Erenumab is a fully human antibody and the only mAb acting on the CGRP pathway by blocking its receptor. It is the first of the CGRP mAb class approved by the US Food and Drug Administration (May 2018) and the European Medicines Agency (July 2018). Erenumab exists in two different doses (70 mg and 140 mg) and it is administered with monthly subcutaneous injections. This review summarises erenumab pharmacological characteristics, clinical trials data, focusing on the potential role of this treatment in clinical practice.

Role of High-Dose Intravenous Frusemide Therapy in the Management of Chronic Renal Failure

1975 ◽  
Vol 3 (4) ◽  
pp. 245-250
Author(s):  
Mam Chandra ◽  
M K Mitra ◽  
N N Gupta
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Side Effects ◽  
Treated Group ◽  
Fixed Dose ◽  
High Dose ◽  
Dose Regime ◽  
Diuretic Response ◽  
High Doses

The results of using high doses of intravenous frusemide in the management of 28 patients suffering from chronic renal failure are presented. The results are compared with those obtained from 14 patients also suffering from chronic renal failure, who received identical ‘conservative management’ but were not treated with diuretics. Large doses of intravenous frusemide produced a satisfactory diuretic response in a higher percentage of treated patients (71%) compared with controls (36%). It was also observed that in the treated group of patients a significant diuretic response could be obtained in patients with a creatinine clearance below 4 ml per minute. The study also demonstrated that in the group of patients receiving frusemide the response was better in those who were given a progressive-dose regime; 88% of patients improved with this regime compared with 68% of patients who were treated with a fixed dose of frusemide. Transient deafness with tinnitus and vertigo were the only side-effects observed. However these effects were only seen in patients who received 1000 mg or more frusemide in one day, administered over a period of one to two hours. It is concluded that all patients suffering from chronic renal failure should be given a trial of large doses of intravenous frusemide therapy, along with other conventional measures, particularly where facilities for dialysis are not immediately available.

The Role of Implant Temperature in the Formation of Thin Buried Oxide Layers

1986 ◽  
Vol 74 ◽  
Author(s):  
Alice E. White ◽  
K. T. Short ◽  
L. N. Pfeiffer ◽  
K. W. West ◽  
J. L. Batstone
Keyword(s):  
High Temperature ◽  
Crystalline Material ◽  
High Dose ◽  
Si Substrate ◽  
High Temperature Anneal ◽  
Damage Structure ◽  
Amorphous Si ◽  
Substrate Temperatures

AbstractFrom the early work on high dose oxygen implantation for buried SiO2 formation, it is apparent that the temperature of the Si substrate during the implant has a strong influence on the quality of both the SiO2 layer and the overlying Si. This, in turn, can be related to the damage from the oxygen implant. For substrate temperatures < ∼ 300°C, amorphous Si is created during the implant and leads to the formation of twins or polycrystalline Si during the subsequent high temperature (>1300°C) anneal. At higher substrate temperatures (<∼400°C), dynamic annealing eliminates the amorphous Si, but the implanted oxygen appears to segregate during the implant leading to oxygen-rich amorphous regions imbedded in regions of crystalline material. As the amorphous regions start to coalesce and form SiO2 during the high temperature anneal, they trap crystalline Si which cannot escape by diffusion. This process can be circumvented by using a randomizing Si implant to change the damage structure from the oxygen implant before annealing. We have seen these effects clearly in sub-stoichiometric implants, and believe they are also operative during stoichiometric implants.

scholarly journals Role of high dose octreotide LAR for the treatment of GEP-NETs

2009 ◽  
Vol 3 (1) ◽  
pp. 7-14
Author(s):  
Giulia M. Franchi ◽  
Chiara Cappelletti ◽  
Valentina V. Villa ◽  
Emanuele Bosi ◽  
Marco F. Manzoni
Keyword(s):  
Quality Of Life ◽  
Tumour Growth ◽  
Neuroendocrine Tumours ◽  
Clinical Symptoms ◽  
Standard Dose ◽  
Diagnostic Tools ◽  
High Dose ◽  
Octreotide Lar

Neuroendocrine Tumours (NETs) are a heterogeneous group of rare neoplasms that account for 0,5% of all malignancies. The increased incidence observed in the last few decades may be accounted for by increased awareness, improved diagnostic tools and a revision in the definition. The main primary sites are the gastro-entero-pancreatic (GEP) tract (62-67%), and the lung (22-27%). In patients with GEP-NETs, the strongest predictor of 5-years survival is the staging. An adequate clinical management of GEP-NETs should be multidisciplinary and should aim at assuring a good quality of life. Somatostatin (sst) analogues are widely used in these tumours, which often express sst receptors, since they are demonstrated to reduce clinical symptoms and tumour growth. Herein we explore the usefulness of doubling octreotide LAR dose in selected patients after escaping from symptoms control and/or tumour stabilization in course of treatment with standard dose.

Hakikat dan Konsep-Konsep Dasar Psikologi Pendidikan, Belajar dan Pembelajaran Serta Faktor-Faktor yang Mempengaruhinya

2014 ◽  
Vol 3 (2) ◽  
pp. 156-164
Author(s):  
Rusdi Rusdi
Keyword(s):  
Learning Outcomes ◽  
Educational Psychology ◽  
Business Education ◽  
Teaching And Learning ◽  
Educational Process ◽  
Human Beings ◽  
Psychological Knowledge ◽  
Actual Teaching

Is a must for every educator who is responsible, that he was in carrying out his duties,act in a manner consistent with the \"state\" of the students. In this context, the role of psychology as a scienceknowledge which seeks to understand human beings, with the goal to be able to treat it with moreright. Therefore, the psychological knowledge of students in the educational process is necessary andimportant for every educator; so that every educator should be a requirement to have knowledgeon educational psychology. The central issue in educational psychology is a matter of learning andlearning. This is not surprising, because the actual teaching and learning is a follow implementationin business education. In seeking to educate, children students learn and the teachers do the teachingto the students. The quality of students' learning outcomes are determined by the learning process that caninfluenced by many factors, both internal and external.

scholarly journals Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: a pragmatic, randomised, non-inferiority clinical trial (OB12)

BMJ Open ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. e033687
Author(s):  
Teresa Sanz-Cuesta ◽  
Esperanza Escortell-Mayor ◽  
Isabel Cura-Gonzalez ◽  
Jesus Martin-Fernandez ◽  
Rosario Riesgo-Fuertes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Oral Route ◽  
Treatment Quality ◽  
Factors Affecting ◽  
Administration Routes ◽  
Intention To Treat ◽  
The Difference

ObjectivesTo compare the effectiveness of oral versus intramuscular (IM) vitamin B12 (VB12) in patients aged ≥65 years with VB12 deficiency.DesignPragmatic, randomised, non-inferiority, multicentre trial in 22 primary healthcare centres in Madrid (Spain).Participants283 patients ≥65 years with VB12 deficiency were randomly assigned to oral (n=140) or IM (n=143) treatment arm.InterventionsThe IM arm received 1 mg VB12 on alternate days in weeks 1–2, 1 mg/week in weeks 3–8 and 1 mg/month in weeks 9–52. The oral arm received 1 mg/day in weeks 1–8 and 1 mg/week in weeks 9–52.Main outcomesSerum VB12 concentration normalisation (≥211 pg/mL) at 8, 26 and 52 weeks. Non-inferiority would be declared if the difference between arms is 10% or less. Secondary outcomes included symptoms, adverse events, adherence to treatment, quality of life, patient preferences and satisfaction.ResultsThe follow-up period (52 weeks) was completed by 229 patients (80.9%). At week 8, the percentage of patients in each arm who achieved normal B12 levels was well above 90%; the differences in this percentage between the oral and IM arm were −0.7% (133 out of 135 vs 129 out of 130; 95% CI: −3.2 to 1.8; p>0.999) by per-protocol (PPT) analysis and 4.8% (133 out of 140 vs 129 out of 143; 95% CI: −1.3 to 10.9; p=0.124) by intention-to-treat (ITT) analysis. At week 52, the percentage of patients who achieved normal B12 levels was 73.6% in the oral arm and 80.4% in the IM arm; these differences were −6.3% (103 out of 112 vs 115 out of 117; 95% CI: −11.9 to −0.1; p=0.025) and −6.8% (103 out of 140 vs 115 out of 143; 95% CI: −16.6 to 2.9; p=0.171), respectively. Factors affecting the success rate at week 52 were age, OR=0.95 (95% CI: 0.91 to 0.99) and having reached VB12 levels ≥281 pg/mL at week 8, OR=8.1 (95% CI: 2.4 to 27.3). Under a Bayesian framework, non-inferiority probabilities (Δ>−10%) at week 52 were 0.036 (PPT) and 0.060 (ITT). Quality of life and adverse effects were comparable across groups. 83.4% of patients preferred the oral route.ConclusionsOral administration was no less effective than IM administration at 8 weeks. Although differences were found between administration routes at week 52, the probability that the differences were below the non-inferiority threshold was very low.Trial registration numbersNCT 01476007; EUDRACT (2010-024129-20).

scholarly journals Comparison of Effect of Clonidine Added to Bupivacaine-Fentanyl Mixture on the Quality of Spinal Anaesthesia and Peri-Op Analgesia with Bupivacaine-Fentanyl or Bupivacaine-Clonidine Mixture in Major Orthopaedic Lower Limb Surgeries

2017 ◽  
pp. 97
Author(s):  
Milin Raju Shah ◽  
Gauri Diwan
Keyword(s):  
Side Effects ◽  
Spinal Anaesthesia ◽  
High Dose ◽  
Motor Blockade ◽  
Randomised Study ◽  
Group I ◽  
Analgesia Requirement ◽  
Mean Time ◽  
Effective Analgesia

Introduction: With side effects of central neuroaxial opioids or of high dose intrathecal clonidine in combination with bupivacaine in spinal anaesthesia, my study is to ascertain if small dose of clonidine when added to bupivacaine-fentanyl mixture improves spinal anaesthesia, without producing side effects, as compared to bupivacaine-fentanyl or bupivacaineclonidine mixture. Methods: It’s a prospective, double blinded randomised study of 90 ASA grade I-II patients, aged between 20-60 yrs, of either sex, weighing between 40-70 kgs, scheduled for major orthopaedic surgeries. Patients were randomly divided into 3 groups of 30 patients each as Group I (BCF): Bupivacaine 0.5%H 2.6ml + Fentanyl 20mcg + Clonidine 30mcg Group II (BC): Bupivacaine 0.5%H 2.6ml + Clonidine 30mcg Group III (BF): Bupivacaine 0.5%H 2.6ml + Fentanyl 20mcg Duration of sensory and motor blockade and effective analgesia mean time till two segment regression, haemodynamic profile, post-op pain and analgesia requirement were recorded. Results: The duration of sensory and motor blockade, effective analgesia and mean time till two segment regression were significantly longer in group BCF as compared to group BC (P – 0.002) and in group BC as compared to group BF (P – 0.01). The incidence of intra-op pain and requirement of postop analgesia in the first 24 hours was significantly more in group BF as compared to other groups (P-0.01). Conclusion: Low dose Clonidine when added to Bupivacaine-Fentanyl mixture improves the quality of peri-op analgesia without significant side effects.

scholarly journals The Role of Chloroquine and Hydroxychloroquine in Prophylaxis of Covid-19: A Literature Review

2020 ◽  
Author(s):  
Dewi Indra Sari ◽  
◽  
Mardiati Nadjib ◽  
Keyword(s):  
Public Health ◽  
Observational Studies ◽  
Cochrane Library ◽  
Post Exposure Prophylaxis ◽  
High Dose ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Exposure Prophylaxis

ABSTRACT Background: A pandemic potential Covid-19 spread rapidly worldwide. Ministry of Health, Republic Indonesia recommended one of the Covid-19 treatments with combination of hydroxychloroquine/ chloroquine and azithromycin. However, the effectiveness and safety of antimalaria regime remain debating topic. This study aimed to investigate the role of chloroquine and hydroxychloroquine in prophylaxis of Covid-19. Subjects and Method: A systematic review was conducted by searching from PubMed, SpringerLink, and Cochrane Library databases. The keywords were “prophylaxis”, “chloroquine” OR “hydroxychloroquine” “SARS-CoV-2” OR “Covid-19”. The inclusion criteria were phase IIb clinical trials, double masking, comparative observational studies, open access articles published until August 2020. The exclusion criteria were inaccessible and duplicate articles. The quality of selected articles was critically appraised. The data were reported by PRISMA flow chart. Results: Three articles out of 117 articles met the criteria inclusion. The findings showed that hydroxychloroquine could not prevent Covid-19 compatible disease or confirmed infections when used as post-exposure prophylaxis. High dose chloroquine was not recommended for critically ill COVID-19 patients because of its potential side effects, especially when administered with azithromycin and oseltamivir. Covid-19 patients with the need for oxygenation were not suggested to use hydroxychloroquine. Conclusion: There is scarce evidence to support prophylaxis and treatment effects of chloroquine or hydroxychloroquine in COVID-19 patients. Further research on the safety and use of chloroquine or hydroxychloroquine is required in the management of Covid-19. Keywords: prophylaxis, Chloroquine, Hydroxychloroquine, SARS-CoV-2, Covid-19 Correspondence: Dewi Indra Sari. Masters Program in Public Health, Faculty of Public Health, Universitas Indonesia, Depok, West Java. Email: [email protected]. Mobile: +628121983-6600. DOI: https://doi.org/10.26911/the7thicph.05.33

scholarly journals The Role of Technological Teaching Methods Used in Education on the Development

2017 ◽  
Vol 6 (2) ◽  
pp. 333
Author(s):  
Aslı ÖZTOPCU ◽  
Diğdem ENEREM
Keyword(s):  
Human Capital ◽  
Civil Society ◽  
Teaching Methods ◽  
Crime Rates ◽  
Human Beings ◽  
Teaching Tools ◽  
Made In

Different teaching methods are used to make individuals' learning easier and effective. Technological teaching tools are often used in this context. Technological teaching methods create socioeconomic effects while increase human capital, because investments made in human beings provide benefits, both for individuals and society in a long term. In this study, firstly the use of technological teaching methods is investigated and secondly, the role of the gains obtained in the development is analyzed. According to the results obtained, technological teaching methods cause externalities such as reduction of crime rates, revitalization of the economy thanks to investments, increase in the quality of relations of civil society, increase in HDI and increase in employment.

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