scholarly journals Nicotinamide Riboside for the Prevention and Treatment of Doxorubicin Cardiomyopathy. Opportunities and Prospects

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3435
Author(s):  
Ekaterina Podyacheva ◽  
Yana Toropova
Keyword(s):  
High Efficiency ◽  
Experimental Models ◽  
Symptomatic Therapy ◽  
Vitamin B3 ◽  
Nicotinamide Riboside ◽  
Pathological Conditions ◽  
The World ◽  
Hematological Tumors ◽  
Published Research ◽  
Doxorubicin Cardiomyopathy

Despite the progress in the development of new anticancer strategies, cancer is rapidly spreading around the world and remains one of the most common diseases. For more than 40 years, doxorubicin has been widely used in the treatment of solid and hematological tumors. At the same time, the problem of its cardiotoxicity remains unresolved, despite the high efficiency of this drug. Symptomatic therapy is used as a treatment for side-effects of doxorubicin or pathological conditions that have already appeared in their background. To date, there are no treatment methods for doxorubicin cardiomyopathy as such. A drug such as nicotinamide riboside can play an important role in solving this problem. Nicotinamide riboside is a pyridine nucleoside similar to vitamin B3 that acts as a precursor to NAD+. There is no published research on nicotinamide riboside effects on cardiomyopathy, despite the abundance of works devoted to the mechanisms of its effects in various pathologies. The review analyzes information about the effects of nicotinamide riboside on various experimental models of pathologies, its role in the synthesis of NAD+, and also considers the possibility and prospects of its use for the prevention of doxorubicin cardiomyopathy.

scholarly journals Nicotinamide Riboside for the Prevention and Treatment of Doxorubicin Cardiomyopathy. Opportunities and Prospects.

2021 ◽  
Author(s):  
Ekaterina Podyacheva ◽  
Yana Toropova
Keyword(s):  
High Efficiency ◽  
Experimental Models ◽  
Symptomatic Therapy ◽  
Vitamin B3 ◽  
Nicotinamide Riboside ◽  
Independent Form ◽  
Oncological Diseases ◽  
Hematological Tumors ◽  
Late Stages ◽  
Doxorubicin Cardiomyopathy

Abstract Despite the progress in the development of new anticancer strategies, cancer is rapidly spreading around the world and remains one of the most common diseases. At the same time, oncological diseases are detected in patients with late stages of the course in the overwhelming majority of cases. This fact necessitates chemotherapy both as part of a combination and in the view of an independent form of treatment. For more than 40 years, doxorubicin has been widely used in the treatment of solid and hematological tumors. At the same time, the problem of its cardiotoxicity remains unresolved, despite the high efficiency of this drug. Symptomatic therapy is used as a treatment for side-effects of doxorubicin or pathological conditions that have already appeared on their background. To date, there are no treatment methods for doxorubicin cardiomyopathy as such. A drug such as nicotinamide riboside can play an important role in solving this problem. Nicotinamide riboside is a pyridine nucleoside similar to vitamin B3 that acts as a precursor to NAD+. There are no such works in cardiomyopathy, despite the abundance of works devoted to the mechanisms of realization of the effects of nicotinamide riboside in various pathologies. The review analyzes information about the effects of NR on various experimental models of pathologies, its role in the synthesis of NAD+, and also considers the possibility and prospects of its use for the prevention of doxorubicin cardiomyopathy.

scholarly journals Equilibrative Nucleoside Transporters Mediate the Import of Nicotinamide Riboside and Nicotinic Acid Riboside into Human Cells

2021 ◽  
Vol 22 (3) ◽  
pp. 1391
Author(s):  
Andrey Kropotov ◽  
Veronika Kulikova ◽  
Kirill Nerinovski ◽  
Alexander Yakimov ◽  
Maria Svetlova ◽  
...  
Keyword(s):  
Nicotinic Acid ◽  
Mammalian Cells ◽  
Experimental Models ◽  
The Body ◽  
Nucleoside Transporters ◽  
Hek293 Cells ◽  
Nucleoside Transporter ◽  
Vitamin B3 ◽  
Animal Cells ◽  
Nicotinamide Riboside

Nicotinamide riboside (NR), a new form of vitamin B3, is an effective precursor of nicotinamide adenine dinucleotide (NAD+) in human and animal cells. The introduction of NR into the body effectively increases the level of intracellular NAD+ and thereby restores physiological functions that are weakened or lost in experimental models of aging and various pathologies. Despite the active use of NR in applied biomedicine, the mechanism of its transport into mammalian cells is currently not understood. In this study, we used overexpression of proteins in HEK293 cells, and metabolite detection by NMR, to show that extracellular NR can be imported into cells by members of the equilibrative nucleoside transporter (ENT) family ENT1, ENT2, and ENT4. After being imported into cells, NR is readily metabolized resulting in Nam generation. Moreover, the same ENT-dependent mechanism can be used to import the deamidated form of NR, nicotinic acid riboside (NAR). However, NAR uptake into HEK293 cells required the stimulation of its active utilization in the cytosol such as phosphorylation by NR kinase. On the other hand, we did not detect any NR uptake mediated by the concentrative nucleoside transporters (CNT) CNT1, CNT2, or CNT3, while overexpression of CNT3, but not CNT1 or CNT2, moderately stimulated NAR utilization by HEK293 cells.

scholarly journals The Main Progress of Perovskite Solar Cells in 2020–2021

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Tianhao Wu ◽  
Zhenzhen Qin ◽  
Yanbo Wang ◽  
Yongzhen Wu ◽  
Wei Chen ◽  
...  
Keyword(s):  
Solar Cells ◽  
High Efficiency ◽  
Perovskite Solar Cells ◽  
Lead Free ◽  
Manufacturing Cost ◽  
Practical Application ◽  
The World ◽  
Photovoltaic Technology

AbstractPerovskite solar cells (PSCs) emerging as a promising photovoltaic technology with high efficiency and low manufacturing cost have attracted the attention from all over the world. Both the efficiency and stability of PSCs have increased steadily in recent years, and the research on reducing lead leakage and developing eco-friendly lead-free perovskites pushes forward the commercialization of PSCs step by step. This review summarizes the main progress of PSCs in 2020 and 2021 from the aspects of efficiency, stability, perovskite-based tandem devices, and lead-free PSCs. Moreover, a brief discussion on the development of PSC modules and its challenges toward practical application is provided.

scholarly journals Research progress of viscoelastic surfactants for enhanced oil recovery

2021 ◽  
pp. 014459872098020
Author(s):  
Ruizhi Hu ◽  
Shanfa Tang ◽  
Musa Mpelwa ◽  
Zhaowen Jiang ◽  
Shuyun Feng
Keyword(s):  
Enhanced Oil Recovery ◽  
Oil Recovery ◽  
High Efficiency ◽  
Research Progress ◽  
Surfactant Flooding ◽  
Sweep Efficiency ◽  
The World ◽  
Washing Efficiency ◽  
Viscoelastic Surfactants ◽  
Viscoelastic Surfactant

Although new energy has been widely used in our lives, oil is still one of the main energy sources in the world. After the application of traditional oil recovery methods, there are still a large number of oil layers that have not been exploited, and there is still a need to further increase oil recovery to meet the urgent need for oil in the world economic development. Chemically enhanced oil recovery (CEOR) is considered to be a kind of effective enhanced oil recovery technology, which has achieved good results in the field, but these technologies cannot simultaneously effectively improve oil sweep efficiency, oil washing efficiency, good injectability, and reservoir environment adaptability. Viscoelastic surfactants (VES) have unique micelle structure and aggregation behavior, high efficiency in reducing the interfacial tension of oil and water, and the most important and unique viscoelasticity, etc., which has attracted the attention of academics and field experts and introduced into the technical research of enhanced oil recovery. In this paper, the mechanism and research status of viscoelastic surfactant flooding are discussed in detail and focused, and the results of viscoelastic surfactant flooding experiments under different conditions are summarized. Finally, the problems to be solved by viscoelastic surfactant flooding are introduced, and the countermeasures to solve the problems are put forward. This overview presents extensive information about viscoelastic surfactant flooding used for EOR, and is intended to help researchers and professionals in this field understand the current situation.

scholarly journals Effect of Green Construction on a Building’s Carbon Emission and Its Price at Materialization

2021 ◽  
Vol 13 (2) ◽  
pp. 642
Author(s):  
Shuangxi Zhou ◽  
Zhenzhen Guo ◽  
Yang Ding ◽  
Jingliang Dong ◽  
Jianming Le ◽  
...  
Keyword(s):  
Greenhouse Gases ◽  
Emission Reduction ◽  
Carbon Emission ◽  
High Efficiency ◽  
Carbon Price ◽  
Carbon Trading ◽  
Construction Companies ◽  
Green Construction ◽  
The World ◽  
Total Price

Buildings consume many resources and generate greenhouse gases during construction. One of the main sources of greenhouse gases is carbon emission associated with buildings. This research is based on the computing rule of carbon emission at the materialization stage. By taking the features of green construction into consideration, quantitative analysis on construction carbon emission was undertaken via Life Cycle Assessment (LCA). Making use of Vensim (a system dynamics software package), we analyzed the amount of carbon emission at the materialization stage and determined the major subsystems affecting the carbon emission, then took into comprehensive consideration the differences of each subsystem’s carbon emission under different construction technologies. Under the mechanism of carbon trade at the materialization stage, the total price of carbon trades remains unchanged, while the trading price of each subsystem is adjusted. Under these conditions, a coefficient for step-wise increases in carbon price was proposed. By establishing such a system of gradient prices, construction companies are encouraged to adopt high-efficiency emission reduction technologies. Meanwhile, the system also provides a reference for the formulation of price-based policies about buildings’ carbon trading, and accelerates the process of energy conservation and emission reduction in China and the world at large.

scholarly journals Design of a High-Power High-Efficiency Multi-Receiver Wireless Power Transfer System

Electronics ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1308
Author(s):  
Yuyu Zhu ◽  
Hanyu Zhang ◽  
Zuming Wang ◽  
Xin Cao ◽  
Renyin Zhang
Keyword(s):  
Power Distribution ◽  
Power Flow ◽  
High Efficiency ◽  
Control Method ◽  
Experimental Models ◽  
Wireless Power ◽  
Multiple Receivers ◽  
Combined Operation ◽  
Wireless Power Transfer System ◽  
Good Agreement

This paper proposes a new control method to regulate the power flow into multiple receivers. This system consists of one transmitter controller and three receiver controllers. They work independently to decide the power distribution with their combined operation. The simulated and experimental models have been built, and the experimental results are in good agreement with the theoretical analysis results. The proposed method is robust, flexible, and generalizable, and can be employed under various wireless charging conditions.

scholarly journals The Role of Immune-Related miRNAs in the Pathology of Kidney Transplantation

Biomolecules ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1198
Author(s):  
Emanuela Boštjančič ◽  
Željka Večerić-Haler ◽  
Nika Kojc
Keyword(s):  
Immune Response ◽  
Kidney Transplantation ◽  
Kidney Diseases ◽  
Experimental Models ◽  
Regulatory Rna ◽  
Limited Data ◽  
Pathological Conditions ◽  
Monitoring Response ◽  
Disease Specific

MicroRNAs (miRNAs) are members of the non-coding regulatory RNA family that play pivotal roles in physiological and pathological conditions, including immune response. They are particularly interesting as promising therapeutic targets, prognostic and diagnostic markers due to their easy detection in body fluids and stability. There is accumulating evidence that different miRNAs provide disease-specific signatures in liquid samples of distinct kidney injuries. Using experimental models and human samples, there have been numerous suggestions that immune-related miRNAs are also important contributors to the development of different kidney diseases as well as important markers for monitoring response after kidney transplantation. However, there are limited data for understanding their function in the molecular pathways of allograft pathologies. In our review, we focused on microRNAs that are related to different aspects of immune response after kidney transplantation.

scholarly journals Children of Heaven

2019 ◽  
Vol 5 (2) ◽  
Author(s):  
Olenka Kawchuk
Keyword(s):  
Low Temperature ◽  
South America ◽  
Geographic Origin ◽  
High Elevation ◽  
Human Sacrifice ◽  
Inca Empire ◽  
Pathological Conditions ◽  
The World ◽  
The Subject ◽  
Ritual Process

Ruling over western South America for nearly 100 years, the Inca Empire was one of many global cultures that practiced human sacrifice, though few other rituals of human sacrifice are as captivating as the Inca child sacrifice of capacocha. Capacocha children were chosen to be representatives of the Inca people in the afterlife. As such, they were afforded an elevated position in society before their death. Following their selection, children would undergo a year-long pilgrimage terminating at a mountain top shrine where they would be killed. As a result of the low temperature and oxygen levels present at such a high elevation, the bodies of capacocha children were protected against decomposition, creating some of the best-preserved natural mummies in the world. These mummies have been the subject of numerous bioarchaeological analyses to determine their age, sex, geographic origin, pathological conditions, diet, and cause of death. Beyond these, however, the mummies present a unique opportunity to study how the capacocha ritual process — including the sudden ascension in status — manifested itself on the children's bodies. This paper aims to review the bioarchaeological data garnered from the mummies in order to reconstruct the experience of a child chosen for capacocha. Results suggest higher variability between children selected for capacocha than was originally outlined by Spanish chroniclers.

scholarly journals Payload Configurations for Efficient Image Acquisition – Indian Perspective

2014 ◽  
Vol XL-8 ◽  
pp. 1201-1206 ◽  
Author(s):  
D. R. M. Samudraiah ◽  
M. Saxena ◽  
S. Paul ◽  
P. Narayanababu ◽  
S. Kuriakose ◽  
...  
Keyword(s):  
Remote Sensing ◽  
Data Acquisition ◽  
High Efficiency ◽  
Image Acquisition ◽  
Image Data ◽  
Space Research ◽  
Remotely Sensed Data ◽  
Data Utilization ◽  
Spectral Bands ◽  
The World

The world is increasingly depending on remotely sensed data. The data is regularly used for monitoring the earth resources and also for solving problems of the world like disasters, climate degradation, etc. Remotely sensed data has changed our perspective of understanding of other planets. With innovative approaches in data utilization, the demands of remote sensing data are ever increasing. More and more research and developments are taken up for data utilization. The satellite resources are scarce and each launch costs heavily. Each launch is also associated with large effort for developing the hardware prior to launch. It is also associated with large number of software elements and mathematical algorithms post-launch. The proliferation of low-earth and geostationary satellites has led to increased scarcity in the available orbital slots for the newer satellites. Indian Space Research Organization has always tried to maximize the utility of satellites. Multiple sensors are flown on each satellite. In each of the satellites, sensors are designed to cater to various spectral bands/frequencies, spatial and temporal resolutions. Bhaskara-1, the first experimental satellite started with 2 bands in electro-optical spectrum and 3 bands in microwave spectrum. The recent Resourcesat-2 incorporates very efficient image acquisition approach with multi-resolution (3 types of spatial resolution) multi-band (4 spectral bands) electro-optical sensors (LISS-4, LISS-3* and AWiFS). The system has been designed to provide data globally with various data reception stations and onboard data storage capabilities. Oceansat-2 satellite has unique sensor combination with 8 band electro-optical high sensitive ocean colour monitor (catering to ocean and land) along with Ku band scatterometer to acquire information on ocean winds. INSAT- 3D launched recently provides high resolution 6 band image data in visible, short-wave, mid-wave and long-wave infrared spectrum. It also has 19 band sounder for providing vertical profile of water vapour, temperature, etc. The same system has data relay transponders for acquiring data from weather stations. The payload configurations have gone through significant changes over the years to increase data rate per kilogram of payload. Future Indian remote sensing systems are planned with very high efficient ways of image acquisition. <br><br> This paper analyses the strides taken by ISRO (Indian Space research Organisation) in achieving high efficiency in remote sensing image data acquisition. Parameters related to efficiency of image data acquisition are defined and a methodology is worked out to compute the same. Some of the Indian payloads are analysed with respect to some of the system/ subsystem parameters that decide the configuration of payload. Based on the analysis, possible configuration approaches that can provide high efficiency are identified. A case study is carried out with improved configuration and the results of efficiency improvements are reported. This methodology may be used for assessing other electro-optical payloads or missions and can be extended to other types of payloads and missions.

scholarly journals A review of anatomical, physiological, biological characteristics and uses of Plectranthus neochilus

2020 ◽  
Vol 42 ◽  
pp. e12
Author(s):  
Bruna Piaia Ramborger ◽  
Maria Elisabeth Gomes Paz ◽  
Elton Luiz Gasparoto Denardin ◽  
Jefferson De Jesus Soares ◽  
Rafael Roehrs
Keyword(s):  
Essential Oil ◽  
Respiratory Infections ◽  
Experimental Models ◽  
Traditional Use ◽  
Scientific Databases ◽  
Environmental Resistance ◽  
Biological Character ◽  
The World ◽  
Antischistosomal Activity ◽  
Digestive Disorders

Plectranthus neochilus’ tea is widely used for medicinal purposes like digestive disorders, liver problems, hangover and to a lesser extend, for treating respiratory infections. It is one type of “boldo” used in different corners of the world because it has a year-round growth, easy adaptation and environmental resistance, tolerating intense sun and demanding little manipulation. This review aims to compile the up-to-date information about P. neochilus obtained from scientific databases (ScienceDirect, Springer, Google Scholar and PubMed). The plant was recently identified and differentiated anatomically and microscopically from anothers also called “boldo”. Many compounds were identified in their extracts (aqueous, ethanolic, hexane among others). The most recent studies point out the importance of its essential oil, rich in mono and sesquiterpenes. Some activities presented by these extracts or essencial oil are: antioxidant, insecticidal, antibacterial, antifungal, anticancer and antischistosomal activity. In relation to the non-traditional use of the plant, it is used to promote phytoremediation or to be used in green roof. P. neochilus has versatility use and high valuable biological character therefore, more studies are necessary with more extracts and formulations of their oil in order to verify activities in different experimental models.

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