scholarly journals Effects of Hydrophobic Modifications on the Solution Self-Assembly of P(DMAEMA-co-QDMAEMA)-b-POEGMA Random Diblock Copolymers

Polymers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 338
Author(s):  
Martha Kafetzi ◽  
Stergios Pispas
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Diblock Copolymers ◽  
Raft Polymerization ◽  
Temperature Response ◽  
High Mass ◽  
Alkyl Chains ◽  
Release Studies ◽  
Solution Preparation ◽  
Assembly Behavior

In this work, the synthesis and the aqueous solution self-assembly behavior of novel partially hydrophobically modified poly(2-(dimethylamino) ethyl methacrylate)-b-poly(oligo(ethylelene glycol) methyl ether methacrylatetabel) pH and temperature responsive random diblock copolymers (P(DMAEMA-co-Q6/12DMAEMA)-b-POEGMA), are reported. The chemical modifications were accomplished via quaternization with 1-iodohexane (Q6) and 1-iodododecane (Q12) and confirmed by 1H-NMR spectroscopy. The successful synthesis of PDMAEMA-b-POEGMA precursor block copolymers was conducted by RAFT polymerization. The partial chemical modification of the diblocks resulted in the permanent attachment of long alkyl chains on the amine groups of the PDMAEMA block and the presence of tertiary and quaternary amines randomly distributed within the PDMAEMA block. Light scattering techniques confirmed that the increased hydrophobic character results in the formation of nanoaggregates of high mass and tunable pH and temperature response. The characteristics of the aggregates are also affected by the aqueous solution preparation protocol, the nature of the quaternizing agent and the quaternization degree. The incorporation of long alkyl chains allowed the encapsulation of indomethacin within the amphiphilic diblock copolymer aggregates. Nanostructures of increased size were detected due to the encapsulation of indomethacin into the interior of the hydrophobic domains. Drug release studies demonstrated that almost 50% of the encapsulated drug can be released on demand by aid of ultrasonication.

scholarly journals Complex Self-Assembly Behavior of Bis-hydrophilic PEO-b-PCL-b-PMOXA Triblock Copolymers in Aqueous Solution

2017 ◽  
Vol 50 (18) ◽  
pp. 7155-7168 ◽  
Author(s):  
Evgeniia V. Konishcheva ◽  
Ulmas E. Zhumaev ◽  
Maximilian Kratt ◽  
Valentin Oehri ◽  
Wolfgang Meier
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Assembly Behavior

Synthesis of poly[(decanoic acid)-block-styrene] diblock copolymers and their self-assembly behavior in aqueous medium

2008 ◽  
Vol 57 (4) ◽  
pp. 571-576 ◽  
Author(s):  
Dongshuang Li ◽  
Ke Sha ◽  
Yapeng Li ◽  
Peng Ai ◽  
Xiaotian Liu ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Self Assembly ◽  
Diblock Copolymers ◽  
Decanoic Acid ◽  
Assembly Behavior

Synthesis and self-assembly behavior of POSS-embedded hyperbranched polymers

2015 ◽  
Vol 51 (39) ◽  
pp. 8296-8299 ◽  
Author(s):  
Dawei Li ◽  
Yuguang Niu ◽  
Yanyu Yang ◽  
Xing Wang ◽  
Fei Yang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Hyperbranched Polymers ◽  
Simple Approach ◽  
Morphological Transition ◽  
Assembly Behavior

We demonstrate a simple approach to prepare POSS-embedded hyperbranched amphiphiles, presenting morphological transition from micelle to vesicle in aqueous solution.

scholarly journals On the Aqueous Solution Behavior of C-Substituted 3,1,2-Ruthenadicarbadodecaboranes

Inorganics ◽  
2019 ◽  
Vol 7 (7) ◽  
pp. 91 ◽  
Author(s):  
Marta Gozzi ◽  
Benedikt Schwarze ◽  
Peter Coburger ◽  
Evamarie Hey-Hawkins
Keyword(s):  
Aqueous Solution ◽  
Aqueous Solutions ◽  
Self Assembly ◽  
Self Assembling ◽  
Vis Spectroscopy ◽  
Assembly Behavior ◽  
Biological Performance ◽  
Type 3

3,1,2-Ruthenadicarbadodecaborane complexes bearing the [C2B9H11]2− (dicarbollide) ligand are robust scaffolds, with exceptional thermal and chemical stability. Our previous work has shown that these complexes possess promising anti-tumor activities in vitro, and tend to form aggregates (or self-assemblies) in aqueous solutions. Here, we report on the synthesis and characterization of four ruthenium(II) complexes of the type [3-(η6-arene)-1,2-R2-3,1,2-RuC2B9H9], bearing either non-polar (R = Me (2–4)) or polar (R = CO2Me (7)) substituents at the cluster carbon atoms. The behavior in aqueous solution of complexes 2, 7 and the parent unsubstituted [3-(η6-p-cymene)-3,1,2-RuC2B9H11] (8) was investigated via UV-Vis spectroscopy, mass spectrometry and nanoparticle tracking analysis (NTA). All complexes showed spontaneous formation of self-assemblies (108–109 particles mL−1), at low micromolar concentration, with high polydispersity. For perspective applications in medicine, there is thus a strong need for further characterization of the spontaneous self-assembly behavior in aqueous solutions for the class of neutral metallacarboranes, with the ultimate scope of finding the optimal conditions for exploiting this self-assembling behavior for improved biological performance.

Modeling and self-assembly behavior of PEG–PLA–PEG triblock copolymers in aqueous solution

Nanoscale ◽  
2013 ◽  
Vol 5 (19) ◽  
pp. 9010 ◽  
Author(s):  
Xiaohan Wu ◽  
Suming Li ◽  
Fanny Coumes ◽  
Vincent Darcos ◽  
Joséphine Lai Kee Him ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Assembly Behavior

scholarly journals Synthesis and characteristics of novel azo-based diblock copolymers and their self-assembly behavior via solvents and thermal annealing

e-Polymers ◽  
2017 ◽  
Vol 17 (6) ◽  
pp. 523-535 ◽  
Author(s):  
Athmen Zenati ◽  
Yang-Kyoo Han
Keyword(s):  
Self Assembly ◽  
Nematic Phase ◽  
Weight Control ◽  
Liquid Crystalline ◽  
Diblock Copolymers ◽  
Raft Polymerization ◽  
Gel Permeation Chromatography ◽  
Kinetic Studies ◽  
Morphological Properties ◽  
Scanning Calorimetry

AbstractA series of azo-based diblock copolymers (DBCs) with various compositions were successfully synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization in anisole with PCAEMA-CTA (macro-CTA), DOPAM (new acrylamide monomer) and AIBN (initiator). Kinetic studies on diblock copolymerization manifested a controlled/living manner with good molecular weight control. Structures and properties of monomers and DBCs were determined by 1H nuclear magnetic resonance (NMR), differential scanning calorimetry (DSC) and gel permeation chromatography (GPC). Liquid crystalline (LC) phases and morphological properties were investigated using optical polarizing microscope (OPM), atomic force microscopy (AFM), scanning electron microscopy (SEM) and small-angle X-ray scattering (SAXS). Experimental results demonstrated that the prepared PCAEMA-CTA and DBCs possessed low polydispersity index (≤1.37). All DBCs revealed sharp endothermic transition peaks corresponding to the smectic-to-nematic phase. DBCs with high azo contents showed batonnet textures of the smectic phase whereas DBCs of low azo segments displayed threaded textures of the nematic phase. DBC with 49 wt% of azo side-chains generated a lamellar compared to DBCs with low azo block (≤41 wt%) or non-azo block (≤38 wt%) which produced hexagonal-type nanostructures. In addition, all DBCs exhibited reversible trans-cis photoisomerization behavior under UV irradiation and dark storage at different intervals of time.

Self-assembly behavior of pH- and thermo-responsive hydrophilic ABCBA-type pentablock copolymers synthesized by consecutive RAFT polymerization

RSC Advances ◽  
2013 ◽  
Vol 3 (35) ◽  
pp. 15085 ◽  
Author(s):  
Jiucun Chen ◽  
Mingzhu Liu ◽  
Chunmei Gao ◽  
Shaoyu Lü ◽  
Xinyu Zhang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Raft Polymerization ◽  
Pentablock Copolymers ◽  
Assembly Behavior

scholarly journals A mild and quantitative route towards well-defined strong anionic/hydrophobic diblock copolymers: synthesis and aqueous self-assembly

2019 ◽  
Vol 10 (45) ◽  
pp. 6109-6115
Author(s):  
Anton H. Hofman ◽  
Remco Fokkink ◽  
Marleen Kamperman
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Diblock Copolymers

Well-defined hydrophobic/strong anionic diblock copolymers were synthesized through a protected hydrophobic intermediate. Their self-assembly in aqueous solution was subsequently studied.

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