Faculty Opinions recommendation of Gene expression during the life cycle of Drosophila melanogaster.

2002 ◽  
Author(s):  
Klaus Mayer
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Life Cycle

scholarly journals Dynamics of Wolbachia pipientis Gene Expression Across the Drosophila melanogaster Life Cycle

2015 ◽  
Vol 5 (12) ◽  
pp. 2843-2856 ◽  
Author(s):  
Florence Gutzwiller ◽  
Catarina R. Carmo ◽  
Danny E. Miller ◽  
Danny W. Rice ◽  
Irene L. G. Newton ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Life Cycle ◽  
Wolbachia Pipientis

Gene Expression During the Life Cycle of Drosophila melanogaster

Science ◽  
2002 ◽  
Vol 297 (5590) ◽  
pp. 2270-2275 ◽  
Author(s):  
M. N. Arbeitman
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Life Cycle

scholarly journals Regulating the UAS/GAL4 system in adultDrosophilawith Tet-off GAL80 transgenes

PeerJ ◽  
2017 ◽  
Vol 5 ◽  
pp. e4167 ◽  
Author(s):  
Taylor Barwell ◽  
Brian DeVeale ◽  
Luc Poirier ◽  
Jie Zheng ◽  
Frederique Seroude ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Life Cycle ◽  
Anatomical Location ◽  
Regulate Gene Expression ◽  
Aging Adult ◽  
Specific Tissue ◽  
Tetracycline Induction ◽  
Age And Sex ◽  
Regulate Gene

The UAS/GAL4 system is the most used method inDrosophila melanogasterfor directing the expression of a gene of interest to a specific tissue. However, the ability to control the temporal activity of GAL4 with this system is very limited. This study constructed and characterized Tet-off GAL80 transgenes designed to allow temporal control of GAL4 activity in aging adult muscles. By placing GAL80 under the control of a Tet-off promoter, GAL4 activity is regulated by the presence or absence of tetracycline in the diet. Almost complete inhibition of the expression of UAS transgenes during the pre-adult stages of the life cycle is obtained by using four copies and two types of Tet-off GAL80 transgenes. Upon treatment of newly emerged adults with tetracycline, induction of GAL4 activity is observed but the level of induction is influenced by the concentration of the inducer, the age, the sex and the anatomical location of the expression. The inhibition of GAL4 activity and the maintenance of induced expression are altered in old animals. This study reveals that the repressive ability of GAL80 is affected by the age and sex of the animal which is a major limitation to regulate gene expression with GAL80 in agedDrosophila.

scholarly journals Comparative approaches to the study of physiology: Drosophila as a physiological tool

2013 ◽  
Vol 304 (3) ◽  
pp. R177-R188 ◽  
Author(s):  
Wendi S. Neckameyer ◽  
Kathryn J. Argue
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Pattern Formation ◽  
Signaling Pathways ◽  
Human Disease ◽  
Cognitive Disorders ◽  
Model System ◽  
Critical Questions ◽  
Developmental Signaling ◽  
Shed Light

Numerous studies have detailed the extensive conservation of developmental signaling pathways between the model system, Drosophila melanogaster, and mammalian models, but researchers have also profited from the unique and highly tractable genetic tools available in this system to address critical questions in physiology. In this review, we have described contributions that Drosophila researchers have made to mathematical dynamics of pattern formation, cardiac pathologies, the way in which pain circuits are integrated to elicit responses from sensation, as well as the ways in which gene expression can modulate diverse behaviors and shed light on human cognitive disorders. The broad and diverse array of contributions from Drosophila underscore its translational relevance to modeling human disease.

Regulation of tubulin gene expression during embryogenesis in drosophila melanogaster

Cell ◽  
1982 ◽  
Vol 28 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Elizabeth C. Raff ◽  
Margaret T. Fuller ◽  
Thomas C. Kaufman ◽  
Kenneth J. Kemphues ◽  
Jane E. Rudolph ◽  
...  
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Tubulin Gene
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