Faculty Opinions recommendation of Functional characterization of a novel promoter element required for an innate immune response in Drosophila.

2003 ◽  
Author(s):  
Laurence Rahme
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Functional Characterization ◽  
Innate Immune ◽  
Promoter Element

scholarly journals Functional Characterization of a Novel Promoter Element Required for an Innate Immune Response in Drosophila

2003 ◽  
Vol 23 (22) ◽  
pp. 8272-8281 ◽  
Author(s):  
Hanna Uvell ◽  
Ylva Engström
Keyword(s):  
Gene Expression ◽  
Antimicrobial Peptide ◽  
Functional Characterization ◽  
Binding Activity ◽  
Innate Immune ◽  
Site Directed Mutagenesis ◽  
Promoter Element ◽  
Peptide Gene ◽  
Inducible Genes

ABSTRACT Innate immune reactions are crucial processes of metazoans to protect the organism against overgrowth of faster replicating microorganisms. Drosophila melanogaster is a precious model for genetic and molecular studies of the innate immune system. In response to infection, the concerted action of a battery of antimicrobial peptides ensures efficient killing of the microbes. The induced gene expression relies on translocation of the Drosophila Rel transcription factors Relish, Dif, and Dorsal to the nucleus where they bind to κB-like motifs in the promoters of the inducible genes. We have identified another putative promoter element, called region 1 (R1), in a number of antimicrobial peptide genes. Site-directed mutagenesis of the R1 site diminished Cecropin A1 (CecA1) expression in transgenic Drosophila larvae and flies. Infection of flies induced a nuclear R1-binding activity that was unrelated to the κB-binding activity in the same extracts. Although the R1 motif was required for Rel protein-mediated CecA1 expression in cotransfection experiments, our data argue against it being a direct target for the Drosophila Rel proteins. We propose that the R1 and κB motifs are targets for distinct regulatory complexes that act in concert to promote high levels of antimicrobial peptide gene expression in response to infection.

scholarly journals Baseline and innate immune response characterization of a Zfp30 knockout mouse strain

2020 ◽  
Vol 31 (7-8) ◽  
pp. 205-214
Author(s):  
Lucas T. Laudermilk ◽  
Adelaide Tovar ◽  
Alison K. Homstad ◽  
Joseph M. Thomas ◽  
Kathryn M. McFadden ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Mouse Strain ◽  
Knockout Mouse ◽  
Innate Immune

Characterization of the innate immune response in a novel murine model mimicking bronchopulmonary dysplasia

2020 ◽  
Author(s):  
Chanèle Cyr-Depauw ◽  
Maria Hurskainen ◽  
Arul Vadivel ◽  
Ivana Mižíková ◽  
Flore Lesage ◽  
...  
Keyword(s):  
Immune Response ◽  
Bronchopulmonary Dysplasia ◽  
Innate Immune Response ◽  
Murine Model ◽  
Innate Immune

scholarly journals Characterization of the adaptive and innate immune response to intravenous oncolytic reovirus (Dearing type 3) during a phase I clinical trial

Gene Therapy ◽  
2008 ◽  
Vol 15 (12) ◽  
pp. 911-920 ◽  
Author(s):  
C L White ◽  
K R Twigger ◽  
L Vidal ◽  
J S De Bono ◽  
M Coffey ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Immune Response ◽  
Phase I ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Phase I Clinical Trial ◽  
Type 3

scholarly journals Characterization of Amphioxus IFN Regulatory Factor Family Reveals an Archaic Signaling Framework for Innate Immune Response

2015 ◽  
Vol 195 (12) ◽  
pp. 5657-5666 ◽  
Author(s):  
Shaochun Yuan ◽  
Tingting Zheng ◽  
Peiyi Li ◽  
Rirong Yang ◽  
Jie Ruan ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Regulatory Factor

Characterization of NODs and TLRs in innate immune response of human cementoblast cells

Oral Diseases ◽  
2012 ◽  
Vol 19 (4) ◽  
pp. 374-380 ◽  
Author(s):  
MY Ahn ◽  
H-E Yoon ◽  
J-H Park ◽  
J Lee ◽  
S-K Min ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Innate Immune
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