District of Namaacha in Maputo Province of Mozambique presents a high wind potential, with an average wind speed of around 7.5 m/s and huge open fields that are favourable to the installation of wind farms. However, in order to make better use of the wind potential, it is necessary to evaluate the operating conditions of the turbines and guide the independent power producers (IPPs) on how to efficiently use wind power. The investigation of the wind farm operating conditions is justified by the fact that the implementation of wind power systems is quite expensive, and therefore, it is imperative to find alternatives to reduce power losses and improve energy production. Taking into account the power needs in Mozambique, this project applied hybrid optimisation of multiple energy resources (HOMER) to size the capacity of the wind farm and the number of turbines that guarantee an adequate supply of power. Moreover, considering the topographic conditions of the site and the operational parameters of the turbines, the system advisor model (SAM) was applied to evaluate the performance of the Vestas V82-1.65 horizontal axis turbines and the system’s power output as a result of the wake effect. For any wind farm, it is evident that wind turbines’ wake effects significantly reduce the performance of wind farms. The paper seeks to design and examine the proper layout for practical placements of wind generators. Firstly, a survey on the Namaacha’s electricity demand was carried out in order to obtain the district’s daily load profile required to size the wind farm’s capacity. Secondly, with the previous knowledge that the operation of wind farms is affected by wake losses, different wake effect models applied by SAM were examined and the Eddy–Viscosity model was selected to perform the analysis. Three distinct layouts result from SAM optimisation, and the best one is recommended for wind turbines installation for maximising wind to energy generation. Although it is understood that the wake effect occurs on any wind farm, it is observed that wake losses can be minimised through the proper design of the wind generators’ placement layout. Therefore, any wind farm project should, from its layout, examine the optimal wind farm arrangement, which will depend on the wind speed, wind direction, turbine hub height, and other topographical characteristics of the area. In that context, considering the topographic and climate features of Mozambique, the study brings novelty in the way wind farms should be placed in the district and wake losses minimised. The study is based on a real assumption that the project can be implemented in the district, and thus, considering the wind farm’s capacity, the district’s energy needs could be met. The optimal transversal and longitudinal distances between turbines recommended are 8Do and 10Do, respectively, arranged according to layout 1, with wake losses of about 1.7%, land utilisation of about 6.46 Km2, and power output estimated at 71.844 GWh per year.