scholarly journals Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine)

Toxics ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 251
Author(s):  
Pascal Kintz ◽  
Laurie Gheddar ◽  
Camille Paradis ◽  
Mickael Chinellato ◽  
Alice Ameline ◽  
...  

A 43-year-old male, sport coach, presented him-self at the Emergency unit of a local hospital for epigastric pain, myalgia pain and severe headache. He claimed having used for some days a combination of GW1516 (cardarine), a peroxisome proliferator-activated receptor delta agonist (PPAR- δ) and MK2866 (ostarine), a selective androgen receptor modulator (SARM) to gain skeletal muscles. Cytolysis with marked increase of alanine aminotransferase or ALT (up to 922 UI/L) and aspartate aminotransferase or AST (up to 2558 UI/L) and massive rhabdomyolysis with elevated creatine phosphokinase or CPK (up to 86435 UI/L) were the main unusual biochemistry parameters. Using a specific liquid chromatography coupled to tandem mass spectrometry method, cardarine and ostarine tested positive in blood at 403 and 1 ng/mL, respectively. In urine, due to extensive metabolism, the parent GW1516 was not identified, while ostarine was at 88 ng/mL. Finally, both drugs were identified in hair (2 cm in length, brown in colour), at 146 and 1105 pg/mg for cardarine and ostarine, respectively. This clearly demonstrates repetitive abuse over the last 2 months. Asthenia was persistent for 2 weeks and 6 weeks after the admission, the subject fully recovered.

2011 ◽  
pp. P3-207-P3-207
Author(s):  
Shehzad Basaria ◽  
Lauren Collins ◽  
Melinda Sheffield-Moore ◽  
Edgar L Dillon ◽  
Katie Orwoll ◽  
...  

Endocrinology ◽  
2018 ◽  
Vol 159 (4) ◽  
pp. 1774-1792 ◽  
Author(s):  
Takako Kawanami ◽  
Tomoko Tanaka ◽  
Yuriko Hamaguchi ◽  
Takashi Nomiyama ◽  
Hajime Nawata ◽  
...  

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